Frontiers in Pediatrics最新文献

{"title":"Measuring attraction to screen devices in early childhood: development of the Affinity-TV and Affinity-Mobile scales.","authors":"Darcy A Thompson, Laura K Kaizer, Sarah J Schmiege, Natasha J Cabrera, Lauren Clark, Haley Ringwood, Estefania Miramontes Valdes, Jeanne M Tschann","doi":"10.3389/fped.2025.1496225","DOIUrl":"10.3389/fped.2025.1496225","url":null,"abstract":"<p><strong>Introduction: </strong>With the increasing integration of digital screen devices into our everyday life, there has been increased attention regarding the risk of \"problematic\" use or pathological use. Because children start using screen devices in the first few years of life, early identification of those at risk for future problematic use could inform early prevention efforts. Children's attraction to screen devices in early childhood may identify those at risk for future problematic use; however currently, there are no measures of toddlers' attraction or affinity to screen devices. The objective of this study was to develop survey measures of toddler affinity to screen media, inclusive of televisions, smartphones, and tablets.</p><p><strong>Methods: </strong>Measures were developed using an exploratory sequential mixed methods (qualitative -> quantitative) approach. Participants were Mexican American mothers of toddlers 15-26 months old. Findings from semi-structured interviews were used to develop items reflecting parental reports of child affinity to screen devices. Items were administered by phone to 384 mothers. Analyses included evaluation of the factor structure and psychometric properties of Affinity-TV (10 items) and Affinity-Mobile (12 items), and evaluations of correlations between each scale with social emotional outcomes and demographic characteristics.</p><p><strong>Results: </strong>Factor analysis supported a one-factor solution for each scale. Reliabilities were acceptable for both scales (Cronbach's alpha > .75). There was a significant positive correlation between Affinity-TV and Affinity-Mobile (rs = 0.44, <i>p</i> < 0.001). Affinity-TV was significantly positively correlated with toddler average daily minutes of TV use (rs = 0.27, <i>p</i> < 0.001) and average daily minutes of mobile use (rs = 0.10, <i>p</i> < 0.05). Affinity-Mobile was significantly positively correlated with toddler average daily minutes of mobile use (rs = 0.31, <i>p</i> < 0.001), but not with average daily minutes of TV (rs = -0.04, NS). Each scale was correlated with social emotional developmental outcomes.</p><p><strong>Discussion: </strong>The Affinity-TV and Affinity-Mobile scales have good initial reliability and adequate predictive validity. These findings support the use of Affinity-TV and Affinity-Mobile in toddlers as measures of children's attraction to screen devices. These measures may help to identify early risk for problematic use, and they offer a novel way to evaluate a child's behavioral reaction to screen devices in early childhood.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1496225"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of risks in child development in Spanish-speaking countries: content validity.","authors":"Luis Felipe Llanos, María Martínez de Anguita","doi":"10.3389/fped.2025.1444104","DOIUrl":"10.3389/fped.2025.1444104","url":null,"abstract":"<p><strong>Introduction: </strong>Early detection of developmental disorders like ADHD, ASD, and LD is critical for improving educational outcomes and enabling timely interventions. This study aimed to develop a reliable, practical screening scale for Spanish-speaking children entering primary education, addressing gaps in early identification within the region.</p><p><strong>Methods: </strong>In total, 151 items were identified. With a qualitative methodology and with the help of 18 specialists in child therapy from various Spanish-speaking countries, stabilized content validity. The analysis was articulated in its aspects of relevance.</p><p><strong>Results: </strong>The validation process identified 18 items with strong psychometric properties. These items demonstrated high levels of agreement among experts and strong content validity, forming the foundation for a culturally relevant screening tool. The scale is designed to identify developmental risks early and support timely interventions in educational and clinical settings.</p><p><strong>Discussion: </strong>The study underscores the importance of efficient screening tools for primary education, especially in regions with limited access to early childhood education. Future research will validate the scale in larger, diverse samples to ensure its reliability, establish cutoff points, and confirm its generalizability across Spanish-speaking contexts.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1444104"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of children with severe preschool asthma prior to starting the TIPP study.","authors":"S Zielen, J Wosniok, N Wollscheid, T Nickolay, C Grimmel, D Scheele, F Sattler, F Prenzel, M Lorenz, B Schaub, C Lex, M Dahlheim, J Trischler, H Donath, S Lau, E Hamelmann, C Vogelberg, M Gerstlauer, M Wetzke, R Schubert, L Schollenberger, M Gappa","doi":"10.3389/fped.2025.1558256","DOIUrl":"10.3389/fped.2025.1558256","url":null,"abstract":"<p><strong>Objective: </strong>Children with preschool asthma suffer disproportionally more often from severe asthma exacerbations with emergency visits and hospital admissions than school children. However, there are only a few reports on characteristics, hospitalization, phenotypes and symptoms in this age cohort.</p><p><strong>Patients and methods: </strong>This analysis of an ongoing prospective trial of Tiotropium bromide in preventing severe asthma exacerbations (the TIPP study) assessed baseline characteristics, hospitalizations and symptoms in 100 children with severe preschool asthma. Children aged 1-5 years were analyzed at study enrollment and daily symptoms were recorded by an electronic diary [Pediatric Asthma Caregiver Diary (PACD)] for the following four weeks until randomization.</p><p><strong>Results: </strong>At enrollment, the total number of severe asthma exacerbations, defined as three days systemic steroid use or hospitalization in the last 24 months, was mean (±SD) 5.8 ± 5.7 and the test for respiratory and asthma control in kids (TRACK) was mean 46.9 ± 19.0. Daily recording of symptoms by the PACD revealed that only 7 patients were controlled at randomization, whereas 35 were partially and 58 were uncontrolled according to GINA.</p><p><strong>Conclusion: </strong>Despite protective therapy with inhaled corticosteroids (ICS), most children of this severe asthma cohort were only partially or uncontrolled according to GINA guidelines.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1558256"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professional benefits perception among pediatric nurses: a cross-sectional survey.","authors":"Jia Wang, Hui Wang, Xiuli Chen, Yu Sheng","doi":"10.3389/fped.2025.1539376","DOIUrl":"10.3389/fped.2025.1539376","url":null,"abstract":"<p><strong>Background: </strong>The perception of professional benefits is a critical determinant of job stability and work efficacy among healthcare professionals. This perception can directly influence patient care quality, nurse job satisfaction and retention, as well as overall organizational efficiency. The current understanding of how pediatric nurses perceive their professional benefits is limited. This study aimed to elucidate the status and determinants of professional benefit perception among pediatric nurses to inform evidence-based clinical care.</p><p><strong>Methods: </strong>We conducted a survey of pediatric nurses at our hospital from September 1, 2024, to November 26, 2024. Participants were selected using a convenience sampling method. The Nurses' Professional benefit perception Scale was employed to assess professional benefit perception. Pearson correlation and multiple linear regression analyses were utilized to identify factors influencing professional benefit perception. These statistical methods were chosen due to their suitability for examining relationships between continuous variables and for controlling potential confounding factors in the regression model.</p><p><strong>Results: </strong>A total of 366 pediatric nurses participated in the study. The mean score of professional benefit perception was (108.26 ± 17.32). Pearson correlation analysis revealed significant positive associations between professional benefit perception scores and several demographic and professional variables. Specifically, age (<i>r</i> = 0.517), years of experience in pediatric nursing (<i>r</i> = 0.604), educational level (<i>r</i> = 0.564), professional title (<i>r</i> = 0.559), marital status (<i>r</i> = 0.623), and average monthly income (<i>r</i> = 0.647) were all significantly correlated with professional benefit perception scores. Further analysis using multiple linear regression identified these variables as significant predictors of professional benefit perception scores, collectively accounting for 57.20% of the variance (<i>R</i>² = 0.572). This indicates that a substantial portion of the variation in professional benefit perception can be explained by these demographic and professional factors.</p><p><strong>Conclusion: </strong>The perceived level of professional benefits among pediatric nurses is found to be moderate. It is recommended that nursing administrators develop targeted intervention strategies based on the identified influencing factors. Such strategies may include enhancing professional development opportunities, improving financial compensation, and fostering a supportive work environment.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1539376"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of team-building sports games on the resilience of Chinese rural children: evidence from Nanxian county, Hunan province.","authors":"Bo Liu, Jizhi You, Yunxiang Fan, Yunping Xia, Hui Wang, Xiang Zhang, Yang Zhang","doi":"10.3389/fped.2025.1552597","DOIUrl":"10.3389/fped.2025.1552597","url":null,"abstract":"<p><strong>Purpose: </strong>Participation in competitive sports has been shown to enhance children's mental health. However, evidence regarding the impact of group sports within traditional physical education on children's mental development is scarce. This study designed a team-building-focused physical education program and examined its effects on the resilience of rural students.</p><p><strong>Methods: </strong>A total of 86 rural elementary school students (mean age: 11 years) were cluster-randomized into the intervention and control groups. Both groups participated in regular physical education classes three times per week. In the intervention group, the first 15-min warm-up period was replaced with sports games. From a social perspective, all games subtly encourage children to forge new social relationships by engaging in physical contact, interacting with new team members, and collaborating to achieve shared goals in a sportsmanlike manner. Resilience was assessed using the Resilience Scale for Chinese Adolescents before and after the 12-week intervention.</p><p><strong>Results: </strong>After 12 weeks, the intervention group showed significant improvements in affect control, positive thinking, and help-seeking compared to the control group. Overall, both the individual and supportive dimensions of resilience improved following participation in team-building sports games.</p><p><strong>Conclusions: </strong>Whether winning or losing as a team member, these experiences positively enhance children's emotional regulation, their understanding of their social roles within a team, and the development of help-seeking and concern for a distressed other. As a result, children may build new and broader social connections that extend beyond the physical education class, fostering a sportsmanlike civic virtue in their daily lives.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1552597"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of bundled care interventions in improving outcomes for pediatric patients with congenital heart disease: a retrospective clinical evaluation.","authors":"Li Zhang, Yu-Ting Song","doi":"10.3389/fped.2025.1525020","DOIUrl":"10.3389/fped.2025.1525020","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) in pediatric patients requires comprehensive care to address complex medical and psychological needs. Traditional approaches may lack the structure and coordination to optimize recovery fully. This study evaluates the association of Bundled Care Interventions, a structured multidisciplinary approach, in improving clinical outcomes and quality of life in pediatric CHD patients.</p><p><strong>Materials and methods: </strong>A retrospective evaluation was conducted at our hospital from January 2021 to December 2023. Pediatric patients (<i>n</i> = 136) under 14 years of age diagnosed with CHD were included, with 70 receiving Bundled Care Interventions (observation group) and 66 receiving conventional care (control group). The bundled care model included preoperative education, optimized intraoperative management, personalized postoperative rehabilitation, home-based care, and medication management. Primary outcome measures included oxygenation status, quality of life, adverse events, and complications. Statistical analyses were performed using independent <i>t</i>-tests and chi-square tests.</p><p><strong>Results: </strong>Patients in the Bundled Care Interventions group showed significant improvements in oxygenation (PaO₂ and FiO₂; <i>p</i> < 0.001) and quality of life across all dimensions (<i>p</i> < 0.001) compared to the control group. Additionally, adverse event incidence was lower in the observation group (4.29% vs. 15.2%; <i>p</i> = 0.031), as was the incidence of postoperative complications (5.71% vs. 18.2%; <i>p</i> = 0.024).</p><p><strong>Conclusions: </strong>Bundled Care Interventions might improve oxygenation levels, enhance quality of life, and reduce adverse events and complications in pediatric CHD patients. This structured, multidisciplinary approach could offer a promising model for optimizing clinical outcomes and supporting comprehensive rehabilitation in this vulnerable population.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1525020"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal autoimmune diseases and the risk of tics and Tourette's disorder in offspring: insights from Taiwan's real-world data.","authors":"Yi-Feng Lee, Meng-Che Wu, Yen-Chu Huang, Jing-Yang Huang, James Cheng-Chung Wei","doi":"10.3389/fped.2025.1440366","DOIUrl":"10.3389/fped.2025.1440366","url":null,"abstract":"<p><strong>Background: </strong>Currently, tics and Tourette's disorder are burdensome neurological disorders that manifest in vocal and motor tics with onset during childhood. Previous studies have demonstrated that maternal autoimmune diseases may cause several neurodevelopmental disorders in offspring via maternal immune activation. However, the association between them has never been thoroughly researched. Thus, in this study, we aimed to explore whether maternal autoimmune diseases are associated with the risk of tics and Tourette's disorder in offspring in a real-world nationwide population-based cohort study.</p><p><strong>Methods: </strong>We analyzed offspring with or without autoimmune disease exposure between 2009 and 2016 from national population databases in Taiwan. Multivariate analysis, multiple Cox regression analyses, and stratified analyses were conducted in the study.</p><p><strong>Results: </strong>In total, 76,411 offspring with autoimmune disease exposure and 1,211,936 offspring without maternal autoimmune disease exposure were selected and analyzed in this study. The incidence of childhood tics and Tourette's disorder was 2.35 [95% confidence interval (CI) 2.23-4.86] and 1.89 (95% CI 1.86-1.92) per 10,000 person-months in children exposed to maternal autoimmune disease and non-exposed children, respectively. The children whose mothers had an autoimmune disease had a 1.26-fold risk of tics and Tourette's disorder compared to children whose mothers did not have an autoimmune disease [crude hazard ratio: 1.26; 95% CI, 1.20-1.34, adjusted hazard ratio (aHR): 1.22; 95% CI, 1.15-1.29]. Offspring of mothers with rheumatoid arthritis (aHR: 1.46, 95% CI, 1.07-1.97), system lupus erythematosus (aHR: 1.57, 95% CI, 1.18-2.09), Sjogren's syndrome (aHR: 1.28, 95% CI, 1.09-1.50), ankylosing spondylitis (aHR: 1.49, 95% CI, 1.07-2.09), Graves' disease (aHR: 1.26, 95% CI, 1.15-1.37), Hashimoto's thyroiditis (aHR: 1.59, 95% CI, 1.29-1.98), and type I diabetes (aHR: 1.68, 95% CI, 1.13-2.50) had a significantly higher risk of developing tics and Tourette's disorder. Aside from maternal autoimmune diseases, mothers with urinary tract infections, diabetes mellitus, hyperlipidemia, anemia, a sleep disorder, endometriosis, and depression were also associated with childhood tics and Tourette's disorder.</p><p><strong>Conclusion: </strong>Maternal autoimmune diseases appeared to be associated with tics and Tourette's disorder in offspring, especially in mothers with the abovementioned diseases. Further research is warranted to investigate the possible pathogenetic mechanisms of these associations.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1440366"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Late coronary complication of Kawasaki disease.","authors":"Inès Bucher, Stéphane Cook, Amel Brahim Mathiron","doi":"10.3389/fped.2025.1527714","DOIUrl":"10.3389/fped.2025.1527714","url":null,"abstract":"<p><p>Kawasaki disease, a common cause of acquired heart disease in children, can lead to long-term cardiovascular complications such as coronary aneurysms and stenosis. This case describes a 17-year-old male with a past medical history of Kawasaki disease at ages 3 and 8, treated with IV immunoglobulin leading to a moderate right coronary aneurysm, who presented for a cardiac check-up. He reports only a slight dyspnoea on exertion and atypical chest pain. Despite normal findings on routine ECG and exercise tests, advanced imaging revealed significant coronary stenosis requiring angioplasty. This highlights the limitations of standard diagnostic modalities and underscores the importance of multimodal imaging and tailored management strategies in such patients.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1527714"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical thyroid manifestation in Cowden disease: a case report and literature review.","authors":"Marion Garcia, Isabelle Oliver Petit, Camille Franchet, Olivier Abbo, Audrey Cartault, Frédérique Savagner","doi":"10.3389/fped.2025.1499664","DOIUrl":"10.3389/fped.2025.1499664","url":null,"abstract":"<p><strong>Background: </strong>Cowden syndrome (CS) is a complex and rare hereditary disorder characterized by a high risk of developing both benign and malignant tumors. Germline variants in the <i>PTEN</i> gene lead to this autosomal dominant syndrome, which predisposes individuals to lesions of the skin and mucous membranes, as well as breast, thyroid, endometrial, and kidney cancers. Early identification of symptoms is essential for implementing effective therapeutic strategies, especially in managing thyroid cancer risk.</p><p><strong>Case presentation: </strong>During a tonsillectomy in an 8-year-old boy, the surgeon incidentally noted a left lateralized thyroid swelling. The clinical picture of Cowden syndrome was further supported by the presence of macrocephaly and intellectual disability since birth along with rare and atypical thyroid disorder marked by a toxic adenoma. Genetic analysis of both the tissue and blood samples confirmed the diagnosis. The clinical manifestation of thyroid issues in a young child may indicate CS, a condition that is often poorly assessed by clinicians. Family history revealed that the boy's father and sister also carry the same heterozygous variant, presenting a spectrum of Cowden syndrome manifestations.</p><p><strong>Conclusion: </strong>Molecular analysis of the <i>PTEN</i> gene should be considered in young patients with thyroid nodules or nodules associated with abnormal thyroid function test, even without clear evidence of Cowden syndrome, particularly if there is a family history of thyroid, breast, or hamartoma-related conditions.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1499664"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Siblings with neonatal lupus erythematosus.","authors":"Pengyue Tang, Huan Zhang, Ping Li","doi":"10.3389/fped.2025.1518881","DOIUrl":"10.3389/fped.2025.1518881","url":null,"abstract":"<p><p>Neonatal lupus erythematosus (NLE) is a rare autoimmune disorder characterized by cutaneous and/or cardiac manifestations resulting from the transplacental passage of maternal antibodies, including anti-SSA/Ro, anti-SSB/La, and occasionally anti-U1RNP. This report describes two siblings with distinct NLE presentations, emphasizing the importance of early diagnosis and management, particularly in light of the rising rates of multiple births. A 15-day-old girl (Case 1) presented with classic annular skin lesions and strongly positive SSA and SSB antibodies. Six years later, her brother (Case 2) developed atypical red papules with similar serologic findings. Their mother, diagnosed with Sjögren's syndrome after the first child's (Case 1) presentation, demonstrated suboptimal treatment adherence, which may have contributed to the occurrence of NLE in her second child (Case 2). Neither sibling exhibited systemic involvement, including cardiac manifestations; however, regular monitoring remains essential. These cases highlight the variable NLE phenotype, even within families. In pregnancies with SSA/SSB antibody positivity, close monitoring of antibody titers, electrocardiograms (ECGs), and echocardiograms is paramount for early NLE detection and optimal management, especially given inconsistent maternal treatment. These cases underscore the need for heightened vigilance and proactive strategies in high-risk pregnancies.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1518881"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}