Frontiers in Pediatrics最新文献

{"title":"Evaluation of phenol treatment for pilonidal sinus in adolescents.","authors":"Ayten Başak Kılıç, Merve Nur Muti Acar, Sinan Kılıç, Gülşen Ekingen","doi":"10.3389/fped.2025.1595749","DOIUrl":"10.3389/fped.2025.1595749","url":null,"abstract":"<p><strong>Objective: </strong>Pilonidal sinus disease (PSD) is chronic condition predominantly affecting adolescents, often associated with risk factors such as obesity, poor hygiene, and prolonged sitting. Minimally invasive treatments like phenol procedure have gained attention as alternatives to traditional surgical methods due to their simplicity and potential for shorter recovery. This study aims to evaluate the efficacy and safety of phenol procedure in adolescents with pilonidal sinus, focusing on success rates, recurrence, and complications.</p><p><strong>Material and method: </strong>Total number of 28 adolescent patients with non-complicated PSD were included in this retrospective study.</p><p><strong>Results: </strong>This study included 28 adolescent patients (mean age: 15.04 ± 1.40 years), of which 60.7% were female. A total of 46.4% of the patients presented with a single sinus opening, while 53.6% had multiple sinus openings. Phenol procedure was administered with a mean of 3.32 ± 1.49 courses, resulting in complete healing in 75.0% of patients and an overall success rate of 82.1% after pre- or post-surgical procedure. Complications were observed in 14.3% of cases, while recurrence occurred in 21.4%. Persistent discharge was reported in 7.1% of patients, necessitating surgical excision.</p><p><strong>Conclusions: </strong>Our findings support that phenol treatment is a safe and effective minimally invasive approach for managing pilonidal sinus, demonstrating success rates comparable to conventional surgical methods. Furthermore, phenol procedure offers notable advantages, including preservation of tissue integrity, ease of implementation, and reduced recovery times, rendering it particularly advantageous for adolescent patients.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1595749"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the rare disease paediatric clinical trial availabilities in Europe.","authors":"Eva Degraeuwe, Mark A Turner, Ricardo M Fernandes, Ann Raes, Johan Vande Walle, Franz Schaefer","doi":"10.3389/fped.2025.1523847","DOIUrl":"10.3389/fped.2025.1523847","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence and complexity of rare diseases (RDs) require concerted efforts in research and clinical trial capabilities. This paper aims to map the clinical trial sites within the Collaborative Network for European Clinical Trials for Children (conect4children, c4c) consortium and the European Reference Networks for Rare Diseases (ERNs), assessing their potential overlap and opportunities for synergies to optimize the selection and preparedness of sites for paediatric RD clinical trials.</p><p><strong>Method: </strong>A quantitative cross-mapping analysis was performed with publicly available data from ERN and c4c sites across 19 countries, complemented by information on paediatric site capabilities through interviews with network coordinators. Site analyses were done at country and setting levels. Heatmaps and an interactive matrix tool were developed using RStudio (v2023.12.0).</p><p><strong>Results: </strong>The highest overlap between ERN and c4c networks is found in the Netherlands, Belgium, Sweden, Denmark, and the Czech Republic, indicating strong integration in these regions, while Nordic (Sweden and Denmark), Eastern, and Southern European countries show varying levels of overlap. The median proportion of regional sites to University sites is 0.05 (IQR 0.12) across ERNs and 0.25 (IQR 0.37) across c4c national networks. The matrix tool can identify overlap and its absence for both university and regional hospitals, enhancing the preparedness and reach of paediatric rare disease trials. ERN representatives confirm the heatmap and matrix tool's utility in improving site selection and fostering network cooperation.</p><p><strong>Conclusion: </strong>Heatmap analyses reveal a significant but incomplete overlap of RD clinical trial sites between ERNs and c4c in parts of Europe, suggesting strong potential for cross-network collaboration to enhance paediatric RD trial recruitment and outcomes.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1523847"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a machine learning based prognostic prediction model for children with traumatic brain injury.","authors":"Yongwei Wei, Jiandong Wang, Yu Su, Fan Zhou, Huaili Wang","doi":"10.3389/fped.2025.1581945","DOIUrl":"10.3389/fped.2025.1581945","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to establish a prediction model for the short-term prognosis of children with traumatic brain injury (TBI) using machine learning algorithms.</p><p><strong>Methods: </strong>The clinical data of children with TBI who were treated in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. All children were divided into a modeling group and a validation group. In the laboratory indicators of the modeling group, the least absolute shrinkage and selection operator (LASSO) and multivariate Logistic regression analysis were used to screen out the independent influencing factors of poor prognosis in TBI, and a laboratory indicator model (LIM) was established. The risk scores of all patients were calculated. Then, the risk scores and other indicators were used to construct an extended prediction model through the extreme gradient boosting (XGBoost) algorithm. The discrimination, calibration, and clinical utility of the model were evaluated, and the extended model was explained using SHAP analysis. Finally, a subgroup analysis was performed using the risk scores to assess the robustness of the laboratory indicator model.</p><p><strong>Results: </strong>Among the laboratory indicators, lactate dehydrogenase (LDH), N-terminal pro-B-type natriuretic peptide (NT-proBNP), hydrogen ion concentration index (pH), hemoglobin (Hb), serum albumin (Alb), and C-reactive protein to albumin ratio (CRP/Alb) were the independent influencing factors for the prognosis of children with brain injury. The extended model demonstrated excellent predictive performance in both the modeling and validation populations. SHAP analysis showed the contribution values of the Glasgow Coma Scale (GCS), the laboratory indicator model, the location of the head hematoma, the pupillary light reflex, and the injury severity score in the prediction of the overall patient prognosis. The subgroup analysis showed that there were differences in the risk scores of children with different GCS scores, pupillary light reflexes, and head hematoma locations, and there were also differences in the prognosis between the high-risk score group and the low-risk score group within them.</p><p><strong>Conclusion: </strong>The extended model can accurately predict the prognosis of TBI patients and has strong clinical utility. The core model has good stratification ability and provides an effective risk stratification and personalized patient management tool for clinicians.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1581945"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CPAP caps are associated with restricted head growth and altered skull morphology in newborn infants.","authors":"Sebastian Jacob, Nancy Wetzel, Annett Bläser, Ulrich Herbert Thome, Rudolf Georg Ascherl","doi":"10.3389/fped.2025.1514853","DOIUrl":"10.3389/fped.2025.1514853","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Continuous positive airway pressure (CPAP) devices for preterm infants are commonly affixed using snug-fitting caps. Monitoring of head growth is standard practice in preterm infants, as stagnant head growth has been associated with impaired neurodevelopmental outcome. However, a stagnant head circumference may not mean stagnant head growth since vertical head distortion has been repeatedly observed. Previously established centiles for ear-to-ear distances and head volume indices allow the evaluation of three-dimensional head growth. We hypothesized that CPAP duration may be associated with restricted head circumference gain, altered skull morphology, and possibly neurodevelopment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;All 4590 infants treated with CPAP in the neonatal wards of Leipzig University Medical Center between 2009 and 2020 were included in our study. Body weight, body length, occipitofrontal head circumference (OFC), and transvertical (vEED) and transfontanellar ear-to-ear (fEED) distances were measured repeatedly. Head eccentricity (ECC) (a measure of disproportional head growth) and head volume indices (HVI) were calculated. Anthropometric data were z-transformed. A total of 367 infants were followed up for assessment of neurodevelopmental outcomes using the Bayley Scales of Infant and Toddler Development (third edition). Associations between cumulative cap time and anthropometric data were examined using unconditional growth models with linear mixed effects. Associations between head growth development and neurodevelopmental outcome were examined by correlating individual regression slopes of anthropometric data with Bayley scores.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Cumulative cap time was negatively associated with z-scores of OFC ( &lt;math&gt;&lt;mi&gt;β&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;1.32&lt;/mn&gt; &lt;mo&gt;×&lt;/mo&gt; &lt;msup&gt;&lt;mn&gt;10&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msup&gt; &lt;/math&gt; , &lt;math&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;mo&gt;&lt;&lt;/mo&gt; &lt;mn&gt;0.005&lt;/mn&gt;&lt;/math&gt; ), vEED ( &lt;math&gt;&lt;mi&gt;β&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;6.65&lt;/mn&gt; &lt;mo&gt;×&lt;/mo&gt; &lt;msup&gt;&lt;mn&gt;10&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;3&lt;/mn&gt;&lt;/mrow&gt; &lt;/msup&gt; &lt;/math&gt; , &lt;math&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;mo&gt;&lt;&lt;/mo&gt; &lt;mn&gt;0.005&lt;/mn&gt;&lt;/math&gt; ], fEED ( &lt;math&gt;&lt;mi&gt;β&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;1.05&lt;/mn&gt; &lt;mo&gt;×&lt;/mo&gt; &lt;msup&gt;&lt;mn&gt;10&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;3&lt;/mn&gt;&lt;/mrow&gt; &lt;/msup&gt; &lt;/math&gt; , &lt;math&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;mo&gt;&gt;&lt;/mo&gt; &lt;mn&gt;0.05&lt;/mn&gt;&lt;/math&gt; ), and HVI ( &lt;math&gt;&lt;mi&gt;β&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;1.59&lt;/mn&gt; &lt;mo&gt;×&lt;/mo&gt; &lt;msup&gt;&lt;mn&gt;10&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msup&gt; &lt;/math&gt; , &lt;math&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;mo&gt;&lt;&lt;/mo&gt; &lt;mn&gt;0.005&lt;/mn&gt;&lt;/math&gt; ), while it was positively associated with ECC ( &lt;math&gt;&lt;mi&gt;β&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mn&gt;5.18&lt;/mn&gt; &lt;mo&gt;×&lt;/mo&gt; &lt;msup&gt;&lt;mn&gt;10&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt;-&lt;/mo&gt; &lt;mn&gt;3&lt;/mn&gt;&lt;/mrow&gt; &lt;/msup&gt; &lt;/math&gt; , &lt;math&gt;&lt;mi&gt;p&lt;/mi&gt; &lt;mo&gt;&lt;&lt;/mo&gt; &lt;mn&gt;0.005&lt;/mn&gt;&lt;/math&gt; ). Individual OFC z-score slopes show low correlation with cognition (&lt;i&gt;R&lt;/i&gt; = 0.07), language (&lt;i&gt;R&lt;/i&gt; = 0.06), and motor (&lt;i&gt;R&lt;/i&gt; = 0.01) Bayley scores. Individual vEED z-scores slopes s","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1514853"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a novel reprocessed bCPAP system on sepsis rates among preterm neonates with respiratory distress: a randomized controlled trial.","authors":"Sarah Badin, Navid Roodaki, Daisy Evangeline C Garcia, Rochelle Abila-Cariaga, Thomas F Burke","doi":"10.3389/fped.2025.1569437","DOIUrl":"10.3389/fped.2025.1569437","url":null,"abstract":"<p><strong>Introduction: </strong>Bubble CPAP (bCPAP) is highly effective in the treatment of respiratory distress syndrome of prematurity and other causes of newborn respiratory insufficiency. To overcome barriers to bCPAP access a novel system was developed that is designed to be cleaned, disinfected, and reused. This study evaluated whether use of reprocessed bCPAP systems increases the rate of sepsis in neonates.</p><p><strong>Methods: </strong>A <i>post hoc</i> analysis of a single-center randomized controlled trial (registration no. NCT06082674) was conducted that compared mechanical ventilator driven CPAP devices (MV-CPAP) with single-use circuits to reusable bCPAP systems that were cleaned and disinfected after each use. The primary outcome was a composite of treatment escalation or death.</p><p><strong>Results: </strong>Seventy-five neonates were randomized to the two CPAP treatment arms. No significant differences in death (5 vs. 4), escalation of care (10 vs. 9), and the composite outcome (OR = 0.84; 95% CI: 0.30-2.35, <i>p</i> = 0.743) were detected in the MV-CPAP and bCPAP groups respectively. There were no clinically significant differences in any of the secondary outcomes.</p><p><strong>Discussion: </strong>Use of a reprocessed bCPAP system designed to increase global access to CPAP did not increase rates of neonatal sepsis.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, identifier, (NCT06082674).</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1569437"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on human adenovirus sepsis.","authors":"Wei Jianhua, Zeng Lingjian, Huang Yanhao, Liao Jing, Liu Enmei, Zang Na","doi":"10.3389/fped.2025.1552958","DOIUrl":"10.3389/fped.2025.1552958","url":null,"abstract":"<p><p>Human adenovirus is a significant viral pathogen causing lower respiratory tract infections in children, prone to developing into severe pneumonia and systemic inflammation with a high mortality rate, especially in immunocompromised children, drawing widespread attention worldwide. Sepsis, a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection, has historically been focused on bacterial origins. However, nearly all viruses can cause sepsis, which is often underestimated in clinical settings. In recent years, severe infections and even sepsis caused by adenovirus have shown a trend of periodic outbreaks. Early diagnosis of adenovirus-induced sepsis can not only prevent the overuse of broad-spectrum antibiotics but also ensure that patients receive timely and appropriate antiviral treatment. This article aims to provide a comprehensive review of the epidemiology, pathogenesis, diagnostic methods, and recent advances in treatment strategies for viral sepsis caused by adenovirus.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1552958"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rationale of using angiotensin receptor blocker instead of pulmonary vasodilators to treat pulmonary hypertension in bronchopulmonary dysplasia: a case report and literature review.","authors":"Lars Lindberg","doi":"10.3389/fped.2025.1504180","DOIUrl":"10.3389/fped.2025.1504180","url":null,"abstract":"<p><p>This case report highlights the challenges in treating bronchopulmonary dysplasia (BPD) in a premature infant with severe pulmonary hypertension, recurrent pulmonary hypertensive crises, and the need of 100% oxygen to achieve acceptable arterial oxygen saturations. Key factors in the infant's improvement involved switching from pulmonary vasodilation to systemic afterload reduction using losartan, an angiotensin II type 1 receptor blocker. This alteration in treatment strategy led to a pronounced and prompt decrease in pulmonary arterial pressure, reduced oxygen dependency and resolution of pulmonary hypertensive crises. The infant's remarkable clinical response suggests that the pulmonary hypertension in BPD may have a pulmonary post-capillary cause, possibly driven by angiotensin II. A literature review corroborates this revision of the current understanding of the pathophysiologic mechanism involved in BPD and suggests that therapies targeting the renin-angiotensin-aldosterone system rather than pulmonary vasodilation may be an effective treatment strategy.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1504180"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure controlled ventilation with volume guarantee improves outcomes in neonatal thoracoscopic esophageal atresia surgery.","authors":"Lv Kaimin, Luo Bijun, Luo Cheng, Wang Xiaoxia","doi":"10.3389/fped.2025.1524883","DOIUrl":"10.3389/fped.2025.1524883","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal thoracoscopic repair of esophageal atresia requires one-lung ventilation (OLV), which poses challenges due to immature lung development and low compliance, increasing risks of hypoxemia and barotrauma. While volume-controlled ventilation (VCV) ensures stable tidal volume, it may cause excessive airway pressures, whereas pressure-controlled ventilation (PCV) lacks volume guarantee. This study compared PCV with volume guarantee (PCV-VG) and conventional VCV to improve respiratory outcomes during OLV.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on neonates (aged 1-7 days) undergoing thoracoscopic esophageal atresia repair with OLV. Patients were categorized into PCV-VG and VCV groups. Respiratory parameters (PaO₂, PaCO₂, airway pressures, dynamic compliance) were measured before, during, and after OLV. Propensity score matching (PSM) was used to balance baseline characteristics.</p><p><strong>Results: </strong>After PSM, 74 neonates (37 per group) were included. During OLV, the PCV-VG group exhibited significantly lower PaCO₂, peak/mean airway pressures, and higher dynamic compliance compared to the VCV group (all <i>P</i> < 0.05). Postoperatively, PCV-VG was associated with shorter mechanical ventilation duration, ICU stay, and hospital stay (<i>P</i> < 0.05). Postoperative complication rates did not differ between groups (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>PCV-VG offers superior ventilation parameters and faster recovery in neonatal thoracoscopic esophageal atresia repair, though it does not affect postoperative complication rates.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1524883"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Gastric intramural hematoma with acute upper gastrointestinal bleeding in a child.","authors":"Ming Xiao, Jin Lu, Yu Chen, Weiwei Sun, Youcheng Sun, Yutian Li, Yang Jiang, Xingchen Lian, Zhengqiang Zhou, Xin Qi","doi":"10.3389/fped.2025.1533324","DOIUrl":"10.3389/fped.2025.1533324","url":null,"abstract":"<p><p>Gastric hematoma is an exceptionally rare condition in pediatric patients. It is characterized by the accumulation of blood within the gastric wall, resulting in the formation of a mass. Coagulopathy is the most common cause of gastric hematoma, although other etiologies include gastric ulcer, amyloidosis, pancreatitis, and splanchnic vascular aneurysms. However, the pathophysiology of gastric hematoma remains incompletely understood. It is presumed to be caused by ruptures of the submucosal vessels, leading to dissection of the muscular layer and the formation of a false lumen. Herein, we report the case of a 4 year-old girl who was admitted to our hospital with a large intragastric mass. She presented with hematemesis, and a large hematoma was visualized via gastroscopy. After treatment, the patient underwent a second follow-up gastroscopy, which showed that the gastric mass had subsided, and multiple gastric ulcers were found in the gastric wall. After excluding other causes, we considered that the gastric hematoma may have been caused by the ulcers. By discussing the clinical presentation and treatment options in this case, we hope to improve the understanding of pediatric gastric hematoma so that serious complications can be avoided in future cases.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1533324"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets.","authors":"Yue-Chuan Shen, Dao-Jun Yu, Ze Yu, Xue Zhao","doi":"10.3389/fped.2025.1518908","DOIUrl":"10.3389/fped.2025.1518908","url":null,"abstract":"<p><p>Pediatric sepsis is a serious condition causing organ failure owing to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment. This study aims to identify key genes involved in pediatric sepsis using three gene expression datasets from the Gene Expression Omnibus. We first identified differentially expressed genes (DEGs) with R, then conducted a gene set enrichment analysis, and integrated DEGs with important module genes from weighted gene coexpression network analysis. We also screened adult sepsis datasets to find genes specific to pediatric cases, ultimately validating XCL1 as a key gene. This study suggests that XCL1 is crucial in understanding pediatric sepsis etiology and its molecular mechanisms.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1518908"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}