Frontiers in Pediatrics最新文献

{"title":"Clinical presentation and early predictors of progression to dilated cardiomyopathy in children with acute myocarditis.","authors":"Liu Luo, Yanyun Huang, Xiaoyu Qiao, Yusheng Pang","doi":"10.3389/fped.2025.1616751","DOIUrl":"https://doi.org/10.3389/fped.2025.1616751","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to describe the characteristics and outcomes of acute myocarditis (AM) patients while seeking accessible and valid early predictors for the development of dilated cardiomyopathy (DCM).</p><p><strong>Methods: </strong>We conducted a retrospective evaluation of 136 consecutive AM patients admitted to our hospital. The patients were categorized into two groups according to their left ventricular ejection fraction (LVEF) at presentation: those with an impaired LVEF of ≤55% and those with a normal LVEF of >55%. Multivariate logistic regression analyses were conducted to identify early predictors of DCM.</p><p><strong>Results: </strong>The median age of the study participants was 10.35 years (5.60-14.70), and most of the participants (66.91%) were males. Thirty-eight (27.94%) patients had an LVEF of ≤55%. Compared with those with an LVEF >55%, patients with an LVEF ≤55% presented significantly elevated levels of cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), as well as more pronounced clinical manifestations, including a greater prevalence of fulminant myocarditis, New York Heart Association (NYHA) class II-IV, abnormal electrocardiogram results, and enlargement of the left ventricle on echocardiography. Univariate analysis revealed that patients with an LVEF of ≤55% had an increased risk of poor outcomes and DCM development. These patients faced the greatest likelihood of death and heart transplantation within the first year following discharge. During short-term follow-up, 15.44% of the children with AM progressed to DCM. According to the multivariable analysis, a higher baseline LV end-diastolic diameter z score (LVEDD z-score) independently predicted this progression (odds ratio [OR], 2.685; 95% confidence interval [CI], 1.232-5.851; <i>P</i> = 0.013).</p><p><strong>Conclusions: </strong>Patients with AM and LVEF ≤55% had a more severe clinical course, higher rates of poor outcomes, and increased risk of DCM progression. Moreover, this subgroup was at the greatest risk for death and heart transplant within the first year post-discharge. During short-term follow-up, 15.44% of the children diagnosed with AM progressed to DCM, with a higher baseline LVEDD z-score identified as a potential early predictor for this progression.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1616751"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing pediatric asthma management in underdeveloped regions through ChatGPT training for doctors: a randomized controlled trial.","authors":"Liwen Zhang, Guijun Yang, Jiajun Yuan, Shuhua Yuan, Jing Zhang, Jiande Chen, Mingyu Tang, Yunqin Zhang, Jilei Lin, Liebin Zhao, Yong Yin","doi":"10.3389/fped.2025.1519751","DOIUrl":"https://doi.org/10.3389/fped.2025.1519751","url":null,"abstract":"<p><strong>Background: </strong>Childhood asthma represents a significant challenge globally, especially in underdeveloped regions. Recent advancements in Large Language Models (LLMs), such as ChatGPT, offer promising improvements in medical service quality.</p><p><strong>Methods: </strong>This randomized controlled trial assessed the effectiveness of ChatGPT in enhancing physicians' childhood asthma management skills. A total of 192 doctors from varied healthcare environments in China were divided into a control group, receiving traditional medical literature training, and an intervention group, trained in utilizing ChatGPT. Assessments conducted before and after training, and a 2-week follow-up, measured the training's impact.</p><p><strong>Results: </strong>The intervention group showed significant improvement, with scores of test questions increasing by approximately 20 out of 100 (improving to 72 ± 8 from a baseline, vs. the control group's increase to 50 ± 9). Post-training, ChatGPT's regular usage among the intervention group jumped from 6.3% to 62%, markedly above the control group's 4.3%. Moreover, physicians in the intervention group reported higher levels of familiarity, effectiveness, satisfaction, and intention for future use of ChatGPT.</p><p><strong>Conclusion: </strong>ChatGPT training significantly improves childhood asthma management among physicians in underdeveloped regions. This underscores the utility of LLMs like ChatGPT as effective educational tools in medical training, highlighting the need for further research into their integration and patient outcome impacts.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1519751"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A pediatric case of the clear-cell variant of mucoepidermoid carcinoma in the palate harboring <i>MAML2</i> gene rearrangement.","authors":"Hengkun Wang, Xiaoya Wang","doi":"10.3389/fped.2025.1600823","DOIUrl":"https://doi.org/10.3389/fped.2025.1600823","url":null,"abstract":"<p><p>The clear-cell variant of mucoepidermoid carcinoma (MEC) is a rare subtype, with pediatric cases being extremely rare. A 13-year-old girl presented with a lesion on the right palate, which had been noted for 3 months. The patient reported pain, rupture, and bleeding of the tumor for nearly a month. Computed tomography scans revealed a quasi-circular soft tissue mass on the right hard palate. Microscopically, the tumor cells showed predominant clear cells and scattered mucous cells. The tumor cells were positive for cytokeratin (CK), CK7, CK5/6, epithelial membrane antigen, P63, and P40. A rearrangement of mastermind-like transcriptional coactivator 2 (<i>MAML2</i>) (11q21) gene was identified in the tumor cells by fluorescence <i>in situ</i> hybridization. The histological features supported a diagnosis of clear-cell variant of MEC, medium grade, with a tumor stage of pT1N0M0. The patient underwent a complete excision of the palatal mass followed by superficial bone removal. After surgery, the patient recovered well and was recurrence-free at the 1-year follow-up. Based on repeated pathological evaluations, we report this rare pediatric case of a clear-cell variant of MEC of the palate. Only surgical resection resulted in a favorable outcome.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1600823"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 8-week exergame-based exercise training program improves cardiovascular endurance, muscular strength and endurance performances among primary school children in Taiwan.","authors":"Chi-Fang Lin, Po-Fu Lee, Yan-Jhu Su, I-Tung Lin, Hsiao-Fang Kao, Yi-Chuan Hung, Mei-Ling Chao, Chien-Chang Ho","doi":"10.3389/fped.2025.1566838","DOIUrl":"https://doi.org/10.3389/fped.2025.1566838","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to determine the effects of an 8-week exergame-based exercise training program on health-related physical fitness performances among primary school children in Taiwan.</p><p><strong>Materials and methods: </strong>The study employed a randomized controlled trial (RCT) design, recruiting 68 elementary school children with an average age of 10.76 ± 0.49 years. Participants were randomly divided into an experimental group (<i>n</i> = 35) and a control group (<i>n</i> = 33). The experimental group completed an 8-week exergame-based exercise training program, performed three times per week. Each session consisted of three one-minute rounds. In contrast, the control group did not undergo any training and continued their usual daily activities. Data collection included demographic surveys, anthropometric assessments, and health-related physical fitness evaluations conducted at baseline (Week 0) and after the intervention (week 8).</p><p><strong>Results: </strong>After the 8-week exergame-based exercise training program, the results indicated that compared to the control group, the experimental group significantly reduced their 800-m run time [<i>β</i> = -21.771, <i>p</i> = 0.005 (enhanced cardiovascular endurance)] and increased their performance in bent-leg sit-ups [<i>β</i> = 4.036, <i>p</i> = 0.021 (muscular strength and endurance)] after adjusting for age, gender, and other health-related physical fitness indicators.</p><p><strong>Conclusion: </strong>This suggests that 8-week exergame-based exercise training program can be a fun exercise alternative for improving cardiovascular endurance, muscular strength and endurance performances among primary school children in Taiwan.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1566838"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical manifestation and diagnostic features of Kawasaki-like phenotypes in pediatric multisystem inflammatory syndrome: a comparative retrospective study in Ukraine.","authors":"Nataliia Bodnarchuk-Sokhatska, Halyna Pavlyshyn, Kateryna Kozak, Iryna Avramenko","doi":"10.3389/fped.2025.1593190","DOIUrl":"https://doi.org/10.3389/fped.2025.1593190","url":null,"abstract":"<p><strong>Background: </strong>The clinical overlap syndrome between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD), particularly in the context of SARS-CoV-2 infection, presents diagnostic challenges. The presence of both complete and incomplete Kawasaki-like phenotypes (KLP) further complicates differentiation. This study aimed to analyze Kawasaki-like phenotype of MIS-C, its clinical features, and improve diagnostic accuracy, patient outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 48 pediatric patients diagnosed with MIS-С between 2020 and 2022. All cases met the MIS-C diagnostic criteria established by the Council of State and Territorial Epidemiologists (2022) and were classified according to the American Heart Association Kawasaki disease criteria (2017). Patients were grouped as non-Kawasaki-like or Kawasaki-like MIS-C phenotypes, with the latter subdivided into complete and incomplete subtypes. Clinical and echocardiographic features were compared using appropriate statistical methods.</p><p><strong>Results: </strong>Among the 48 MIS-C cases analyzed, 22 patients (46%) met the Kawasaki disease criteria, equally divided between complete and incomplete Kawasaki-like phenotypes. btion was longest in the complete phenotype (9.7 days) and shortest in the incomplete phenotype (5.5 days). Patients with neurological involvement experienced longer febrile periods (8.3 vs. 5.4 days). All 100% patients with the complete phenotype exhibited neurological symptoms vs. 46% of incomplete cases. Half of the Kawasaki-like phenotype patients demonstrated echocardiographic abnormalities vs. 15% of non-Kawasaki-like (NKL); highest in the incomplete phenotype (91%) compared to 15% in non-Kawasaki-like and 9% in complete KLP. The highest incidence of coronary dilatation was recorded in the incomplete phenotype (73%) vs. 9% in the complete and 15% in the non-Kawasaki-like MIS-C.</p><p><strong>Discussion: </strong>Kawasaki-like MIS-C phenotypes display distinct clinical and cardiovascular profiles. Accurate phenotypic identification is crucial for risk stratification and optimizing patient management. Further research is necessary to refine classification criteria and establish effective long-term monitoring strategies for affected children.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1593190"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of single-center fecal calprotectin in the early diagnosis and assessment of necrotizing enterocolitis in premature infants.","authors":"Chen ZongLi, Luo KeYong, Jiang Liang","doi":"10.3389/fped.2025.1598448","DOIUrl":"https://doi.org/10.3389/fped.2025.1598448","url":null,"abstract":"<p><strong>Objective: </strong>To explore the value of fecal calprotectin (FC) in the early diagnosis of necrotizing enterocolitis (NEC) in premature infants.</p><p><strong>Methods: </strong>From September 2021 to June 2024, 84 premature infants with NEC were selected as the NEC group, and 84 premature infants with feeding intolerance (feeding intolerance group) and 168 healthy premature infants (healthy group) were selected at the same time. ROC curves were used to analyze the value of FC in the early diagnosis and condition evaluation of NEC in premature infants, and Spearman correlations were used to analyze the relationships between FC and the occurrence and severity of NEC in premature infants.</p><p><strong>Results: </strong>FC levels in the NEC group were greater than those in the feeding intolerance group and healthy group (<i>P</i> < 0.05), and there was no significant difference between the feeding intolerance group and the healthy group (<i>P</i> > 0.05). The FC level of premature infants with NEC III was greater than that of premature infants with NEC Ⅰ and Ⅱ, and the FC level of premature infants with NEC II was greater than that of premature infants with NEC Ⅰ (<i>P</i> < 0.05). ROC curve analysis revealed that the best diagnostic values of FC for premature infants with NEC and their conditions were 8.40 μg/g and 53.50 μg/g, respectively, and the AUCs were 0.651 and 0.901, respectively, with sensitivities of 42.86% and 85.71%, specificities of 89.23% and 82.61%, respectively. Spearman correlation analysis revealed that FC was positively correlated with the occurrence and severity of NEC in premature infants (<i>r</i> _s = 0.401, 0.853; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The level of FC in premature infants with NEC is abnormally high, and FC has high clinical value for early diagnosis and condition evaluation of premature infants with NEC, which is worthy of further investigation.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1598448"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile polyposis syndrome in a child with von Willebrand disease: a case report and literature review.","authors":"Yang Yang, Qiong Chen","doi":"10.3389/fped.2025.1573544","DOIUrl":"https://doi.org/10.3389/fped.2025.1573544","url":null,"abstract":"<p><strong>Background: </strong>Juvenile polyposis syndrome (JPS) is a rare autosomal dominant genetic disorder characterized by multiple gastrointestinal juvenile polyps. Endoscopic polypectomy is the primary therapeutic approach, minor post-polypectomy bleeding is the most common complication. We report an exceptional case of massive hemorrhage (approximately 400 ml) in a child with JPS.The cause of the post-polypectomy bleeding was relatively rare and was ultimately diagnosed as von Willebrand disease (VWD).</p><p><strong>Case presentation: </strong>A six-year-old girl with JPS and no prior bleeding history underwent endoscopic polypectomy for 11 colorectal polyps.Laboratory tests showed normal platelet count, activated partial thromboplastin time (APTT), prothrombin time (PT), and plasma fibrinogen levels. However, approximately 70 hours after endoscopic polypectomy, she developed hematochezia with significant blood loss (approximately 400 ml). Emergent endoscopic findings did not support technical complications (e.g., clip dislodgement) as the primary etiology of the post-polypectomy hemorrhage.Genetic testing identified a mutation in the von Willebrand factor (VWF) gene [c.1707(exon14)delC, heterozygous], leading to a diagnosis of type 1 von Willebrand disease, which subsequently led to the unexpected post-polypectomy bleeding.</p><p><strong>Conclusion: </strong>The rare case of juvenile polyposis syndrome with von Willebrand disease in a child underscores the necessity of taking extrinsic gastrointestinal factors into account when delayed post-polypectomy bleeding arises following endoscopic polypectomy. Clinicians ought to be watchful for coagulation disorders, such as VWD, which might be manifested through atypical clinical symptoms. Timely identification of the cause of delayed post-polypectomy bleeding can improve prognosis.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1573544"},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Intra-articular injection of tocilizumab for arthritis treatment in chronic graft-vs.-host disease.","authors":"Mingyu Xie, Qin Liu, Huiting Yuan, Yumei Chen, Xian Zou, Zhenhong Zhang, Baimao Zhong, Huasong Zeng, Haisheng Zeng","doi":"10.3389/fped.2025.1515706","DOIUrl":"https://doi.org/10.3389/fped.2025.1515706","url":null,"abstract":"<p><strong>Background: </strong>Chronic graft-vs.-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation. It is a leading cause of long-term morbidity, non-relapse mortality, and impaired health-related quality of life. cGVHD is a multifactorial syndrome that can manifest with articular involvement. Approximately 50% of cGVHD survivors do not respond to glucocorticoid therapy used for arthritis. Subsequently, we shall present a case of a juvenile patient with arthritis and cGVHD, who responded well to intra-articular injection of tocilizumab, after bone marrow transplantation.</p><p><strong>Case pressentation: </strong>A male adolescent with acute myeloid leukemia successfully underwent marrow stem cell transplantation. However, he developed arthritis in the elbow and knee joints and had difficulty walking more than 3 months after transplantation. He was administered anti-rejection drugs with cyclosporine, ruxolitinib, and methylprednisolone by his physician, which did not work. He was subsequently treated with intravenous tocilizumab under the supervision of his rheumatologist. Although his clinical symptoms showed remission at early stages, his knee joints were more swollen, and he could not stand after being infected with COVID-19. Both of his knee joints was injected with tocilizumab at 0, 2, 4, 6, 7, 11, and 19 weeks. Interleukin (IL)-6 levels in the peripheral blood continuously decreased. After treatment for 4 months, the patient could walk a few hundred meters with minimal exertion.</p><p><strong>Conclusion: </strong>An intra-articular injection of tocilizumab could be a viable treatment option for arthritis; however, large-scale clinical trials are warranted to confirm its efficacy.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1515706"},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Third generation sequencing transforms the way of the screening and diagnosis of thalassemia: a mini-review.","authors":"Lixia Zhan, Chunrong Gui, Wei Wei, Juliang Liu, Baoheng Gui","doi":"10.3389/fped.2025.1637415","DOIUrl":"https://doi.org/10.3389/fped.2025.1637415","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fped.2023.1199609.].</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1637415"},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Neonatal right atrial mass of uncertain etiology.","authors":"Libor Svoboda, Sabine Mank, Sabine Meier, Marcel Vollroth, Alexandra Kiess, Christian Schürer","doi":"10.3389/fped.2025.1621500","DOIUrl":"https://doi.org/10.3389/fped.2025.1621500","url":null,"abstract":"<p><strong>Background: </strong>Neonatal intracardiac masses are rare and pose significant diagnostic and therapeutic challenges, particularly in differentiating thrombi from tumors.</p><p><strong>Case summary: </strong>We present the case of a preterm neonate with a right atrial mass of uncertain etiology. Multimodal imaging, including echocardiography and cardiac MRI, suggested the presence of a thrombus-consistent with thrombi being the most common type of intracavitary cardiac mass. As a result, primary anticoagulation therapy was initiated. However, after 16 days without significant change in the mass and given the high risk of embolization and the possibility of a benign tumor, surgical excision was performed. Histopathological analysis of the excised tissue could not definitively distinguish between an organized thrombus and a regressed benign neoplasm, although no malignant cells were identified.</p><p><strong>Conclusions: </strong>This case highlights the diagnostic uncertainty surrounding neonatal intracardiac masses and the limitations of imaging and pathology in achieving definitive diagnosis. A multidisciplinary approach and long-term follow-up are essential, particularly when the true nature of the mass remains unclear.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1621500"},"PeriodicalIF":2.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}