YueXu Ou, Jie Cao, Bin Qin, ZhengXiu Luo, HongQiang Du, YuanHui Duan, FengHua Chen, JiWei Zhou, YuanYuan Li, YingLan Zheng, XiaoMing Gan
{"title":"小儿肺炎支原体肺炎238例肺实变吸收时间分析。","authors":"YueXu Ou, Jie Cao, Bin Qin, ZhengXiu Luo, HongQiang Du, YuanHui Duan, FengHua Chen, JiWei Zhou, YuanYuan Li, YingLan Zheng, XiaoMing Gan","doi":"10.3389/fped.2025.1606834","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the lung consolidation absorption time and rate in children with mycoplasma pneumoniae pneumonia (MPP) and evaluate the impact of bronchoalveolar lavage (BAL) on absorption.</p><p><strong>Methods: </strong>Children hospitalized with MPP and lung consolidation in Children's Hospital of Chongqing Medical University, between January 2018 and May 2024, were included for analysis. Patients were divided into BAL and non-BAL groups. Propensity score matching (PSM) was used to adjust for baseline differences between groups, and sub-group analyses were performed to assess the effect of BAL on lung consolidation absorption speed.</p><p><strong>Results: </strong>Among 238 children with MPP and lung consolidation, females slightly outnumbered males (129 vs. 109), with a mean age of approximately 5 years. Most children received azithromycin as the first-line treatment. Lung consolidation accounted for 4.48% (IQR: 2.61%-7.35%) of the total lung volume pre-treatment, with an absorption rate of 96.08% (IQR: 88.02%-98.95%) observed during follow-up at a median interval of 17 days (IQR: 15-21 days). The median absorption speed was 2.15 cc/day (IQR: 1.23-4.01 cc/day), with complete absorption occurring within 18.96 days (IQR: 16.14-23.33 days). Comparative analysis of the BAL and non-BAL groups revealed significant differences in fever duration, hs-CRP levels, consolidation-to-total lung volume ratio at admission, follow-up intervals, and consolidation absorption speed. Following 1:1 propensity score matching (PSM) to control for confounding factors, a statistically significant but small-to-medium effect persisted, with the median absorption rate remaining higher in the BAL group (2.13 cc/day) compared to the non-BAL group (1.60 cc/day).</p><p><strong>Conclusions: </strong>Using CT scan to evaluate consolidation changes in children with Mycoplasma pneumonia, most children have 96% resolution within 2-3 weeks timeframe. Those who had a bronchoscopy may have a faster resolution rate but undertaking a flexible bronchoscopy under these circumstances is not a standard procedure in most settings.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1606834"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504092/pdf/","citationCount":"0","resultStr":"{\"title\":\"Lung consolidation absorption time in 238 pediatric cases of mycoplasma pneumoniae pneumonia.\",\"authors\":\"YueXu Ou, Jie Cao, Bin Qin, ZhengXiu Luo, HongQiang Du, YuanHui Duan, FengHua Chen, JiWei Zhou, YuanYuan Li, YingLan Zheng, XiaoMing Gan\",\"doi\":\"10.3389/fped.2025.1606834\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the lung consolidation absorption time and rate in children with mycoplasma pneumoniae pneumonia (MPP) and evaluate the impact of bronchoalveolar lavage (BAL) on absorption.</p><p><strong>Methods: </strong>Children hospitalized with MPP and lung consolidation in Children's Hospital of Chongqing Medical University, between January 2018 and May 2024, were included for analysis. Patients were divided into BAL and non-BAL groups. Propensity score matching (PSM) was used to adjust for baseline differences between groups, and sub-group analyses were performed to assess the effect of BAL on lung consolidation absorption speed.</p><p><strong>Results: </strong>Among 238 children with MPP and lung consolidation, females slightly outnumbered males (129 vs. 109), with a mean age of approximately 5 years. Most children received azithromycin as the first-line treatment. Lung consolidation accounted for 4.48% (IQR: 2.61%-7.35%) of the total lung volume pre-treatment, with an absorption rate of 96.08% (IQR: 88.02%-98.95%) observed during follow-up at a median interval of 17 days (IQR: 15-21 days). The median absorption speed was 2.15 cc/day (IQR: 1.23-4.01 cc/day), with complete absorption occurring within 18.96 days (IQR: 16.14-23.33 days). Comparative analysis of the BAL and non-BAL groups revealed significant differences in fever duration, hs-CRP levels, consolidation-to-total lung volume ratio at admission, follow-up intervals, and consolidation absorption speed. Following 1:1 propensity score matching (PSM) to control for confounding factors, a statistically significant but small-to-medium effect persisted, with the median absorption rate remaining higher in the BAL group (2.13 cc/day) compared to the non-BAL group (1.60 cc/day).</p><p><strong>Conclusions: </strong>Using CT scan to evaluate consolidation changes in children with Mycoplasma pneumonia, most children have 96% resolution within 2-3 weeks timeframe. Those who had a bronchoscopy may have a faster resolution rate but undertaking a flexible bronchoscopy under these circumstances is not a standard procedure in most settings.</p>\",\"PeriodicalId\":12637,\"journal\":{\"name\":\"Frontiers in Pediatrics\",\"volume\":\"13 \",\"pages\":\"1606834\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504092/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fped.2025.1606834\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fped.2025.1606834","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Lung consolidation absorption time in 238 pediatric cases of mycoplasma pneumoniae pneumonia.
Objective: To investigate the lung consolidation absorption time and rate in children with mycoplasma pneumoniae pneumonia (MPP) and evaluate the impact of bronchoalveolar lavage (BAL) on absorption.
Methods: Children hospitalized with MPP and lung consolidation in Children's Hospital of Chongqing Medical University, between January 2018 and May 2024, were included for analysis. Patients were divided into BAL and non-BAL groups. Propensity score matching (PSM) was used to adjust for baseline differences between groups, and sub-group analyses were performed to assess the effect of BAL on lung consolidation absorption speed.
Results: Among 238 children with MPP and lung consolidation, females slightly outnumbered males (129 vs. 109), with a mean age of approximately 5 years. Most children received azithromycin as the first-line treatment. Lung consolidation accounted for 4.48% (IQR: 2.61%-7.35%) of the total lung volume pre-treatment, with an absorption rate of 96.08% (IQR: 88.02%-98.95%) observed during follow-up at a median interval of 17 days (IQR: 15-21 days). The median absorption speed was 2.15 cc/day (IQR: 1.23-4.01 cc/day), with complete absorption occurring within 18.96 days (IQR: 16.14-23.33 days). Comparative analysis of the BAL and non-BAL groups revealed significant differences in fever duration, hs-CRP levels, consolidation-to-total lung volume ratio at admission, follow-up intervals, and consolidation absorption speed. Following 1:1 propensity score matching (PSM) to control for confounding factors, a statistically significant but small-to-medium effect persisted, with the median absorption rate remaining higher in the BAL group (2.13 cc/day) compared to the non-BAL group (1.60 cc/day).
Conclusions: Using CT scan to evaluate consolidation changes in children with Mycoplasma pneumonia, most children have 96% resolution within 2-3 weeks timeframe. Those who had a bronchoscopy may have a faster resolution rate but undertaking a flexible bronchoscopy under these circumstances is not a standard procedure in most settings.
期刊介绍：
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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