Frontiers in Pediatrics最新文献

{"title":"Acute small bowel obstruction caused by a fan-shaped congenital band in a child: a case report.","authors":"Qingnan Lan, Jianhua Zhong, Yi Wang, Haiwei Zhu, Xin Liu, Yanping Guo, Zhibo Qu","doi":"10.3389/fped.2025.1539677","DOIUrl":"10.3389/fped.2025.1539677","url":null,"abstract":"<p><p>Congenital bands are rare abnormal structures that can occur anywhere in the gastrointestinal tract, and intestinal obstruction caused by these bands is uncommon in children. To our knowledge, there have been no reported cases of small bowel obstruction (SBO) resulting from a wide, fan-shaped congenital band located on the surface of the ileum and mesentery. We present the case of a 13-year-old girl who developed SBO due to a unique fan-shaped band that compressed a segment of the ileum. The diagnosis of intestinal obstruction was confirmed through x-ray and CT imaging, and the location and cause of the obstruction were further elucidated during exploratory laparotomy. The band was excised, with no bowel resections required. Congenital or spontaneous bands are rare causes of bowel obstruction, and accurately diagnosing this condition prior to surgery can be challenging. When considering the potential causes of intestinal obstruction, it is crucial to include congenital bands in the differential diagnosis.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1539677"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are school-based behavioural interventions an effective strategy for improving physical activity and sedentary behaviour in children and adolescents? A meta-analysis.","authors":"Liangru Guo, Hengwang He, Chaochao Wang","doi":"10.3389/fped.2025.1532035","DOIUrl":"10.3389/fped.2025.1532035","url":null,"abstract":"<p><strong>Objective: </strong>This systematic evaluation and meta-analysis [PROSPERO CRD42024598218] was conducted in order to summarise the effectiveness of a body of school-based behavioural interventions on physical activity (PA) and sedentary behaviour in children and adolescents.</p><p><strong>Methods: </strong>We conducted a systematic search of the literature up to November 2024 using PubMed, Web of Science and SCOPUS. The methodological quality of the included literature was assessed using the Cochrane Risk Assessment Tool.</p><p><strong>Results: </strong>Of the 6,071 search records initially identified, 26 studies were considered eligible for systematic evaluation and meta-analysis. School-based behavioural interventions were effective in increasing moderate-intensity physical activity [standardised mean difference (SMD), 0.18 (95% CI, 0.04-0.31), <i>p</i> = 0.01]. School-based behavioural interventions failed to reduce ST (sedentary time) [-0.04 (95% CI, -0.08 to -0.01), <i>p</i> = 0.12] and failed to improve low-intensity PA (LPA) [0.18 (95% CI, -0.07-0.44), <i>p</i> = 0.16]. Subgroup analyses showed that school-based behavioural interventions were more effective in improving moderate-intensity PA in children and adolescents who were in school [0.46 (95% CI, 0.20-0.72), <i>p</i> = 0.02]. School-based behavioral interventions do not differentiate moderate-intensity physical activity among children and adolescents of different ages, [0.18 (95% CI, 0.05-0.31), <i>p</i> = 0.1], nor do they make a difference in moderate-intensity physical activity among children and adolescents in different regions [0.18 (95% CI, 0.04-0.31), <i>p</i> = 0.12].</p><p><strong>Conclusion: </strong>School-based behavioural interventions are effective in increasing moderate-intensity PA among children and adolescents, particularly those who were in school.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/recorddashboard, PROSPERO [CRD42024598218].</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1532035"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The incidence of periungual desquamation and thrombocytosis in Kawasaki disease and the importance of systematic observation in the subacute phase.","authors":"Beom Joon Kim, Arum Choi, Suk-Il Kim, Ji-Whan Han","doi":"10.3389/fped.2025.1564036","DOIUrl":"https://doi.org/10.3389/fped.2025.1564036","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fped.2024.1384015.].</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1564036"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope.","authors":"Tetiana Kovalchuk, Oksana Boyarchuk, Nataliya Balatska","doi":"10.3389/fped.2025.1553428","DOIUrl":"10.3389/fped.2025.1553428","url":null,"abstract":"<p><strong>Aim of the study: </strong>The aim of the study was to assess the effectiveness of vitamin B6, B9, B12, and D3 supplements in reducing symptoms and the frequency of syncope, improving autonomic nervous system functions, and enhancing quality of life (QOL) in children following an episode of vasovagal syncope (VVS).</p><p><strong>Materials and methods: </strong>The study involved 68 adolescents with VVS who consistently took vitamin B and D supplements and returned for the examination after 3 months. The effectiveness of the therapy was assessed using the CSSS (Calgary Syncope Seizure Score) and MCSSS (Modified Calgary Syncope Seizure Score), serum vitamin profiles (measured using the ELISA method), heart rate variability, blood pressure variability, and the PedsQL™ (Pediatric Quality of Life Inventory™) 4.0 Generic Core Scales and PedsQL™ 2.0 Family Impact Module surveys.</p><p><strong>Results: </strong>The study demonstrated that 3 months of vitamin supplementation were associated with a significant reduction in the frequency of symptoms and syncope episodes (<i>p</i> < 0.05). A marked decrease in serum homocysteine levels was observed, from 13.8 (9.9-17.9) µmol/L to 8.5 (7.6-10.8) µmol/L (<i>p</i> < 0.001). Vitamin supplementation also resulted in improved heart rate variability, evidenced by a significant increase in the SDANN index (<i>p</i> = 0.03) and reductions in TP (<i>p</i> = 0.002), LF (<i>p</i> = 0.004), and LF/HF (<i>p</i> = 0.01), indicating a decrease in sympathotonic influences on the cardiovascular system. Additionally, improved cardiac autonomic function in children with VVS during therapy was reflected by a higher prevalence of dipper profiles for systolic (<i>p</i> = 0.008) and diastolic (<i>p</i> < 0.001) blood pressure. During the 3-month therapy, the QOL in children showed improvements in physical, emotional, and school functioning (<i>p</i> < 0.05). In parents of children with a history of VVS, there were enhancements in physical, emotional, social, and cognitive functioning, as well as in communication and a reduction in worry levels. Among family members, daily activities and family relationships also improved (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The use of vitamin B6, B9, B12, and D3 supplements in therapeutic and preventive doses over 3 months in patients with a history of VVS is associated with a reduction in symptoms and syncope frequency, a decrease in serum homocysteine levels, a reduction in autonomic dysregulation, and an improvement in the QOL for children and their families.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1553428"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic features of Wu et al. type A2 congenital thumb duplication and implications for management: new subtypes and surgical strategies.","authors":"JianPing Wu, ShiJie Liao, YuQuan Li, FuLong Xu, Hai Zhao, ChenYang Li, YanHan Liu, XinWang Zhi, HongHong Lin, ZheHui Tu, LiLi Shu, JingChun Li, YiQiang Li, Federico Canavese, HongWen Xu, YuanZhong Liu","doi":"10.3389/fped.2025.1536872","DOIUrl":"10.3389/fped.2025.1536872","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the radiographic features of patients diagnosed with congenital thumb duplication (CTD) type A2 based on the Wu et al. classification, describe the different subtypes of duplications and propose a classification system that permits identifying various surgical strategies.</p><p><strong>Methods: </strong>We evaluated 665 patients (680 thumbs) diagnosed with type A2 CTDs by examining the alignment of the interphalangeal (IP) and metacarpophalangeal (MP) joints of the primary thumb on posteroanterior (PA) radiographs. The classification system has four types: Type I (no deviation); Type II (ulnar deviation); Type III (hypertrophic epiphysis); and Type IV (convergent). Types I-IV were compared to Hung et al.'s system Type A-D (Hypoplastic, Ulnar Deviation, Divergent, and Convergent).</p><p><strong>Results: </strong>Of the 680 fingers, 436 (64.1%) were determined to be Wassel type IV while 244 (35.9%) were classified as Wassel type VII. All of the 436 fingers could be categorized according to the subtypes of the Hung et al. system; in particular, 369 (84.6%) were identified as type B, 52 (11.9%) as type D, and 15 cases (3.4%) as type C. The proposed classification system worked effectively for all CTDs (<i>n</i> = 680). 494 cases were classified as type II (72.6%), while 75 cases were classified as type I (11.0%). The remaining 111 cases were further classified as either type IV (9.3%) or type III (7.1%). The Wu et al. systems showed excellent intra-rater (0.881) and inter-rater (0.873) reliability compared to the Hung et al. systems (0.842 and 0.823, respectively).</p><p><strong>Conclusions: </strong>The proposed radiographic pathoanatomical system has the potential to improve communication and guide optimal procedure selection for different subtypes of CTD depending on the attachment of the extra digit to the main thumb and the alignment of the interphalangeal and metacarpophalangeal joints of the primary thumb (Wu et al. type A2).</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1536872"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring long-term psychological effects of bronchiolitis and influenza in school-aged children.","authors":"Pankaj Soni, Jenny Cheriathu","doi":"10.3389/fped.2025.1536571","DOIUrl":"10.3389/fped.2025.1536571","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review assessed the long-term psychological effects of severe respiratory infections-namely, bronchiolitis and influenza-in school-aged children (5-12 years).</p><p><strong>Methods: </strong>PubMed, EMBASE, and the Cochrane Library were searched for randomized controlled trials, cohort and longitudinal studies on school-aged children (5-12 years) with a history of bronchiolitis or influenza infection in early childhood published between 2014 and 2022. Studies evaluating long-term psychological outcomes at least 6 months post-infection were included.</p><p><strong>Results: </strong>Several studies that were included in this review reported increased risks of anxiety disorders, depression, and attention deficit among those with severe respiratory infections in early childhood. Additionally, studies with prolonged follow-up periods often reported a higher incidence of psychological morbidity in children. However, some studies did not detect significant long-term adverse effects, implying that timely interventions and supportive care may minimize negative psychological outcomes. This review underscores the necessity of mental health support following respiratory infections in children, highlights the need for further research on the biological and psychosocial pathways linking respiratory illnesses to psychological outcomes, and emphasizes the value of multidisciplinary treatment strategies for children with such comorbidities.</p><p><strong>Conclusions: </strong>The findings of this review provide insights for healthcare practitioners, policymakers, and researchers to consider strategies aimed at improving the outcomes of respiratory illnesses in affected children.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1536571"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice.","authors":"Rosan Meyer, Lauren Arpe, Aydan Kansu, Veronica Kelly, Keith Lindley, Mairéad O'Meara, Maria Del Carmen Rivero, Suzanne van Zundert, Saioa Vicente-Santamaría, Orjena Žaja, Elena Oliveros, Leanne Olivier, Koen Joosten","doi":"10.3389/fped.2025.1523613","DOIUrl":"10.3389/fped.2025.1523613","url":null,"abstract":"<p><p>Undernutrition is defined as \"a condition resulting from imbalanced nutrition or abnormal utilization of nutrients.\" In this paper, the term malnutrition is used to refer to undernutrition. Malnutrition may be driven by poor socioeconomic conditions or by disease, and it is estimated that disease-related malnutrition (DRM) impacts up to 28% of hospitalized children in Europe. Malnutrition results in alterations in gastrointestinal function that lead to malabsorption of macro- and micro-nutrients. It can lead to altered gut motility and a deficiency of stomach acid, which can result in intestinal colonization by pathogens, causing diarrhoea and high burdens of intestinal infection. The presence of compromised gastrointestinal function in children with DRM is critical as it negatively impacts the efficacy of nutritional support and recovery. When choosing novel strategies and nutritional therapies for malnourished children, consideration should be given to gut-protective interventions that promote better treatment tolerance. When breastmilk is unavailable, whole protein feeds are currently considered as first-line treatment for malnutrition in children with a normal functioning gastrointestinal tract. However, peptide-based feeds have been associated with improved gastrointestinal tolerance and absorption, reduced diarrhoea, reduced inflammation, improved growth and have restored gut integrity compared with free amino acid and whole-protein feeds. At a recent meeting, experts in this area have identified significant research gaps in the literature on peptide-based feeds in children and possible gaps in clinical practice. Whilst the group acknowledges that further work is needed, this paper provides an overview on this topic to further drive research in this area.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1523613"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of surgical treatment of Hoffa fractures in pediatric population: 8-case series.","authors":"Yuan Xiao, Clement Arthur, Xin Liu","doi":"10.3389/fped.2025.1552420","DOIUrl":"10.3389/fped.2025.1552420","url":null,"abstract":"<p><strong>Objectives: </strong>Hoffa's fractures are extremely rare in children. Very few cases have been published in connection with this condition. The present study highlights the healing outcomes of surgical treatment in pediatric Hoffa's fractures without direct comparison to conservative treatment.</p><p><strong>Methods: </strong>During this interval, on average, eight children with Hoffa fractures were treated in our department for 10.1 years. Seven had unicondylar fractures (4 lateral and 3 medial), and one had a bicondylar fracture. Unicondylar cases were operated upon with the lateral parapatellar approach, and a combination of direct lateral and medial access with PPA was applied for the bicondylar fracture. A Cannulated Compression Screw was used for fixation. The postoperative care included restricted weight-bearing for 10 weeks and removal of the fixation at 6 months. Follow-up was conducted on knee function and pain, and Letenneur scores were evaluated.</p><p><strong>Results: </strong>The bone union was obtained between 12 and 18 weeks. In the unicondylar cases, knee function was satisfactory, and most outcome measures showed supporting results. There was limited mobility in the bicondylar case and some mild varus; the Letenneur score was fair. Unicondylar fractures with bedding and early functional exercises did well in the long term, while the results of bicondylar fractures were poor.</p><p><strong>Conclusion: </strong>This study presents a surgical treatment approach for pediatric Hoffa fractures and monitors the results. However, it does not provide a comparison with conservative measures. The findings also offer insight into the surgical protocols needed for better long-term outcomes in children with Hoffa fractures.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1552420"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Cerebral venous sinus thrombosis in the setting of iron deficiency anemia and a high level of lipoprotein (a) in a child.","authors":"Yomara Yarden Bustamante, Ulrike Seebeck, Martina Bührlen, David Overberg","doi":"10.3389/fped.2025.1449323","DOIUrl":"10.3389/fped.2025.1449323","url":null,"abstract":"<p><p>Cerebral venous sinus thrombosis (CVST) is a rare but life-threatening condition among children. Several case reports have linked CVST formation to severe iron deficiency anemia (IDA). Iron deficiency anemia remains a public health problem, even in high-income countries. Among the thrombophilic factors accepted by some authors is an elevated lipoprotein (a). This is a case of a two-year-old girl with cerebral venous sinus thrombosis in the setting of IDA and high lipoprotein (a). These factors have been correlated with increased frequency in several clinical reports.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1449323"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage.","authors":"Jyoti V Jethe, YuBing Y Shen, Edmund F La Gamma, Govindaiah Vinukonda, Jonathan A N Fisher","doi":"10.3389/fped.2025.1512613","DOIUrl":"10.3389/fped.2025.1512613","url":null,"abstract":"<p><p>Intraventricular hemorrhage (IVH) is a common complication in premature infants and is associated with white matter injury and long-term neurodevelopmental disabilities. Standard diagnostic tools such as cranial ultrasound and MRI are widely used in both preclinical drug development and clinical practice to detect IVH. However, these methods are limited to endpoint assessments of blood accumulation and do not capture real-time changes in germinal matrix blood flow leading to IVH. This limitation could potentially result in missed opportunities to advance drug candidates that may have protective effects against IVH. In this pilot study, we aimed to develop a noninvasive optical approach using diffuse correlation spectroscopy (DCS) to monitor real-time hemodynamic changes associated with hemorrhagic events and pre-hemorrhagic blood flow in a preclinical rabbit model of IVH. DCS measurements were conducted during the experimental induction of IVH, and results were compared with ultrasound and histological analysis to validate findings. Significant changes in hemodynamics were detected in all animals subjected to IVH-inducing procedures, including those that did not show clear positive results on ultrasound 18 h later. The study revealed progressively elevated coefficients of variation in blood flow, largely driven by temporal fluctuations in the <0.25 Hz range. Our findings suggest that real-time optical monitoring with DCS can provide critical insights heralding pathological blood flow changes, offering a more sensitive and informative tool for evaluating potential therapeutics that may help avert the progression to IVH.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1512613"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}