Frontiers in Pediatrics最新文献

{"title":"Automated information sharing in foster care: perspectives on impact and expansion.","authors":"Nathan M Lutz, Mary V Greiner, Lisa Vaughn, Amanda Schondelmeyer, Elizabeth Freehling, Katie Fox, Sarah J Beal","doi":"10.3389/fped.2025.1543076","DOIUrl":"10.3389/fped.2025.1543076","url":null,"abstract":"<p><strong>Introduction: </strong>For youth in foster care, healthcare information is often not communicated to relevant individuals, including foster caregivers and healthcare staff. Technology solutions designed to bridge that gap have been shown to increase information available, decrease time spent searching for information, and improve access to services. The feasibility of technology-based information sharing has been demonstrated with caseworkers.</p><p><strong>Methods: </strong>This qualitative study builds upon existing knowledge about the benefits of technology-based information exchange systems, utilizing interviews with healthcare staff (<i>n</i> = 41) and foster caregivers (<i>n</i> = 7). The purpose of this work is to understand their perspectives related to the utility of information-exchange technology, barriers faced, and potential improvements.</p><p><strong>Results: </strong>Three themes were identified: (1) Impact and Benefits: The high-yield benefits of automated, on-demand information-sharing platforms for children in foster care; (2) User Experience and Efficiency: Streamlined workflows and improved outcomes; and (3) Opportunities for Platform Expansion: How information sharing can be further improved. Healthcare staff and caregivers alike said using technology to share health and child welfare information was efficient and easy in a system that is fragmented. They also identified opportunities for expansion, such as including more sources of information (e.g., information from caregivers themselves).</p><p><strong>Discussion: </strong>These findings add to the evidence that information exchange platforms in child welfare increase the capacity of healthcare staff and caregivers while decreasing workload in an otherwise overburdened system. Expanding access to and use of information-exchange platforms in healthcare settings that serve youth in foster care may support the workforce who serve these children.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1543076"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the correlation between core competencies of pediatric nurses and occupational benefit perception and its influencing factors.","authors":"Huihui Zhang, Jianxin Wang, Chunhui Li, Xinyu Liu, Qianmei Xiang","doi":"10.3389/fped.2025.1559572","DOIUrl":"10.3389/fped.2025.1559572","url":null,"abstract":"<p><strong>Purpose: </strong>Analyzed the correlation between core competencies and career benefits in pediatric nurse specialists, and examined the factors influencing core competencies in pediatric nurse specialists. Provided references for pediatric nursing managers to improve nurses' core competencies and stabilize the standardized training of pediatric nurse specialists.</p><p><strong>Method: </strong>Using a convenience sampling method, pediatric nurse specialists from Hebei Children's Hospital, Qinhuangdao Maternal and Child Health Hospital, and Baoding Children's Hospital were selected as study subjects between August and September 2023. A questionnaire survey was conducted using a general information questionnaire, a career benefit scale, and a specialist pediatric nurse core competency scale. Pearson correlation and multiple linear regression analyses were employed to examine relationships and influencing factors.</p><p><strong>Results: </strong>The total score of career benefits perception for the 128 pediatric nurse specialists was 117.72 ± 12.34, and the total score of core competencies was 132.23 ± 18.96, both of which were above-average. There were significant differences in the total core competency scores among pediatric nurse specialists of different ages, years of work experience, technical titles, and employment forms. There was a significant positive correlation between the core competencies of pediatric nurse specialists and each dimension of career benefits perception (<i>p</i> < 0.01). Multiple linear regression analysis showed that employment form, years of work experience, and total score of career benefits perception were independent influencing factors of the core competencies of pediatric nurse specialists.</p><p><strong>Conclusion: </strong>The career benefits perception and core competencies of pediatric nurse specialists are both at an above-average level, with a close and mutually influential relationship. The form of employment, years of experience, and total score of career benefits influence the core competencies of pediatric nurse specialists. Nursing managers should take targeted intervention measures based on these influencing factors to improve the core competencies of pediatric nurse specialists.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1559572"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-splenectomy accessory spleen hyperfunction in children with hereditary spherocytosis: a rare case report and literature review.","authors":"Yuan-Fei He, Shi-Qin Qi, Jian Bian, Cheng-Xiao Zhou, Pei Zhang","doi":"10.3389/fped.2025.1572397","DOIUrl":"10.3389/fped.2025.1572397","url":null,"abstract":"<p><strong>Objective: </strong>To enhance the understanding of splenectomy in children with hereditary spherocytosis, specifically focusing on the preservation of accessory spleens or partial splenectomy.</p><p><strong>Methods: </strong>A retrospective review of clinical data and surgical methods of a child with hereditary spherocytosis who underwent surgery for accessory spleen hyperfunction 7 years after splenectomy at the General Surgery Department of Anhui Provincial Children's Hospital, along with a literature review.</p><p><strong>Results: </strong>The child successfully underwent single-port plus one laparoscopic accessory spleenectomy. The surgery lasted 195 min, with an estimated blood loss of 600 ml. The postoperative hospital stay was 8 days, and at 6 months of follow-up, there were no complications such as bleeding, wound infection, thrombosis, or adhesive intestinal obstruction.</p><p><strong>Conclusion: </strong>For children with hereditary spherocytosis, the decision to preserve the spleen or accessory spleens during surgical treatment offers important reference value.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1572397"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiamine deficiency secondary to intestinal surgery leading to shoshin beriberi and Wernicke encephalopathy: a case report.","authors":"Peiyu Huang, Junyu Chen, Zhixuan Deng, Weiguo Yang","doi":"10.3389/fped.2025.1576805","DOIUrl":"10.3389/fped.2025.1576805","url":null,"abstract":"<p><strong>Purpose: </strong>Thiamine is an essential micronutrient, and its deficiency, also known as beriberi, can have significant clinical implications. Thiamine deficiency impairs oxidative metabolic pathways, leading to reduced adenosine triphosphate (ATP) synthesis and energy production. This deficiency primarily affects energy-demanding organs, such as the brain and heart, resulting in central and peripheral neuropathies, severe metabolic acidosis, or even circulatory failure. Due to its nonspecific clinical presentation, thiamine deficiency is often misdiagnosed or overlooked, making early recognition and intervention critical for improving outcomes.</p><p><strong>Case report: </strong>This report describes a case of shoshin beriberi with concurrent neurological involvement caused by thiamine deficiency following intestinal surgery. Remarkably, the patient's condition improved significantly with timely thiamine supplementation.</p><p><strong>Conclusion: </strong>In individuals at high risk of thiamine deficiency, such as those with prolonged fasting, gastrointestinal disorders, or chronic malnutrition, early identification and timely intervention are crucial for improving prognosis and reducing mortality. Early recognition and treatment are critical to reducing mortality associated with this condition.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1576805"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Clinical management of a severe DBA patient with a novel RPS19 mutation.","authors":"Junfen Zhou, Jiayi Zhong, Yisha Zhao, Miaojun Mo, Xianbo Chen, Huangjia Zhou, Luya Zhang, Li Lin, Yichi Zhang, Xiaohong Tao, Xianhua Mao, Haiting Li, Enfu Tao","doi":"10.3389/fped.2025.1590183","DOIUrl":"10.3389/fped.2025.1590183","url":null,"abstract":"<p><p>Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure disorder characterized by defective erythropoiesis, typically caused by mutations in ribosomal protein (RP) genes, most commonly <i>RPS19</i>. It usually presents in early infancy with severe anemia, growth retardation, and an increased risk of congenital malformations and malignancies. However, cases of DBA leading to severe anemia and shock are exceedingly rare. This case report describes a life-threatening presentation of DBA in a 56-day-old female infant who presented with severe anemia and shock. The infant was admitted with a 2-day history of poor feeding and persistent crying, accompanied by hypothermia (34.4°C), unresponsiveness, and profound pallor. Initial laboratory findings revealed critical anemia (hemoglobin 18 g/L) and severe metabolic acidosis (pH 6.61, base excess -36.06 mmol/L). Hemodynamic instability, including undetectable blood pressure and prolonged capillary refill time, indicated shock. Immediate interventions, including volume expansion with normal saline, correction of acidosis with sodium bicarbonate, and packed red blood cells (PRBCs) transfusion, stabilized the infant. Genetic testing identified a <i>de novo</i> heterozygous mutation in the <i>RPS19</i> gene (c.3G > T), confirming the diagnosis of DBA. Over the course of a 1-year follow-up, the infant required regular blood transfusions at approximately 4-week intervals to sustain hemoglobin levels within the range of 69-86 g/L. Growth retardation and poor appetite were observed, consistent with the known complications of DBA. This case highlights the importance of early recognition and aggressive management of severe anemia in infants, particularly in the context of DBA, to prevent life-threatening complications such as shock and metabolic acidosis. The role of genetic testing in confirming the diagnosis and guiding long-term management is emphasized. This report also reviews the literature on DBA, focusing on the pathophysiology of anemia, the association between <i>RPS19</i> mutations and clinical phenotypes, and the challenges of managing transfusion-dependent patients. The findings underscore the need for a multidisciplinary approach to DBA, including regular monitoring for complications such as iron overload, growth retardation, and malignancy risk. Early genetic counseling and tailored therapeutic strategies are crucial for improving outcomes in this rare and complex disorder.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1590183"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MFAP4 as a novel biomarker for predicting liver fibrosis and prognosis in infants with biliary atresia through the integration of bioinformatics with clinical data analysis.","authors":"Chunxiao Yang, Jianghua Zhan","doi":"10.3389/fped.2025.1611564","DOIUrl":"10.3389/fped.2025.1611564","url":null,"abstract":"<p><strong>Background: </strong>Biliary atresia (BA) is a progressive obliteration of intrahepatic and extrahepatic bile ducts. Our study aimed to identify and validate hub genes that are differentially expressed in BA, and to investigate their relationship with liver fibrosis.</p><p><strong>Methods: </strong>The BA microarray datasets GSE46960 and GSE15235 were downloaded from the Gene Expression Omnibus (GEO) database. Clinical BA liver tissue samples were collected for quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting (WB). Serum samples were analyzed for MFAP4 content using enzyme-linked immunosorbent assay (ELISA), and the corresponding clinical data of pediatric patients were collected. The relationship between serum MFAP4 levels and liver fibrosis, as well as prognosis, was investigated using ROC curve analysis. Furthermore, Kaplan-Meier (KM) curves were used to validate the prognostic significance of MFAP4 levels.</p><p><strong>Results: </strong>Through bioinformatics analysis and experimental validation, MFAP4 was identified as a hub gene. MFAP4 via PCR and immunohistochemistry is significantly upregulated in biliary atresia compared to total functional cyst liver tissue. Serum MFAP4 levels accurately reflects the degree of liver fibrosis in patients with BA. High serum MFAP4 levels predicted a poorer native liver survival rate one year after Kasai surgery.</p><p><strong>Conclusions: </strong>We discovered that MFAP4 is a crucial BA-associated gene, and validated its expression in BA. Furthermore, serum MFAP4 levels may serve as predictive markers for the degree of liver fibrosis and autologous liver survival after Kasai surgery.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1611564"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torsion of a giant epididymal cyst in a pediatric patient: a rare cause of acute scrotal pain-case report and literature review.","authors":"Chenghao Zhanghuang, Jinrong Li, Na Long, Qiong Duan, Fengming Ji, Yucheng Xie, Zhen Yang, Bing Yan","doi":"10.3389/fped.2025.1605254","DOIUrl":"10.3389/fped.2025.1605254","url":null,"abstract":"<p><p>Torsion of an enlarged epididymal cyst (EC) represents an uncommon yet critical differential diagnosis in acute scrotal emergencies. Large ECs, particularly those localized to the epididymal head, demonstrate diminished anatomical stability due to their superior positioning and increased mobility, rendering them susceptible to torsion under predisposing conditions. This mechanical disruption precipitates elevated intracystic pressure, compromised vascular perfusion, and subsequent infective complications, necessitating urgent surgical intervention. We present a case of a 12-year-old male who presented with left scrotal swelling and pain persisting for 48 h. Initial clinical evaluation suggested spermatic cord torsion concomitant with hydrocele, prompting emergency exploration. Intraoperative findings unexpectedly revealed a torsioned giant cyst (5.2 × 3.8 cm) originating from the left epididymal head. Successful detorsion followed by complete cyst excision was performed while preserving testicular integrity and epididymal architecture. Histopathological analysis confirmed the lesion as a mesonephric duct remnant cyst.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1605254"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental awareness and knowledge of first aid for children in Saudi Arabia: a multiregional cross-sectional study.","authors":"Ola Alotaibi, Sarah Alrayya, Shahad Alotaibi, Yara Algoraini","doi":"10.3389/fped.2025.1575783","DOIUrl":"10.3389/fped.2025.1575783","url":null,"abstract":"<p><strong>Background: </strong>First aid (FA) knowledge is crucial for parents to effectively respond to pediatric emergencies, and it can potentially save lives and reduce injury severity. Despite the high rates of childhood accidents such as burns, choking, and drowning, limited data exist on parental awareness of FA in Saudi Arabia across various situations. The aim of this study was to assess parental knowledge and awareness regarding FA for children in Saudi Arabia.</p><p><strong>Methods: </strong>This cross-sectional study using a self-administered electronic questionnaire was conducted via social networking sites between March and April 2024. The questionnaire was developed from a literature review and validated by experts. A total of 1,421 parents aged ≥18 years and residing in Saudi Arabia participated. Data were analyzed using descriptive statistics and logistic regression analysis.</p><p><strong>Results: </strong>The participants were predominantly women (59.3%), Saudi nationals (85.1%), married (90.6%), and university graduates (68.3%). While 73.6% believed they had good FA knowledge, only 25.6% had attended a formal FA course. With regard to knowledge gaps, 44.12% parents incorrectly believed that they should encourage a choking child aged <1 year to cough, while 61.44% incorrectly believed that ice should be applied to burns; only 51.02% parents knew that cool water should be run over burns. Logistic regression analysis showed that non-Saudi nationality and previous FA experience were significant predictors of willingness to attend FA courses (<i>p</i> = 0.045 and <i>p</i> = 0.012, respectively). Barriers to FA knowledge included underestimation of the problem (39.3%) and lack of information from healthcare personnel (28.1%). Preferred methods for gaining FA knowledge were inclusion of FA in educational curricula (59.7%) and programs in primary healthcare centers (19.5%).</p><p><strong>Conclusion: </strong>There are significant gaps in parental knowledge regarding FA for children in Saudi Arabia. These gaps need to be addressed through structured educational programs and accessible resources in order to enhance preparedness for pediatric emergencies among parents. Recommendations include implementation of FA training programs, integration of FA into school curricula, development of educational materials in Arabic, and promotion of mandatory FA training during prenatal and postnatal care visits.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1575783"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.","authors":"Xueli Zhang, Mingqiu Chen, Yanfei Zhang, Jieer Zhou, Tingyan Wei, Zhangbin Yu, Yuqin Yan, Zhangxing Wang","doi":"10.3389/fped.2025.1519029","DOIUrl":"10.3389/fped.2025.1519029","url":null,"abstract":"<p><strong>Background: </strong>Neonatal necrotizing enterocolitis (NEC) is the leading cause of death due to gastrointestinal disease in preterm neonates. Quality improvement bundles could reduce the incidence of NEC in preterm infants, but their replication in neonatal intensive care units has had inconsistent outcomes.</p><p><strong>Objective: </strong>Quality improvement may reduce the incidence and severity of NEC in preterm infants. We evaluated quality improvement interventions (QIIs) that sought to prevent or reduce the severity of NEC.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, Web of Science, Wanfang Database, China National Knowledge Infrastructure (CNKI), VIP Chinese Journal Service Platform (VIP), Chinese BioMedical Literature Database (CBM), and citations of selected articles were searched. QIIs that reduced the incidence or severity of NEC in preterm infants were the primary outcome. Paired reviewers independently extracted data from selected studies.</p><p><strong>Results: </strong>In total, 13 quality improvement interventions involving 17,961 infants were included. Nearly all of the QIIs included improving breastfeeding rates. Moreover, 16 of the 19 QIIs resulted in a significant reduction in the incidence of NEC after their implementation. Application of the quality criteria of the quality improvement showed that all the interventions were considered to be of medium to high quality, with the lowest score being 8 and 13 of the interventions having scores more than 10. The studies had heterogeneity with significant variations in intervention characteristics, implementation units, personnel, sample size, time, and outcomes.</p><p><strong>Conclusion: </strong>QIIs resulted in reductions in the incidence and severity of NEC in preterm infants in some but not all settings. The specific interventions and quality improvement methods that were responsible for those reductions and why they were successful in some settings but not others are unclear. This systematic review can assist teams in identifying potentially better practices for reducing NEC.</p><p><strong>Systematic reviews registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024601939, PROSPERO (CRD42024601939).</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1519029"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of anatomical characteristics of congenital pulmonary airway malformation lesions based on CT images.","authors":"Yongxuan Peng, Yuejuan Xu, Jiazhong Tang, Ziling Qian, Jie Hu, Wei Liu, Yulian Xia, Xin Sun, Kun Sun, Kai Bai, Yanan Lu","doi":"10.3389/fped.2025.1576380","DOIUrl":"10.3389/fped.2025.1576380","url":null,"abstract":"<p><strong>Objective: </strong>The surgical treatment of congenital pulmonary airway malformations (CPAM) remains a subject of debate. This study aimed to deeply analyze the preoperative CT imaging data to explore the anatomical characteristics of CPAM lesions, providing additional information to guide surgical treatment for such conditions.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical records of children with congenital pulmonary airway malformations who underwent surgery between 2020 and 2024 at our hospital. Preoperative CT images were processed using 3D Slicer software to analyze the volume, external boundaries, vascular and airway branching, and resection planes (lung venous branch planes) of the lesions. The primary analysis indicators included lesion volume, the volume ratio of the lesion to the affected lung lobe, and the real airway, artery, and venous branches supplying the lesion, as well as the airway, artery, and venous branches that might be severed during resection.</p><p><strong>Results: </strong>A total of 17 cases and 18 corresponding preoperative CT images were included, with 7 cases using enhanced CT scans. The mean age of the patients was 68.9 ± 38.9 months. Most lesions (72.2%) were located in the lower lung. The average volume of the lesions was 47.5 cm³ (range: 25.6-91.4 cm³), which occupied 26.6 ± 12.7% of the affected lung lobe. There was no significant correlation between lesion volume and age (<i>r</i> = 0.25), and a weak negative correlation between the volume ratio and age (<i>r</i> = -0.48). The proportion of lesions with real supplying airway, artery, and venous branches was 16.7%, 77.8%, and 83.3%, respectively. The proportions of lesions requiring the severance of additional airway, artery, and venous branches during resection were 27.8%, 16.7%, and 5.5%, respectively. The external boundaries of the lesions were most clearly exposed.</p><p><strong>Conclusion: </strong>The use of preoperative CT imaging and corresponding image processing software allows for a comprehensive analysis of the anatomical characteristics of congenital pulmonary airway malformation lesions. This may help improve the understanding of CPAM and the effectiveness of lesion resection surgeries.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1576380"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}