Frontiers in Pediatrics最新文献

{"title":"Pediatric herpes zoster: should I be concerned for immunodeficiency? A review.","authors":"Steven Zhang, Vy H D Kim, Eyal Grunebaum","doi":"10.3389/fped.2025.1561339","DOIUrl":"10.3389/fped.2025.1561339","url":null,"abstract":"<p><p>Herpes zoster (HZ), caused by reactivation of varicella-zoster virus (VZV), is an uncommon cause of rash in pediatrics, which can lead to concerns of an underlying immunodeficiency. We reviewed studies on HZ in pediatric patients. The diagnosis of HZ can usually be established based on clinical and epidemiological features. HZ is associated with T-cell immune defects that can be secondary to infections with HIV, tuberculosis, and other pathogens, as well as conditions such as diabetes, malnutrition, cancer, or primary immunodeficiency. Important clinical clues indicating that HZ is due to an underlying immunodeficiency include recurrent HZ during a short period; disseminated HZ; new lesions more than a week after presentation; prolonged course despite antiviral medications; a history of recurrent, invasive, or prolonged infections by other pathogens; and a family history of immunodeficiency or consanguinity. Reassuring features include exposure to VZV prior to 1 year of age or a compromised or incomplete VZV vaccination schedule. Initial laboratory analysis may include confirmation of normal newborn screening for profound T-cell immunodeficiency; a complete blood count with differential, quantitative serum immunoglobulins; lymphocyte subset analysis; and the presence of IgG to VZV. In children previously vaccinated for VZV, the possibility of vaccine-type HZ needs to be considered. In conclusion, isolated and uncomplicated childhood HZ is unlikely to be the sole harbinger of an underlying immunodeficiency. Therefore, most children with HZ can be adequately diagnosed through medical history and readily available laboratory evaluations. The presence of concerning clinical or laboratory features should prompt an evaluation by an experienced specialist.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1561339"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customized 3D printed helmet in the treatment of metopic craniosynostosis in a 7-month-old infant, a case report.","authors":"Huthaifa Atallah, Rabee Naeem, Amneh Alshawabka, Anas S Said, Huda Alfatafta, Evelin Derkács, Dorottya Varga, Bálint Molics","doi":"10.3389/fped.2025.1474412","DOIUrl":"10.3389/fped.2025.1474412","url":null,"abstract":"<p><strong>Introduction: </strong>Metopic craniosynostosis results in a deformed skull and hence, impacts brain growth and development. Surgery is usually applied to treat this trigonocephalic head malformation. Helmet therapy is also utilized in craniosynostosis treatment after the surgery. However, data on use of 3D printed helmets in treatment of metopic craniosynostosis is lacking. Most of the studies are published about molding helmets. Moreover, there is a lack of evidence on its clinical outcomes. Therefore, the aim of this study was to assess the use of a 3D printed helmet in treating a metopic craniosynostosis, after the endoscopy-assisted craniotomy surgical intervention.</p><p><strong>Case description: </strong>A 7-month-old infant who was diagnosed with metopic craniosynostosis was referred from the neurosurgeon for a custom-made 3D printed helmet, after a surgical intervention. A certified orthotist has performed further assessment, scanning, designing, and printing a customized 3D printed helmet. Thereafter, fitting and delivery were successfully completed. Patient has come for two follow-up appointments, at 2 and 5 months.</p><p><strong>Results: </strong>Five months after the initial fitting, the head shape correction and reduction of deformity were noticed through anthropometric measures. The cranial vault asymmetrical index (CVAI) decreased from 7% to 2% and the cranial vault asymmetry (CVA) reduced from 7 mm to 3 mm.</p><p><strong>Conclusion: </strong>This case report illustrates the utilization of 3D printing technology in the treatment of metopic craniosynostosis. 3D printed helmets may offer an appropriate option for treating selective infants with metopic craniosynostosis. Thus, would introduce the 3D helmet as a following intervention for such cases after the endoscopy-assisted craniotomy surgical intervention. Further studies with a higher number of cases are compulsory to assess the effectiveness of treating metopic craniosynostosis by 3D printed helmets instead of molding helmets.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1474412"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Home initiation of nocturnal non-invasive ventilation in two adolescents with Duchenne muscular dystrophy and comorbid autism spectrum disorder and ADHD.","authors":"Pien M M Weerkamp, Mark Voermans, Moniek Finders, Arno Brouwers, Philippe Collin, Sylvia Klinkenberg, Jos G M Hendriksen","doi":"10.3389/fped.2025.1525365","DOIUrl":"10.3389/fped.2025.1525365","url":null,"abstract":"<p><p>This case report describes initiation of Nocturnal Non-Invasive Ventilation in home settings for two adolescents with Duchenne Muscular Dystrophy and different neuropsychiatric and neurocognitive comorbidities: one has Autism Spectrum Disorder, and the other has Attention Deficit Hyperactivity Disorder, obsessive thinking and anxiety. This report emphasizes the need for a multidisciplinary team approach, incorporating medical, psychological and psychopharmacological interventions for successful Non-Invasive Ventilation implementation. Challenges include recognition of neuropsychiatric and neurocognitive comorbidities often seen in Duchenne Muscular Dystrophy. Lessons learned from these cases underscore the importance of: coordinated multidisciplinary efforts, early advanced care planning, accurate psychoeducation, cautious psychopharmacological interventions, and parental and patient involvement. To our knowledge, this is the first case report describing implementing Nocturnal Non-Invasive Ventilation in home settings in adolescents with Duchenne Muscular Dystrophy and neuropsychiatric and neurocognitive comorbidities. In conclusion, implementation at home can be successful and become a realistic target for each individual with Duchenne Muscular dystrophy.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1525365"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A resilient health system? Well-child visits before and after COVID-19 in Chile.","authors":"Carolina Acevedo","doi":"10.3389/fped.2025.1497358","DOIUrl":"10.3389/fped.2025.1497358","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood is a critical period where access to medical controls and health policies can severely affect health equity.</p><p><strong>Objectives: </strong>Analyzed to subnational Chile health system's resilience in the face of the COVID-19 pandemic regarding child health. The focus of the research was to assess the performance of Chile Crece Contigo's social policy, specifically the Well-Child Visit Program, which provides health checks to one million children annually through the primary health network.</p><p><strong>Methods: </strong>Using a subnational post-pandemic recovery rate, a regression analysis with municipal controls was performed to observe recovery facilitators. A percentage based on the total child population was obtained for the commune of each country and year of study (2015-2022). Data was collected from the Monthly Statistical Reports (REM) of the Ministry of Health, the Socioeconomic Characterization Survey (CASEN), and the National Institute of Statistics of Chile (INE).</p><p><strong>Results: </strong>Recovery rate at the national level was -3.2%. However, when examining the subnational reality, it was found that 66% of Chilean municipalities are unable to reach pre-pandemic figures and are also territorially concentrated in certain regions of the country. The analysis revealed that municipalities with the worst recovery rate results had negative health expenditure per population.</p><p><strong>Conclusions: </strong>Examining this phenomenon through a subnational lens invites contemplation on the importance of contextualizing it within the theoretical framework of health system resilience. The child health system's capacity must build knowledge based on developing public policies, governance, financing, and coordination in the territories to overcome the crisis.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1497358"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Diagnosis of Gaucher disease in a toddler with acute respiratory failure.","authors":"Sarah Householder, Ruchit Nagar, Nisarg Shah, Jodi Forward, Sean Bickerton, Pramod Mistry, E Vincent S Faustino","doi":"10.3389/fped.2025.1476541","DOIUrl":"10.3389/fped.2025.1476541","url":null,"abstract":"<p><p>A 22-month-old male infant presented with cyanosis and stridor after a trivial fall and then developed acute respiratory distress. The respiratory status of the patient progressed rapidly to severe acute respiratory distress syndrome. Additional findings of hypersplenism prompted a comprehensive multidisciplinary approach and consideration of an inborn error of metabolism. Rapid whole-genome sequence showed a compound heterozygote mutation in the <i>GBA1</i> gene involving a maternally inherited known pathogenic variant, p.L484P, and a paternally inherited novel likely pathogenic variant, p.P358l. The diagnosis of Gaucher disease was confirmed with low leukocyte acid β-glucosidase activity and the patient received recombinant macrophage-targeted enzyme replacement therapy. The patient eventually recovered, but subsequent work-up demonstrated severe bulbar dysfunction with evidence of aspiration. Two months after discharge, the patient arrived at the hospital in a condition of cardiac arrest after a suspected aspiration event associated with hemoptysis. This case illustrates a previously undescribed presentation of Gaucher disease and a new likely pathogenic genetic variant for Gaucher disease. It highlights the role of a multidisciplinary approach, including rapid whole-genome sequencing, to establish timely diagnosis and provide appropriate therapy for Gaucher disease.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1476541"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac complications associated with COVID-19: a single-center study from Southern Iran.","authors":"Marjan Tariverdi, Mohammadbagher Rahmati, Maryam Mohammadian, Shahrokh Rajaei, Mohammadreza Kargarfard Jahromy, Niloufar Rahimi, Saeed Hosseini Teshnizi, Mohammad Tamaddondar, Shiva Badri, Hossein Abdollahi","doi":"10.3389/fped.2025.1452353","DOIUrl":"10.3389/fped.2025.1452353","url":null,"abstract":"<p><strong>Background: </strong>Children account for a small percentage of COVID-19 cases and tend to exhibit milder symptoms compared to adults. Cardiovascular involvement has been observed in pediatric COVID-19 cases. This study aimed to determine the frequency of cardiac disorders in children hospitalized with COVID-19.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on pediatric patients admitted to Bandar Abbas Children Hospital, Iran, from March to September 2020. Patients with negative RT-PCR results for SARS-CoV-2, non-COVID-19 pulmonary involvement or pre-existing cardiovascular conditions were excluded. COVID-19 diagnostic subgroups were determined based on national guidelines. Clinical evaluations included chest CT scans to assess pulmonary involvement and cardiac assessments such as clinical symptoms, electrocardiography and echocardiography. Cardiac abnormalities were defined as clinical heart failure, dysrhythmias or abnormal echocardiography. Multivariable logistic regression was applied to analyze the associations between cardiac abnormalities, age and lung involvement, with statistical significance set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>This cross-sectional study was conducted in 2020 on 475 children aged 1 month to 14 years. Among the participants, 48.4% had suspected, 30.5% had probable, and 21.1% had confirmed COVID-19. Cardiac abnormalities were identified in 35.2% of patients, including dysrhythmia (20.2%), heart failure (7.6%), and abnormal echocardiography findings (13.1%). The odds of cardiac abnormalities were 3.3 times higher in children with unilateral lung involvement and 5.9 times higher in those with bilateral lung involvement compared to those without lung involvement. Additionally, older age was associated with a 5.7% reduction in the odds of cardiac abnormalities.</p><p><strong>Conclusions: </strong>Cardiac abnormalities in pediatric COVID-19 patients show a significant correlation with pulmonary involvement, highlighting their link to disease severity. Routine cardiac assessments may help identify complications and guide management, especially during sporadic cases and seasonal outbreaks.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1452353"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota modulation for infectious complications following allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies.","authors":"Wei Dai, Xiaofan Chen, Huanhuan Zhou, Ning Liu, Mengdi Jin, Zhi Guo","doi":"10.3389/fped.2025.1509612","DOIUrl":"10.3389/fped.2025.1509612","url":null,"abstract":"<p><p>The intervention of microbiota modulation in the treatment of infection complications after allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies has shown potential benefits. Through the use of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT), these interventions modulate the gut microbiota and enhance immune function to prevent and treat infections. They have been shown to reduce the incidence of diarrhea and intestinal infections, mitigate the issue of antibiotic resistance, and promote the recovery of gut microbiota. Future research is needed to further assess the safety and efficacy of these interventions and to establish standardized treatment protocols.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1509612"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A case of cutaneous polyarteritis nodosa in a child following a streptococcal infection.","authors":"Wei Cheng, Wei Yin, Fan Liu, Wen Yin","doi":"10.3389/fped.2025.1553118","DOIUrl":"10.3389/fped.2025.1553118","url":null,"abstract":"<p><strong>Background: </strong>Polyarteritis nodosa is a rare systemic necrotizing vasculitis that is often overlooked and misdiagnosed in clinical practice. Patients may exhibit fever, rash, myalgia, and further symptoms; in severe instances, this may result in damage to the kidney, heart, and other important organs, and may even be life-threatening. Consequently, prompt diagnosis and intervention might mitigate the occurrence of complications and improve patient prognosis.</p><p><strong>Patient presentation: </strong>An 11-year-old girl was admitted to our hospital with multi-joint pain for 7 days, accompanied by worsening fever for 4 days. The physical examination on admission revealed alterations in the skin texture characterized by scaling, a bluish-purple rash, and sensitive subcutaneous nodules on the extremities with limited mobility. Following admission, laboratory testing revealed high serum inflammatory markers, and positive anti-chain \"O,\" rheumatic fever was initially considered. The symptoms were not relieved after the use of antibiotics and aspirin. After reviewing the literature, polyarteritis nodosa was highly suspected, and a skin biopsy indicated necrotizing vasculitis, therefore confirming polyarteritis nodosa. The child's symptoms were alleviated with the use of glucocorticoids in conjunction with immunosuppressive medication.</p><p><strong>Conclusion: </strong>This case involves a child diagnosed with nodular polyarteritis subsequent to a streptococcal infection. For patients with a strong suspicion of polyarteritis nodosa, a timely skin biopsy or arterial angiography should be conducted to confirm the diagnosis and increase survival rates.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1553118"},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical guidance on the prevention and treatment of childhood respiratory syncytial virus infection in Kurdistan.","authors":"Azad A Haleem, Azhar Alsaqee, Lana A Dizayi, Sasan L Hanna, Abbas A Rabaty, Serdar Pedawi, Aso F Salih","doi":"10.3389/fped.2025.1551734","DOIUrl":"10.3389/fped.2025.1551734","url":null,"abstract":"<p><p>Without an available vaccine in Kurdistan, Respiratory Syncytial Virus (RSV) infection threatens younger children, burdens the healthcare system and contributes to household expenditure on health. Immunoprophylaxis remains the only preventive option in Kurdistan. Expert pediatricians recommend palivizumab to children at RSV risk; particularly infants (1) born within 29 gestational weeks and <1-year-old at RSV season start, (2) born premature (>29 gestational weeks) at risk for RSV hospitalization, (3) with congenital lung disease requiring oxygen therapy for >1 month and are <2 years old at RSV season start, and (4) with hemodynamically significant congenital heart disease and acyanotic heart and who are <2 years of age at RSV season start. We call onto health authorities to support palivizumab immunoprophylaxis to all children at risk for RSV.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1551734"},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative and oncologic outcomes of robotic surgery for pediatric solid abdominal tumors: a single-center 10-year experience.","authors":"Ashitosh Pokharkar, Priyank Yadav, Deepak K Kandpal, Amita Mahajan, Sujit Kumar Chowdhary","doi":"10.3389/fped.2025.1453718","DOIUrl":"10.3389/fped.2025.1453718","url":null,"abstract":"<p><strong>Introduction: </strong>Minimally invasive surgery (MIS) has revolutionized oncological surgery with benefits such as smaller incisions and quicker recovery. However, its use in pediatric population is debated due to concerns about complete tumor resection and complications. Robotic surgery, offering enhanced visualization and precision, may address these issues. This study reviews a decade of robotic surgery for pediatric solid abdominal tumors at a single center, assessing perioperative and oncological outcomes.</p><p><strong>Methods: </strong>This prospective, single-arm study involved patients aged over six months, treated between 2013 and 2023 for solid abdominal tumors. Exclusion criteria included weight <6 kg, distant metastasis, and tumors >6 cm in shortest diameter. All patients underwent thorough preoperative assessment, including imaging and multidisciplinary evaluation. Surgeries were performed using the da Vinci Si Surgical System and data on patient demographics, perioperative outcomes, and follow-up were systematically collected.</p><p><strong>Results: </strong>The study cohort included 20 patients (9 boys and 11 girls) with a median age of 3.5 years. The median operative time was 114 min, with a median hospital stay of 3 days. Conversion to open surgery was necessary in 10% of cases. R0 resection was achieved in all cases, with a satisfactory lymph node sampling. Median follow-up of 5 years showed overall survival and event-free survival rates of 90%.</p><p><strong>Conclusion: </strong>Robotic surgery for pediatric abdominal tumors is safe and effective, reducing blood loss and hospital stays without compromising oncological outcomes. Proper case selection and adherence to oncological principles are essential. Further multicenter studies are needed to validate these findings and optimize the use of robotic surgery in pediatric oncology.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1453718"},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}