Frontiers in Pediatrics最新文献

{"title":"Case Report: Unmasking a sporadic pediatric tumor emergency: superior vena cava syndrome.","authors":"Gui-Liang Liu, Min Wang, Min Zhang, Yan Dai, Di-Wen Zhang","doi":"10.3389/fped.2025.1517745","DOIUrl":"10.3389/fped.2025.1517745","url":null,"abstract":"<p><strong>Introduction: </strong>Superior Vena Cava Syndrome (SVCS) is a rare but serious oncologic emergency in pediatric patients, most commonly caused by mediastinal masses such as lymphomas or leukemias. This condition results from the obstruction of the superior vena cava (SVC), leading to impaired venous return and respiratory and cardiovascular complications, progressive exacerbation in a short period, and an extremely high fatality rate. We report the case of a 12-year-old boy with SVCS caused by a mediastinal mass.</p><p><strong>Main symptoms/findings: </strong>The patient presented with progressive dyspnea, orthopnea, and swelling of the head and neck. He also exhibited chest tightness, dry cough, and shortness of breath. A chest CT revealed a large anterior mediastinal mass compressing the SVC and main bronchi.</p><p><strong>Diagnosis treatment outcomes: </strong>The patient was diagnosed with SVCS secondary to T-cell lymphoblastic lymphoma. Treatment began immediately with oxygen therapy and intravenous dexamethasone to reduce mediastinal compression. Significant clinical improvement was observed within 48 h, with a reduction in dyspnea and swelling. A biopsy confirmed T-cell lymphoblastic lymphoma and multidisciplinary care was pivotal to successful management.</p><p><strong>Conclusion: </strong>Early recognition and treatment of pediatric SVCS are essential to prevent life-threatening complications. Combined with a multidisciplinary approach, corticosteroid therapy was crucial for the patient's rapid recovery. Further research is needed to optimize treatment protocols and improve outcomes for pediatric SVCS cases.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1517745"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental satisfaction with care given in neonatal intensive care units, multicentre referral hospitals in eastern Ethiopia.","authors":"Mekdes Workie Dagnew, Aboma Motuma, Arsema Gebreyesus, Kasiye Shiferaw","doi":"10.3389/fped.2025.1417869","DOIUrl":"10.3389/fped.2025.1417869","url":null,"abstract":"<p><strong>Background: </strong>Parental satisfaction is an important dimension of the quality of a child's care and has been shown to improve health outcomes, including adherence to therapeutic regimens and understanding of medical information. Parental satisfaction is low in resource-limited countries like Ethiopia, with the paucity of evidence. This study aimed to determine the magnitude of parental satisfaction with care given in neonatal intensive care and its associated factors among parents of neonates admitted to neonatal intensive care units (NICUs) at referral hospitals in eastern Ethiopia from June to August 2023.</p><p><strong>Method: </strong>A facility-based cross-sectional study was conducted among 418 parents whose new-borns were admitted to the NICU and who were selected using a systematic random sampling technique. A pretested semi structured questionnaire was used to collect the data through face-to-face interviews with participants, and a checklist was used to review the charts/records by trained and experienced bachelor nurse/midwife data collectors. The data were coded, entered into Epi-Data version 4.6, and transferred to SPSS version 25 for analysis. We used binary logistic regression analysis to identify factors associated with the outcome variable. An adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to report the findings, and a <i>p</i>-value ≤0.05 was considered to indicate statistical significance.</p><p><strong>Results: </strong>The magnitude of parental satisfaction with care given in the NICU was 50.5% (95% CI: 45.6-55.5). Being a rural resident (AOR = 2.13; 95% CI: 1.33-3.43), having a shorter hospital stay (AOR = 4.25, 95% CI: 2.08-8.69), being able to breastfeed (AOR = 2.46; 95% CI: 1.48-4.09), having a single birth (AOR = 4.16; 95% CI: 1.91-9.03), and the availability and quality of the family room (AOR = 2.36; 95% CI:1.40-3.99) were significantly independent associated factors with parental satisfaction with care given in the NICU.</p><p><strong>Conclusion: </strong>Only one in two parents were satisfied with the care given in the NICU. The present study highlights that shortening hospital stays, mothers' ability to breastfeed their newborns, having a single birth, and the availability and quality of the family room contribute to enhancing parental satisfaction with care given in the NICU in eastern Ethiopia.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1417869"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primitive reflexes in infants with cerebral palsy due to Congenital Zika Syndrome and its relationship with other motor features.","authors":"Leticia Serra, Débora Patrícia Rios, Mino Rios, Breno Lima de Almeida, Kelly de Souza Fernandes, Rita Lucena, Isadora Cristina de Siqueira","doi":"10.3389/fped.2025.1483959","DOIUrl":"10.3389/fped.2025.1483959","url":null,"abstract":"<p><strong>Background: </strong>The Zika virus outbreak, which occurred from 2015 to 2016 in Brazil, resulted in the birth of neonates with brain malformations arising from Congenital Zika Syndrome (CZS). The characterization of primitive reflexes and their relationships with other motor characteristics, easily clinically detectable by health professionals, can aid in establishing motor prognosis in affected children.</p><p><strong>Objective: </strong>To describe reflex patterns in children with Cerebral Palsy (CP) due to CZS, and investigate associations with other motor features. Method: Observational cross-sectional study involving infants with CZS aged between 12 and 36 months. Primitive reflexes, protective reaction and markers of motor phenotype were evaluated.</p><p><strong>Results: </strong>48 children, median age: 19 months, were enrolled, most (79.2%) presented very severe CP (GMFCS 5), the persistence of more than 5 primitive reflexes (55%) and motor development age between 3 and 6 months (33.3%) (Bayley-III). A reduced ability to acquire motor skills was associated with the total number of persistent reflexes (rho = -0.45, <i>p</i> < 0.01). Asymmetrical Tonic Neck Reflex (ATNR) correlated with GMFCS level (rho = 0.49, <i>p</i> < 0.001). Lower motor development age was linked to abnormal posturing (<i>p</i> < 0.001) and absence of Parachute Reaction (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Infants with CP due to CZS present severe motor abnormalities. Lower motor development age is associated with the persistence of more than 5 primitive reflexes, abnormal posturing and the absence of Parachute Reaction. Parachute Reaction appears to be a prognostic marker of motor impairment severity in CZS-affected infants.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1483959"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children.","authors":"Yanyun Huang, Yuting Chen, Danyan Su, Suyuan Qin, Cheng Chen, Dongli Liu, Bingbing Ye, Yuqin Huang, Piaoliu Yuan, Yusheng Pang","doi":"10.3389/fped.2025.1562782","DOIUrl":"10.3389/fped.2025.1562782","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its long-term effects are not well understood. We aimed to assess the safety, effectiveness, and outcome of this procedure in children with CHD-PAH.</p><p><strong>Methods: </strong>We included 210 children with CHD-PAH at our hospital from 2012 to 2021 and collected their general, laboratory, echocardiographic, and hemodynamic data for analysis. A logistic regression analysis identified risk factors for persistent postclosure PAH (PP-PAH).</p><p><strong>Results: </strong>Among the 210 patients, 84.29% had mild PAH, 8.57% had moderate PAH, and 7.14% had severe PAH. The device was successfully implanted in 98.10% of patients. Early adverse events occurred in 12.14% (<i>n</i> = 25) of patients, with residual shunts and arrhythmia being the most common complications, each affecting 2.91% (<i>n</i> = 6) of patients. Most complications were minor and temporary, except for two cases of residual shunt-one required surgical repair, and one case of complete left bundle branch block led to occluder removal. Postintervention, pulmonary arterial pressure (PAP) decreased significantly, and cardiomegaly resolved. PP-PAH was detected in 13 patients (6.31%). Preoperative pulmonary arterial systolic pressure [odds ratio [OR] = 1.033, 95% confidence interval [CI] = 1.005-1.061, <i>P</i> = 0.019] and right ventricular diameter (OR = 1.111, 95% CI = 1.039-1.187, <i>P</i> = 0.002) were found to be risk factors for PP-PAH.</p><p><strong>Conclusion: </strong>Transcatheter closure is effective and safe for children with correctable CHD-PAH. Preoperative pulmonary arterial systolic pressure and right ventricular diameter are risk factors for PP-PAH.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1562782"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing risk factor identification for pediatric lobar pneumonia: the promise of machine learning technologies.","authors":"Li Shen, Jiaqiang Wu, Min Lu, Yiguo Jiang, Xiaolan Zhang, Qiuyan Xu, Shuangqin Ran","doi":"10.3389/fped.2025.1490500","DOIUrl":"10.3389/fped.2025.1490500","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired pneumonia (CAP) is a prevalent pediatric condition, and lobar pneumonia (LP) is considered a severe subtype. Early identification of LP is crucial for appropriate management. This study aimed to develop and compare machine learning models to predict LP in children with CAP.</p><p><strong>Methods: </strong>A total of 25 clinical and laboratory variables were collected. Missing data (<2%) were imputed, and the dataset was split into training (60%) and validation (40%) sets. Univariable logistic regression and Boruta feature selection were used to identify significant predictors. Four machine learning algorithms-Logistic Regression (LR), Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), and Decision Tree (DT)-were compared using area under the curve (AUC), balanced accuracy, sensitivity, specificity, and F1 score. SHAP analysis was performed to interpret the best-performing model.</p><p><strong>Results: </strong>A total of 278 patients with CAP were included in this study, of whom 65 were diagnosed with LP. The XGBoost model demonstrated the best performance with an AUC of 0.880 (95% CI: 0.807-0.934) in the training set and 0.746 (95% CI: 0.664-0.843) in the validation set. SHAP analysis identified age, CRP, CD64 index, lymphocyte percentage, and ALB as the top five predictive factors.</p><p><strong>Conclusion: </strong>The XGBoost model showed superior performance in predicting LP in children with CAP. The model enabled early diagnosis and risk assessment of LP, thereby facilitating appropriate clinical decision-making.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1490500"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The early diagnostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in neonatal late-onset sepsis.","authors":"Qigai Yin, Jing Yin, Lu Shen, Qin Zhou, WeiDong Xu","doi":"10.3389/fped.2025.1483522","DOIUrl":"10.3389/fped.2025.1483522","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to investigate the early diagnostic value of the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C-reactive protein (CRP) in neonatal late-onset sepsis (LOS), as well as to evaluate the combined diagnostic utility of these markers for the early detection of neonatal LOS.</p><p><strong>Methods: </strong>The late-onset sepsis of newborns admitted to the neonatal intensive care unit of our hospital were retrospectively collected. 142 children with Late-Onset Sepsis (LOS) were selected as the LOS group, 50 neonates with systemic infection were selected as the systemic infection group, 50 neonates who underwent physical examination were selected as the non-systemic infection group. The differences of NLR, PLR, platelet-to-neutrophil ratio (PNR), and C-reactive protein (CRP), Procalcitonin among the three groups were compared.</p><p><strong>Results: </strong>The levels of NLR and PLR in LOS group were significantly higher than those in systemic infection group and non-systemic infection group. The Receiver Operating Characteristic (ROC) curve result revealed that the area under ROC (AUC, Area Under Curve) of NLR for the diagnosis of LOS was 0.903. When the optimal cut-off value was 1.30, the sensitivity and specificity were 89.4% and 81.0%. The AUC of PLR for the diagnosis of LOS was 0.833. When the optimal truncation value was 57.86, the sensitivity and specificity were 92.3% and 68.0%. The AUC of CRP for the diagnosis of LOS was 0.876, and the sensitivity and specificity were 76.8% and 87.0% when the optimal cut-off value was 10.21 mg/dl. When NLR, PLR, and CRP were combined to diagnosis LOS, The AUC was 0.942, the sensitivity and specificity were 90.8% and 86.0%.</p><p><strong>Conclusions: </strong>The levels of NLR and PLR in the LOS were higher, which have certain value in the early diagnosis of LOS, and combined with CRP can improve the diagnostic efficiency.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1483522"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for peripherally inserted central catheter malposition in preterm infants: a multicenter retrospective study.","authors":"Chunyan Liang, Jinming Liu, Yingzi Tang, Wenpiao Zhao, Ruining Xin, Xiaoqun Gu, Fang Huang, Yu'e Lai, Wangjin Huang, Yanhong Liu, Mei Lin, Lili Pan, Guirong Cao, Sudan Tan, Chunliu Wei, Fangyuan Lin","doi":"10.3389/fped.2025.1534799","DOIUrl":"10.3389/fped.2025.1534799","url":null,"abstract":"<p><strong>Objective: </strong>To explore the risk factors affecting peripherally inserted central catheter (PICC) tip malposition in preterm infants.</p><p><strong>Methods: </strong>A retrospective collection of clinical data from preterm infants who underwent PICC placement in the neonatal departments of Guangxi Maternal and Child Health Hospital and eight other hospitals from January 2021 to April 2024 was conducted. The incidence of catheter tip malposition was analyzed. The infants were divided into two groups based on the occurrence of catheter tip malposition: the malposition group and the non-malposition group. Multifactorial logistic regression and multimodel logistic regression analyses were employed to explore the influencing factors of PICC tip malposition in preterm infants.</p><p><strong>Results: </strong>A total of 1,449 infants were ultimately included in the study, with an incidence of catheter tip displacement of 12.56% (182 out of 1,449). Adjusted results from multimodel regression analysis of covariates indicated that Sample selection location in Guilin (OR = 2.30, 95% CI:1.24∼4.25), Yulin (OR = 4.35, 95% CI: 2.27∼8.34) and Qinzhou (OR = 2.63, 95% CI:1.37∼5.08), duration of catheter insertion procedure (OR = 1.01, 95% CI: 1.01∼1.02), duration of catheter dwell (OR = 1.04, 95% CI: 1.02∼1.07), weight percentile at the time of catheter malpositioning (OR = 11.39, 95% CI:4.81∼26.95), extremely preterm group (<28 weeks gestation) (OR = 4.42, 95% CI: 1.29∼15.16) were risk factors for catheter tip displacement. Additionally, site of PICC catheterization in neck as a risk factor (OR = 3.48, 95% CI: 1.89∼6.40).</p><p><strong>Conclusion: </strong>Sample selection location in Guilin, Yulin and Qinzhou, duration of catheter insertion procedure, duration of catheter dwell, weight percentile at catheter removal, extremely preterm group (<28 weeks gestation) and site of PICC catheterization in neck may increase the risk of PICC catheter tip malposition.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1534799"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Prolonged survival in Schinzel-Giedion syndrome featuring megaureter and <i>de novo SETBP1</i> mutation.","authors":"Glenda M Beaman, Benjamin W Jarvis, Anju Goyal, David J B Keene, Max Cervellione, Filipa M Lopes, Kay A Metcalfe, Adrian S Woolf, William G Newman","doi":"10.3389/fped.2025.1534192","DOIUrl":"10.3389/fped.2025.1534192","url":null,"abstract":"<p><strong>Background: </strong>Rare early-onset lower urinary tract (REOLUT) disorders affect the ureter, urinary bladder, or urethra and manifest before birth or in childhood. Monogenic causes have been reported in a subset of such individuals.</p><p><strong>Objectives: </strong>A possible genetic cause was considered in a child with a megaureter who had syndromic features.</p><p><strong>Subjects and methods: </strong>Whole-exome sequencing was undertaken in individuals with megaureter. Immunohistochemistry was performed in urinary tract tissues of unaffected human fetuses.</p><p><strong>Results: </strong>The index case presented at 6 months with urosepsis and was found to have a unilateral primary non-refluxing megaureter which required stenting of its distal portion. This, together with dysmorphic features and developmental delay, led to a clinical diagnosis of Schinzel-Giedion syndrome (SGS). She was found to carry a <i>de novo</i> missense variant in <i>SET binding protein 1</i> (<i>SETBP1</i>), c.2613T>G (GenBank: NM_015559.3) (p.Ile871Met), a gene previously implicated in SGS. She was in good general health at 11 years of age, an unusual outcome given that most individuals with SGS die in the first 2 years of life. SETBP1 was detected in the fetal urinary tract, both in the urothelium and in nerve trunks in the kidney hilum and around the ureter. No <i>SETBP1</i> gene variants were detected in eight further cases of megaureter.</p><p><strong>Conclusions: </strong>This case indicates the value of genetic testing when a REOLUT disorder is accompanied by syndromic signs outside the urinary tract. SETBP1 may drive the functional differentiation of the human fetal ureter.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1534192"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean nutrient adequacy ratio and associated factors of complementary foods among children aged 6-23 months in Northeast Ethiopia.","authors":"Abdulkerim Kassaw, Tefera Chane Mekonnen, Erkihun Tadesse Amsalu, Eyob Tilahun ABeje, Chala Daba, Yawkal Tsega, Abel Endawkie","doi":"10.3389/fped.2025.1446431","DOIUrl":"10.3389/fped.2025.1446431","url":null,"abstract":"<p><strong>Background: </strong>Inadequate intake of macro- and micronutrients is a significant public health challenge in Ethiopia. Ethiopia carries a substantial burden of both macro- and micronutrient deficiencies, with far-reaching consequences. However, there is limited evidence on the determinants and mean nutrient adequacy of complementary foods among children aged 6-23 months. Therefore, this study aims to determine the mean nutrient adequacy ratio and associated factors of complementary feeding among children aged 6-23 months in Northeast Ethiopia.</p><p><strong>Methods: </strong>A study was conducted in Northeast Ethiopia between 1 March and 30 April 2023, among 255 children aged 6-23 months. The study employed a systematic sampling technique to select 255 children. The data were collected using a 24-h dietary recall method. Linear regression analysis was conducted to identify factors associated with the nutrient adequacy of complementary foods. In the multivariable analysis, variables with <i>p</i>-values <0.05 were considered statistically significant.</p><p><strong>Results: </strong>The study found that the mean nutrient adequacy ratio of complementary foods among children aged 6-23 months in Northeast Ethiopia was 63% (95% CI 60.8-65.14). The adequacy of nutrients in complementary foods varied: energy (90%), fat (93%), carbohydrate (70%), protein (88%), calcium (57%), zinc (52%), vitamin B1 (50%), vitamin A (52%), and vitamin C (60%). The age of the child, mother's education, wealth index, feeding frequency, dietary diversity, minimum acceptable diet, source of information during antenatal care, postnatal care, food insecurity, and the number of children aged under 5 were associated with mean nutrient adequacy of complementary feeding.</p><p><strong>Conclusions: </strong>The study concludes that the mean nutrient adequacy ratio of complementary foods among children aged 6-23 months in Northeast Ethiopia is alarmingly low, indicating a significant gap in meeting the nutritional recommendations set by the World Health Organization. Various factors, including the child's age, maternal education, household wealth index, food insecurity, and dietary diversity, were identified as critical determinants of nutrient adequacy. These findings underscore the urgent need for comprehensive interventions at multiple levels, including education, food security, and health services, to enhance the consumption of adequate and diverse complementary foods. By addressing these factors, stakeholders can improve the nutritional status of young children, ultimately contributing to better health outcomes and development in the region.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1446431"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of Crohn's disease in children, 2014-2024.","authors":"Yanjing Zhu, Yunhong Ma, Zhengjiu Cui, Yueli Pan, Juanjuan Diao","doi":"10.3389/fped.2025.1515251","DOIUrl":"10.3389/fped.2025.1515251","url":null,"abstract":"<p><strong>Background: </strong>In recent years, the incidence of Crohn's disease has risen significantly in the pediatric population, and its prolongation has had a major impact on children's physical and mental health as well as on the quality of life of their families, and has therefore received extensive attention from scholars around the world. A large number of articles have been published on Crohn's disease in children; however, there is still a lack of studies that use visualization methods for bibliometric analysis of relevant literature. The purpose of this paper is to statistically analyze the published literature in the field of Crohn's disease in children in order to help in the future diagnosis and treatment of Crohn's disease in children.</p><p><strong>Methods: </strong>Literature meeting the inclusion criteria was screened from the Web of Science Core Collection database. Literature was visualized and analyzed by author, country, institution, journal, reference, and keyword using Citespace (6.2.R4) and VOSviewer (1.6.18).</p><p><strong>Results: </strong>A total of 3,177 eligible publications were included. There is an overall increasing trend in the number of annual publications.Turner, Dan published the most number of articles with 78 and has a high impact in the field of CD. The most cited author was Levine, A. Among countries and institutions, the United States and Tel Aviv University had the highest number of publications. The journal with the most publications is Journal Of Pediatric Gastroenterology And Nutrition. The most co-cited journal was Inflammatory Bowel Diseases. The most cited document was ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents, and the most cited document with the highest outbreak intensity was The Medical Management of Paediatric Crohn's Disease: an ECCO-ESPGHAN Guideline Update.The most frequent keyword was \"inflammatory bowel disease\".</p><p><strong>Conclusion: </strong>This study provides a visual summary of information for the field of pediatric Crohn's disease and contributes to international collaboration to promote research in the field of pediatric Crohn's disease.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1515251"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}