儿童蘑菇中毒的流行病学和临床方面:15年回顾性分析。

IF 2 3区 医学 Q2 PEDIATRICS
Frontiers in Pediatrics Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI:10.3389/fped.2025.1621891
ShaoCong Zheng, Xuejiao Miao, Shan He
{"title":"儿童蘑菇中毒的流行病学和临床方面:15年回顾性分析。","authors":"ShaoCong Zheng, Xuejiao Miao, Shan He","doi":"10.3389/fped.2025.1621891","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mushroom poisoning is a significant public health concern, particularly in pediatric populations, where developmental differences in toxin metabolism and organ vulnerability pose unique clinical challenges. Despite its geographic and seasonal patterns, pediatric mushroom poisoning remains underrepresented in the literature, necessitating further investigation into its epidemiological and clinical characteristics.</p><p><strong>Methods: </strong>This 15-year retrospective cohort study analyzed 73 pediatric cases (aged ≤14 years) of mushroom poisoning at a tertiary hospital in Southwest China. Epidemiological, clinical, and laboratory data were collected, and statistical analyses were performed using SPSS 26.0.</p><p><strong>Results: </strong>Epidemiological data revealed seasonal clustering in summer and autumn, predominantly affecting older children (≥7 years). <i>Boletus spp.</i> accounted for most cases (71.2%), followed by <i>Amanita</i> (8.2%). Clinical presentations included gastrointestinal (72.6%) and neurotoxic symptoms (69.9%), with hallucinations more prevalent in non-liver injury cases (56.9% vs. 0%, <i>p</i> = 0.02). Severe hepatic injury, marked by elevated liver enzymes (ALT, AST, LDH) and coagulation dysfunction (APTT, PT), correlated with higher HOPE6 scores (≥3) and 100% mortality (4 deaths). The HOPE6 scoring system demonstrated prognostic utility, with a pediatric-specific threshold (≥3) predicting adverse outcomes, contrasting with adult thresholds (≥2).</p><p><strong>Conclusions: </strong>This study highlights the critical role of hepatic injury in mortality and underscores age-dependent variations in clinical thresholds for risk stratification in pediatric mushroom poisoning. Early intensive care is advocated to improve outcomes. Future research should focus on multicenter prospective cohorts to further validate these findings and assess therapeutic interventions.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1621891"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488608/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis.\",\"authors\":\"ShaoCong Zheng, Xuejiao Miao, Shan He\",\"doi\":\"10.3389/fped.2025.1621891\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mushroom poisoning is a significant public health concern, particularly in pediatric populations, where developmental differences in toxin metabolism and organ vulnerability pose unique clinical challenges. Despite its geographic and seasonal patterns, pediatric mushroom poisoning remains underrepresented in the literature, necessitating further investigation into its epidemiological and clinical characteristics.</p><p><strong>Methods: </strong>This 15-year retrospective cohort study analyzed 73 pediatric cases (aged ≤14 years) of mushroom poisoning at a tertiary hospital in Southwest China. Epidemiological, clinical, and laboratory data were collected, and statistical analyses were performed using SPSS 26.0.</p><p><strong>Results: </strong>Epidemiological data revealed seasonal clustering in summer and autumn, predominantly affecting older children (≥7 years). <i>Boletus spp.</i> accounted for most cases (71.2%), followed by <i>Amanita</i> (8.2%). Clinical presentations included gastrointestinal (72.6%) and neurotoxic symptoms (69.9%), with hallucinations more prevalent in non-liver injury cases (56.9% vs. 0%, <i>p</i> = 0.02). Severe hepatic injury, marked by elevated liver enzymes (ALT, AST, LDH) and coagulation dysfunction (APTT, PT), correlated with higher HOPE6 scores (≥3) and 100% mortality (4 deaths). The HOPE6 scoring system demonstrated prognostic utility, with a pediatric-specific threshold (≥3) predicting adverse outcomes, contrasting with adult thresholds (≥2).</p><p><strong>Conclusions: </strong>This study highlights the critical role of hepatic injury in mortality and underscores age-dependent variations in clinical thresholds for risk stratification in pediatric mushroom poisoning. Early intensive care is advocated to improve outcomes. Future research should focus on multicenter prospective cohorts to further validate these findings and assess therapeutic interventions.</p>\",\"PeriodicalId\":12637,\"journal\":{\"name\":\"Frontiers in Pediatrics\",\"volume\":\"13 \",\"pages\":\"1621891\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488608/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fped.2025.1621891\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fped.2025.1621891","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:蘑菇中毒是一个重要的公共卫生问题,特别是在儿科人群中,毒素代谢和器官易感性的发育差异构成了独特的临床挑战。尽管其地理和季节模式,儿童蘑菇中毒在文献中仍然代表性不足,需要进一步调查其流行病学和临床特征。方法:对西南地区某三级医院73例儿童(年龄≤14岁)食用菌中毒病例进行15年回顾性队列研究。收集流行病学、临床和实验室资料,采用SPSS 26.0软件进行统计学分析。结果:流行病学资料显示季节性聚集在夏季和秋季,主要影响年龄较大的儿童(≥7岁)。以肉毒杆菌最多(71.2%),其次是毒伞菌(8.2%)。临床表现包括胃肠道(72.6%)和神经毒性症状(69.9%),幻觉在非肝损伤病例中更为普遍(56.9%比0%,p = 0.02)。严重的肝损伤,以肝酶(ALT、AST、LDH)升高和凝血功能障碍(APTT、PT)为标志,与较高的HOPE6评分(≥3)和100%的死亡率(4例死亡)相关。HOPE6评分系统显示出预后效用,与成人阈值(≥2)相比,儿科特异性阈值(≥3)预测不良结局。结论:本研究强调了肝损伤在死亡率中的关键作用,并强调了儿童蘑菇中毒风险分层的临床阈值的年龄依赖性变化。提倡早期重症监护以改善预后。未来的研究应侧重于多中心前瞻性队列,以进一步验证这些发现并评估治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis.

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis.

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis.

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis.

Background: Mushroom poisoning is a significant public health concern, particularly in pediatric populations, where developmental differences in toxin metabolism and organ vulnerability pose unique clinical challenges. Despite its geographic and seasonal patterns, pediatric mushroom poisoning remains underrepresented in the literature, necessitating further investigation into its epidemiological and clinical characteristics.

Methods: This 15-year retrospective cohort study analyzed 73 pediatric cases (aged ≤14 years) of mushroom poisoning at a tertiary hospital in Southwest China. Epidemiological, clinical, and laboratory data were collected, and statistical analyses were performed using SPSS 26.0.

Results: Epidemiological data revealed seasonal clustering in summer and autumn, predominantly affecting older children (≥7 years). Boletus spp. accounted for most cases (71.2%), followed by Amanita (8.2%). Clinical presentations included gastrointestinal (72.6%) and neurotoxic symptoms (69.9%), with hallucinations more prevalent in non-liver injury cases (56.9% vs. 0%, p = 0.02). Severe hepatic injury, marked by elevated liver enzymes (ALT, AST, LDH) and coagulation dysfunction (APTT, PT), correlated with higher HOPE6 scores (≥3) and 100% mortality (4 deaths). The HOPE6 scoring system demonstrated prognostic utility, with a pediatric-specific threshold (≥3) predicting adverse outcomes, contrasting with adult thresholds (≥2).

Conclusions: This study highlights the critical role of hepatic injury in mortality and underscores age-dependent variations in clinical thresholds for risk stratification in pediatric mushroom poisoning. Early intensive care is advocated to improve outcomes. Future research should focus on multicenter prospective cohorts to further validate these findings and assess therapeutic interventions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Frontiers in Pediatrics
Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
3.60
自引率
7.70%
发文量
2132
审稿时长
14 weeks
期刊介绍: Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信