Frontiers in Pediatrics最新文献

{"title":"Clinical relevance of bacterial and/or viral coinfection in acute bronchiolitis in an Italian neonatal unit during the 2021-2023 seasons.","authors":"Venere Cortazzo, Marilena Agosta, Domenico Umberto De Rose, Valeria Fox, Velia Chiara Di Maio, Gianluca Vrenna, Martina Rossitto, Barbara Lucignano, Stefania Ranno, Annamaria Sisto, Cristina Russo, Annabella Braguglia, Maria Paola Ronchetti, Andrea Dotta, Carlo Federico Perno, Paola Bernaschi","doi":"10.3389/fped.2025.1577913","DOIUrl":"10.3389/fped.2025.1577913","url":null,"abstract":"<p><strong>Background: </strong>Acute bronchiolitis is a leading cause of hospitalization in young children worldwide, and literature reports conflicting data regarding the role of coinfections.</p><p><strong>Objective: </strong>To evaluate the possible clinical relevance of bacterial and/or viral respiratory coinfection in a cohort of newborns/infants hospitalized for bronchiolitis.</p><p><strong>Methods: </strong>Neonates and infants younger than three months admitted to neonatal units from October 2021 to March 2023 because of acute bronchiolitis were included in this retrospective study. Analyses were performed with Stata 11.1 (<i>p</i> < 0.05). Data were summarized as medians (IQR) or counts (%). Appropriate tests were used based on data type and distribution, with Benjamini-Hochberg correction for multiple comparisons. Odd Ratios (ORs) were unadjusted.</p><p><strong>Results: </strong>In a cohort of 240 patients, respiratory coinfection was associated with a longer hospital stay (<i>p</i> < 0.001) and the need for invasive mechanical ventilation (<i>p</i> < 0.001) compared to viral mono-infection, highlighting a potential role in patient outcome. Moreover, we observed that premature patients are more likely to contract a respiratory coinfection than a viral mono-infection (<i>p</i> = 0.011).</p><p><strong>Conclusion: </strong>Coinfections increased the clinical severity of bronchiolitis more than simple viral mono-infection in our cohort, contributing to a longer hospital stay and the need for invasive mechanical ventilation.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1577913"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices of polio vaccination among mothers attending vaccination sites in Gaza during the conflict.","authors":"Abdel Hamid El Bilbeisi, Amany El Afifi, Samer Abuzerr, Isra Kanan Alwahedy, Saja Kanan Alwahedy","doi":"10.3389/fped.2025.1569650","DOIUrl":"10.3389/fped.2025.1569650","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the knowledge, attitudes, and practices (KAP) related to polio vaccination among mothers attending vaccination sites in Gaza during the ongoing conflict.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted from 1 to 12 September, 2024, targeting a representative sample of 474 mothers from ten primary healthcare centers across the governorates of Gaza. Participants were randomly selected using a cluster sampling method. Data on socio-demographics and KAP towards polio vaccination were collected through a validated, interview-based questionnaire. Statistical analysis was performed using SPSS version 26.</p><p><strong>Results: </strong>Of the 474 mothers surveyed, 44.7% were between 26 and 30 years old. Around 35.4% had a primary-level education, 48.1% were employed, 48.5% had two to three children, and 49.4% had children aged between one day and less than twelve months. The majority of mothers exhibited good knowledge (85.7%), positive attitudes (86.1%), and good practices (67.1%) regarding childhood vaccination. Knowledge scores were significantly associated with the mother's age, number of children, and the children's age. Attitude scores were significantly related to the mother's age and number of children (<i>P</i> < 0.05 for all). However, no significant relationship was observed between socio-demographic factors and practice scores.</p><p><strong>Conclusion: </strong>Most mothers demonstrated good knowledge and positive attitudes towards polio vaccination, although only about two-thirds reported good vaccination practices. Younger mothers and those with younger children had better knowledge, while middle-aged mothers expressed more positive attitudes. Importantly, socio-demographic factors were not linked to practice levels. The relatively low adherence to vaccination practices requires further attention.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1569650"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases.","authors":"Xiaoben Liang, Rong Xu, Hongming Xu, Jiarui Chen, Xiaoyan Li","doi":"10.3389/fped.2025.1499656","DOIUrl":"10.3389/fped.2025.1499656","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the clinical appearances of infantile subglottic hemangioma (SGH) and the diagnostic value of flexible fiberoptic laryngoscopy (FFL) combined with contrast-enhanced CT (CECT).</p><p><strong>Methods: </strong>We retrospectively analyzed the data of 25 children diagnosed with SGH from January 2012 to January 2022.</p><p><strong>Results: </strong>FFL showed a smooth, rounded, vascular-appearing submucosal lesion in the subglottic wall, while CECT revealed an enhancing lesion, obscuring the airway lumen. Among the 25 cases (8 males and 17 females; 10 left-sided, 11 right-sided, and 4 middle), the clinical appearances contained stridor (25), respiratory distress (13), three-concave sign (10), barking cough (9), feeding difficulty (8), cyanosis (2), and hoarseness (2). SGH with cutaneous hemangiomas accounted for 24% (6/25). The age at presentation ranged from 1 day to 8 months (median, 33 days), including 96% (24/25) of cases aged <6 months. Moreover, 92% (23/25) of cases had a history of misdiagnosis, 22 respiratory infections, 5 laryngomalacia, 1 laryngeal cyst, and 1 asthma, individually or in combination. Except for one case that died of polygenic abnormality and another case lost to follow-up, the remaining 23 cases were cured after oral propranolol.</p><p><strong>Conclusions: </strong>For an infant with respiratory symptoms, who has repeated condition or poor effect after routine treatment, SGH should be considered, especially in infants under 6 months old. FFL combined with CECT is recommended to make a definite diagnosis of SGH.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1499656"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of physical activity and screen time with vitamin D status among children with disabilities.","authors":"Wen Wang, Zhe Wang, Haixia Sun, Guowei Li, Su Liu, Zheng Xue","doi":"10.3389/fped.2025.1558685","DOIUrl":"10.3389/fped.2025.1558685","url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) and screen time (ST) may influence vitamin D status in children with disabilities, yet their relationships remain understudied in this population.</p><p><strong>Methods: </strong>We analyzed data from 645 children with disabilities aged 3-19 years. PA and ST were categorized into quartiles. Multiple linear regression models were used to examine associations between PA, ST, and vitamin D levels, adjusting for demographic and clinical characteristics.</p><p><strong>Results: </strong>Higher PA was positively associated with vitamin D levels (<i>β</i> = 0.984, 95% CI: 0.388-1.58, <i>p</i> = 0.003) in fully adjusted models. Participants in the highest PA quartile had significantly higher vitamin D levels compared to the lowest quartile (<i>β</i> = 6.884, 95% CI: 2.736-11.031, <i>p</i> = 0.003). Conversely, ST showed an inverse association with vitamin D levels (<i>β</i> = -0.8, 95% CI: -1.414 to -0.186, <i>p</i> = 0.015), with the highest ST quartile showing significantly lower vitamin D levels compared to the lowest quartile (<i>β</i> = -8.098, 95% CI: -13.318 to -2.877, <i>p</i> = 0.005). Males were more likely to engage in high PA (66.31%), and both PA and ST showed significant age-related patterns.</p><p><strong>Conclusions: </strong>Our findings reveal clear links between physical activity, screen time, and vitamin D levels in children with disabilities. Promoting physical activity and reducing screen time may be effective strategies to improve vitamin D status in this population.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1558685"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tachycardia and persistent pulmonary hypertension of the newborn.","authors":"Ourania Kaltsogianni, Ravindra Bhat, Anne Greenough, Theodore Dassios","doi":"10.3389/fped.2025.1607907","DOIUrl":"10.3389/fped.2025.1607907","url":null,"abstract":"<p><strong>Background: </strong>It is not known whether tachycardia in persistent pulmonary hypertension of the newborn (PPHN) is due to the use of inotropic agents or is a pathophysiological process related to the disease <i>per se</i>. In this study, we aim to test the hypothesis that tachycardia in PPHN would be related to non-invasive indices of PPHN.</p><p><strong>Methods: </strong>This is a retrospective study of ventilated infants with echocardiographically confirmed PPHN at the Neonatal Intensive Care Unit of King's College Hospital NHS Foundation Trust. The difference of the partial pressure of arterial (PaCO₂) to end-tidal CO₂ (EtCO₂) or PaCO₂-EtCO₂ gradient was calculated as an index of PPHN severity and was related to the level of tachycardia at acute PPHN and after the resolution of PPHN (pre-extubation).</p><p><strong>Results: </strong>Fifteen infants with PPHN were studied, whose median (interquartile range, IQR) gestational age was 35.7 (34.1-40.3) weeks and birth weight was 2.95 (2.17-3.20) kg. It was found that the median (IQR) heart rate was higher during acute PPHN [158 (122-169) bpm] compared with that during pre-extubation [119 (111-136) bpm, <i>p</i> = 0.016]. The difference in the heart rate at acute illness and pre-extubation was significantly related to the difference in the PaCO₂-EtCO₂ gradient (correlation coefficient = 0.732, <i>p</i> = 0.016).</p><p><strong>Conclusions: </strong>There was a significant association between tachycardia and the severity of PPHN in ventilated infants, possibly describing that tachycardia is the result of PPHN <i>per se</i>, as well as the effect of inotropes.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1607907"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Transient myeloproliferative disorder with trisomy 21 in blast cells.","authors":"Aleksandra Zacny, Barbara Saniewska, Maria Orzeł, Beata Borek-Dzięcioł, Bożena Kociszewska-Najman","doi":"10.3389/fped.2025.1604803","DOIUrl":"10.3389/fped.2025.1604803","url":null,"abstract":"<p><strong>Background: </strong>Transient myeloproliferative disorder is a clonal myeloproliferative syndrome that occurs in the presence of mutations in the GATA1 gene and chromosome 21 trisomy. It affects almost exclusively newborns with Down syndrome and usually resolves spontaneously. Neonatal leukemia is a rare childhood disease. Its prognosis is worse. We report a novel case of transient myeloproliferative disorder in a neonate without phenotypic features of Down syndrome, emphasizing the importance of comprehensive genetic diagnostics in atypical presentations.</p><p><strong>Case presentation: </strong>We present a case of a 4-day-old female neonate without phenotypic features of Down syndrome with suspected proliferative hematopoietic disease. A blood smear at birth showed severe anemia, leukocytosis and the presence of blasts. Abdominal ultrasound showed hepatosplenomegaly. In the bone marrow, 70.2% blast cell infiltration was described. An abnormal karyotype of 47XX+21 and GATA1 mutation were detected only in the blood cells. Transient myeloproliferative syndrome with t21 mosaicism was diagnosed. The patient received cytoreductive treatment according to the AML BFM protocol.</p><p><strong>Conclusions: </strong>This case highlights the importance of genetic testing in neonates with congenital anemia and hyperleukocytosis, particularly when Down syndrome is not phenotypically apparent. Detecting trisomy 21 mosaicism and the GATA1 mutation is critical for diagnosing transient myeloproliferative disorder, planning the best treatment and determining prognosis.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1604803"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival assessment in extremely preterm neonates in a middle-income setting.","authors":"Maria J Rodriguez-Sibaja, Olivo Herrera-Ortega, Mario I Lumbreras-Marquez, Deneb Morales-Barquet, Sandra Acevedo-Gallegos, Yazmin Copado-Mendoza, Dulce M Camarena-Cabrera, Juan M Gallardo-Gaona","doi":"10.3389/fped.2025.1574613","DOIUrl":"10.3389/fped.2025.1574613","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, an estimated 15.1 million preterm neonates are born annually, with 1% classified as extremely preterm (i.e., <28.0 weeks of gestation). The survival and outcomes of this vulnerable population are influenced by multiple factors, particularly gestational age, birth weight, and available medical resources. This study aimed to describe the hospital discharge survival of extremely preterm infants born in a middle-income setting. As a secondary objective, we assessed the neonatal morbidity associated with this group.</p><p><strong>Material and methods: </strong>In this cross-sectional study of singleton pregnancies<b>,</b> neonatal survival following extremely preterm birth was determined using three different denominators and expressed as prevalence (i.e., percentages): (1) the total number of extremely preterm births, including intrapartum fetal deaths; (2) the total number of all live births, including neonatal deaths in the delivery room, and (3) the total number of preterm neonates admitted to the neonatal intensive care unit (<i>N</i>ICU). Neonatal morbidity was assessed as a secondary outcome.</p><p><strong>Results: </strong>There were no live births between 22.0 and 23.6 weeks of gestation. Overall mortality decreased with increasing gestational age, from 100% (22/22) at <24.0 weeks of gestation to 87% (14/16), 42% (16/38), and 21% (11/52) at a gestational age of 25, 26, and 27 weeks, respectively. The survival rate to NICU discharge among extremely preterm infants was 49% (65/132), 67% (65/97), and 69% (65/93), depending on whether survival was calculated based on all births, all live births, or NICU admissions, respectively. None of the neonates born before 24.6 weeks of gestation survived to discharge. Notably, 97.0% of NICU survivors were diagnosed with major morbidity.</p><p><strong>Conclusion: </strong>The survival rate at NICU discharge exceeds 50% from 26 weeks onwards in a middle-income setting. Importantly, survival rates varied significantly depending on the denominator used, highlighting the need to carefully select inclusion criteria in neonatal survival analyses. Notably, survival after extremely preterm birth was associated with significant morbidity.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1574613"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Congenital obstruction of the urinary tract.","authors":"Irene Paraboschi, Massimo Garriboli","doi":"10.3389/fped.2025.1626486","DOIUrl":"10.3389/fped.2025.1626486","url":null,"abstract":"","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1626486"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of laparoscopic orchopsis for transverse testicular ectopia via the Hesselbach route.","authors":"Xu Zhuofan, Zhao Xudong, Yuan Boxiang","doi":"10.3389/fped.2025.1514662","DOIUrl":"10.3389/fped.2025.1514662","url":null,"abstract":"<p><strong>Background: </strong>Testicular transverse ectopia (TTE) is a rare congenital abnormality in which both testicles descend into the same hemiscrotum via a solitary inguinal canal. This condition is frequently linked with inguinal hernias and various urogenital irregularities, and it may manifest as an unoccupied opposite scrotum or as a discernible lump in the groin or scrotal area.</p><p><strong>Patient presentation: </strong>A 9-month-old boy was diagnosed with a right inguinal hernia, which presented as a 3 cm × 3 cm palpable mass without pain upon examination. During surgery, both testicles were discovered to be undescended, fused by their ligaments, and had independent vas deferens, vascular supplies, and epididymides. The poorly developed testicles were fixed in the scrotum via Hei's triangle. Postoperative follow-up revealed normal testicular positioning, with no retraction, atrophy, or hernia recurrence.</p><p><strong>Conclusions: </strong>Orchiopexy via Hei's triangle is a new surgical option for patients with Type I TTE who have insufficient length spermatic cord blood vessels.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1514662"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram for predicting serum vitamin D deficiency in children/adolescents with new-onset type 1 diabetes: a single-center study in China.","authors":"Xin Yang, Hui Jiang, Min Liao, Meng Lin, Jin Wu","doi":"10.3389/fped.2025.1554833","DOIUrl":"10.3389/fped.2025.1554833","url":null,"abstract":"<p><strong>Objective: </strong>The vitamin D-type 1 diabetes (T1D) association has been debated in public health. The purpose of this study was to develop a vitamin D deficiency prediction model and investigate vitamin D deficiency risk factors in children and adolescents with new-onset T1D.</p><p><strong>Methods: </strong>A single-centre, retrospective analysis of paediatric patients (1-18 years) with new-onset T1D and initial 25-hydroxyvitamin D assessments was performed at a tertiary hospital in China between January 2020 and July 2024 (<i>n</i> = 353). The patients were divided into two groups according to whether their vitamin D deficiency exceeded 12 ng/ml. After identifying vitamin D deficiency risk factors in children/adolescents with new-onset T1D, a receiver operating characteristic (ROC) curve model was developed to predict the probability of vitamin D deficiency in these individuals. That model was represented with a nomogram. Calibration and clinical decision analysis curves were used to evaluate the model's effectiveness after internal validation via bootstrapping.</p><p><strong>Results: </strong>The prevalence rate of serum vitamin D deficiency among patients with new-onset T1D was 26.35% (93/353). Multivariate logistic regression analysis revealed that minority status (X1), weight (X2), diabetic ketoacidosis severity (X3), serum vitamin D testing season (X4), free triiodothyronine (X5), and high-density lipoprotein (X6) were closely associated with serum vitamin D deficiency development in children/adolescents with new-onset T1D (<i>P</i> < 0.05). The model was logit (P) =e^x/(1 + e^x), X = 4.626-1.878*X1-0.038*X2-0.821*X3-0.88*X4 + 0.351*X5 + 0.532*X6. The area under the curve (AUC) of the serum vitamin D deficiency predictive model among patients with new-onset T1D was 0.769 (95% CI = 0.711-0.826). The predicted probability's best cut-off value was 0.671.</p><p><strong>Conclusions: </strong>The established risk prediction model has good efficacy, providing a reference for screening high-risk vitamin D deficiency groups among children/adolescents with new-onset T1D and taking preventive and protective measures. The nomogram was developed based on a single-center cohort in China, and its generalizability needs further validation in more extensive populations.</p>","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1554833"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}