Predictors of preterm neonatal mortality in the neonatal intensive care unit at a tertiary medical institution in Ethiopia.

IF 2 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2025-09-19 eCollection Date: 2025-01-01 DOI:10.3389/fped.2025.1414127

Tihun Feleke, Gudeta Kaweti

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引用次数: 0

Abstract

Background: Premature death is a serious health concern in developing countries, including Ethiopia.

Methods: A retrospective cohort study was conducted in Hawassa University Comprehensive Specialized Hospital from 9 May 2019 to 22 April 2021. A total of 723 preterm neonates were enrolled in this study. The Kaplan-Meier survival curve was used to calculate the survival rate. The Cox proportional hazard ratio was used to evaluate the relationship between the dependent and independent variables. A 95% confidence level was used to check for significance.

Results: Preterm neonatal mortality accounted for 33.3% of neonatal admissions. Early neonatal sepsis [adjusted hazard ratio (AHR) = 1.34; 95% CI: 1.003, 1.79], a 5-min Apgar score of less than 7 (AHR = 1.73; 95% CI: 1.17, 2.55), perinatal asphyxia (AHR = 2.25; 95% CI: 1.67, 3.02), and recent multiple pregnancies (AHR = 1.66; 95% CI: 1.22, 2.26) were predictors of preterm neonatal mortality.

Conclusion: Early breastfeeding, prevention and early treatment of perinatal hypoxia and neonatal infections, identification, and monitoring of multiple pregnancies could help to reduce preterm neonatal mortality.

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埃塞俄比亚三级医疗机构新生儿重症监护病房早产儿死亡率预测因素

背景：在包括埃塞俄比亚在内的发展中国家，过早死亡是一个严重的健康问题。方法：于2019年5月9日至2021年4月22日在哈瓦萨大学综合专科医院进行回顾性队列研究。本研究共纳入723例早产儿。采用Kaplan-Meier生存曲线计算生存率。采用Cox比例风险比评价因变量与自变量之间的关系。采用95%置信水平检验显著性。结果：早产儿死亡率占新生儿入院率的33.3%。新生儿早期脓毒症[校正危险比(AHR) = 1.34；95% CI: 1.003, 1.79]、5分钟Apgar评分小于7 （AHR = 1.73; 95% CI: 1.17, 2.55）、围产期窒息（AHR = 2.25; 95% CI: 1.67, 3.02）和近期多胎妊娠（AHR = 1.66; 95% CI: 1.22, 2.26）是早产新生儿死亡率的预测因素。结论：早期母乳喂养、围产期缺氧和新生儿感染的预防和早期治疗、多胎妊娠的识别和监测有助于降低早产儿死亡率。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.