Future cardiologyPub Date : 2025-05-01Epub Date: 2025-04-02DOI: 10.1080/14796678.2025.2482383
Jed Black, Rorey Smith, Elizabeth C Dabrowski, Ben Taylor, Virend K Somers
{"title":"Risk of cardiovascular disease in people with narcolepsy: a plain language summary of publication.","authors":"Jed Black, Rorey Smith, Elizabeth C Dabrowski, Ben Taylor, Virend K Somers","doi":"10.1080/14796678.2025.2482383","DOIUrl":"10.1080/14796678.2025.2482383","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"339-348"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-05-01Epub Date: 2025-03-31DOI: 10.1080/14796678.2025.2484961
Saadullah H Ahmed, Amit N Vora, Tayyab Shah, Alexandra J Lansky
{"title":"Preventing cerebrovascular events in patients undergoing TAVR: the current and future landscape.","authors":"Saadullah H Ahmed, Amit N Vora, Tayyab Shah, Alexandra J Lansky","doi":"10.1080/14796678.2025.2484961","DOIUrl":"10.1080/14796678.2025.2484961","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"335-337"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-05-01Epub Date: 2025-03-10DOI: 10.1080/14796678.2025.2477947
Vikrant Rai
{"title":"Current and future role of biomarkers in the monitoring and prognosis of coronary artery disease.","authors":"Vikrant Rai","doi":"10.1080/14796678.2025.2477947","DOIUrl":"10.1080/14796678.2025.2477947","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"331-333"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-world evidence comparing oral anticoagulants for NVAF in Europe: a systematic review and network meta-analysis.","authors":"Allie Cichewicz, Shantanu Jawla, Priccila Zuchinali, Morodoluwa Akin-Fajiye, Daniela Massierer, Italo Porto, Xavier Garcia-Moll","doi":"10.1080/14796678.2025.2484119","DOIUrl":"10.1080/14796678.2025.2484119","url":null,"abstract":"<p><strong>Aim: </strong>Atrial fibrillation is the most commonly sustained cardiac arrhythmia, increasing the risk of stroke and systemic embolic events. This systematic review and network meta-analysis (NMA) aimed to compare real-world evidence (RWE) on the effectiveness and safety of edoxaban with other direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (NVAF) in Europe.</p><p><strong>Materials & methods: </strong>Searches from January 2013 to December 2022 identified comparative observational studies assessing effectiveness/safety outcomes in patients with NVAF. Bayesian NMA estimated comparative effectiveness/safety of edoxaban with other DOACs and VKAs.</p><p><strong>Results: </strong>The review identified 57 studies analyzing data from 24 unique databases; 33 studies were included in the base-case analyses. DOACs showed benefit over VKAs for most outcomes, of which major bleeding and all-cause mortality were most commonly reported. Edoxaban demonstrated a comparable effectiveness/safety profile to other DOACs and significantly reduced risk of major bleeding (hazard ratio [95% credible interval]: 0.67 [0.54, 0.84]) and intracranial hemorrhage (0.69 [0.51, 0.94]) versus rivaroxaban.</p><p><strong>Conclusion: </strong>This NMA provides valuable insights into the real-world effectiveness and safety of DOACs and VKAs in Europe, supporting clinical decision-making and adding to the existing evidence base from clinical trials.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"371-390"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-05-01Epub Date: 2025-03-30DOI: 10.1080/14796678.2025.2484958
Jude ElSaygh, Laura Bradel, Kevin Pink, Lu Chen, Jonathan Arnedo, Bharath Reddy, Brian Wong, Jeremy Berman, Stephen J Peterson, Wilber S Aronow, Gioia Turitto
{"title":"Do gender differences persist in ICD implantation in patients with acute on chronic heart failure?","authors":"Jude ElSaygh, Laura Bradel, Kevin Pink, Lu Chen, Jonathan Arnedo, Bharath Reddy, Brian Wong, Jeremy Berman, Stephen J Peterson, Wilber S Aronow, Gioia Turitto","doi":"10.1080/14796678.2025.2484958","DOIUrl":"10.1080/14796678.2025.2484958","url":null,"abstract":"<p><strong>Background: </strong>Implantable Cardiac Defibrillators (ICDs) prolong survival in patients with heart failure with reduced ejection fraction (HFrEF). Despite strong data suggesting their benefit, there is concern for disparities related to ICD implantation rates.</p><p><strong>Methods: </strong>A retrospective analysis of 551 patients admitted to a single tertiary institution from June 2020 to May 2023, who met the guideline criteria for ICD implantation for primary prevention of sudden cardiac death, was carried out.</p><p><strong>Results: </strong>Our population constituted of 56% African Americans, 20% Caucasians, 1% Asians and 2% Native Americans. Of those patients, 47% (157/337) of males and 33% (71/213) of females underwent ICD implantation before discharge, creating a statistically significant gender difference at <i>p</i> = 0.007. Patients aged 50 or greater (218/509) were more likely to receive an ICD compared to younger patients (10/41) at <i>p</i> = 0.000. Of those offered an ICD, 46% deferred to outpatient, 30% refused, and 8% of patient had history of noncompliance, were medically unstable, or were undecided.</p><p><strong>Conclusion: </strong>Females and younger patients were less likely to have an ICD at discharge. Despite strong recommendations for ICD implantation in eligible patients, most patients did not receive an ICD. This study showcases the limited access to care and highlights potential avenues of improvement.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"365-370"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-05-01Epub Date: 2025-03-21DOI: 10.1080/14796678.2025.2483155
Irene Cappadona, Augusto Ielo, Maria Pagano, Anna Anselmo, Giuseppe Micali, Fabio Mauro Giambò, Antonio Duca, Piercataldo D'Aleo, Daniela Costanzo, Giuseppa Carcione, Claudio Dispenzieri, Francesco Speciale, Placido Bramanti, Alessia Bramanti, Marina Garofano, Francesco Corallo
{"title":"Observational protocol on neuropsychological disorders in cardiovascular disease for holistic prevention and treatment.","authors":"Irene Cappadona, Augusto Ielo, Maria Pagano, Anna Anselmo, Giuseppe Micali, Fabio Mauro Giambò, Antonio Duca, Piercataldo D'Aleo, Daniela Costanzo, Giuseppa Carcione, Claudio Dispenzieri, Francesco Speciale, Placido Bramanti, Alessia Bramanti, Marina Garofano, Francesco Corallo","doi":"10.1080/14796678.2025.2483155","DOIUrl":"10.1080/14796678.2025.2483155","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. In view of the close correlation between the functions of the body, which cannot be examined in a piecemeal manner but as an integrated system, a holistic approach allows for a comprehensive assessment of the patient. Our study aims to (i) examine the connection between CVD and cognitive deficits; (ii) examine the presence of anxiety and depression; (iii) evaluate the presence of dysphagia, pneumophonic coordination disorders, respiratory and sleep disorders; (iv) analyze the impact of CVD on the caregiver; and (v) evaluate the effectiveness of psychoeducational intervention. At least 218 patients will participate in the survey. At T0, they will undergo neuropsychological, psychological and associated clinical condition assessment through standardized tests. In addition, at least one psychoeducation meeting will be held. After 6 months (T1), the same tests will be repeated, and the effectiveness of psychoeducation will be evaluated. Assessment of associated disorders will provide a comprehensive view of the patient. In addition, it will be observed how psychoeducational intervention can make changes on general well-being. Comprehensive, multi-step observation allows for identification of risk factors, tailoring of treatment, and prevention of future complications.<b>Clinical Trial Registration:</b> registered on Clinicaltrials.gov (ID: NCT06413823).</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"349-358"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-05-01Epub Date: 2025-03-26DOI: 10.1080/14796678.2025.2484964
Andreas Mitsis, Christos Eftychiou, Athanasios Samaras, Apostolos Tzikas, Nikolaos Fragakis, George Kassimis
{"title":"Left atrial appendage occlusion in atrial fibrillation: shaping the future of stroke prevention.","authors":"Andreas Mitsis, Christos Eftychiou, Athanasios Samaras, Apostolos Tzikas, Nikolaos Fragakis, George Kassimis","doi":"10.1080/14796678.2025.2484964","DOIUrl":"10.1080/14796678.2025.2484964","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is the most common cardiac arrhythmia, significantly increasing the risk of thromboembolic events, particularly ischemic stroke. The left atrial appendage (LAA) is the predominant site of thrombus formation in patients with AF, making it a crucial target for stroke prevention strategies. Left atrial appendage occlusion (LAAO) has emerged as an important therapeutic alternative to oral anticoagulation, particularly in patients with contraindications to long-term anticoagulant therapy. This review examines the role of LAAO in AF management, discussing current indications, patient selection, procedural techniques, and clinical outcomes. We also explore the latest evidence from major clinical trials and real-world studies, highlighting the efficacy and safety of LAAO compared to standard anticoagulation. Additionally, we consider the unresolved questions and the potential future directions for this intervention, including emerging technologies and the integration of LAAO into broader AF management protocols. Our review underscores the growing importance of LAAO in reducing thromboembolic risk in AF patients, particularly those unable to tolerate traditional anticoagulation, and offers insights into the ongoing evolution of this treatment modality in clinical practice.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"391-404"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Threading a needle: percutaneous closure of an incompletely ligated left atrial appendage.","authors":"Abhinav Sood, Channing Pezet, Fnu Parul, Anubhav Sood, Jagadeesh Kalavakunta, Vishal Gupta","doi":"10.1080/14796678.2025.2499449","DOIUrl":"https://doi.org/10.1080/14796678.2025.2499449","url":null,"abstract":"<p><p>Atrial fibrillation increases the risk of ischemic stroke by increasing left atrial appendage thrombus formation. Previously surgically ligated atrial appendages can recanalize, which increases stroke risk. Percutaneous ligation of such appendages is technically challenging due to altered morphology but feasible. We present a case of a successful percutaneous closure of a previously incompletely ligated atrial appendage using a WATCHMAN FLX device and discuss our approach to similar cases with challenging anatomy. Thorough pre-procedural imaging for case planning is indispensable and dictates feasibility and procedural success.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-04-29DOI: 10.1080/14796678.2025.2498866
Cheilas Vasileios, Filandrianos Giorgos, Martinos Antonios, Kostopoulou Anna
{"title":"AI-based prediction of left bundle branch block risk post-TAVI using pre-implantation clinical parameters.","authors":"Cheilas Vasileios, Filandrianos Giorgos, Martinos Antonios, Kostopoulou Anna","doi":"10.1080/14796678.2025.2498866","DOIUrl":"https://doi.org/10.1080/14796678.2025.2498866","url":null,"abstract":"<p><strong>Background and aims: </strong>Transcatheter Aortic Valve Implantation (TAVI) has revolutionized the treatment of severe aortic stenosis. Although its clinical efficacy is well established, the development of new-onset left bundle branch block (LBBB) following TAVI remains a frequent and concerning complication. This study aims to develop pre-implantation predictive models for new-onset LBBB after TAVI using both conventional machine learning (ML) algorithms and Large Language Models (LLMs).</p><p><strong>Methods: </strong>Of the 1113 patients who underwent TAVI over a 15-year period, 469 were included after excluding those with preexisting LBBB, pacing rhythm, or missing relevant data. Pre-procedural clinical parameters - such as valve type, valve size, patient demographics, and comorbidities - were analyzed. The dataset was split into training and testing sets. Several ML algorithms were employed, and performance was evaluated using accuracy, precision, and F1 score. Additionally, LLMs (GPT-3.5 and GPT-4) were assessed using Few-Shot and Chain of Thought (CoT) prompting.</p><p><strong>Results: </strong>New-onset persistent LBBB occurred in 15.29% of patients. Among ML models, XGBoost performed best. GPT-4 with CoT prompting demonstrated superior predictive performance compared to both conventional ML and GPT-3.5.</p><p><strong>Conclusions: </strong>The current study establishes a predictive model leveraging pre-implantation parameters to anticipate the occurrence of new-onset left bundle branch block (LBBB) post-Transcatheter Aortic Valve Implantation (TAVI).</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-04-21DOI: 10.1080/14796678.2025.2490397
Muhammad Umer Sohail, Eliza Aisha, Saad Ahmed Waqas, Muhammad Saad, Muhammad Sameer Arshad, Aymen Ahmed, Muhammad Ovais Sohail, Zara Naveed, Emaan Amin, Sahej Arora, Hafsa Jawaid, Aakriti Jain, Muhammad Mustafa Memon
{"title":"Trends in obesity-related ischemic heart disease mortality among adults in the United States from 1999 to 2020.","authors":"Muhammad Umer Sohail, Eliza Aisha, Saad Ahmed Waqas, Muhammad Saad, Muhammad Sameer Arshad, Aymen Ahmed, Muhammad Ovais Sohail, Zara Naveed, Emaan Amin, Sahej Arora, Hafsa Jawaid, Aakriti Jain, Muhammad Mustafa Memon","doi":"10.1080/14796678.2025.2490397","DOIUrl":"https://doi.org/10.1080/14796678.2025.2490397","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a critical risk factor for ischemic heart disease (IHD), affecting 42% of the U.S. population. This study examines trends in obesity-related IHD mortality among U.S. adults aged 25 and older from 1999 to 2020, using the CDC WONDER database.</p><p><strong>Research design and methods: </strong>We analyzed IHD as the primary cause and obesity as a contributing factor, calculating age-adjusted (AAMRs) and crude mortality rates (CMRs) per 100,000 individuals. Joinpoint regression assessed annual percent changes (APC), stratifying by race, sex, age, and region.</p><p><strong>Results: </strong>From 1999 to 2020, 139,644 obesity-related IHD deaths were recorded. AAMR rose from 1.92 to 4.69 per 100,000. Rates were higher in men (3.79) than women (2.10), with Black Americans showing the highest AAMR (4.07). Older adults (65+) had the highest CMR (5.73). Nonmetropolitan areas exhibited higher AAMRs (3.47) than metropolitan regions (2.78). States with the highest mortality included Vermont, Oklahoma, Wyoming, Wisconsin and Iowa while Alabama, Virginia, Massachusetts, Connecticut and Georgia had the lowest.</p><p><strong>Conclusion: </strong>The findings indicate a 2.5-fold increase in obesity-related IHD mortality, highlighting the need for targeted public health interventions and further research to address this growing public health concern.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}