{"title":"Contemporary antiarrhythmic pharmacotherapy: revisiting the Old, exploring the New.","authors":"Stefan Totolici, Raluca Popescu, G-Andrei Dan","doi":"10.1080/14796678.2025.2534323","DOIUrl":null,"url":null,"abstract":"<p><p>With a significant impact on morbidity and mortality rates worldwide, arrhythmias are a growing global health concern. The most common sustained arrhythmia, atrial fibrillation (AF), affects approximately 2% of the general population, with its prevalence increasing with age. Although significant advancements have been made in non-pharmacological therapies, such as catheter ablation and implantable devices, the basis of arrhythmia management remains antiarrhythmic drugs (AADs). Yet the development of safer and more effective AADs has not kept pace with the increasing burden of arrhythmias. This article aims to briefly explore the current landscape of antiarrhythmic treatment, emerging pharmacological targets, and the potential for innovative drug therapies to reshape clinical practice.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-6"},"PeriodicalIF":1.6000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/14796678.2025.2534323","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
With a significant impact on morbidity and mortality rates worldwide, arrhythmias are a growing global health concern. The most common sustained arrhythmia, atrial fibrillation (AF), affects approximately 2% of the general population, with its prevalence increasing with age. Although significant advancements have been made in non-pharmacological therapies, such as catheter ablation and implantable devices, the basis of arrhythmia management remains antiarrhythmic drugs (AADs). Yet the development of safer and more effective AADs has not kept pace with the increasing burden of arrhythmias. This article aims to briefly explore the current landscape of antiarrhythmic treatment, emerging pharmacological targets, and the potential for innovative drug therapies to reshape clinical practice.
期刊介绍：
Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.
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