Future cardiologyPub Date : 2024-09-05DOI: 10.1080/14796678.2024.2355057
Ashley Molloy, Neil Tailor, Ronak Naik, Nithya Swaminathan, Mohammed Absi, Anthony Merlocco, Jason Johnson, Shyam Sathanandam
{"title":"Off-label uses of the Amplatzer Piccolo Occluder in children with congenital and acquired heart diseases.","authors":"Ashley Molloy, Neil Tailor, Ronak Naik, Nithya Swaminathan, Mohammed Absi, Anthony Merlocco, Jason Johnson, Shyam Sathanandam","doi":"10.1080/14796678.2024.2355057","DOIUrl":"https://doi.org/10.1080/14796678.2024.2355057","url":null,"abstract":"<p><p><b>Aim:</b> The Amplatzer Piccolo Occluder (APO) is approved for patent ductus arteriosus (PDA) occlusion in infants weighing >700 g but could offer versatility to treat other lesions.<b>Methods:</b> Retrospective review of children in whom APO was utilized for defects other than PDA between January 2022 and June 2023.<b>Results:</b> The APO was used in nine patients; three for ventricular septal defects, four with coronary fistulas, one for a ventricular pseudoaneurysm and one where APO deployed within a fenestration of a previously placed Amplatzer Septal Occluder. All nine patients had successful occlusions without complications.<b>Conclusion:</b> The APO is a versatile device that can be used to treat various small diameter lesions in children besides the PDA for which it is currently approved for.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-09-04DOI: 10.1080/14796678.2024.2392995
Andy Wang, Juliet Meir, Aaqib Malik, Tzvi Fishkin, Subo Dey, Julio A Panza, Syed Haidry
{"title":"Acute coronary syndrome due to coronary vasospasm: a case report.","authors":"Andy Wang, Juliet Meir, Aaqib Malik, Tzvi Fishkin, Subo Dey, Julio A Panza, Syed Haidry","doi":"10.1080/14796678.2024.2392995","DOIUrl":"https://doi.org/10.1080/14796678.2024.2392995","url":null,"abstract":"<p><p>Coronary vasospasm can lead to decreased cardiac perfusion and result in acute coronary syndrome. Here is a case of a 49-year-old man presented to the emergency department with epigastric pain and nausea with normal initial electrocardiogram. However, 6 h later, the patient experienced severe chest pain prompting a repeat electrocardiogram demonstrating inferior ST-segment elevation with troponin I levels peaked at 1.2 ng/ml (normal range: 0.00-0.02 ng/ml). Coronary angiography revealed angiographic stenosis in the left circumflex territory of a left dominant system which resolved with intracoronary nitroglycerin administration indicating ischemia with nonobstructive coronary arteries secondary to coronary vasospasm. He was discharged on isosorbide mononitrate and amlodipine therapy and had no recurrence of symptoms during follow-up.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-09-04DOI: 10.1080/14796678.2024.2387516
Huzaifa Ul Haq Ansari, Farea Noman Dar, Narmeen Shaikh, Ayesha Noman, Kamran Ahmed, Uzair Asad, Khansa Khalid, Moiz Ahmed, Ahmad Zakarya, Usman Leel, Ruhina Adil Shaikh, Kiran Abbas
{"title":"Impact of complete versus culprit-only revascularization on major adverse cardiovascular event in diverse subpopulations.","authors":"Huzaifa Ul Haq Ansari, Farea Noman Dar, Narmeen Shaikh, Ayesha Noman, Kamran Ahmed, Uzair Asad, Khansa Khalid, Moiz Ahmed, Ahmad Zakarya, Usman Leel, Ruhina Adil Shaikh, Kiran Abbas","doi":"10.1080/14796678.2024.2387516","DOIUrl":"https://doi.org/10.1080/14796678.2024.2387516","url":null,"abstract":"<p><p><b>Background:</b> Myocardial infarction management relies on pharmaceuticals and interventions like percutaneous coronary intervention (PCI). While complete PCI has shown noninferiority to culprit-only PCI, its impact on major adverse cardiovascular events (MACE) outcomes in multiple subpopulations has been unknown.<b>Methods:</b> A systematic literature search (from January 2000 to May 2024) identified four relevant randomized controlled trials involving ST-segment elevation myocardial infarction patients. Data analysis employed a random-effects model with inverse variance weighting.<b>Results:</b> MACE risk was significantly lower in males than females undergoing complete PCI compared with culprit-only PCI (hazard ratio: 0.52; 95% CI: 0.39-0.68; <i>p</i> < 0.01; I2 = 53%). Furthermore, complete PCI significantly lowered the risk of MACE outcomes in patients without diabetes and in patients under the 65-year age limit in comparison to culprit-only PCI.<b>Conclusion:</b> Complete PCI reduces MACE risk in male, nondiabetic ST-segment elevation myocardial infarction patients under 65 with multivessel coronary artery disease, necessitating further investigation into outcome differences among different subpopulations.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-09-04DOI: 10.1080/14796678.2024.2393031
Tamara Pereira, Raquel Menezes Fernandes, Emídio Mata, Olga Azevedo, Dina Bento, Ilídio Jesus, António Lourenço
{"title":"Transthyretin amyloid cardiomyopathy in severe aortic stenosis submitted to valve replacement: a multicenter study.","authors":"Tamara Pereira, Raquel Menezes Fernandes, Emídio Mata, Olga Azevedo, Dina Bento, Ilídio Jesus, António Lourenço","doi":"10.1080/14796678.2024.2393031","DOIUrl":"https://doi.org/10.1080/14796678.2024.2393031","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the prevalence of TTR amyloid cardiomyopathy (ATTR-CM) in severe aortic stenosis (SAS) patients, and to determine the independent predictors of major adverse events (MAE).<b>Patients & methods:</b> 91 SAS patients >65 years with an interventricular septum thickness ≥12.5 mm were referred for aortic valve replacement (AVR). 99mTc-DPD scintigraphy was applied to diagnose ATTR-CM, in the absence of monoclonal protein.<b>Results:</b> ATTR-CM was found in 11%. 78% of patients underwent AVR, but only 2 had ATTR-CM. There were no significant differences in the composite of all cause-mortality or cardiovascular hospitalizations. Lower left ventricle ejection fraction and not performing AVR were independent predictors of MAE.<b>Conclusion:</b> Not performing AVR was an independent predictor of MAE, regardless the ATTR-CM diagnosis.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-19DOI: 10.1080/14796678.2024.2385872
Shaunak Mangeshkar, Pawel Borkowski, Nikita Singh, Panagiotis Zoumpourlis, Maisha Maliha, Sanjana Nagraj, Amrin Kharawala, Robert Faillace
{"title":"Sex differences in Chronic Thromboembolic Pulmonary Hypertension.","authors":"Shaunak Mangeshkar, Pawel Borkowski, Nikita Singh, Panagiotis Zoumpourlis, Maisha Maliha, Sanjana Nagraj, Amrin Kharawala, Robert Faillace","doi":"10.1080/14796678.2024.2385872","DOIUrl":"https://doi.org/10.1080/14796678.2024.2385872","url":null,"abstract":"<p><p>Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed sequela of acute pulmonary embolism with varied clinical presentation causing significant morbidity among the affected population. There exist important differences in the occurrence, clinical features and diagnosis of CTEPH between men and women, with women carrying a greater predisposition for the disease. Ongoing studies have also pointed out variations among men and women, in the treatment offered and long-term outcomes including mortality. This focused review article highlights important sex-associated differences in multiple aspects of CTEPH including its epidemiology, clinical features, diagnosis, treatment and outcomes as reported in current literature and highlights the need for future research to facilitate a clearer understanding of these differences.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-14DOI: 10.1080/14796678.2024.2388478
Muhammad Hamayal, Warda Shahid, Chaudhary Humayun Akhtar, Fnu Shekiba, Iqra Iftikhar, Muhammad Danyal Tahir, Muhammad Awwab, Saima Hussain, Saman Naeem, Momina Hafeez
{"title":"Risk of cardiovascular outcomes with bempedoic acid in high-risk statin intolerant patients: a systematic review and meta analysis.","authors":"Muhammad Hamayal, Warda Shahid, Chaudhary Humayun Akhtar, Fnu Shekiba, Iqra Iftikhar, Muhammad Danyal Tahir, Muhammad Awwab, Saima Hussain, Saman Naeem, Momina Hafeez","doi":"10.1080/14796678.2024.2388478","DOIUrl":"https://doi.org/10.1080/14796678.2024.2388478","url":null,"abstract":"<p><p><b>Aim:</b> Statin intolerance and myopathy is a major issue with prolonged use of statins myopathy. Bempedoic acid can be a good alternative for those intolerant to statins. This systematic review aims to observe incidence of major adverse cardiovascular events (MACE) and other adverse events, in high-risk statin intolerant patients receiving bempedoic acid. <b>Methods:</b> Literature search was conducted via Google Scholar, Science Direct and PubMed, after which screening, selection and data extraction of articles was done. Meta-analysis was performed on RevMan 5.4. Subgroup analysis was also conducted and heterogeneity was evaluated. Risk of bias was performed using ROB2 assessment scale. (CRD42024536827). <b>Results:</b> Only six randomized controlled trials were used in final analysis consisting of 17,844 patients. Treatment with bempedoic acid was associated with a reduced risk of MACE compared with placebo (RR 0.86; 95% CI [0.79, 0.94] <i>p</i> = 0.0005), with myocardial infarction significantly reduced. Incidence of adverse effects was increased with bempedoic acid (RR: 1.02; 95% [1.00, 1.03] <i>p</i> = 0.01) but no significant difference was observed. Incidence of myalgia was reduced in bempedoic group as well. <b>Conclusion:</b> Bempedoic acid is a safe and effective alternative to statins in high-risk patients intolerant to statins, decreasing the risk of MACE.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-13DOI: 10.1080/14796678.2024.2387939
Sarah Meskal, Manrit Gill, Mohammad Reza Movahed, Mehrtash Hashemzadeh, Mehrnoosh Hashemzadeh
{"title":"Major depression is not associated with higher myocardial infarction rates: insights from a large database.","authors":"Sarah Meskal, Manrit Gill, Mohammad Reza Movahed, Mehrtash Hashemzadeh, Mehrnoosh Hashemzadeh","doi":"10.1080/14796678.2024.2387939","DOIUrl":"https://doi.org/10.1080/14796678.2024.2387939","url":null,"abstract":"<p><p><b>Background:</b> Depression has been suggested to increase the risk of cardiovascular disease, but many studies assessed depression after heart disease onset. This study evaluated the association between depression and myocardial infarction (MI) using a large inpatient database.<b>Methods:</b> We analyzed patients from the National Inpatient Sample hospitals from 2005 to 2020, selecting those aged >30 with ICD-9 and ICD-10 codes for segment elevation (ST) elevation myocardial infarction (STEMI), non-ST elevation myocardial elevation (NSTEMI) and major depression.<b>Results:</b> Our data included 4413,113 STEMI patients (224,430 with depression) and 10,421,346 NSTEMI patients (437,058 with depression). No significant association was found between depression and MI. For STEMI, the 2005 odds ratio was 0.12 (95% CI: 0.10-0.15, <i>p</i> < 0.001) and the 2020 odds ratio was 0.71 (95% CI: 0.69-0.73, <i>p</i> < 0.001). Similar patterns were observed for NSTEMI.<b>Conclusion:</b> Depression may not independently be a significant risk factor for MI.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-12DOI: 10.1080/14796678.2024.2388472
Felice Gragnano, Vincenzo De Sio, Arturo Cesaro, Paolo Calabrò
{"title":"Ticagrelor monotherapy after acute coronary syndrome: lessons from the ULTIMATE-DAPT trial.","authors":"Felice Gragnano, Vincenzo De Sio, Arturo Cesaro, Paolo Calabrò","doi":"10.1080/14796678.2024.2388472","DOIUrl":"https://doi.org/10.1080/14796678.2024.2388472","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-07DOI: 10.1080/14796678.2024.2384239
Stefano De Servi, Antonio Landi
{"title":"A new goal for secondary prevention of cardiovascular diseases: the reduction of neutrophil count.","authors":"Stefano De Servi, Antonio Landi","doi":"10.1080/14796678.2024.2384239","DOIUrl":"https://doi.org/10.1080/14796678.2024.2384239","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-08-06DOI: 10.1080/14796678.2024.2345023
Bernardo Cortese, Sara Malakouti, Jacinthe Khater, Amit Munjal
{"title":"Magic Touch sirolimus-coated balloon: animal and clinical evidence of a coronary sirolimus drug-coated balloon.","authors":"Bernardo Cortese, Sara Malakouti, Jacinthe Khater, Amit Munjal","doi":"10.1080/14796678.2024.2345023","DOIUrl":"https://doi.org/10.1080/14796678.2024.2345023","url":null,"abstract":"<p><p>The Magic Touch sirolimus-coated balloon (SCB) was recently introduced in Europe and features robust clinical technology different from other devices on the market. This device is able to deliver a sufficient sirolimus dose to the target segment to reduce neointimal proliferation with very little exposure downstream and no apparent adverse effects at sustained high drug concentrations. The SCB represents a promising novelty within the drug-coated balloon arena due to its mid-term efficacy and safety in the treatment of coronary artery disease, especially in <i>de novo</i> and small-vessel coronary lesions. The purpose of this article is to provide an up-to-date overview of the currently available animal and clinical trial results, as well as to highlight ongoing trials on the Magic Touch SCB.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}