Future cardiologyPub Date : 2025-10-11DOI: 10.1080/14796678.2025.2573566
Maria-Ecaterina Olariu, Alexandru Burlacu, Crischentian Brinza, Adrian Iftene
{"title":"Large language models for ESC guideline interpretation: a targeted review of accuracy and applicability.","authors":"Maria-Ecaterina Olariu, Alexandru Burlacu, Crischentian Brinza, Adrian Iftene","doi":"10.1080/14796678.2025.2573566","DOIUrl":"https://doi.org/10.1080/14796678.2025.2573566","url":null,"abstract":"<p><p>The European Society of Cardiology (ESC) guidelines provide detailed, evidence-based recommendations for managing cardiovascular diseases. However, their complexity and frequent updates can make them challenging to apply consistently in clinical settings. Artificial intelligence (AI), particularly large language models (LLMs), offers a novel solution by assisting in the interpretation and application of these guidelines more effectively. A narrative review was conducted to assess the role of large language models (LLMs) and related artificial intelligence (AI) systems in supporting the interpretation of ESC guidelines. From 102 records screened, seven studies met the inclusion criteria. Clinical Decision Support Systems (CDSSs) built on ESC guidelines demonstrated improvements in diagnostic accuracy and standardization. Comparative studies revealed that large language models (LLMs), including ChatGPT-4, showed high concordance with expert clinical decisions (up to 86% accuracy for acute coronary syndrome-related questions). Emerging tools, such as MedDoc-Bot, have highlighted the feasibility of direct ESC guideline interpretation by LLMs. LLMs show promise in enhancing clinician understanding and application of ESC guidelines. Although performance is encouraging, further validation and thoughtful integration into clinical practice are necessary to maximize their utility and safety.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-10-10DOI: 10.1080/14796678.2025.2556635
Genevieve Lyons, Jeffrey Thompson, Isabelle Lousada, Julia Catini, Richa Manwani, Mathew S Maurer
{"title":"Diagnostic pathways, cardiac manifestations, and outcomes in light chain amyloidosis: a plain language summary.","authors":"Genevieve Lyons, Jeffrey Thompson, Isabelle Lousada, Julia Catini, Richa Manwani, Mathew S Maurer","doi":"10.1080/14796678.2025.2556635","DOIUrl":"https://doi.org/10.1080/14796678.2025.2556635","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-13"},"PeriodicalIF":1.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-10-10DOI: 10.1080/14796678.2025.2573561
Friederike I Schoettler, Mortaza Fatehi Hassanabad, Nicole A Webb, Jeffery Clark, Geoffrey Gotto, William T Kidd, Ali Fatehi Hassanabad
{"title":"Intraoperative urothelial carcinoma tumor thrombus embolization to the heart: a case report.","authors":"Friederike I Schoettler, Mortaza Fatehi Hassanabad, Nicole A Webb, Jeffery Clark, Geoffrey Gotto, William T Kidd, Ali Fatehi Hassanabad","doi":"10.1080/14796678.2025.2573561","DOIUrl":"https://doi.org/10.1080/14796678.2025.2573561","url":null,"abstract":"<p><p>Urothelial carcinoma (UC) rarely presents with an inferior vena cava (IVC) tumor thrombus. Herein, we report the case of a patient with UC in whom the thrombus embolized to the right atrium during resection. Intraoperative echocardiography identified the large embolus measuring greater than 4 cm and prolapsing through the tricuspid valve. The tumor thrombus was removed via sternotomy. This case is significant for the following learning points: 1) tumor thrombus should be managed with care during removal as it can embolize; 2) intraoperative transesophageal echocardiography is vital in these cases; and 3) a multidisciplinary approach including cardiac surgery is imperative to ensure optimal outcomes.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-10-03DOI: 10.1080/14796678.2025.2569264
E A Hart, A O Kraaijeveld, M K Szymanski
{"title":"Recent advances in percutaneous temporary RV mechanical support.","authors":"E A Hart, A O Kraaijeveld, M K Szymanski","doi":"10.1080/14796678.2025.2569264","DOIUrl":"https://doi.org/10.1080/14796678.2025.2569264","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-09-24DOI: 10.1080/14796678.2025.2564017
Yomary Jimenez, Christina Tsai, Fatima Mrizigue, Mustafa M Ahmed
{"title":"Optimizing left ventricular assist device speed: a systematic review for the heart failure clinician.","authors":"Yomary Jimenez, Christina Tsai, Fatima Mrizigue, Mustafa M Ahmed","doi":"10.1080/14796678.2025.2564017","DOIUrl":"https://doi.org/10.1080/14796678.2025.2564017","url":null,"abstract":"<p><strong>Introduction: </strong>Left ventricular assist devices have been demonstrated to improve both quality of life and improve survival in patients with end-stage heart failure. Ideal speed setting of these devices is necessary to provide adequate left ventricular unloading while not disadvantaging the right heart. This highlights the potential utility of speed titration studies.</p><p><strong>Methods: </strong>PubMed, Scopus, and the Cumulative Index to Nursing and Allied Health Literature databases were searched for: (LVAD) OR (Left Ventricular Assist Device) OR (VAD) OR (Ventricular Assist Device) AND (Speed Optimization) OR (Ramp Study) from inception to April 2025.</p><p><strong>Results: </strong>22 studies with 749 total patients were included, 45% of whom had a Heart Mate 3. Outcomes of interest included mortality, readmission, RV function, speed change at conclusion of the study, and quality of life. Only 1 out of 22 studies reported all 5 outcomes, with 64% reporting 2 or fewer outcomes of interest.</p><p><strong>Conclusion: </strong>There exists limited data on speed optimization in the HM3, and that which has been reported lacks a standardization regarding method of evaluation as well as outcomes reporting. Prospective studies, with a standard method of speed optimization and more detailed outcomes reporting, are necessary in order to define best practices.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-09-23DOI: 10.1080/14796678.2025.2564029
Zhengjun Wu, Hong Liu, Mingfang He
{"title":"Association of triglyceride-glucose index with risk of stroke and all-cause mortality in individuals with diabetes.","authors":"Zhengjun Wu, Hong Liu, Mingfang He","doi":"10.1080/14796678.2025.2564029","DOIUrl":"https://doi.org/10.1080/14796678.2025.2564029","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride - glucose (TyG) index is a surrogate of insulin resistance and may predict vascular risk. We evaluated whether baseline TyG is associated with incident stroke and all-cause mortality in adults with diabetes.</p><p><strong>Methods: </strong>We analyzed 10,000 UK Biobank participants with diabetes and no baseline cardiovascular disease. TyG was calculated from fasting triglycerides and glucose and categorized into quartiles. Outcomes (stroke; all-cause mortality) were ascertained via hospital and death registries. Cox models estimated hazard ratios (HRs) adjusting for demographic, lifestyle, and clinical covariates.</p><p><strong>Results: </strong>Over a median 12.8 years, 620 strokes and 688 deaths occurred. Compared with Q1, Q4 had higher risks of stroke (HR 1.45, 95% CI 1.18-1.80) and mortality (HR 1.42, 95% CI 1.17-1.73). Each 1-SD higher TyG was associated with ~ 19% higher stroke risk (HR 1.19, 95% CI 1.07-1.32) and ~ 16% higher mortality risk (HR 1.16, 95% CI 1.05-1.29). Associations were consistent across age, sex, and BMI subgroups and robust in sensitivity analyses, including extended adjustment.</p><p><strong>Conclusions: </strong>Higher TyG is independently associated with increased risks of stroke and all-cause mortality among individuals with diabetes. As an inexpensive measure derived from routine tests, TyG may aid risk stratification and inform targeted prevention in this high-risk population.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-09-16DOI: 10.1080/14796678.2025.2560223
Vincenzo Ezio Santobuono, Alessio Falagario, Lorenzo Giovannico, Paolo Basile, Maria Cristina Carella, Riccardo Memeo, Giuseppe Fischetti, Federica Mazzone, Francesco Monitillo, Daniela Santoro, Tomaso Bottio, Marco Matteo Ciccone, Andrea Igoren Guaricci
{"title":"Subcutaneous ICD after heart transplantation due to idiopathic fatal arrhythmias in the donor: a first experience.","authors":"Vincenzo Ezio Santobuono, Alessio Falagario, Lorenzo Giovannico, Paolo Basile, Maria Cristina Carella, Riccardo Memeo, Giuseppe Fischetti, Federica Mazzone, Francesco Monitillo, Daniela Santoro, Tomaso Bottio, Marco Matteo Ciccone, Andrea Igoren Guaricci","doi":"10.1080/14796678.2025.2560223","DOIUrl":"https://doi.org/10.1080/14796678.2025.2560223","url":null,"abstract":"<p><p>The ongoing global shortage of donor hearts dictates the need for innovative solutions to enlarge the donor pool and to reduce mortality of patients on the waiting list. The extended-heart-transplantation-criteria premise is to match patients who fall outside traditional eligibility criteria with donor hearts that have high risk features. In our case, the donor experienced ventricular fibrillation episodes. Given the idiopathic arrhythmogenic substrate of the transplanted heart, we decided to protect the receiver with a subcutaneous implantable cardioverter defibrillator in the short-term post heart transplantation. It represents the first experience worldwide in this specific setting of sudden cardiac death.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-09-15DOI: 10.1080/14796678.2025.2560216
Lorik Berisha, Anton Camaj, Samin K Sharma
{"title":"Current and future role of drug-coated balloons in the treatment of coronary artery disease.","authors":"Lorik Berisha, Anton Camaj, Samin K Sharma","doi":"10.1080/14796678.2025.2560216","DOIUrl":"https://doi.org/10.1080/14796678.2025.2560216","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-09-14DOI: 10.1080/14796678.2025.2560713
Behnam Subin, Patrick Badertscher
{"title":"Conduction disturbances after TAVI: from procedural complication to therapeutic opportunity.","authors":"Behnam Subin, Patrick Badertscher","doi":"10.1080/14796678.2025.2560713","DOIUrl":"https://doi.org/10.1080/14796678.2025.2560713","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}