Association of triglyceride-glucose index with risk of stroke and all-cause mortality in individuals with diabetes.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2025-09-23 DOI:10.1080/14796678.2025.2564029

Zhengjun Wu, Hong Liu, Mingfang He

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引用次数: 0

Abstract

Background: The triglyceride - glucose (TyG) index is a surrogate of insulin resistance and may predict vascular risk. We evaluated whether baseline TyG is associated with incident stroke and all-cause mortality in adults with diabetes.

Methods: We analyzed 10,000 UK Biobank participants with diabetes and no baseline cardiovascular disease. TyG was calculated from fasting triglycerides and glucose and categorized into quartiles. Outcomes (stroke; all-cause mortality) were ascertained via hospital and death registries. Cox models estimated hazard ratios (HRs) adjusting for demographic, lifestyle, and clinical covariates.

Results: Over a median 12.8 years, 620 strokes and 688 deaths occurred. Compared with Q1, Q4 had higher risks of stroke (HR 1.45, 95% CI 1.18-1.80) and mortality (HR 1.42, 95% CI 1.17-1.73). Each 1-SD higher TyG was associated with ~ 19% higher stroke risk (HR 1.19, 95% CI 1.07-1.32) and ~ 16% higher mortality risk (HR 1.16, 95% CI 1.05-1.29). Associations were consistent across age, sex, and BMI subgroups and robust in sensitivity analyses, including extended adjustment.

Conclusions: Higher TyG is independently associated with increased risks of stroke and all-cause mortality among individuals with diabetes. As an inexpensive measure derived from routine tests, TyG may aid risk stratification and inform targeted prevention in this high-risk population.

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甘油三酯-葡萄糖指数与糖尿病患者中风和全因死亡率风险的关系

背景：甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的替代指标，可以预测血管风险。我们评估了基线TyG是否与成人糖尿病患者的卒中事件和全因死亡率相关。方法：我们分析了10,000名英国生物银行参与者，他们患有糖尿病，无基线心血管疾病。TyG由空腹甘油三酯和葡萄糖计算，并按四分位数分类。结果（中风、全因死亡率）通过医院和死亡登记确定。Cox模型估计了调整人口统计学、生活方式和临床协变量后的风险比（hr）。结果：在平均12.8年的时间里，发生了620例中风和688例死亡。与Q1相比，Q4有更高的卒中风险（HR 1.45, 95% CI 1.18-1.80）和死亡率（HR 1.42, 95% CI 1.17-1.73）。TyG每升高1-SD，卒中风险增加19% (HR 1.19, 95% CI 1.07-1.32)，死亡风险增加16% （HR 1.16, 95% CI 1.05-1.29）。关联在年龄、性别和BMI亚组中是一致的，在敏感性分析中是稳健的，包括扩展调整。结论：糖尿病患者中TyG升高与卒中风险和全因死亡率增加独立相关。作为一种来自常规检测的廉价措施，TyG可能有助于这一高危人群的风险分层和有针对性的预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.