Optimizing left ventricular assist device speed: a systematic review for the heart failure clinician.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2025-09-24 DOI:10.1080/14796678.2025.2564017

Yomary Jimenez, Christina Tsai, Fatima Mrizigue, Mustafa M Ahmed

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引用次数: 0

Abstract

Introduction: Left ventricular assist devices have been demonstrated to improve both quality of life and improve survival in patients with end-stage heart failure. Ideal speed setting of these devices is necessary to provide adequate left ventricular unloading while not disadvantaging the right heart. This highlights the potential utility of speed titration studies.

Methods: PubMed, Scopus, and the Cumulative Index to Nursing and Allied Health Literature databases were searched for: (LVAD) OR (Left Ventricular Assist Device) OR (VAD) OR (Ventricular Assist Device) AND (Speed Optimization) OR (Ramp Study) from inception to April 2025.

Results: 22 studies with 749 total patients were included, 45% of whom had a Heart Mate 3. Outcomes of interest included mortality, readmission, RV function, speed change at conclusion of the study, and quality of life. Only 1 out of 22 studies reported all 5 outcomes, with 64% reporting 2 or fewer outcomes of interest.

Conclusion: There exists limited data on speed optimization in the HM3, and that which has been reported lacks a standardization regarding method of evaluation as well as outcomes reporting. Prospective studies, with a standard method of speed optimization and more detailed outcomes reporting, are necessary in order to define best practices.

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优化左心室辅助装置速度：心力衰竭临床医生的系统回顾。

导言：左心室辅助装置已被证明可以改善终末期心力衰竭患者的生活质量和生存率。理想的速度设置这些装置是必要的，以提供足够的左心室卸载，而不是不利的右心脏。这突出了快速滴定研究的潜在效用。方法：检索PubMed、Scopus、护理和联合健康文献数据库累积索引（Cumulative Index to Nursing and Allied Health Literature database）：从成立到2025年4月的（LVAD） OR（左心室辅助装置）OR (VAD) OR（心室辅助装置）和（速度优化）OR （Ramp Study）。结果：22项研究共纳入749例患者，其中45%的患者有Heart Mate 3。关注的结果包括死亡率、再入院、RV功能、研究结束时的速度变化和生活质量。22项研究中只有1项报告了所有5项结果，64%的研究报告了2项或更少的结果。结论：HM3在速度优化方面的研究数据有限，且在评价方法和结果报告方面缺乏标准化。为了确定最佳实践，有必要进行前瞻性研究，采用标准的速度优化方法和更详细的结果报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.