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Clinicians' self-reported efficacy in cardiovascular prevention practice in the southeastern United States. 美国东南部临床医生自我报告的心血管预防实践疗效。
IF 1.7
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-11-02 DOI: 10.2217/fca-2023-0040
Trevor Caldarera, Cynthia Ponir, Austin Seals, Megha Penmetsa, Edward Ip, Charles A German, Salim S Virani, Animita Saha, Hayden B Bosworth, Justin B Moore, Michael D Shapiro, Yashashwi Pokharel
{"title":"Clinicians' self-reported efficacy in cardiovascular prevention practice in the southeastern United States.","authors":"Trevor Caldarera, Cynthia Ponir, Austin Seals, Megha Penmetsa, Edward Ip, Charles A German, Salim S Virani, Animita Saha, Hayden B Bosworth, Justin B Moore, Michael D Shapiro, Yashashwi Pokharel","doi":"10.2217/fca-2023-0040","DOIUrl":"10.2217/fca-2023-0040","url":null,"abstract":"<p><p><b>Aim:</b> We assessed self-reported efficacy in cardiovascular prevention practice among internal medicine, family medicine, endocrinology and cardiology clinicians. <b>Patients & methods:</b> We emailed a 21-item questionnaire to 956 physicians, nurse practitioners, physician assistants and pharmacists. <b>Results:</b> 264 clinicians responded (median age: 39 years, 55% women, 47.9% specialists). Most expressed high self-efficacy in lifestyle counselling, prescribing statins, metformin, and aspirin in primary prevention, but low self-efficacy in managing specialized conditions like elevated lipoprotein(a). Compared with specialists, PCPs expressed lower self-efficacy in managing advanced lipid disorders and higher self-efficacy in prescribing sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists. <b>Conclusion:</b> Self-efficacy in cardiovascular prevention varied across specialties. Future research should explore relevant provider, clinic and system level factors to optimize cardiovascular prevention.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71422740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right ventricle toxicity in cancer treatment: a focused review on cardiac imaging. 癌症治疗中的右心室毒性：心脏影像学重点综述。
IF 1.7
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-10-13 DOI: 10.2217/fca-2022-0024
Ghazal Sanadgol, Sahar Samimi, Dorsa Shirini, Pooria Nakhaei, Mina Mohseni, Azin Alizadehasl
{"title":"Right ventricle toxicity in cancer treatment: a focused review on cardiac imaging.","authors":"Ghazal Sanadgol, Sahar Samimi, Dorsa Shirini, Pooria Nakhaei, Mina Mohseni, Azin Alizadehasl","doi":"10.2217/fca-2022-0024","DOIUrl":"10.2217/fca-2022-0024","url":null,"abstract":"<p><p><b>Background:</b> The right ventricle (RV) remains the 'forgotten chamber' in the clinical assessment of cancer therapy-related cardiac dysfunction (CTRCD). <b>Aim:</b> We aimed to review the role that various cardiac imaging modalities play in RV assessment as part of the integrative management of patients undergoing cancer therapy. <b>Discussion:</b> RV assessment remains challenging by traditional 2D echocardiography. In this review we discuss other parameters such as right atrial strain, and other echocardiographic modalities such as 3D and stress echocardiography. We also elaborate on the specific role that cardiac magnetic resonance imaging and equilibrium radionuclide angiocardiography can play in assessing the RV. <b>Conclusion:</b> Biventricular function should be monitored following chemotherapy for early detection of subclinical CTRCD and possible solitary RV changes.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41198035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for cardiogenic shock in thyroid storm: a retrospective and case-series study. 甲状腺风暴并发心源性休克的危险因素：一项回顾性和病例系列研究。
IF 1.7
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-10-13 DOI: 10.2217/fca-2023-0043
Kevin Pink, Aaron C Yee, Edward T Ha, Maxim Kashin, Benjamin Berson, Stephen J Peterson, Shudhanshu Alishetti, Wilbert Aronow, Kumudha Ramasubbu
{"title":"Risk factors for cardiogenic shock in thyroid storm: a retrospective and case-series study.","authors":"Kevin Pink, Aaron C Yee, Edward T Ha, Maxim Kashin, Benjamin Berson, Stephen J Peterson, Shudhanshu Alishetti, Wilbert Aronow, Kumudha Ramasubbu","doi":"10.2217/fca-2023-0043","DOIUrl":"10.2217/fca-2023-0043","url":null,"abstract":"<p><p><b>Aim:</b> Thyroid storm (TS) occurs in 10% of thyrotoxicosis patients and 1% of TS patients experience cardiogenic shock (CS), which is associated with poor prognosis. <b>Methods:</b> This is a single institution, retrospective study in which 56 patients with TS were evaluated. <b>Results:</b> BMI (p = 0.002), history of heart failure (OR 8.33 [1.91, 36.28]; p = 0.004), pro-BNP elevation (p = 0.04), chest x-ray showing interstitial edema (OR 3.33 [1.48, 7.52]; p = 0.01) and Burch-Wartofsky score (62.5 vs 40; p = 0.004) showed association with CS. CS patients had increased length of stay (16.5 vs 4 days; p = 0.01) and higher in-hospital mortality (OR 24.5 [2.90, 207.29]; p < 0.001). <b>Conclusion:</b> These risk factors are useful to risk stratify TS patients on admission, institute therapy in a timely manner and decrease mortality.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41198036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using whole genome sequence findings to assess gene-disease causality in cardiomyopathy and arrhythmia patients. 利用全基因组序列研究结果评估心肌病和心律失常患者的基因疾病因果关系。
IF 1.7
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-10-13 DOI: 10.2217/fca-2023-0082
Aishwarya Rajesh Krishnan, Marci Lb Schwartz, Cherith Somerville, Qiliang Ding, Raymond H Kim
{"title":"Using whole genome sequence findings to assess gene-disease causality in cardiomyopathy and arrhythmia patients.","authors":"Aishwarya Rajesh Krishnan, Marci Lb Schwartz, Cherith Somerville, Qiliang Ding, Raymond H Kim","doi":"10.2217/fca-2023-0082","DOIUrl":"10.2217/fca-2023-0082","url":null,"abstract":"<p><p><b>Aim:</b> The genetic etiologies of cardiomyopathies and arrhythmias have not been fully elucidated. <b>Materials & methods:</b> Research findings from genome analyses in a cardiomyopathy and arrhythmia cohort were gathered. Gene-disease relationships from two databases were compared with patient phenotypes. A literature review was conducted for genes with limited evidence. <b>Results:</b> Of 43 genes with candidate findings from 18 cases, 23.3% of genes had never been curated, 15.0% were curated for cardiomyopathies, 16.7% for arrhythmias and 31.3% for other conditions. 25.5% of candidate findings were curated for the patient's specific phenotype with 11.8% having definitive evidence. <i>MYH6</i> and <i>TPCN1</i> were flagged for recuration. <b>Conclusion:</b> Findings from genome sequencing in disease cohorts may be useful to guide gene-curation efforts.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41198038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Welcome to the Rising Stars in Cardio-Oncology Special Focus Issue. 欢迎收看《心脏肿瘤学新星》特别关注期。
IF 1.7
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-10-18 DOI: 10.2217/fca-2022-0111
Ashling Cannon, Jolie Neill
{"title":"Welcome to the Rising Stars in Cardio-Oncology Special Focus Issue.","authors":"Ashling Cannon, Jolie Neill","doi":"10.2217/fca-2022-0111","DOIUrl":"10.2217/fca-2022-0111","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal STRO-1/STRO-3+ precursor cells for the treatment of chronic heart failure with reduced ejection fraction. 间充质STRO-1/STRO-3+前体细胞用于治疗射血分数降低的慢性心力衰竭。
IF 1.6
Future cardiology Pub Date : 2023-09-01 Epub Date: 2023-11-07 DOI: 10.2217/fca-2023-0081
Andrew Sundin, Simona I Ionescu, Wayne Balkan, Joshua M Hare
{"title":"Mesenchymal STRO-1/STRO-3<sup>+</sup> precursor cells for the treatment of chronic heart failure with reduced ejection fraction.","authors":"Andrew Sundin, Simona I Ionescu, Wayne Balkan, Joshua M Hare","doi":"10.2217/fca-2023-0081","DOIUrl":"10.2217/fca-2023-0081","url":null,"abstract":"<p><p>The heart is susceptible to proinflammatory and profibrotic responses after myocardial injury, leading to further worsening of cardiac dysfunction. Important developments in the management of heart failure with reduced ejection fraction have reduced morbidity and mortality; however, these therapies focus on optimizing cardiac function through hemodynamic and neurohormonal pathways and not by repairing the underlying cardiac injury. The potential of cell-based therapy to reverse cardiac injury has received substantial attention. Herein are examined the phase II and III studies of bone marrow-derived mesenchymal STRO-1<sup>+</sup> or STRO-1/STRO-3<sup>+</sup> precursor cells in patients with ischemic and nonischemic heart failure with reduced ejection fraction, addressing the safety and efficacy of cell-based therapy throughout multiple clinical trials, the optimal dose and the steps toward revolutionizing the treatment of heart failure.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consequences of different cut-off values for high-sensitivity cardiac troponin for risk stratification of patients suspected for NSTE-ACS with a modified HEART score. 用改良的HEART评分对疑似NSTE-ACS患者进行风险分层的高敏肌钙蛋白不同临界值的后果。
IF 1.7
Future cardiology Pub Date : 2023-08-01 Epub Date: 2023-09-13 DOI: 10.2217/fca-2023-0038
Rudolf T Tolsma, Marion J Fokkert, Jan Paul Ottervanger, Dominique N van Dongen, Erik A Badings, Aize van der Sluis, Arnoud Wj Van't Hof, Robbert J Slingerland
{"title":"Consequences of different cut-off values for high-sensitivity cardiac troponin for risk stratification of patients suspected for NSTE-ACS with a modified HEART score.","authors":"Rudolf T Tolsma,&nbsp;Marion J Fokkert,&nbsp;Jan Paul Ottervanger,&nbsp;Dominique N van Dongen,&nbsp;Erik A Badings,&nbsp;Aize van der Sluis,&nbsp;Arnoud Wj Van't Hof,&nbsp;Robbert J Slingerland","doi":"10.2217/fca-2023-0038","DOIUrl":"10.2217/fca-2023-0038","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to enhance prehospital risk assessment for suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) patients using the HEART-score. By incorporating novel point-of-care high-sensitivity cardiac troponin devices, a modified HEART-score was developed and compared with the conventional approach. <b>Patients & methods:</b> Troponin points within the modified HEART-score are based on values below the limit of quantitation (LoQ), between the LoQ and 99th percentile and above the 99th percentile of the used device. A total HEART-score of three or lower is considered low-risk for major adverse cardiac events. <b>Results & conclusion:</b> The number of low-risk patients decreased based on the modified HEART-score. The sensitivity and negative predictive value increased which suggests increasing safety in ruling out patients with suspected NSTE-ACS.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Indigo® Aspiration System for thrombectomy in pulmonary embolism. Indigo®抽吸系统用于肺栓塞血栓切除术。
IF 1.7
Future cardiology Pub Date : 2023-08-01 Epub Date: 2023-09-25 DOI: 10.2217/fca-2022-0134
Hassan A Raza, James Horowitz, Eugene Yuriditsky
{"title":"Indigo<sup>®</sup> Aspiration System for thrombectomy in pulmonary embolism.","authors":"Hassan A Raza,&nbsp;James Horowitz,&nbsp;Eugene Yuriditsky","doi":"10.2217/fca-2022-0134","DOIUrl":"10.2217/fca-2022-0134","url":null,"abstract":"<p><p>Anticoagulation is mainstay therapy for patients with acute pulmonary embolism while systemic thrombolysis is reserved for those with hemodynamic instability. Over the last decade, percutaneous interventional options have entered the landscape aimed to achieve rapid pharmacomechanical pulmonary artery recanalization. The Penumbra Indigo<sup>®</sup> Aspiration System (Penumbra Inc., CA, USA) is a US FDA-approved large-bore aspiration thrombectomy device for the treatment of pulmonary embolism. Recent data has demonstrated improved radiographic end points with low rates of major adverse events in cases of intermediate-risk pulmonary embolism. In this review article, we outline device technology, applications, evidence and future directions.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocardiogram changes as predictors for new imaging findings in repeat transthoracic echocardiography. 心电图变化作为重复经胸超声心动图新成像结果的预测因素。
IF 1.6
Future cardiology Pub Date : 2023-08-01 Epub Date: 2023-09-18 DOI: 10.2217/fca-2023-0045
Anis John Kadado, Abdullah Pervaiz, Kyle Gobeil, Saima Shikari, Petal Elder, Ayman Battisha, Ritika Walia, William Hiser, Tara Lagu, Quinn R Pack
{"title":"Electrocardiogram changes as predictors for new imaging findings in repeat transthoracic echocardiography.","authors":"Anis John Kadado, Abdullah Pervaiz, Kyle Gobeil, Saima Shikari, Petal Elder, Ayman Battisha, Ritika Walia, William Hiser, Tara Lagu, Quinn R Pack","doi":"10.2217/fca-2023-0045","DOIUrl":"10.2217/fca-2023-0045","url":null,"abstract":"<p><p><b>Aim:</b> To determine if electrocardiogram (EKG) findings may be a useful tool to predict changes in repeat transthoracic echocardiogram (TTE). <b>Methods:</b> We evaluated patients who underwent TTE during hospitalization and their EKGs, and whether findings differed between studies. <b>Results:</b> Of 229 hospitalized patients who underwent repeat TTE, 183 (80%) were abnormal. Each minor and major EKG abnormality resulted in a 1.8 (1.2 to 2.6; p = 0.002) and 2.1 (1.3 to 3.3; p < 0.001) increased odds of abnormal imaging on TTE, respectively. The negative likelihood ratio for an unchanged EKG to predict an unchanged TTE was 0.68 (95% CI = 0.62 to 0.73). <b>Conclusion:</b> Among hospitalized patients with prior imaging results, an unchanged EKG predicts an unchanged TTE.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10636174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asundexian: an oral small molecule factor XIa inhibitor for the treatment of thrombotic disorders. 阿须得仙：一种口服小分子因子XIa抑制剂，用于治疗血栓性疾病。
IF 1.7
Future cardiology Pub Date : 2023-08-01 Epub Date: 2023-10-13 DOI: 10.2217/fca-2023-0051
Nicasia D'Allesandro, Brandon Cave, Augustus Hough
{"title":"Asundexian: an oral small molecule factor XIa inhibitor for the treatment of thrombotic disorders.","authors":"Nicasia D'Allesandro,&nbsp;Brandon Cave,&nbsp;Augustus Hough","doi":"10.2217/fca-2023-0051","DOIUrl":"10.2217/fca-2023-0051","url":null,"abstract":"<p><p>Oral anticoagulants, including warfarin and direct oral anticoagulants, are the standard of care for thrombosis prevention and treatment; however, concerns of bleeding often dictate treatment decisions. Inhibition of the intrinsic coagulation system via factor XIa may allow for selective inhibition of the coagulation cascade without significantly impacting hemostasis after injury. Asundexian is an oral small molecule factor XIa inhibitor that, via this novel mechanism, may prove to be a safe and effective option compared with available anticoagulants. Early clinical data for asundexian was promising as a safer alternative to current therapies and prompted further analysis in certain patient populations at increased thrombotic risk. Currently, studies are ongoing to evaluate the safety and efficacy in stroke prevention in atrial fibrillation and in patients following an acute noncardioembolic ischemic stroke or high-risk transient ischemic attack.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41198034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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