Future cardiologyPub Date : 2024-01-01Epub Date: 2024-09-04DOI: 10.1080/14796678.2024.2393031
Tamara Pereira, Raquel Menezes Fernandes, Emídio Mata, Olga Azevedo, Dina Bento, Ilídio Jesus, António Lourenço
{"title":"Transthyretin amyloid cardiomyopathy in severe aortic stenosis submitted to valve replacement: a multicenter study.","authors":"Tamara Pereira, Raquel Menezes Fernandes, Emídio Mata, Olga Azevedo, Dina Bento, Ilídio Jesus, António Lourenço","doi":"10.1080/14796678.2024.2393031","DOIUrl":"10.1080/14796678.2024.2393031","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the prevalence of TTR amyloid cardiomyopathy (ATTR-CM) in severe aortic stenosis (SAS) patients, and to determine the independent predictors of major adverse events (MAE).<b>Patients & methods:</b> 91 SAS patients >65 years with an interventricular septum thickness ≥12.5 mm were referred for aortic valve replacement (AVR). 99mTc-DPD scintigraphy was applied to diagnose ATTR-CM, in the absence of monoclonal protein.<b>Results:</b> ATTR-CM was found in 11%. 78% of patients underwent AVR, but only 2 had ATTR-CM. There were no significant differences in the composite of all cause-mortality or cardiovascular hospitalizations. Lower left ventricle ejection fraction and not performing AVR were independent predictors of MAE.<b>Conclusion:</b> Not performing AVR was an independent predictor of MAE, regardless the ATTR-CM diagnosis.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"419-430"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-10-28DOI: 10.1080/14796678.2024.2412910
Gustavo J Duarte, Jose Lopez, Franklin Sosa, Guarina Molina, Mohammed Shaban, Justin Mark, Asma Khizar, Aathira Sreenivasan, An Tran, Miguel Rodriguez Guerra
{"title":"Proton pump inhibitors and cardiovascular risk: a critical review.","authors":"Gustavo J Duarte, Jose Lopez, Franklin Sosa, Guarina Molina, Mohammed Shaban, Justin Mark, Asma Khizar, Aathira Sreenivasan, An Tran, Miguel Rodriguez Guerra","doi":"10.1080/14796678.2024.2412910","DOIUrl":"10.1080/14796678.2024.2412910","url":null,"abstract":"<p><p>Proton pump inhibitors (PPI) are widely used medications for gastrointestinal disorders. Recent research suggests a potential association between long-term PPI use and increased cardiovascular (CV) risk, creating a complex clinical dilemma. This review critically evaluates the current evidence for this association, considering the limitations of observational studies and the lack of definitive confirmation from randomized controlled trials.This review delves into the reported association between PPIs and adverse CV events, examining proposed mechanisms such as drug interactions, electrolyte imbalances induced by PPIs and their potential impact on cardiac and vascular function. Evidence suggests these mechanisms converge, with varying influence depending on patient populations.Clinicians require a risk-benefit analysis for each patient considering their CV risk profile. Alternative gastrointestinal therapies should be explored for high-bleeding risk patients. Medications with lower cytochrome-P450 interaction potential may be preferable among essential PPI users. Elucidating the specific mechanisms by which PPIs might influence CV health, assessing long-term vascular effects and investigating interactions with newer anticoagulant medications are crucial for future research.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"779-794"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-06-20DOI: 10.1080/14796678.2024.2363717
Ana Rita Teixeira, Francisco Barbas de Albuquerque, Tiago Pereira-da-Silva, Duarte Cacela, Rui Cruz Ferreira
{"title":"A rare case of CardioMEMS™ sensor migration.","authors":"Ana Rita Teixeira, Francisco Barbas de Albuquerque, Tiago Pereira-da-Silva, Duarte Cacela, Rui Cruz Ferreira","doi":"10.1080/14796678.2024.2363717","DOIUrl":"10.1080/14796678.2024.2363717","url":null,"abstract":"<p><p>The CardioMEMS™ system remotely monitors changes in pulmonary artery pressures, which allows for early detection of heart failure worsening. It is a safe and reliable invasive monitoring system. We report a case in which there was a late migration of the device at 6 months of follow-up to the contralateral pulmonary artery. The mechanisms, consequences, and management of device migration are discussed. To our knowledge, there are very few published data on late sensor migration.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"453-458"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-07-02DOI: 10.1080/14796678.2024.2363712
Kornel Pawlak, Dorota Danielak, Paweł Burchardt, Łukasz Kruszyna, Marta Karaźniewicz-Łada
{"title":"The influence of P2Y<sub>12</sub> gene polymorphisms on clopidogrel therapy in patients after percutaneous coronary intervention.","authors":"Kornel Pawlak, Dorota Danielak, Paweł Burchardt, Łukasz Kruszyna, Marta Karaźniewicz-Łada","doi":"10.1080/14796678.2024.2363712","DOIUrl":"10.1080/14796678.2024.2363712","url":null,"abstract":"<p><p><b>Aim:</b> We aimed to define the influence of P2Y12 polymorphisms (rs6801273, rs2046934, and rs6809699), diabetes, hypertension, obesity, hypercholesterolemia, statins intake, and smoking habit on clopidogrel therapy in patients undergoing percutaneous coronary intervention.<b>Materials & methods:</b> We used PCR-RFLP and PCR-ASO for P2Y<sub>12</sub> genotype analysis. The effectiveness of the therapy was measured with the VerifyNow method and defined in platelet reactivity units.<b>Results:</b> Studied polymorphisms had no statistically significant influence on PRU before (PRU<sup>0</sup>) and 6 months (PRU<sup>6</sup>) after the procedure. H1/H1 diabetic carriers had significantly higher PRU<sup>6</sup> values than patients without diabetes. Obese H1/H2 subjects had significantly lower PRU<sup>6</sup> values than H1/H2 non-obese carriers.<b>Conclusion:</b> We found that obesity and diabetes may influence the long-term outcome of antiplatelet therapy.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"377-387"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-09-13DOI: 10.1080/14796678.2024.2400855
Ting-Yu Lin, Wei-Ming Huang, Yi-Lin Tsai
{"title":"Quadricuspid aortic valve and its rare association with left main obstruction: case report and literature review.","authors":"Ting-Yu Lin, Wei-Ming Huang, Yi-Lin Tsai","doi":"10.1080/14796678.2024.2400855","DOIUrl":"10.1080/14796678.2024.2400855","url":null,"abstract":"<p><p>The quadricuspid aortic valve (QAV) is a rare congenital anomaly. We report a 51-year-old woman with QAV who experienced intermittent chest pain due to fibrotic tissue overgrowth from the small left coronary cusp, obstructing the left main coronary artery (LM). Angiography revealed a large \"Vieussens' arterial ring,\" which acted as a collateral channel from the right coronary artery to the left coronary artery, preserving coronary blood flow and left ventricular function. Surgery successfully removed the tissue, maintaining both aortic valve function and coronary patency. This case highlights the need to consider QAV complications and use various imaging modalities for accurate diagnosis and treatment planning, including evaluating potential issues like aortic regurgitation and coronary anomalies.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"605-611"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-09-23DOI: 10.1080/14796678.2024.2378648
Ryaan El-Andari, Jimmy Jh Kang, Surita Sidhu, Matthew Cwinn, James Green, Michael L Ma, Anoop Mathew, Benjamin D Tyrrell, Robert C Welsh, Jeevan Nagendran
{"title":"Transcarotid transcatheter aortic valve replacement utilizing monitored anesthesia care: a case report.","authors":"Ryaan El-Andari, Jimmy Jh Kang, Surita Sidhu, Matthew Cwinn, James Green, Michael L Ma, Anoop Mathew, Benjamin D Tyrrell, Robert C Welsh, Jeevan Nagendran","doi":"10.1080/14796678.2024.2378648","DOIUrl":"10.1080/14796678.2024.2378648","url":null,"abstract":"<p><p>Transcatheter aortic valve replacement (TAVR) has become the standard of care for high surgical risk patients with aortic stenosis. The most common approach to TAVR is transfemoral utilizing monitored anesthesia care or general anesthesia. On occasion, transfemoral access is not possible and alternative access to TAVR is required. Herein, we describe the case of a patient undergoing a transcarotid approach to TAVR with regional anesthesia and monitored anesthesia care utilizing a multidisciplinary heart team.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"447-451"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-10-09DOI: 10.1080/14796678.2024.2406651
Hussein Sliman, Rim Kasem Ali Sliman, Paul Knaapen, Alex Nap, Jose Henriques, Niels Verouden, Bimmer EPM Claessen
{"title":"The role of chronic total occlusions in non-infarct-related arteries in acute coronary syndrome patients: a systematic review.","authors":"Hussein Sliman, Rim Kasem Ali Sliman, Paul Knaapen, Alex Nap, Jose Henriques, Niels Verouden, Bimmer EPM Claessen","doi":"10.1080/14796678.2024.2406651","DOIUrl":"10.1080/14796678.2024.2406651","url":null,"abstract":"<p><p><b>Aim:</b> This systematic review evaluated the impact of a chronic total occlusion (CTO) in a non-infarct-related artery (non-IRA) on clinical outcomes in acute coronary syndrome (ACS) patients and assessed the benefits of staged revascularization.<b>Methods:</b> We performed a comprehensive systematic review to provide further insight into the impact of a CTO in a non-IRA on clinical outcomes after ACS. Moreover, we review the currently available evidence on the clinical significance of staged revascularization for a CTO in a non-IRA patients with ACS and propose whether prophylactic CTO percutaneous coronary intervention (PCI) could improve outcomes in patients who subsequently develop an ACS.<b>Results:</b> Our search identified 999 studies, from which 30 were selected and ten were included in the analysis. The results showed a trend of higher all-cause mortality and major adverse cardiac event rates in the culprit-only-PCI group compared with the multivessel (MV)-PC I group in ST elevation myocardial infarction patients, with varying statistical significance across different outcomes.<b>Conclusion:</b> This review highlights the significant impact of non-IRA CTOs in ACS. Successful CTO revascularization may provide benefits, particularly in ST elevation myocardial infarction, but the optimal management approach remains uncertain. The presence of a non-IRA CTO, especially in cardiogenic shock, predicts worse outcomes. Further research is warranted to determine the effective strategies to improve survival.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":"20 10","pages":"581-590"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2024-01-01Epub Date: 2024-10-16DOI: 10.1080/14796678.2024.2406111
Ashley Wong, Daniel Cortez
{"title":"Implantable loop recorder via subscapular approach in 2.7 kg neonate.","authors":"Ashley Wong, Daniel Cortez","doi":"10.1080/14796678.2024.2406111","DOIUrl":"10.1080/14796678.2024.2406111","url":null,"abstract":"<p><p>Implantable loop records allow continuous heart rhythm monitoring with the ability to be stored and viewed remotely. The limited use in the pediatric population stems from the unknown indications of use and feasibility of implantation. We describe the case of a 2.7kg female with Long QT3. A loop recorder helped identify breakthrough tachycardia and helped her transition to the next stage of care. Placement was at the left subscapular region with no complications. Implantable loop recorder placement is achievable in a 2.7 kg patient at corrected gestational age 38 weeks for LQT3 syndrome monitoring and management.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"689-693"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hearts in the sky: understanding the cardiovascular implications of air travel.","authors":"Tavishi Katoch, Sravya Pinnamaneni, Raunak Medatwal, Fnu Anamika, Kanishk Aggarwal, Shreya Garg, Rohit Jain","doi":"10.1080/14796678.2024.2396257","DOIUrl":"10.1080/14796678.2024.2396257","url":null,"abstract":"<p><p>Air travel is widely regarded as the safest mode of transportation, with the United States leading in airline passengers. However, travelers with pre-existing heart conditions face acute cardiovascular risks. Flight pilots and cabin crew are particularly vulnerable to air travel's physiological changes, which can significantly impair their health and performance. Cabin pressure differences and reduced oxygen levels at cruising altitudes of 5000-8000 feet make air travel challenging for individuals with underlying cardiac and pulmonary problems. This, along with dry air, sleep deprivation, missed medication and prolonged sitting, can lead to physiological changes. In-flight and pre-flight stressors contribute to increased health issues, and studies show a rise in medical emergencies during flights. Prolonged exposure to the airplane environment can lead to various health issues for pilots and cabin crew. These changes include impaired judgment, cognitive function and discomfort in the sinuses and ears due to pressure differentials. Therefore, thorough medical screening, skilled instrument use and compliance with safety measures are essential to mitigate these risks. This article reviews the cardiac implications of air travel, discussing the underlying pathophysiology, associated risks and preventive measures to ensure safer flights for individuals with cardiovascular diseases.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"651-660"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proactive approaches in congestive heart failure: the significance of early goals of care discussion and palliative care.","authors":"Bhupinder Singh, Meet A Patel, Shreya Garg, Vasu Gupta, Amishi Singla, Rohit Jain","doi":"10.1080/14796678.2024.2404323","DOIUrl":"10.1080/14796678.2024.2404323","url":null,"abstract":"<p><p>Congestive Heart Failure (CHF) poses significant challenges to the healthcare system due to its high rates of morbidity and mortality as well as frequent readmissions. All of these factors contribute to increased healthcare delivery costs. Besides the burden on the healthcare system, CHF has far deeper effects on the patient in terms of psychological burden along with debilitating symptoms of dyspnea, all of which reduce quality of life. Prognostic awareness among patients about their disease along with initiating early goals of care discussion by those involved in the care (physicians, nurses, social worker and patient themselves) can help mitigate these challenges. Adopting a proactive approach to address patient preferences, values and end-of-life goals improves patient-centred care, enhances quality of life and reduces the strain on healthcare resources. In this narrative review, studies have been identified using PubMed search to shed knowledge on what is preventing the initiation of goals of care discussions. Some barriers include lack of knowledge about prognosis in both patients and caregivers, inexperience or discomfort in having those conversations and delaying it until CHF becomes too advanced.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":"20 11-12","pages":"661-668"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}