Future cardiologyPub Date : 2025-06-01Epub Date: 2025-05-09DOI: 10.1080/14796678.2025.2503640
Ayesha Shaukat, Muhammad Ahmed Zahoor, Laiba Shakeel, Muniba Ijaz, Zobia Ahmad, Wajiha Zehra, Zaigham Ali, Muhammad Umar Mian, Rabbia Munsab, Zainab Awan, Ismat Fatima, Simran Suleman Panjwani, Muhammad Taha, Juvairia Yousuf, Muhammad Hasanain, Muhammad Umair Anjum, Muhammad Omar Larik
{"title":"Nicorandil for prevention of contrast-induced nephropathy in patients undergoing coronary angiography: a meta-analysis.","authors":"Ayesha Shaukat, Muhammad Ahmed Zahoor, Laiba Shakeel, Muniba Ijaz, Zobia Ahmad, Wajiha Zehra, Zaigham Ali, Muhammad Umar Mian, Rabbia Munsab, Zainab Awan, Ismat Fatima, Simran Suleman Panjwani, Muhammad Taha, Juvairia Yousuf, Muhammad Hasanain, Muhammad Umair Anjum, Muhammad Omar Larik","doi":"10.1080/14796678.2025.2503640","DOIUrl":"10.1080/14796678.2025.2503640","url":null,"abstract":"<p><strong>Introduction: </strong>Contrast-induced nephropathy (CIN) is a feared complication of angiographic procedures, resulting in a sudden decline in renal function.</p><p><strong>Methods: </strong>PubMed, ScienceDirect, and Google Scholar were searched for potentially relevant articles from inception till August 2024. The meta-analysis was conducted using RevMan 5.4 with risk ratios (RR), mean differences (MD), and 95% confidence intervals (95% CI) computed.</p><p><strong>Results: </strong>Ultimately, 13 studies were incorporated in the analysis. Nicorandil portrayed a significant protective effect against CIN (RR: 0.42; 95% CI: 0.33-0.54; <i>p</i> < 0.00001). Subgroup analysis revealed the superiority of the oral administration (RR: 0.38; 95% CI: 0.28-0.50; <i>p</i> < 0.00001). Nicorandil was also effective in reducing CIN in renal dysfunction patients (RR: 0.40; 95% CI: 0.27-0.59; <i>p</i> < 0.00001). Blood urea nitrogen (BUN) and cystatin-C 48-hours post-procedure (MD: -0.42; 95% CI: -0.53--0.30; <i>p</i> < 0.00001 and MD: -0.27; 95% CI: -0.51--0.02; <i>p</i> = 0.03, respectively) were superior in the nicorandil cohort. Serum creatinine was significantly lower in patients receiving nicorandil at 24- and 72-hour intervals (MD: -3.18, MD: -4.26, and MD: -3.75, respectively). There were no increased risks of adverse events in the nicorandil cohort.</p><p><strong>Conclusion: </strong>Nicorandil has promising efficacy and safety in reducing the risk of CIN. However, further trials are necessary in order to validate our conclusions.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"503-513"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-04-21DOI: 10.1080/14796678.2025.2490397
Muhammad Umer Sohail, Eliza Aisha, Saad Ahmed Waqas, Muhammad Saad, Muhammad Sameer Arshad, Aymen Ahmed, Muhammad Ovais Sohail, Zara Naveed, Emaan Amin, Sahej Arora, Hafsa Jawaid, Aakriti Jain, Muhammad Mustafa Memon
{"title":"Trends in obesity-related ischemic heart disease mortality among adults in the United States from 1999 to 2020.","authors":"Muhammad Umer Sohail, Eliza Aisha, Saad Ahmed Waqas, Muhammad Saad, Muhammad Sameer Arshad, Aymen Ahmed, Muhammad Ovais Sohail, Zara Naveed, Emaan Amin, Sahej Arora, Hafsa Jawaid, Aakriti Jain, Muhammad Mustafa Memon","doi":"10.1080/14796678.2025.2490397","DOIUrl":"10.1080/14796678.2025.2490397","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a critical risk factor for ischemic heart disease (IHD), affecting 42% of the U.S. population. This study examines trends in obesity-related IHD mortality among U.S. adults aged 25 and older from 1999 to 2020, using the CDC WONDER database.</p><p><strong>Research design and methods: </strong>We analyzed IHD as the primary cause and obesity as a contributing factor, calculating age-adjusted (AAMRs) and crude mortality rates (CMRs) per 100,000 individuals. Joinpoint regression assessed annual percent changes (APC), stratifying by race, sex, age, and region.</p><p><strong>Results: </strong>From 1999 to 2020, 139,644 obesity-related IHD deaths were recorded. AAMR rose from 1.92 to 4.69 per 100,000. Rates were higher in men (3.79) than women (2.10), with Black Americans showing the highest AAMR (4.07). Older adults (65+) had the highest CMR (5.73). Nonmetropolitan areas exhibited higher AAMRs (3.47) than metropolitan regions (2.78). States with the highest mortality included Vermont, Oklahoma, Wyoming, Wisconsin and Iowa while Alabama, Virginia, Massachusetts, Connecticut and Georgia had the lowest.</p><p><strong>Conclusion: </strong>The findings indicate a 2.5-fold increase in obesity-related IHD mortality, highlighting the need for targeted public health interventions and further research to address this growing public health concern.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"479-487"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-04-18DOI: 10.1080/14796678.2025.2492973
Philip M Croon, Aline F Pedroso, Rohan Khera
{"title":"The emerging role of AI in transforming cardiovascular care.","authors":"Philip M Croon, Aline F Pedroso, Rohan Khera","doi":"10.1080/14796678.2025.2492973","DOIUrl":"10.1080/14796678.2025.2492973","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"547-550"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-04-29DOI: 10.1080/14796678.2025.2498866
Cheilas Vasileios, Filandrianos Giorgos, Martinos Antonios, Kostopoulou Anna
{"title":"AI-based prediction of left bundle branch block risk post-TAVI using pre-implantation clinical parameters.","authors":"Cheilas Vasileios, Filandrianos Giorgos, Martinos Antonios, Kostopoulou Anna","doi":"10.1080/14796678.2025.2498866","DOIUrl":"10.1080/14796678.2025.2498866","url":null,"abstract":"<p><strong>Background and aims: </strong>Transcatheter Aortic Valve Implantation (TAVI) has revolutionized the treatment of severe aortic stenosis. Although its clinical efficacy is well established, the development of new-onset left bundle branch block (LBBB) following TAVI remains a frequent and concerning complication. This study aims to develop pre-implantation predictive models for new-onset LBBB after TAVI using both conventional machine learning (ML) algorithms and Large Language Models (LLMs).</p><p><strong>Methods: </strong>Of the 1113 patients who underwent TAVI over a 15-year period, 469 were included after excluding those with preexisting LBBB, pacing rhythm, or missing relevant data. Pre-procedural clinical parameters - such as valve type, valve size, patient demographics, and comorbidities - were analyzed. The dataset was split into training and testing sets. Several ML algorithms were employed, and performance was evaluated using accuracy, precision, and F1 score. Additionally, LLMs (GPT-3.5 and GPT-4) were assessed using Few-Shot and Chain of Thought (CoT) prompting.</p><p><strong>Results: </strong>New-onset persistent LBBB occurred in 15.29% of patients. Among ML models, XGBoost performed best. GPT-4 with CoT prompting demonstrated superior predictive performance compared to both conventional ML and GPT-3.5.</p><p><strong>Conclusions: </strong>The current study establishes a predictive model leveraging pre-implantation parameters to anticipate the occurrence of new-onset left bundle branch block (LBBB) post-Transcatheter Aortic Valve Implantation (TAVI).</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"489-494"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-05-22DOI: 10.1080/14796678.2025.2509368
Hashim Talib Hashim, Muhammad Osama, Muhammad Haris Khan, Safeena Khan, Nohela Rehman, Mohammedbaqer Ghuraibawi, Muhammad Abdullah Ali, Wajeeh Ur Rehman, Hafsa Arshad Azam Raja, Zeeshan Khan, Malak Bilal Hassan, Zaid Saad Abed Madhi
{"title":"Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: a meta-analysis.","authors":"Hashim Talib Hashim, Muhammad Osama, Muhammad Haris Khan, Safeena Khan, Nohela Rehman, Mohammedbaqer Ghuraibawi, Muhammad Abdullah Ali, Wajeeh Ur Rehman, Hafsa Arshad Azam Raja, Zeeshan Khan, Malak Bilal Hassan, Zaid Saad Abed Madhi","doi":"10.1080/14796678.2025.2509368","DOIUrl":"10.1080/14796678.2025.2509368","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic heart disease leading to obstructive hypertrophy. Radiofrequency ablation (RFA) is a minimally invasive alternative to traditional treatments. This review evaluates RFA's effectiveness and safety for HOCM.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were performed on studies from PubMed, Cochrane, and clinicaltrials.gov up to August 2024. Studies comparing RFA outcomes before and after the procedure were included. Data were analyzed through Revman software, using random-effects models. The funnel plots and Egger test were used for publication bias. Subgroup analysis and sensitivity analysis were also performed.</p><p><strong>Results: </strong>This meta-analysis included 16 cohort studies and 2 case series, encompassing 727 patients with ages ranging from 10.4 to 62 years. The studies were conducted in various countries, including China, the USA, Germany, the UK, India, and Brazil. The analysis revealed significant improvements following radiofrequency ablation (RFA): the LVOT gradient at rest was reduced by MD -58.2 (CI: -71.2 to -56.93, <i>p</i> < 0.00001), and the provoked gradient decreased by MD -81.05 (CI: -97.67 to -64.42, <i>p</i> < 0.00001).</p><p><strong>Conclusion: </strong>RFA effectively reduces both LVOT gradients at rest and provoked, improves NYHA functional class, and decreases septal size in HOCM patients.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"611-619"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of thymosin α1 on Immune response and organ function in acute aortic dissection surgery: PANDA II trial protocol.","authors":"Hong Liu, Si-Chong Qian, Ying-Yuan Zhang, Cheng-Bin Tang, Hong-Hua Yue, Guo-Liang Fan, Xin Zhao, Yi-Yao Jiang, Fu-Hua Huang, Zhi-Hua Zeng, Wei Wang, Xu-Ran Lu, Xiao-Kang Luo, Xiang-Feng Bai, Xiang-Xiang Zheng, Peng Xie, Chao Ma, Sheng Zhao, Hong-Jia Zhang","doi":"10.1080/14796678.2025.2505401","DOIUrl":"10.1080/14796678.2025.2505401","url":null,"abstract":"<p><p>This multicenter randomized controlled trial evaluates the efficacy of thymosin alpha 1 (Tα1) supplementation in preventing organ dysfunction following acute type A aortic dissection (ATAAD) repair. Over 330 patients will be equally assigned to receive either Tα1 plus standard care or placebo with standard management. The primary endpoint involves calculating the difference in mean postoperative Sequential Organ Failure Assessment (SOFA) scores between groups, measured daily from postoperative days 7. By targeting post-operative immune system imbalance, this study aims to establish a novel therapeutic approach for reducing systemic inflammatory response syndrome (SIRS)-mediated organ injury and improving long-term outcomes in this high-risk population. Results will be disseminated through peer-reviewed publications and international conferences.<b>Trial registration</b>: ClinicalTrials.gov Registry (NCT05339529).</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"447-454"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-05-09DOI: 10.1080/14796678.2025.2501443
Raymond N Haddad
{"title":"Transcatheter treatment of perimembranous ventricular septal defects: challenges, controversies, and a paradigm shift.","authors":"Raymond N Haddad","doi":"10.1080/14796678.2025.2501443","DOIUrl":"10.1080/14796678.2025.2501443","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"551-553"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-05-30DOI: 10.1080/14796678.2025.2511428
Nikita Jhawar, Shahyar Michael Gharacholou
{"title":"Imaging and physiologic characteristics of coronary kinks.","authors":"Nikita Jhawar, Shahyar Michael Gharacholou","doi":"10.1080/14796678.2025.2511428","DOIUrl":"10.1080/14796678.2025.2511428","url":null,"abstract":"<p><p>Coronary kinking represents an underrecognized diagnosis which typically arises as a complication of invasive cardiovascular procedures but may also be non-iatrogenic and nonatheromatous. Determining the etiology of coronary kinking poses a diagnostic dilemma with limited guidance in the medical literature. A stenotic lesion on invasive coronary angiography (ICA) may be attributable to intrinsic causes, such as atherosclerosis, fibromuscular dysplasia, coronary vasospasm, spontaneous coronary artery dissection, coronary kinks, and severe tortuosity, or extrinsic causes such as myocardial bridging. Lesions that appear angiographically atypical can be further elucidated with intracoronary imaging using intravascular ultrasound (IVUS) or optical coherence tomography (OCT), which help distinguish coronary kinks from other mimicking etiologies. Coronary kinks have the potential to cause ischemia, arrhythmia, and other structural complications, underscoring the importance of early and accurate detection. In this review, we summarize and appraise published data on coronary kinks. We also share a diagnostic schema on how to investigate coronary kinks with noninvasive and invasive techniques.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"621-627"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-06-01Epub Date: 2025-05-20DOI: 10.1080/14796678.2025.2492958
Pablo Garcia-Pavia, Arnt V Kristen, Brian Drachman, Martin Carlsson, Leslie Amass, Mathew S Maurer
{"title":"Understanding how long people with transthyretin amyloid cardiomyopathy (ATTR-CM) live when they take tafamidis as part of their regular healthcare: a plain language summary.","authors":"Pablo Garcia-Pavia, Arnt V Kristen, Brian Drachman, Martin Carlsson, Leslie Amass, Mathew S Maurer","doi":"10.1080/14796678.2025.2492958","DOIUrl":"10.1080/14796678.2025.2492958","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"433-445"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}