Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-28DOI: 10.1080/14796678.2025.2472590
Bryan Tornabene, David Waldron, Hannah Short, Nicholas Duca
{"title":"An unexpected battle with peripartum cardiomyopathy: a case report.","authors":"Bryan Tornabene, David Waldron, Hannah Short, Nicholas Duca","doi":"10.1080/14796678.2025.2472590","DOIUrl":"10.1080/14796678.2025.2472590","url":null,"abstract":"<p><p>Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy marked by systolic dysfunction that presents in late pregnancy or the early postpartum period with an ejection fraction (EF) of less than 45%. Diagnosing PPCM often presents a diagnostic dilemma due to its nonspecific clinical presentation, which usually resembles physiological changes of pregnancy or peripartum pulmonary embolism. Echocardiography is frequently used as a diagnostic modality of choice with management following the GDMT guidelines and delivery. This case presents a 23-year-old patient with a delayed diagnosis of PPCM, followed by a discussion of goal-directed medical therapy (GDMT) and the benefits of early diagnosis and treatment. Common pitfalls in diagnosing PPCM are introduced to encourage clinicians to consider PPCM during late pregnancy. Currently, a new clinical trial is underway investigating the efficacy of dopamine agonists in conjunction with GDMT for treatment of peripartum cardiomyopathy.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"223-227"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-01-30DOI: 10.1080/14796678.2025.2459542
Muhammad Hamza Shuja, Syed Hasan Shuja, Fabeeha Shaheen, Ramish Hannat, Firzah Shakil, Abeera Farooq Abbasi, Minal Hasan
{"title":"Comparative efficacy of single-coil versus dual-coil ICD leads: a meta-analysis of clinical outcomes.","authors":"Muhammad Hamza Shuja, Syed Hasan Shuja, Fabeeha Shaheen, Ramish Hannat, Firzah Shakil, Abeera Farooq Abbasi, Minal Hasan","doi":"10.1080/14796678.2025.2459542","DOIUrl":"10.1080/14796678.2025.2459542","url":null,"abstract":"<p><strong>Background: </strong>Implantable cardioverter-defibrillators (ICDs) are essential for reducing sudden cardiac death in patients at risk of ventricular arrhythmias. The choice of ICD lead - single-coil or dual-coil - can influence device performance and patient outcomes. This meta-analysis evaluates the comparative efficacy and safety of single-coil versus dual-coil ICD leads to inform clinical decision-making.</p><p><strong>Methods: </strong>A systematic search of PubMed, Cochrane Library, and Google Scholar was performed up to October 2024. Only randomized controlled trials (RCTs) comparing single-coil and dual-coil ICD leads were included. Outcomes assessed included defibrillation threshold (DFT), first-shock efficacy, all-cause mortality, cardiovascular mortality, shock impedance, and peak current.</p><p><strong>Results: </strong>Seven RCTs involving 1,614 patients were analyzed. Single-coil leads demonstrated superior first-shock efficacy (OR: 1.60; <i>p</i> = 0.05), reduced all-cause mortality (RR: 0.63; <i>p</i> = 0.02), and better peak current (MD: -2.29; <i>p</i> = 0.02). DFT and cardiovascular mortality were comparable between groups, while dual-coil leads exhibited lower shock impedance (MD: 18.26; <i>p</i> < 0.00001).</p><p><strong>Conclusions: </strong>Single-coil ICD leads are associated with improved first-shock efficacy and reduced all-cause mortality, suggesting their potential superiority in certain patient populations. Further research is warranted to refine lead selection criteria.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"167-175"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-08DOI: 10.1080/14796678.2025.2463271
Alice Bottussi, Jacopo D'Andria Ursoleo, Viviana Teresa Agosta, Monica De Luca, Fabrizio Monaco
{"title":"The role of amino acids and protein administration in preventing cardiac surgery-associated acute kidney injury.","authors":"Alice Bottussi, Jacopo D'Andria Ursoleo, Viviana Teresa Agosta, Monica De Luca, Fabrizio Monaco","doi":"10.1080/14796678.2025.2463271","DOIUrl":"10.1080/14796678.2025.2463271","url":null,"abstract":"<p><p>Acute kidney injury (AKI) persists as one of the most common complications after cardiac surgery. Beyond being burdened by high morbidity and mortality rates, effective therapeutic options are still lacking. To date, the management of cardiac surgery-associated AKI (CSA-AKI) mainly focuses on preventive strategies, e.g. the implementation of standardized care bundles. Interestingly, recent experimental studies have suggested a potential nephroprotective role for both amino acids (AA) and proteins. As such, these compounds show multiple beneficial renal effects, spanning enhancement of renal blood flow, improved oxygenation, and recruitment of renal functional reserve. Moreover, clinical studies have investigated the therapeutic potential of single AA, AA combinations, and proteins. A recent large multicenter randomized controlled trial showed reduced AKI incidence in cardiac surgery patients receiving intravenous AA supplementation. However, these interventions have not yet demonstrated beneficial effects on major clinical outcomes, such as survival. Given the well-established AA safety profile and the underlying biological rationale supporting their use, this review summarizes the existing literature on the effects of various formulations and combinations of perioperative AA and protein on renal outcomes when administered in cardiac surgery patients.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"191-202"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-12DOI: 10.1080/14796678.2025.2464449
Ubaid Khan, Ahmed Mazen Amin, Amira Mohamed Taha, Yehya Khlidj, Majd M AlBarakat, Mariam Elewidi, Mohamed Abuelazm, Mustafa Turkmani, Basel Abdelazeem, Rida Laeeq
{"title":"The effect of sodium-glucose co-transporter 2 inhibitors on clinical outcomes after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials.","authors":"Ubaid Khan, Ahmed Mazen Amin, Amira Mohamed Taha, Yehya Khlidj, Majd M AlBarakat, Mariam Elewidi, Mohamed Abuelazm, Mustafa Turkmani, Basel Abdelazeem, Rida Laeeq","doi":"10.1080/14796678.2025.2464449","DOIUrl":"10.1080/14796678.2025.2464449","url":null,"abstract":"<p><strong>Introduction: </strong>Sodium-glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular events, especially in diabetic patients. However, the cardioprotective effects of early SGLT2i administration following acute myocardial infarction (AMI) remain unclear.</p><p><strong>Objective: </strong>This study aims to investigate the impact of SGLT2is on clinical outcomes in patients post-AMI.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, CENTRAL, WOS, Scopus, and EMBASE up to April 2024. Risk ratio (RR) was used for dichotomous outcomes and mean difference (MD) for continuous outcomes, with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Seven studies with 11,407 patients were included. SGLT2is did not significantly reduce the incidence of major adverse cardiovascular events (MACE) (RR = 0.94, 95% CI [0.68, 1.29], <i>p</i> = 0.69), all-cause mortality (RR = 1.01, 95% CI [0.84, 1.21], <i>p</i> = 0.93), or stroke (RR = 0.61, 95% CI [0.29,1.28], <i>p</i> = 0.19). However, SGLT2is significantly reduced the risk of heart failure (RR = 0.76, 95% CI [0.63, 0.91], <i>p</i> < 0.01) and improved left ventricular ejection fraction (MD = 1.86, 95% CI [1.58, 2.14], <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>In post-AMI patients, SGLT2is do not significantly affect MACE or mortality but are associated with reduced heart failure risk and improved ejection fraction.</p><p><strong>Protocol registration: </strong>PROSPERO identifier number: CRD42024506806.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"177-190"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-11DOI: 10.1080/14796678.2025.2461425
Albert Wiegman, Robert Pordy
{"title":"Evinacumab for children with homozygous familial hypercholesterolemia: a plain language summary.","authors":"Albert Wiegman, Robert Pordy","doi":"10.1080/14796678.2025.2461425","DOIUrl":"10.1080/14796678.2025.2461425","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"139-147"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-01-08DOI: 10.1080/14796678.2025.2451530
Anna Vittoria Mattioli, Valentina Bucciarelli, Sabina Gallina
{"title":"The role of physical exercise in cancer therapy-related CV toxicity.","authors":"Anna Vittoria Mattioli, Valentina Bucciarelli, Sabina Gallina","doi":"10.1080/14796678.2025.2451530","DOIUrl":"10.1080/14796678.2025.2451530","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"131-134"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-14DOI: 10.1080/14796678.2025.2465214
Sidra Kalsoom, Muhammad Adnan Zaman
{"title":"Reconsidering the role of beta-blockers in post-myocardial infarction patients with preserved ejection fraction.","authors":"Sidra Kalsoom, Muhammad Adnan Zaman","doi":"10.1080/14796678.2025.2465214","DOIUrl":"10.1080/14796678.2025.2465214","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"207-209"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-02-15DOI: 10.1080/14796678.2025.2466995
Muhammad Adnan Zaman, Karly Milton, Warsha Korani, Sidra Kalsoom
{"title":"From Salvador Dali and Von Gogh to BRASH: a case-based systematic literature review of digoxin induced BRASH syndrome.","authors":"Muhammad Adnan Zaman, Karly Milton, Warsha Korani, Sidra Kalsoom","doi":"10.1080/14796678.2025.2466995","DOIUrl":"10.1080/14796678.2025.2466995","url":null,"abstract":"<p><p>BRASH stands for Bradycardia, Renal Failure, Atrioventricular (AV) Nodal Blockade, Shock, and Hyperkalemia. It is a relatively new clinical entity. BRASH treatment focuses on managing each component simultaneously while identifying and addressing the underlying cause early to halt the cascade, especially in emergencies. This article will discuss a case series of digoxin-induced BRASH syndrome.</p>","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"211-216"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future cardiologyPub Date : 2025-03-01Epub Date: 2025-01-28DOI: 10.1080/14796678.2025.2458404
Gurleen Wander, Mark R Johnson
{"title":"Current landscape of congenital heart disease management during pregnancy.","authors":"Gurleen Wander, Mark R Johnson","doi":"10.1080/14796678.2025.2458404","DOIUrl":"10.1080/14796678.2025.2458404","url":null,"abstract":"","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"135-137"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}