Concurrent aortic stenosis and hypertension: mortality trends in US older adults from 1999-2020.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2025-08-01 Epub Date: 2025-07-21 DOI:10.1080/14796678.2025.2530906

Ahmed Raza, Fnu Kalpina, Manayiel Rehmat, Eman Alamgir, Eiman Zeeshan, Mateen Ahmad, Moeen Ikram, Mustafa Turkmani, Ubaid Khan

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引用次数: 0

Abstract

Background: Aortic Stenosis (AS) is a valvular heart disease. Hypertension accelerates stenosis, increasing morbidity and mortality. This study investigates mortality trends in US older adults with AS and hypertension from 1999 to 2020.

Methods: Using the CDC WONDER database, age-adjusted mortality rates (AAMRs) per 100,000 individuals aged 65+ with AS and hypertension were analyzed. Changes in AAMRs were examined through annual percent change (APC) and average APC (AAPC) using Joinpoint regression.

Results: From 1999 to 2020, hypertension caused 99,250 deaths in AS patients in the US, demonstrating an increasing trend (AAPC: 5.51%). Males had higher AAMRs (11.51) than females (9.99). Non-Hispanic (NH) white people (11.32) had the highest AAMRs, followed by Hispanic (7.37), NH Black people (7.27), and NH Asians (6.12). Regionally, the West showed the highest AAMR (13.3), followed by the Midwest (11.38), the Northeast (10.62), and the South (8.53). The states with the highest AAMRs were Vermont and Oregon, while Alabama and Georgia had the lowest. Non-metropolitan areas (11.19) experienced higher mortality than metropolitan areas (10.49).

Conclusion: We report increasing mortality rates in patients with AS and hypertension, especially in males, NH white people, and the West. Target healthcare measures are needed to address the rising mortality.

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并发主动脉瓣狭窄和高血压：1999-2020年美国老年人死亡率趋势

背景：主动脉瓣狭窄（Aortic Stenosis， AS）是一种心脏瓣膜病。高血压加速狭窄，增加发病率和死亡率。本研究调查了1999年至2020年美国老年AS合并高血压患者的死亡率趋势。方法：利用CDC WONDER数据库，分析每10万例65岁以上AS合并高血压患者的年龄调整死亡率（AAMRs）。采用关节点回归，通过年变化百分比（APC）和平均APC （AAPC）检测aamr的变化。结果：1999 - 2020年，美国AS患者高血压死亡99,250例，呈上升趋势（AAPC: 5.51%）。男性AAMRs（11.51）高于女性（9.99）。非西班牙裔（NH）白人（11.32）的aamr最高，其次是西班牙裔（7.37），NH黑人（7.27）和NH亚洲人（6.12）。从地区来看，AAMR最高的地区是西部（13.3），其次是中西部（11.38）、东北部（10.62）、南部（8.53）。aamr最高的州是佛蒙特州和俄勒冈州，而阿拉巴马州和佐治亚州最低。非首都地区（11.19）的死亡率高于首都地区（10.49）。结论：我们报告AS合并高血压患者的死亡率增加，尤其是男性、NH白人和西方。需要有针对性的保健措施来解决死亡率上升的问题。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.