Atrial cardiomyopathy: current clinical perspectives and future insights.

IF 1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2025-08-14 DOI:10.1080/14796678.2025.2548159

Moh'd Alamin Daise, Geran Maule, Mohamed Ismail, Qusai Alqudah, Sanaullah Mojaddedi, Omar Obeidat, Khaled Ismail

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引用次数: 0

Abstract

Atrial cardiomyopathy (ACM) is an underrecognized cardiac entity marked by structural, contractile, or electrophysiological changes in the atria, yet it lacks established clinical diagnostic criteria and management guidelines. These alterations - driven by molecular, mechanical, and genetic factors - lead to atrial remodeling and contribute to arrhythmogenesis, thromboembolic complications, and the progression of heart failure. Despite recent advances in imaging, biomarkers, and histopathological classifications, the pathophysiology of ACM remains complex and multifactorial, involving processes such as inflammation, oxidative stress, and genetic predisposition. This review synthesizes current knowledge on ACM, including its classification, pathophysiologic mechanisms, and clinical relevance in atrial fibrillation, ischemic stroke, and heart failure with preserved ejection fraction (HFpEF). We also explore emerging diagnostic tools and biomarkers that may aid in risk stratification and therapeutic decision-making. Ultimately, we aim to underscore the clinical significance of ACM and advocate for the development of standardized diagnostic frameworks and personalized treatment strategies to improve patient outcomes.

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心房心肌病：目前的临床观点和未来的见解。

心房心肌病（ACM）是一种未被充分认识的心脏疾病，其特征是心房的结构、收缩或电生理变化，但缺乏既定的临床诊断标准和治疗指南。这些由分子、机械和遗传因素驱动的改变导致心房重构，并导致心律失常、血栓栓塞并发症和心力衰竭的进展。尽管最近在影像学、生物标志物和组织病理学分类方面取得了进展，但ACM的病理生理学仍然复杂且多因素，涉及炎症、氧化应激和遗传易感性等过程。本文综述了目前关于ACM的知识，包括其分类、病理生理机制以及与房颤、缺血性卒中和保留射血分数（HFpEF）心力衰竭的临床相关性。我们还探讨了可能有助于风险分层和治疗决策的新兴诊断工具和生物标志物。最终，我们的目标是强调ACM的临床意义，并倡导标准化诊断框架和个性化治疗策略的发展，以改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.