Genetics and Molecular Biology最新文献_第2页

Regulation of long non-coding RNAs by essential oils: Therapeutic implications in human diseases. 精油对长链非编码rna的调控：对人类疾病的治疗意义。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-04-03 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0181

Lívia da Cunha Agostini, Mariane Ster da Silva Teixeira, Glenda Nicioli da Silva

引用次数: 0

The dual role of sertraline: From antidepressant to antifungal drug with broad metabolic disruption. 舍曲林的双重作用：从抗抑郁药到具有广泛代谢紊乱的抗真菌药。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-04-03 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0183

Mayara I G Azevedo, Maria J Santos-Saboya, João Neves-da-Rocha, Monise F Petrucelli, Nilce M Martinez-Rossi, Antonio Rossi

引用次数: 0

Expression Analysis of the orphan receptors GPR161, GPR132, GPR20, and GPR139 in patients with cervicitis and low-grade, and high-grade squamous intraepithelial lesions. 孤儿受体GPR161、GPR132、GPR20和GPR139在宫颈炎和低级别、高级别鳞状上皮内病变患者中的表达分析

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0191

Jessica E Rodríguez, Javier González-Ramírez, Alina Barquet-Nieto, Gladys E Ramírez-Rosales, Lilly G Cruz-Izaguirre, Brenda J Reyes-Solorio, Rosa P Cruz-Nieves, Edgar Torres-Maravilla, Armando Ruiz-Hernández

{"title":"Expression Analysis of the orphan receptors GPR161, GPR132, GPR20, and GPR139 in patients with cervicitis and low-grade, and high-grade squamous intraepithelial lesions.","authors":"Jessica E Rodríguez, Javier González-Ramírez, Alina Barquet-Nieto, Gladys E Ramírez-Rosales, Lilly G Cruz-Izaguirre, Brenda J Reyes-Solorio, Rosa P Cruz-Nieves, Edgar Torres-Maravilla, Armando Ruiz-Hernández","doi":"10.1590/1678-4685-GMB-2025-0191","DOIUrl":"10.1590/1678-4685-GMB-2025-0191","url":null,"abstract":"Cervical cancer is one of the most common types of carcinomas causing morbidity and mortality in women worldwide, primarily caused by high-risk human papillomavirus (hrHPV). However, some cervical tumors, particularly adenocarcinomas, may develop independently of HPV. Chronic cervicitis, often linked to bacterial infections, increases the risk of developing squamous low and high-grade intraepithelial lesions (LSIL and HSIL, respectively) and cervical cancer. Cancer-associated inflammation activates key signaling pathways (NF-κB, STAT, and FOXO), regulating orphan G protein-coupled receptors (oGPCRs) implicated in cancer. Notably, GPR161, GPR132, GPR20, and GPR139 play roles in various tumors. This study analyzed cervical tissue samples from 45 women undergoing colposcopy at UNEME Oncology in Mexicali, Baja California. Patient data, including reproductive history and lifestyle factors, were collected. The histopathological analysis identified 31.1% with cervicitis, 40% with LSIL, and 28.8% with HSIL. mRNA expression of orphan GPRs varied among groups, with GPR132 and GPR20 significantly elevated in LSIL samples (p < 0.05), while GPR139 expression was reduced in LSIL (p < 0.05). No significant difference was found for GPR161. The differential expression of oGPCRs in cervical tissue suggests their involvement in the progression of LSIL and HSIL, offering insights into novel therapeutic targets.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 1","pages":"e20250191"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward the establishment of best practice guidelines for human research in Genomic Medicine in Brazil. 在巴西为人类基因组医学研究建立最佳实践指南。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2024-0230

Fernanda Sperb Ludwig, Osvaldo Artigalás, Nureyev Ferreira Rodrigues, Patricia Ashton Prolla, Ursula da Silveira Matte, Jonas Alex Morales Saute

{"title":"Toward the establishment of best practice guidelines for human research in Genomic Medicine in Brazil.","authors":"Fernanda Sperb Ludwig, Osvaldo Artigalás, Nureyev Ferreira Rodrigues, Patricia Ashton Prolla, Ursula da Silveira Matte, Jonas Alex Morales Saute","doi":"10.1590/1678-4685-GMB-2024-0230","DOIUrl":"10.1590/1678-4685-GMB-2024-0230","url":null,"abstract":"Many countries lack their guidelines for best practices in genomic medicine, whether for clinical practice or research. For the construction of these national guidelines or institutional policies in human genomics research several key criteria must be observed. The determination of variant pathogenicity has become more refined, with specific global recommendations being adopted. A well-conducted consent process, managed by qualified professionals, ensures the protection of research participants' rights. Pre-established sequencing and data analysis parameters are crucial for ensuring reliable results, and clear guidelines must be provided on whether or not to disclose findings to participants. Data storage remains a challenge due to both the size and sensitivity of the generated files. This work discusses these critical aspects and represents an initiative to propose the best practice recommendations for genomic medicine in human research. These recommendations were developed by a working group of experts and were further refined through discussions with members of the scientific community in genetics and genomic medicine.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 1","pages":"e20240230"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of CRISPR-Cas systems in the Haemophilus genus CRISPR-Cas in Haemophilus spp. 嗜血杆菌属CRISPR-Cas系统的表征。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0166

Ying Huang, Xinchao Yi, Xue Yang, Chao Li, Yuan Li, Zufeng Ye, Jun He

{"title":"Characterization of CRISPR-Cas systems in the Haemophilus genus CRISPR-Cas in Haemophilus spp.","authors":"Ying Huang, Xinchao Yi, Xue Yang, Chao Li, Yuan Li, Zufeng Ye, Jun He","doi":"10.1590/1678-4685-GMB-2025-0166","DOIUrl":"10.1590/1678-4685-GMB-2025-0166","url":null,"abstract":"Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) system constitutes a crucial adaptive defense mechanism in prokaryotes against foreign genetic elements. Although CRISPR-Cas systems have been characterized in numerous bacteria, the architecture and function of these systems in the Haemophilus genus remain poorly understood. This study aims to analyze CRISPR-Cas systems in 138Haemophilusstrains and investigate their function, particularly in relation to virulence factors. Results revealed that CRISPR-Cas systems were identified in 31.88% of the Haemophilusstrains. Subtype I-C was the most prevalent, followed by subtypes II-C and III-A. Repeat sequences and thecas1gene were highly conserved within the same subtype. 29.62% of spacer sequences exhibited homology to plasmids or bacteriophages. phiMHaA1 was an important target of the CRISPR-Cas system in Haemophilusgenus. The protospacer adjacent motif sequences (PAM) were determined to be 5'-TTC-3' for subtype I-C and 5'-TTT-3' for subtype II-C. Comparative analysis of virulence genes showed that CRISPR-positive strains carried more ompP2 than CRISPR-negative strains, while the distribution of hmw2C and hmw1C exhibited an opposite trend. These findings provide novel insights into the diversity and function of CRISPR-Cas systems inHaemophilusgenus and propose potential strategies for attenuating the impact ofHaemophilusvirulence factors.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 1","pages":"e20250166"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From natural theology to the extended synthesis: Historical milestones and conceptual expansions in evolutionary biology. 从自然神学到扩展综合：进化生物学的历史里程碑和概念扩展。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-02-13 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0179

Francisco Prosdocimi, Marco Garbin, Francesco Dondero

{"title":"From natural theology to the extended synthesis: Historical milestones and conceptual expansions in evolutionary biology.","authors":"Francisco Prosdocimi, Marco Garbin, Francesco Dondero","doi":"10.1590/1678-4685-GMB-2025-0179","DOIUrl":"10.1590/1678-4685-GMB-2025-0179","url":null,"abstract":"This article explores the historical development of evolutionary biology-from Natural Theology to the Modern Synthesis (MS)-and the ongoing debate around the Extended Evolutionary Synthesis (EES). Over the past 2,500 years, evolutionary thinking has emerged from the interplay between empirical discoveries and dominant philosophical paradigms. Beginning with Aristotle and Saint Augustine, we trace how Darwin and Wallace introduced a scientific framework grounded in natural mechanisms. In the early 20th century, the MS unified Mendelian genetics and Darwinian selection, forming a gene-centered model of evolution focused on mutations and population dynamics. In recent decades, discoveries in epigenetics, phenotypic plasticity, symbiosis, niche construction, and cultural inheritance have challenged the explanatory scope of MS. The EES seeks to incorporate these processes not by discarding Darwinian principles, but by reinterpreting them through a systems biology lens. This mostly represents a conceptual shift in focus: from linear, gene-driven causality to multilevel, reciprocal, and environmentally embedded dynamics. While gaining traction, the EES has been criticized for its lack of formal models and predictive frameworks, remaining a contested proposal. Ultimately, evolutionary biology continues to evolve as a powerful scientific tradition, driven by humanity's enduring quest to understand the origins and evolution of life on Earth.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 suppl 2","pages":"e20250179"},"PeriodicalIF":1.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soybean genetic engineering in Brazil and South America - A review. 巴西和南美大豆基因工程研究综述。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-02-13 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0007

Renata Fuganti-Pagliarini, Mayla Daiane Correa Molinari, João Matheus Kafer, Alexandre Lima Nepomuceno, Liliane Marcia Mertz Henning, Sérgio Hermínio Brommonschenkel, Larissa Goulart Zanardo, Maria Helena Bodanese-Zanettini, Elibio Rech

{"title":"Soybean genetic engineering in Brazil and South America - A review.","authors":"Renata Fuganti-Pagliarini, Mayla Daiane Correa Molinari, João Matheus Kafer, Alexandre Lima Nepomuceno, Liliane Marcia Mertz Henning, Sérgio Hermínio Brommonschenkel, Larissa Goulart Zanardo, Maria Helena Bodanese-Zanettini, Elibio Rech","doi":"10.1590/1678-4685-GMB-2025-0007","DOIUrl":"10.1590/1678-4685-GMB-2025-0007","url":null,"abstract":"Soybean like other commodities brings important income to producer countries. In Brazil, the picture is not different. Thus, due to its economic significance and considering all field challenges, that impose abiotic and biotic constraints to improve yield, research efforts have focused on solving problems by applying biotechnological tools. In this review, a description of genetic engineering being developed in Brazil for soybean crop is addressed, including research in tolerance to abiotic conditions such as drought; to biotic factors such as insects, nematodes and fungal among other categories; as well as the use of soybean as bio-factories. All commercially available soybean events in Brazil and South American countries, for insect resistance and herbicide tolerance are also discussed. An overview of the Brazilian regulatory framework and South American countries for Biotech products is presented as well as the future perspectives for soybean genetic engineering in Brazil. In addition, a list of papers, from 2008 to the present, showing the state of the art of genetic engineering of soybean and by-products in Brazil is made available. The same search on the literature for South American countries did not return papers published on the genetic engineering of soybean and by-products. Although South American countries did not develop science on GM soybean, a search on GM varieties being sowed indicated that these countries adopted GM technology, due to all the advantages that these lines offer.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 1","pages":"e20250007"},"PeriodicalIF":1.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global patterns, biases, and advances in phylogeographic and genetic structure studies in Drosophilidae (Insecta: Diptera). 果蝇科（昆虫亚目：双翅目）系统地理学和遗传结构研究的全球格局、偏差和进展。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0246

Henrique R M Antoniolli, Maríndia Deprá, Lizandra Jaqueline Robe

{"title":"Global patterns, biases, and advances in phylogeographic and genetic structure studies in Drosophilidae (Insecta: Diptera).","authors":"Henrique R M Antoniolli, Maríndia Deprá, Lizandra Jaqueline Robe","doi":"10.1590/1678-4685-GMB-2025-0246","DOIUrl":"10.1590/1678-4685-GMB-2025-0246","url":null,"abstract":"Phylogeographic and genetic structure studies involving Drosophilids have clarified numerous processes that have shaped the evolution of biodiversity over time. In this review, we aim to (i) assess the main biases, gaps, and advances in the scientific literature on this topic; (ii) synthesize the major findings emerging from these studies; and (iii) identify congruencies and discrepancies in the phylogeographical histories of different species and regions. To achieve these goals, we conducted a comprehensive review of peer-reviewed literature on phylogeographic and genetic structure studies of Drosophilidae published between 1987 and 2024. After identifying and filtering relevant studies, we extracted and analyzed key information related to each topic. Overall, we have detected a straightforward predominance of studies involving species of the Drosophila genus, especially within the melanogaster, obscura, and repleta groups. Interestingly, most studies employed nuclear DNA markers, either alone or in combination with mitochondrial markers, and were conducted across more than one biogeographical region, primarily in the Palearctic and Nearctic. Thus, our synthesis underscores the importance of broader taxonomic sampling and increased attention to understudied regions to enhance our understanding of biodiversity dynamics in response to environmental changes at both local and global scales.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 suppl 1","pages":"e20250246"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mitogenome mutation repertoire affects progression of Parkinson's Disease. 有丝分裂基因组突变库影响帕金森病的进展。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0098

Gustavo Barra Matos, Camille Sena Dos Santos, Letícia Cota Cavaleiro de Macêdo, Juliana Paiva Dos Santos Diniz, Tatiane Piedade de Sousa, Giovanna Chaves Cavalcante, Caio Santos Silva, Rebecca Lais da Silva Cruz, Dafne Dalledone Moura, Andrea Ribeiro-Dos-Santos, Bruno Lopes Santos-Lobato, Gilderlanio Santana de Araújo

{"title":"The mitogenome mutation repertoire affects progression of Parkinson's Disease.","authors":"Gustavo Barra Matos, Camille Sena Dos Santos, Letícia Cota Cavaleiro de Macêdo, Juliana Paiva Dos Santos Diniz, Tatiane Piedade de Sousa, Giovanna Chaves Cavalcante, Caio Santos Silva, Rebecca Lais da Silva Cruz, Dafne Dalledone Moura, Andrea Ribeiro-Dos-Santos, Bruno Lopes Santos-Lobato, Gilderlanio Santana de Araújo","doi":"10.1590/1678-4685-GMB-2025-0098","DOIUrl":"10.1590/1678-4685-GMB-2025-0098","url":null,"abstract":"Mitochondrial genome variation is a risk factor for Parkinson's disease, but its role in levodopa-induced dyskinesia remains incompletely understood. This study examines the mitochondrial mutation repertoire as a potential biomarker for levodopa-induced dyskinesia in patients with Parkinson's disease. We analyzed the mitogenome using next-generation sequencing data from 42 controls and 45 people with Parkinson's (25 without dyskinesia and 20 with dyskinesia). The mtDNA-server 2 workflow was applied for variant calling analysis. Transition and transversion rates vary during disease progression, especially in patients without levodopa-induced dyskinesia. Although the occurrence of these mutations does not follow a linear pattern, the frequency of transitions modestly increases with age. Specific coding regions (CO1, CO2, CO3, ND4, ND5, and ND6) and the regulatory region (RNR2) exhibited an enrichment of transitions and transversions in patients without dyskinesia. Additionally, we have upgraded the mtDNA-network tool (https://apps.lghm.ufpa.br/mtdna) with an integrated visual component that summarizes the mitochondrial profile in Parkinson's disease. The study highlights dynamic shifts in the mitochondrial mutation repertoire, with clinical implications for underrepresented populations, underscoring the importance of accounting for genetic characteristics across diverse groups.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 suppl 4","pages":"e20250098"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcal phages as agents of evolution and innovation: From gene flow to next-generation therapeutics. 葡萄球菌噬菌体作为进化和创新的媒介：从基因流到下一代疗法。

IF 1.3 4区生物学

Genetics and Molecular Biology Pub Date : 2026-02-09 eCollection Date: 2026-01-01 DOI: 10.1590/1678-4685-GMB-2025-0131

Ciro César Rossi, Felipe Castro Oliveira de Brito Teixeira, Giarlã Cunha da Silva, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval

{"title":"Staphylococcal phages as agents of evolution and innovation: From gene flow to next-generation therapeutics.","authors":"Ciro César Rossi, Felipe Castro Oliveira de Brito Teixeira, Giarlã Cunha da Silva, Monalessa Fábia Pereira, Marcia Giambiagi-deMarval","doi":"10.1590/1678-4685-GMB-2025-0131","DOIUrl":"10.1590/1678-4685-GMB-2025-0131","url":null,"abstract":"Staphylococcus species include both well-known pathogens and overlooked reservoirs of antimicrobial resistance. With rising resistance rates and limited treatment options, especially for methicillin-resistant strains, interest in alternative therapies has resurged. Among them, bacteriophages (phages) are promising biological agents due to their high specificity, low toxicity, ability to disrupt biofilms, and co-evolution with bacterial hosts. This review explores the biology, pan-genomics, diversity, and therapeutic relevance of staphylococcal phages. We revisit their historical discovery and re-emergence as tools against multidrug-resistant infections, highlighting morphological features, replication strategies, and recent taxonomic updates. Genomic analyses reveal distinct clusters of genome sizes, rare presence of resistance genes, and implications of transduction, bacterial defense systems, and phage-encoded anti-defense mechanisms. Preclinical studies show broad host range and synergistic activity with diverse antimicrobial agents, while engineered phage enzymes expand therapeutic possibilities. Clinical evidence, though limited, supports safety and efficacy in compassionate-use cases and early trials targeting Staphylococcus. Finally, we examine business models translating phage innovation into applied therapies, emphasizing regulatory, logistical, and financial challenges. In this broader context, phage technologies are not just alternatives to antibiotics-they represent an opportunity for innovation in global health. Their full potential depends on coordinated actions across science, industry, and policy.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"49 suppl 1","pages":"e20250131"},"PeriodicalIF":1.3,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0