Genetics and Molecular Biology最新文献_第2页

Yaravirus brasiliense genomic structure analysis and its possible influence on the metabolism. 巴西Yaravirus基因组结构分析及其对代谢的可能影响。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.1590/1678-4685-GMB-2024-0139

Ana Karoline Nunes-Alves, Jônatas Santos Abrahão, Sávio Torres de Farias

{"title":"Yaravirus brasiliense genomic structure analysis and its possible influence on the metabolism.","authors":"Ana Karoline Nunes-Alves, Jônatas Santos Abrahão, Sávio Torres de Farias","doi":"10.1590/1678-4685-GMB-2024-0139","DOIUrl":"10.1590/1678-4685-GMB-2024-0139","url":null,"abstract":"Here we analyze the Yaravirus brasiliense, an amoeba-infecting 80-nm-sized virus with a 45-kbp dsDNA, using structural molecular modeling. Almost all of its 74 genes were previously identified as ORFans. Considering its unprecedented genetic content, we analyzed Yaravirus genome to understand its genetic organization, its proteome, and how it interacts with its host. We reported possible functions for all Yaravirus proteins. Our results suggest the first ever report of a fragment proteome, in which the proteins are separated in modules and joined together at a protein level. Given the structural resemblance between some Yaravirus proteins and proteins related to tricarboxylic acid cycle (TCA), glyoxylate cycle, and the respiratory complexes, our work also allows us to hypothesize that these viral proteins could be modulating cell metabolism by upregulation. The presence of these TCA cycle-related enzymes specifically could be trying to overcome the cycle's control points, since they are strategic proteins that maintain malate and oxaloacetate levels. Therefore, we propose that Yaravirus proteins are redirecting energy and resources towards viral production, and avoiding TCA cycle control points, \"unlocking\" the cycle. Altogether, our data helped understand a previously almost completely unknown virus, and a little bit more of the incredible diversity of viruses.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"48 1","pages":"e20240139"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A variant W chromosome in Centromochlus heckelii (Siluriformes, Auchenipteridae) and the role of repeated DNA in its heteromorphism. 黑斑拟中央蝽W染色体的变异及重复DNA在其异型性中的作用。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.1590/1678-4685-GMB-2024-0071

Chrystian Aparecido Grillo Haerter, Patrik Ferreira Viana, Fábio Hiroshi Takagui, Sandro Tonello, Vladimir Pavan Margarido, Daniel Rodrigues Blanco, Josiane Baccarin Traldi, Roberto Laridondo Lui, Eliana Feldberg

{"title":"A variant W chromosome in Centromochlus heckelii (Siluriformes, Auchenipteridae) and the role of repeated DNA in its heteromorphism.","authors":"Chrystian Aparecido Grillo Haerter, Patrik Ferreira Viana, Fábio Hiroshi Takagui, Sandro Tonello, Vladimir Pavan Margarido, Daniel Rodrigues Blanco, Josiane Baccarin Traldi, Roberto Laridondo Lui, Eliana Feldberg","doi":"10.1590/1678-4685-GMB-2024-0071","DOIUrl":"10.1590/1678-4685-GMB-2024-0071","url":null,"abstract":"Centromochlus heckelii has the lowest diploid chromosome number (2n = 46) and the only described heteromorphic sex chromosome system in Auchenipteridae. This study presents a population of C. heckelii from the Central Amazon basin with subtle variations in the karyotype composition and a variant W chromosome with distinct morphology and increased C-positive heterochromatin content. In this population, the W chromosome is subtelocentric, whereas the only previous study on C. heckelii reported a metacentric W chromosome. Constitutive heterochromatin (CH) and accumulation of microsatellite motifs have significantly contributed to this W chromosome enlargement. Notably, this population exhibits numerous interstitial telomeric sites (ITSs). Some of these ITSs might represent genuine chromosomal fusion points due to the reduced 2n; however, additional mechanisms, such as chromosomal inversions, translocations, transpositions, or association with satellite DNA, are likely responsible for this unusual pattern. The 18S rDNA sites were found in both the Z and W chromosomes of all individuals. However, two individuals exhibited an additional 18S rDNA site in a single homologous of the chromosome pair 20, characterizing an intrapopulation polymorphism. The 5S rDNA sites were found in two chromosome pairs, distinguishing this population from other Centromochlinae species and further supporting it as one of the most efficient cytotaxonomic markers within the subfamily.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"48 1","pages":"e20240071"},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome). 截断的SPAG9作为一种新综合征的新候选基因：面部粗糙，白化病，白内障和发育迟缓（ccd综合征）。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.1590/1678-4685-GMB-2024-0094

Majid Alfadhel, Bashayr S Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

{"title":"Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome).","authors":"Majid Alfadhel, Bashayr S Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan","doi":"10.1590/1678-4685-GMB-2024-0094","DOIUrl":"10.1590/1678-4685-GMB-2024-0094","url":null,"abstract":"Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. We identified two families (A and B) having multisystem features like coarse facial features, albinism, cataracts, skeletal abnormalities, and developmental delay. Whole genome sequencing (WGS) in families A and B revealed a homozygous frameshift variant (c.903del; p.Phe301Leufs*2) in the SPAG9 gene. Sanger sequencing of both families revealed perfect segregation of the identified variant in all family members. 3D protein modeling revealed substantial changes in the protein's secondary structure. Furthermore, RT-qPCR revealed a substantial reduction of SPAG9 gene expression at the mRNA level in the affected individuals of both families, thus supporting the pathogenic nature of the identified variant. For the first time in the literature, biallelic SPAG9 gene variation was linked to multisystem-exhibiting features like coarse facial features, albinism, cataracts, skeletal abnormalities, and developmental delay. Thus, this data supports the notion that SPAG9 plays an important role in a multisystemic disorder in humans.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"48 1","pages":"e20240094"},"PeriodicalIF":1.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MTHFR C677T rs1801133 and TP53 Pro72Arg rs1042522 gene variants in South African Indian and Caucasian psoriatic arthritis patients. 南非印度和高加索银屑病关节炎患者的MTHFR C677T rs1801133和TP53 Pro72Arg rs1042522基因变异

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1590/1678-4685-GMB-2023-0325

Pragalathan Naidoo, Ajesh B Maharaj, Terisha Ghazi, Anil A Chuturgoon

{"title":"MTHFR C677T rs1801133 and TP53 Pro72Arg rs1042522 gene variants in South African Indian and Caucasian psoriatic arthritis patients.","authors":"Pragalathan Naidoo, Ajesh B Maharaj, Terisha Ghazi, Anil A Chuturgoon","doi":"10.1590/1678-4685-GMB-2023-0325","DOIUrl":"10.1590/1678-4685-GMB-2023-0325","url":null,"abstract":"Methylenetetrahydrofolate reductase (MTHFR) gene is involved in homocysteine and folic acid metabolism. Tumour suppressor protein TP53 gene maintains cellular and genetic integrity. To date, no studies associated the MTHFR C677T rs1801133 and TP53 Pro72Arg rs1042522 with CRP levels and methotrexate (a folic acid antagonist) treatment outcomes in psoriatic arthritis (PsA) patients. The present study aimed to investigate whether the MTHFR rs1801133 and TP53 rs1042522 gene variants influences CRP levels and methotrexate treatment outcomes in South African Indian and Caucasian PsA patients. PsA patients (n=114) and healthy controls (n=100) were genotyped for the rs1801133 and rs1042522 using RFLP-PCR. (i) Results for rs1801133 genotyping: Caucasian patients had a higher frequency of the variant T-allele versus healthy Caucasian controls (40% versus 22%; OR=2.31, 95% CI=1.10-4.88, p=0.0379). Patients with the variant CT+TT genotypes had higher median CRP levels at baseline versus wildtype CC genotypes (11.70 (5.3-28.80) mg/mL versus 7.40 (5.00-15.05) mg/mL, p=0.0355). After 6 months of methotrexate treatment median CRP levels between genotypes reduced and remained similar. (ii) Results for rs1042522 genotyping: Indian patients had a higher frequency of the variant Arg-allele versus healthy Indian controls (42% versus 29%; OR=1.75, 95% CI=1.07-2.86, p=0.0275). In conclusion, patients with the MTHFR rs1801133 variant T-allele have elevated CRP levels, which can be ameliorated with methotrexate.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"48 1","pages":"e20230325"},"PeriodicalIF":1.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-evaluating evidence for giant genomes in amoebae. 重新评估阿米巴巨型基因组的证据。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2024-0092

Daniel Barzilay, João P B Alcino, Giulia M Ribeiro, Alfredo L P Sousa, Daniel J G Lahr

{"title":"Re-evaluating evidence for giant genomes in amoebae.","authors":"Daniel Barzilay, João P B Alcino, Giulia M Ribeiro, Alfredo L P Sousa, Daniel J G Lahr","doi":"10.1590/1678-4685-GMB-2024-0092","DOIUrl":"10.1590/1678-4685-GMB-2024-0092","url":null,"abstract":"Here we reassess available evidence for the long-held misconception of amoebae possessing exceptionally large genomes. Traditionally, estimates relied on inaccurate methods like DNA weight measurements, leading to inflated sizes. These methods failed to account for contaminating DNA from prey, endosymbionts, and intrinsic genomic features like ribosomal operon amplification. Modern sequencing techniques unveil a different picture. Fully sequenced amoebozoa genomes range from 14.4 to 52.37 mega basepairs, well within the typical single-celled eukaryote expectation. While the whole genome of the historically relevant Amoeba proteus has not yet been fully sequenced, we provide here a statistical analysis using protein-coding genes from transcriptomic data, suggesting that the genome size is consistent with this range, far smaller than previously claimed. The misconception likely originated in the early 21st century and perpetuated through popular science materials. We conclude that there is no longer reason to reaffirm that amoeba genomes are giant.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"47Suppl 1 Suppl 1","pages":"e20240092"},"PeriodicalIF":1.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complete mitogenome of Argentina brasiliensis Kobyliansky, 2004 and a phylogenetic analyses of the order Argentiniformes. 阿根廷巴西ensis Kobyliansky的完整有丝分裂基因组，2004和阿根廷目的系统发育分析。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2024-0170

Claudio Oliveira, Heloísa De Cia Caixeta, Marcelo Roberto Souto de Melo

{"title":"The complete mitogenome of Argentina brasiliensis Kobyliansky, 2004 and a phylogenetic analyses of the order Argentiniformes.","authors":"Claudio Oliveira, Heloísa De Cia Caixeta, Marcelo Roberto Souto de Melo","doi":"10.1590/1678-4685-GMB-2024-0170","DOIUrl":"10.1590/1678-4685-GMB-2024-0170","url":null,"abstract":"The deep sea environment is the largest environment and host some of the most extreme ecosystems on Earth, therefore, possessing a large and unique fish diversity that encompasses about 15% of all known species. Our knowledge about these fishes is still very limited in many biological fields basically due to the complexity to obtain specimens for research. In the present study, we describe the complete mitochondrial genome of Argentina brasiliensis, aiming a species characterization and the study of the phylogenetic relationships in the order Argentiniformes. The mitogenome is composed by 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and a control region (D-loop), as found in other vertebrates. The phylogenetic results show that the order Argentiniformes is composed by two family groups the first formed by Argentinidae and Opisthoproctidae and the second formed by Bathylagidae and Microstomatidae. Additionally, we found that the genus Argentina is not monophyletic, and we suggest additional studies in the family Argentinidae to better investigate this question.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"47 4","pages":"e20240170"},"PeriodicalIF":1.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first complete mitochondrial genome of sesame (Sesamum indicum L.). 芝麻（Sesamum indicum L.）的首个完整线粒体基因组。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2024-0064

Mingcheng Wang, Rui Li, Xuchen Yang

引用次数: 0

High genetic structure of Spondias mombin in Brazil revealed with SNP markers. 利用SNP标记揭示了巴西mombin Spondias的高遗传结构。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2024-0030

Allison Vieira da Silva, Caroline Bertocco Garcia, Igor Araújo Santos de Carvalho, Wellington Ferreira do Nascimento, Santiago Linorio Ferreyra Ramos, Doriane Picanço Rodrigues, Maria Imaculada Zucchi, Flaviane Malaquias Costa, Alessandro Alves-Pereira, Carlos Eduardo Batista, Edson Ferreira da Silva, Elizabeth Ann Veasey

{"title":"High genetic structure of Spondias mombin in Brazil revealed with SNP markers.","authors":"Allison Vieira da Silva, Caroline Bertocco Garcia, Igor Araújo Santos de Carvalho, Wellington Ferreira do Nascimento, Santiago Linorio Ferreyra Ramos, Doriane Picanço Rodrigues, Maria Imaculada Zucchi, Flaviane Malaquias Costa, Alessandro Alves-Pereira, Carlos Eduardo Batista, Edson Ferreira da Silva, Elizabeth Ann Veasey","doi":"10.1590/1678-4685-GMB-2024-0030","DOIUrl":"10.1590/1678-4685-GMB-2024-0030","url":null,"abstract":"Spondias mombin L. (Anacardiaceae) is an arboreal and allogamous fruit tree native from southern Mexico to southeastern Brazil, with great potential for economic exploitation. This study aimed to evaluate the structure and genomic diversity of yellow mombin accessions collected in nine locations in Brazil using Single Nucleotide Polymorphisms (SNP) markers. Significant genetic structure was observed in the discriminant analysis of principal components (DAPC) and dendrogram construction, in accordance with our hypotheses. The Mantel test identified a highly positive and significant correlation between geographic and genetic distances. The locations from the Amazon biome presented higher genetic diversity values when compared to those from the Atlantic Forest and Cerrado, which is expected considering the higher vulnerability of these biomes. However, although presenting greater genetic diversity, the Amazon biome showed positive inbreeding coefficients (F IS ) in three of the four locations, ranging from 0.0855 to 0.2421, indicating a potential risk of genetic erosion, possibly related to the increased degradation of this biome in recent decades. The results obtained contribute to the understanding of the distribution of genetic variation and conservation status of yellow mombin in Brazil. They could also be used as a subsidy for developing conservation strategies and the genetic improvement of this species.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"47 4","pages":"e20240030"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variants in inflammation-related genes influence the outcomes of physical exercise programs: A longitudinal study in Brazilian adolescents with overweight and obesity. 炎症相关基因的变异影响体育锻炼项目的结果：一项对巴西超重和肥胖青少年的纵向研究。

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI: 10.1590/1678-4685-GMB-2023-0211

Ana Cláudia M B Gomes Torres, Neiva Leite, Ricardo Lehtonen Rodrigues de Souza, Juliana Pizzi, Gerusa Eisfeld Milano-Gai, Leilane Lazarotto, Luciane Viater Tureck, Lupe Furtado-Alle

{"title":"Variants in inflammation-related genes influence the outcomes of physical exercise programs: A longitudinal study in Brazilian adolescents with overweight and obesity.","authors":"Ana Cláudia M B Gomes Torres, Neiva Leite, Ricardo Lehtonen Rodrigues de Souza, Juliana Pizzi, Gerusa Eisfeld Milano-Gai, Leilane Lazarotto, Luciane Viater Tureck, Lupe Furtado-Alle","doi":"10.1590/1678-4685-GMB-2023-0211","DOIUrl":"10.1590/1678-4685-GMB-2023-0211","url":null,"abstract":"The expansion of adipose tissue, characteristic of obesity, releases inflammatory cytokines, leading to metabolic disorders. Physical activity, on the other hand, promotes fat loss and changes inflammatory profile. This study aimed to investigate the associations of 20 gene variants (TLR2, TLR4, IL1B, IL6, NFKB1, TNF, NFKBIA, NLRC4, CARD8 and NEK7) with anthropometric and biochemical changes induced by physical exercise programs. Thus, 58 children and adolescents participated of the 12-week exercise programs. Parameters were collected before and after programs: body mass index, body fat percentage, LDL-C, HDL-C, triglycerides, total cholesterol, insulin, glucose, HOMA-IR and QUICKI. Changes in these parameters were calculated (final - initial measurements) for subsequent analyses. Linear regression analyses were performed to investigate associations between genotypes and changes in the analyzed parameters. We found associations between 14 variants in nine genes with anthropometrical and biochemical outcomes. Observing the distribution of the sample, the groups of individuals who responded less in relation to body fat and TG levels concentrated the highest scores of polygenic indexes as a result of a greater number of risk variants. In conclusion, some genotypes related to the inflammatory profile provided less favorable anthropometrical and biochemical outcomes in response to physical exercise programs.","PeriodicalId":12557,"journal":{"name":"Genetics and Molecular Biology","volume":"47 4","pages":"e20230211"},"PeriodicalIF":1.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: From bench to in silico and backwards: What have we done on genetics of recurrent pregnancy loss and implantation failure and where should we go next? 勘误：从工作台到硅学，再从硅学到工作台：我们在复发性妊娠失败和植入失败的遗传学方面做了哪些工作？

IF 1.7 4区生物学

Genetics and Molecular Biology Pub Date : 2024-11-22 DOI: 10.1590/1678-4685-GMB-2023-0127er

引用次数: 0