Frontiers in Aging Neuroscience最新文献

{"title":"The role of vitamin K2 in cognitive impairment: linking vascular health to brain health.","authors":"Stefanos Roumeliotis, Ioannis Kontogiorgos, Femke de Vries, Katarzyna Maresz, Jean-François Jeanne, Konstantinos Leivaditis, Leon J Schurgers","doi":"10.3389/fnagi.2024.1527535","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1527535","url":null,"abstract":"<p><p>Cognitive impairment, marked by a decline in essential mental aspects such as attention, memory, and problem-solving, is significantly correlated with advancing age. This condition presents a major challenge for the elderly, adversely affecting quality of life, diminishing independence, and imposing substantial burdens on healthcare systems. Recent research indicates that vitamin K2 may be vital for preserving brain health and cognitive function. Traditionally recognized primarily for its role in blood coagulation, vitamin K has emerged in recent years as a nutrient with diverse biological effects essential for healthy aging. A growing body of evidence from both observational and interventional studies underscores the pivotal role of vitamin K2 in mitigating arterial calcification. This mechanism may link vascular health to cognitive function, suggesting that vitamin K2 could play a critical role in the prevention of cognitive impairment in aging populations.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1527535"},"PeriodicalIF":4.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults.","authors":"Hao Shu, Gangyu Ding, Xiaona Xu, Xuerong Huang, Ruqian He","doi":"10.3389/fnagi.2024.1481526","DOIUrl":"10.3389/fnagi.2024.1481526","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have shown that cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 1 (sTREM1) are elevated in individuals with Alzheimer's disease (AD), though the relationship between CSF sTREM1 and hippocampal atrophy remains to be elucidated. The primary aim of this study was to investigate the association between CSF sTREM1 levels and longitudinal changes in hippocampal volumes, and to determine if this relationship is moderated by cognitive status.</p><p><strong>Methods: </strong>We included 576 participants, comprising 152 cognitively unimpaired (CU) and 424 cognitively impaired (CI) individuals. In the cross-sectional analyses, Pearson's correlation tests were conducted to examine the relationship between baseline CSF sTREM1 levels and hippocampal volumes in both CU and CI participants. For the longitudinal analyses, a linear mixed-effects model was employed to assess the significance of the three-way interaction between CSF sTREM1 levels, cognitive status, and follow-up time on adjusted hippocampal volume (aHV). Further stratified analyses based on cognitive status were performed to dissect the specific effects within each group.</p><p><strong>Results: </strong>Our findings revealed significantly elevated baseline CSF sTREM1 levels in CI participants compared to CU participants. Cross-sectional analyses demonstrated that CSF sTREM1 levels were negatively associated with hippocampal volumes in both CU and CI participants. In the longitudinal analyses, the three-way interaction between CSF sTREM1 levels, cognitive status, and follow-up time was found to be significant for aHV. Stratified analyses indicated that, in CI participants, higher CSF sTREM1 levels were associated with a more accelerated rate of hippocampal atrophy, whereas no such association was observed in CU participants.</p><p><strong>Conclusion: </strong>These results underscore the complex interplay between neuroinflammation, as reflected by CSF sTREM1 levels, hippocampal atrophy, and cognitive decline. The data suggest that neuroinflammation may contribute differently to hippocampal atrophy rates in CI versus CU individuals, highlighting the potential for targeted anti-inflammatory interventions in the prevention and treatment of AD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1481526"},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis.","authors":"","doi":"10.3389/fnagi.2025.1557340","DOIUrl":"https://doi.org/10.3389/fnagi.2025.1557340","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.3389/fnagi.2024.1377058.].</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1557340"},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous vagus nerve stimulation for Parkinson's disease: a systematic review and meta-analysis.","authors":"Jiatong Shan, Zehong Li, Minxiu Ji, Miao Zhang, Caidi Zhang, Yikang Zhu, Zhen Feng","doi":"10.3389/fnagi.2024.1498176","DOIUrl":"10.3389/fnagi.2024.1498176","url":null,"abstract":"<p><strong>Background: </strong>Transcutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson's disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect.</p><p><strong>Objectives: </strong>This review aimed to investigate the efficacy of tVNS on motor function, other potential clinical targets and its safety in various treatment conditions.</p><p><strong>Methods: </strong>We searched six databases for randomized controlled trials (RCTs) that involved treating PD patients with tVNS. Primary outcome was motor functions, including severity of motor signs, functional mobility and balance, and gait parameters. Secondary outcomes were cognition, emotion, sleep related impairments, patient reported non-motor outcomes, and any adverse events. All outcomes were classified and analyzed according to the treatment duration and medication condition of an included study. Risk of bias was evaluated by referencing Cochrane risk of bias tool 1.0. Data was analyzed by Revman 5.4.</p><p><strong>Results: </strong>6 RCTs with 176 PD patient were included. Several motor functions and non-motor functions measured during on-medication condition (severity of motor signs -0.48 [95% CI -0.93, -0.04], gait -0.48 [95% CI -0.85, -0.1], patients reported non-motor outcomes -0.4 [95% CI -0.78, -0.03]), improved significantly. However, verbal fluency, sleep-related impairment, and fatigue were negatively impacted by tVNS during on-medication condition. No distinct adverse events were reported.</p><p><strong>Conclusion: </strong>tVNS is a relatively safe adjunct treatment for PD. It has small to moderate therapeutic effects on motor functions and may negatively impact on a few other outcomes. Quality level of the evidence is low and further research is warranted.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42024503322 (PROSPERO).</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1498176"},"PeriodicalIF":4.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer's disease: a bioinformatics and experimental study.","authors":"Shengjie Zhang, Ruqiu Zhang, Zhaoqin Chen, Zihan Shao, An Li, Fan Li, Fang Huang","doi":"10.3389/fnagi.2024.1511668","DOIUrl":"10.3389/fnagi.2024.1511668","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) can generally be divided into focal damage and diffuse damage, and neonate Hypoxia-Ischemia Brain Damage (nHIBD) is one of the causes of diffuse damage. Patients with nHIBD are at an increased risk of developing Alzheimer's disease (AD). However, the shared pathogenesis of patients affected with both neurological disorders has not been fully elucidated.</p><p><strong>Purpose: </strong>We here aim to identify the shared molecular signatures between nHIBD and AD. We used an integrated analysis of the cortex gene expression data, targeting differential expression of genes related to the mechanisms of neurodegeneration and cognitive impairment following traumatic brain injury.</p><p><strong>Methods: </strong>The gene expression profiles of Alzheimer's disease (GSE203206) and that of Neonate Hypoxia-Ischemia Brain Damage (GSE23317) were obtained from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) of Alzheimer's disease and neonate Hypoxia-Ischemia Brain Damage by limma package analysis, five kinds of analyses were performed on them, namely Gene Ontology (GO) and pathway enrichment analysis, protein-protein interaction network, DEG-transcription factor interactions and DEG-microRNA interactions, protein-drug interactions and protein-disease association analysis, and gene-inflammation association analysis and protein-inflammation association analysis.</p><p><strong>Results: </strong>In total, 12 common DEGs were identified including HSPB1, VIM, MVD, TUBB4A, AACS, ANXA6, DIRAS2, RPH3A, CEND1, KALM, THOP1, AREL1. We also identified 11 hub proteins, three central regulatory transcription factors, and three microRNAs encoded by the DEGs. Protein-drug interaction analysis showed that CYC1 and UQCRFS1 are associated with different drugs. Gene-disease association analysis shows Mammary Neoplasms, Neoplasm Metastasis, Schizophrenia, and Brain Ischemia diseases are the most relevant to the hub proteins we identified. Gene-inflammation association analysis shows that the hub gene AREL1 is related to inflammatory response, while the protein-inflammation association analysis shows that the hub proteins AKT1 and MAPK14 are related to inflammatory response.</p><p><strong>Conclusion: </strong>This study provides new insights into the shared molecular mechanisms between AD and nHIBD. These common pathways and hub genes could potentially be used to design therapeutic interventions, reducing the likelihood of Alzheimer's disease development in survivors of neonatal Hypoxic-Ischemia brain injury.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1511668"},"PeriodicalIF":4.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social networks and cognitive impairment among older Chinese adults: the mediating effect of depression.","authors":"Zhuo Zhang, Ying Bian","doi":"10.3389/fnagi.2024.1495694","DOIUrl":"10.3389/fnagi.2024.1495694","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the rationality of the social networks-depression-cognitive impairment pathway and to provide recommendations for the development of mild cognitive impairment intervention strategies.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted in 2021. Sixteen urban communities in Xi 'an, Shaanxi China were selected as sample sites. The cognitive function, social networks and depression were measured by the Montreal Cognitive Assessment (MoCA), the Lubben Social Network Scale-6 (LSNS-6) and the Geriatric Depression Scale-15 (GDS-15), respectively. The generalized linear model was used to analysis the impact of social networks on cognitive impairment, and further analysis the mediating effect of depression.</p><p><strong>Results: </strong>A total of 745 elderly people aged 60 and above was included in this survey, with an average age of 68.90 ± 6.00 years. The prevalence of cognitive impairment was 18.52%, and the prevalence of cognitive impairment increased with age. According to the generalized linear model, poor social networks (relative network, friend network) was associated with higher risk of cognitive impairment (OR = 2.08, 95% CI: 1.27-3.41), and this association was more significant in women and older adults <70 years of age. Mediation analysis results showed that depression was the mediating path between social networks and cognitive impairment, with the indirect effects accounting for 34.44%.</p><p><strong>Conclusion: </strong>Social isolation increases the risk of cognitive impairment and depression has a significant mediating effect on the relationship between social isolation and cognitive impairment.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1495694"},"PeriodicalIF":4.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.","authors":"Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen","doi":"10.3389/fnagi.2024.1513302","DOIUrl":"10.3389/fnagi.2024.1513302","url":null,"abstract":"<p><strong>Purpose: </strong>Differentiating between Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be challenging due to overlapping cognitive and behavioral manifestations. Evidence regarding non-invasive and early-stage biomarkers remains limited. Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.</p><p><strong>Methods: </strong>We included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. Cox proportional hazards models were used to estimate the associations between macular OCT parameters and the risk of AD and FTD. Mediation analysis was used to explore the underlying mechanisms affected by brain structures.</p><p><strong>Results: </strong>The mean age at recruitment was 55.27, and 46.10% of the participants were male. During a mean follow-up of 9.15 ± 2.59 years, 148 patients with AD and eight patients with FTD were identified. Reduced thickness of the ganglion cell-inner plexiform layer (GC-IPL) at baseline was associated with an increased risk of AD (HR, 1.033; 95% CI, 1.001-1.066; <i>P</i> = 0.044), while thinner retinal pigment epithelial in the inner superior subfield at baseline was associated with an elevated risk of FTD (HR, 1.409; 95% CI, 1.060-1.871; <i>P</i> = 0.018). Structurally abnormal visual pathways, including cortical and subcortical gray matter volumes, as well as white matter integrity, mediated the association between the GC-IPL thickness and AD risk.</p><p><strong>Conclusion: </strong>Our findings provide preliminary empirical support for a relationship between prodromal changes in retinal layers and a higher risk of AD or FTD, suggesting that macular OCT may serve as a non-invasive, sensitive biomarker of high-risk years before the onset of dementia.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1513302"},"PeriodicalIF":4.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, national epidemiology and trends of Parkinson's disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.","authors":"Yuanrong Luo, Lichun Qiao, Miaoqian Li, Xinyue Wen, Wenbin Zhang, Xianwen Li","doi":"10.3389/fnagi.2024.1498756","DOIUrl":"10.3389/fnagi.2024.1498756","url":null,"abstract":"<p><strong>Aims: </strong>In light of the escalating global incidence of Parkinson's disease and the dearth of therapeutic interventions that can alter the disease's course, there exists an urgent necessity to comprehensively elucidate and quantify the disease's global burden.</p><p><strong>Methods: </strong>This study analyzed the incidence, prevalence, and disability-adjusted life years (DALYs) of Parkinson's disease at global, regional, and national levels based on the Global Burden of Disease Study 2021. Bayesian age-period cohort (BAPC) analysis was used to predict the burden in Parkinson's disease from 2022 to 2035.</p><p><strong>Results: </strong>In 2021, 11.77 million people worldwide had Parkinson's disease. Age-standardized rates of incidence, prevalence, and DALYs increased to 15.63/100,000, 138.63/100,000, and 89.59/100,000. The burden of Parkinson's disease were higher in males than in females, and showed an increase and then a slight decrease with age. The disease burden was highest in East Asia. BAPC projection showed an increase in all metrics by 2035 except for a slight decrease in the age-standardized DALYs rates.</p><p><strong>Conclusion: </strong>The global burden of Parkinson's disease has risen over the past 32 years, and there is a need to focus on key populations, as well as to improve health policies to prevent and treat Parkinson's disease.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1498756"},"PeriodicalIF":4.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of laser acupuncture on osteoarthritis: a systematic review and meta-analysis.","authors":"Xiangdong Wen, Guojiang Zhang, Jinquan Cui, Yuzhe Tang, Qi Meng, Yang Su, Senbo An, Shui Sun","doi":"10.3389/fnagi.2024.1462411","DOIUrl":"10.3389/fnagi.2024.1462411","url":null,"abstract":"<p><strong>Objectives: </strong>To perform a meta-analysis of previous studies investigating the effects of laser acupuncture on osteoarthritis.</p><p><strong>Study design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>Randomized controlled trials (RCTS) on laser acupuncture for osteoarthritis were searched in the databases of PubMed, Embase, Cochrane Library, and Web of Science with a search deadline of 24 December 2023. After identifying 11 studies, we used Stata 15.0 to analyze the data.</p><p><strong>Results: </strong>In the 11 studies identified, 931 patients were analyzed. Results showed that laser acupuncture significantly improved patients' pain and function compared to the placebo laser group. There were significant differences in VAS pain scores[SMD = -0.924, 95% CI (-1.200, -0.649), <i>p</i> = 0.000], WOMAC pain scores[SMD = -0.425, 95% CI (-0.652, -0.199), <i>p</i> = 0.000], WOMAC function scores[SMD = -0.307, 95% CI (-0.548, -0.065), <i>p</i> = 0.013], WOMAC stiffness scores[SMD = -0.235, 95% CI (-0.388, -0.083), <i>p</i> = 0.002] between the laser acupuncture group and the placebo laser group. The therapeutic effect of laser acupuncture disappeared at 8 weeks. In subgroup analysis, patients who received laser acupuncture with specific parameters had better VAS scores and WOMAC scores than patients in other subgroups.</p><p><strong>Conclusion: </strong>The application of laser acupuncture can improve knee pain and function in patients with osteoarthritis in the short term. It is recommended to use a laser with a power greater than 100 mW and a wavelength greater than 1,000 nm. CO2 lasers and solid-state lasers were shown to be more effective in the results than other types of lasers.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1462411"},"PeriodicalIF":4.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploration of distinguishing subjective cognitive decline and mild cognitive impairment based on resting-state prefrontal functional connectivity assessed by functional near-infrared spectroscopy.","authors":"Zhengping Pu, Hongna Huang, Man Li, Hongyan Li, Xiaoyan Shen, Qingfeng Wu, Qin Ni, Yong Lin, Donghong Cui","doi":"10.3389/fnagi.2024.1468246","DOIUrl":"10.3389/fnagi.2024.1468246","url":null,"abstract":"<p><strong>Purpose: </strong>Functional near-infrared spectroscopy (fNIRS) has shown feasibility in evaluating cognitive function and brain functional connectivity (FC). Therefore, this fNIRS study aimed to develop a screening method for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) based on resting-state prefrontal FC and neuropsychological tests via machine learning.</p><p><strong>Methods: </strong>Functional connectivity data measured by fNIRS were collected from 55 normal controls (NCs), 80 SCD individuals, and 111 MCI individuals. Differences in FC were analyzed among the groups. FC strength and neuropsychological test scores were extracted as features to build classification and predictive models through machine learning. Model performance was assessed based on accuracy, specificity, sensitivity, and area under the curve (AUC) with 95% confidence interval (CI) values.</p><p><strong>Results: </strong>Statistical analysis revealed a trend toward compensatory enhanced prefrontal FC in SCD and MCI individuals. The models showed a satisfactory ability to differentiate among the three groups, especially those employing linear discriminant analysis, logistic regression, and support vector machine. Accuracies of 94.9% for MCI vs. NC, 79.4% for MCI vs. SCD, and 77.0% for SCD vs. NC were achieved, and the highest AUC values were 97.5% (95% CI: 95.0%-100.0%) for MCI vs. NC, 83.7% (95% CI: 77.5%-89.8%) for MCI vs. SCD, and 80.6% (95% CI: 72.7%-88.4%) for SCD vs. NC.</p><p><strong>Conclusion: </strong>The developed screening method based on resting-state prefrontal FC measured by fNIRS and machine learning may help predict early-stage cognitive impairment.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1468246"},"PeriodicalIF":4.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}