Frontiers in Aging Neuroscience最新文献

{"title":"Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment.","authors":"Xiaoyang Feng, Xiaolin Sun, Jia Liu, Yan Li, Yunhai Yao, Jianming Fu, Xudong Gu","doi":"10.3389/fnagi.2025.1590783","DOIUrl":"10.3389/fnagi.2025.1590783","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of computer-assisted cognitive training (CACT) on cognitive function and activities of daily living in patients with post-stroke cognitive impairment. Additionally, it aimed to explore the changes in specific cognitive domains before and after treatment.</p><p><strong>Design: </strong>The study was a double-blind, randomized, controlled trial.</p><p><strong>Setting: </strong>It took place in rehabilitation wards or outpatient clinics.</p><p><strong>Participants: </strong>Sixty patients with post-stroke cognitive impairment took part in the study.</p><p><strong>Interventions: </strong>Participants were randomly assigned to either the control (<i>n</i> = 30) or the intervention group (<i>n</i> = 30). Both groups received conventional rehabilitation and cognitive training, and the intervention group additionally received CACT.</p><p><strong>Main outcome measures: </strong>The primary outcome measures included the Mini-Mental State Examination (MMSE) and event-related potential (ERP) P300 for cognitive function, as well as the modified Barthel Index (MBI) for activities of daily living. Secondary outcomes were the Trail Making Test (TMT), the Symbol-Digit Modalities Test (SDMT), the Auditory Verb Learning Test-Huashan version (AVLT-H), the Boston Naming Test (BNT), and the Clock Drawing Test (CDT), which assessed cognitive function across specific domains.</p><p><strong>Results: </strong>Both groups showed significant improvements in MMSE, MBI, amplitude of P300, and latency of P300, with the intervention group demonstrating more pronounced improvements compared to the control group. In terms of specific cognitive domains, the intervention group exhibited greater improvements than the control group in TMT-A, TMT-B, and AVLT-H. Both groups showed improvements in SDMT and BNT, but the differences between the groups were not statistically significant. Additionally, there was no significant improvement in the CDT for either group before and after treatment.</p><p><strong>Conclusion: </strong>CACT was found to improve patients' cognitive function, especially in areas of attention, executive function, and memory. It also effectively improved activities of daily living.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1590783"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE).","authors":"Sarah Mendorf, Konstantin G Heimrich, Hannah M Mühlhammer, Tino Prell, Aline Schönenberg","doi":"10.3389/fnagi.2025.1632607","DOIUrl":"10.3389/fnagi.2025.1632607","url":null,"abstract":"<p><strong>Introduction: </strong>Previous longitudinal studies have identified numerous factors influencing quality of life (QoL) in people of older age (PoA). However, most of these studies focus on group-level trends and fail to consider individual QoL trajectories or age-specific patterns over time.</p><p><strong>Methods: </strong>We investigated longitudinal changes in QoL among community-dwelling older adults using five waves (2010-2019) of the Survey of Health, Aging and Retirement in Europe (easySHARE). Clinically relevant changes were defined via the minimal clinically important difference (MCID). We applied linear regression and linear mixed models (LMM) to explore predictors of QoL trajectories.</p><p><strong>Results: </strong>Descriptive analyses showed that 2481 PoA (19.7%) experienced stable QoL between waves, based on changes below the MCID threshold of 3.18 points. The remaining participants exhibited consistent improvements or declines, with 1,701 different longitudinal patterns of QoL identified across the five time points. These individual patterns were further examined using LMM. LMM showed that the random effect of ID had the strongest impact on QoL across the five waves, suggesting highly individual QoL patterns. The influence of age was less significant compared to ID and decreased significantly after the addition of covariates.</p><p><strong>Conclusion: </strong>Our findings underscore the importance of individual-level analyses in aging research. While QoL may appear stable at the group level, individual trajectories vary considerably. This has important implications for the use of QoL as a primary endpoint in clinical trials, particularly in geriatric populations. Notably, age alone did not significantly influence QoL over time.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1632607"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.","authors":"Shichu Sun, Qi Zhao, Haojia He, Yujia Liu, Yuchong Nie, You Zhou","doi":"10.3389/fnagi.2025.1657603","DOIUrl":"10.3389/fnagi.2025.1657603","url":null,"abstract":"<p><p>Age-related hearing loss (ARHL), or presbycusis, is characterized by a progressive decline in binaural auditory sensitivity, particularly affecting high-frequency hearing and sound localization. The pathogenesis of ARHL is still unclear, correspondingly reflected in a lack of clinically effective intervention strategies. Recent advancements in audiology and neurobiology have illuminated the black box of the pathogenesis of ARHL. The intricate mechanisms underlying ARHL involve inflammation, oxidative stress, excessive autophagy, cellular signaling dysregulation, and metabolic alterations, which cause substantial damage to cellular function within cochlea. The weakened sound conduction and reduced auditory information processing potentially lead to emotional distress and heightened susceptibility to neurodegenerative conditions like cognitive decline and dementia. Promising interventions targeting these mechanisms are actively being investigated, ranging from pharmacological approaches to genetic therapies and lifestyle interventions. This narrative review summarizes recent research progress in understanding ARHL pathogenesis and discusses emerging strategies for prevention and treatment, highlighting the imperative for targeted interventions to enhance auditory health and overall well-being in aging populations.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1657603"},"PeriodicalIF":4.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis.","authors":"Fumei Yuan, Hong Wang","doi":"10.3389/fnagi.2025.1612913","DOIUrl":"10.3389/fnagi.2025.1612913","url":null,"abstract":"<p><strong>Objective: </strong>To systematically assess the impact of TCE on the efficacy of interventions targeting motor symptoms and mobility in people with Parkinson's disease.</p><p><strong>Methods: </strong>a computerized search was performed for randomized controlled trials assessing TCE intervention for motor symptoms and mobility in Parkinson's disease patients across PubMed, Web of Science, Embase, Cochrane Library, EBSCO, China National Knowledge Infrastructure (CNKI), WanFang data, and VIP database, covering the period from the inception of the databases to January 2025.</p><p><strong>Results: </strong>fourteen publications encompassing 833 Parkinson's disease patients were incorporated into the literature. A meta-analysis indicated that TCE enhanced the UPDRS-III score (MD = -4.38, 95% CI [-5.95, -2.81]), TUGT score (MD = -2.78, 95% CI [-4.02, -1.54]), and BBS score (MD = 3.68, 95% CI [2.09, 5.27]). The effect size was compared with the Minimum Clinically Important Difference (MCID), and it was found that patients could perceive the alleviation of motor symptoms (UPDRS-III). Subgroup analyses indicated that for motor symptoms (UPDRS-III), the optimal exercise regimen was Qigong (MD = -5.54) with an exercise duration of <12 weeks (MD = -4.79), <3times/week (MD = -4.67), and each session duration ≥60 min (MD = -4.86). For functional walking ability (TUGT), the optimal exercise was Tai Chi (MD = -3.41) with an exercise duration of ≥12 weeks (MD = -3.81), exercise frequency <3times/week (MD = -3.04), and each session duration ≥60 min (MD = -3.05). For balance (BBS), the optimal exercise was also Tai Chi (MD = 5.03) with an exercise duration of ≥12 weeks (MD = 3.75), <3times/week (MD = 3.73) and session duration of ≥60 min (MD = 4.16).</p><p><strong>Conclusion: </strong>This meta-analysis indicates, the TCE intervention enhances motor symptoms and mobility in people with PD, with optimal outcomes observed from exercise frequency <3times/week, each session duration ≥60 min. The duration of the patient's disease and the intervention group type influenced the effect size (MD).</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1612913"},"PeriodicalIF":4.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging.","authors":"Simone Varrasi, Sabrina Castellano, Daniele Magistro","doi":"10.3389/fnagi.2025.1679406","DOIUrl":"10.3389/fnagi.2025.1679406","url":null,"abstract":"","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1679406"},"PeriodicalIF":4.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.","authors":"Viana Q Pham, Melike Tutunculer, Halah Al-Dulaimi, Daniel Ardjmand, William Fleischmann, Tomas P Bachor, Allison W Xu","doi":"10.3389/fnagi.2025.1634283","DOIUrl":"10.3389/fnagi.2025.1634283","url":null,"abstract":"<p><p>Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood-brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. To date, adaptive changes in fenestrated vasculature in response to environmental insults remain poorly understood. In this study, we show that fenestrated capillaries in the median eminence (ME) and area postrema (AP)-two distinct circumventricular organs critical for metabolic control-undergo differential remodeling when exposed to circulating monosodium glutamate (MSG), a BBB-impermeable neurotoxin. Upon MSG exposure, fenestrated capillaries and vascular permeability were decreased in the ME but increased in the AP, and these changes were closely associated with the expression of angiogenic factors pleiotrophin (<i>Ptn</i>) and vascular endothelial growth factor A (<i>Vegfa</i>). In both ME and AP, adult tanycytes expressed high levels of <i>Ptn</i> and have processes in close contact with fenestrated capillaries. Significantly, the adaptive regulation of <i>Ptn</i> expression and the ability to modulate fenestrated capillaries and vascular permeability were abolished in both ME and AP of aged animals. Together, our findings suggest that tanycytic expressions of the angiogenic factor PTN, in conjunction with VEGF, are differentially regulated in distinct circumventricular organs upon exposure to neurotoxins, leading to region-specific remodeling of fenestrated endothelium. Our study further demonstrates that the loss of plasticity in fenestrated vasculature may be a hallmark feature of brain aging.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1634283"},"PeriodicalIF":4.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamate-associated research in Parkinson's disease: a bibliometric analysis.","authors":"Yan-Jun Chen, Ming-Rong Xie, Sheng-Qiang Zhou, Fang Liu","doi":"10.3389/fnagi.2025.1569924","DOIUrl":"10.3389/fnagi.2025.1569924","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a common neurodegenerative disease. As an important excitatory neurotransmitter, glutamate plays a key role in the nervous system. The imbalance of glutamate levels, the dysfunction of related receptors, and the abnormal activity of transporters are closely associated with the pathological process of PD. This study aims to explore the research hotspots, frontiers, and development directions of PD and glutamate.</p><p><strong>Method: </strong>The relevant publications were obtained from the Web of Science. CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative evaluation.</p><p><strong>Results: </strong>A total of 2,488 publications related to the research topic were included. From 2001 to 2024, the annual number of publications showed a fluctuating upward trend. The United States was a leader in this field, working closely with China, Italy, the United Kingdom, and France. Karolinska Institute was the most active institution. Core journals were mainly related to neuroscience, covering basic research, clinical applications, and pharmacology. Dr. Conn, P. Jeffrey was the most productive author. The paper \"<i>The functional anatomy of basal ganglia disorders</i>\" was the most co-cited literature. High-frequency keywords included PD, glutamate, basal ganglia, oxidative stress, dopamine (DA), neurons, alpha-synuclein (a-Syn), glutamate receptors, and synaptic plasticity. In recent years, a-Syn and neuroinflammation were the research topics with strong burst power.</p><p><strong>Conclusion: </strong>Research on PD and glutamate focused on countries with increasing aging. The collaboration of different countries and institutions was conducive to promoting the development of this field. The research hotspots included basal ganglia, oxidative stress, DA, neurons, a-Syn, glutamate receptors, and synaptic plasticity. a-Syn and neuroinflammation may be research directions in the future.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1569924"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model.","authors":"Miao Qiao, Ting Zhou, Rui Wang, Yanhui Jiang, Huitao Liang, Lingcui Meng","doi":"10.3389/fnagi.2025.1646916","DOIUrl":"10.3389/fnagi.2025.1646916","url":null,"abstract":"<p><strong>Background and purpose: </strong>Ischemic stroke (IS) is characterized by a high recurrence rate and more serious repercussions. Recently, the Carotid Plaque Reporting and Data System (Carotid Plaque-RADS) has been introduced to gauge and forecast the risk of cerebrovascular incidents. More studies are required to confirm its predictive power for recurrent ischemic stroke (RIS). We aimed to create a nomogram model that can evaluate the likelihood of RIS, with Carotid Plaque-RADS serving as a crucial instrument in this model.</p><p><strong>Methods: </strong>We carried out a retrospective review of 286 patients diagnosed with acute IS at the Second Affiliated Hospital of Guangzhou University of Chinese Medicine between January 2020 and January 2025. The study population consisted of two groups: the IS group (129 patients) and the RIS group (157 patients), depending on whether they experienced a recurrence of IS. Carotid ultrasound examination and clinical data were gathered and classified according to Carotid Plaque-RADS. Independent risk factors for the RIS were determined using multivariate logistic regression analyses. Subsequently, we developed a nomogram model to forecast RIS risk and evaluated its performance.</p><p><strong>Results: </strong>The RIS and IS groups showed significant differences in low-density lipoprotein (LDL), hypertension, atrial fibrillation, severe carotid stenosis, and Carotid Plaque-RADS categories. Multivariate logistic regression analysis identified LDL, hypertension, atrial fibrillation, severe carotid stenosis, and Carotid Plaque-RADS as independent risk factors for RIS. The nomogram model built using these risk factors demonstrated good calibration (H-L goodness-of-fit test <i>P</i> = 0.354). Internal and external validation demonstrated that the calibration curves were consistent with the original curves. The nomogram model combining Carotid Plaque-RADS and clinical features showed area under the curve (AUC) values of 0.79 and 0.76, outperforming models using only clinical features (AUC 0.72 and 0.70) or only Carotid Plaque-RADS (AUC 0.71 and 0.69). The model showed considerable clinical benefit within the 0.2-0.8 threshold range in the decision curve analysis (DCA).</p><p><strong>Conclusion: </strong>The nomogram model based on Carotid Plaque-RADS provides a novel and effective tool for clinical risk assessment and demonstrates favorable predictive performance for RIS.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1646916"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females.","authors":"Tian Wang, Zisu Mao, Yuan Shang, Simona Merlini, Francesca Vitali, Jean-Paul Wiegand, Roberta Diaz Brinton","doi":"10.3389/fnagi.2025.1632877","DOIUrl":"10.3389/fnagi.2025.1632877","url":null,"abstract":"<p><p>Female sex, age, and APOE4 genotype are the greatest risk factors for Alzheimer's disease. Using a translational perimenopause mouse model based on human Stages of Reproductive Aging Works (STRAW) criteria, we investigated the impact of APOE genotype on female midlife endocrine aging, peripheral metabolic indicators, brain bioenergetic pathways, mitochondrial function, neuroimmune activation, and myelination. Compared to APOE3 females, APOE4 females exhibited accelerated endocrine aging that was coincident with failure to mount adaptive bioenergetic reprogramming and significant decline in mitochondrial function that were coupled with increased immune activation and demyelination in brain. In women, APOE4 was associated with early menopause. Further, APOE4 women experiencing early menopause exhibited the highest risk of Alzheimer's. These results provide plausible mechanistic pathways underlying the earlier emergence and greater risk of Alzheimer's in APOE4 postmenopausal females. Collectively, these findings support midlife as a critical window for intervention to prevent or delay the onset of the prodromal stage of Alzheimer's disease in APOE4 carriers.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1632877"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in the weighting of kinematic and contextual information during action prediction.","authors":"Elisa Ravizzotti, Alessandra Finisguerra, Gaia Bonassi, Carola Cosentino, Susanna Mezzarobba, Alessandro Botta, Martina Putzolu, Sara Terranova, Valentina Bianco, Laura Avanzino, Elisa Pelosin, Cosimo Urgesi","doi":"10.3389/fnagi.2025.1622569","DOIUrl":"10.3389/fnagi.2025.1622569","url":null,"abstract":"<p><strong>Introduction: </strong>Predicting others' behaviors is an essential ability to interact efficiently within the social world. Previous evidence suggests that action prediction entails the integration of incoming sensory information with previous experience and contextual expectations. While it is well known that motor and cognitive functions face age-related changes, research examining how action prediction abilities evolve across the lifespan remains limited.</p><p><strong>Methods: </strong>Here, we compared the action prediction performance of 30 young and 30 older adults in a temporal occlusion paradigm displaying everyday actions embedded in breakfast scenarios. We asked participants to predict the outcome (i.e., to eat or to move) of reaching-to-grasp movements towards big or small food objects (i.e., krapfen or cream puff). Actions were embedded in contexts cueing to an eating or a moving intention, either congruently or incongruently with kinematics. We also measured participants' imaginary abilities and level of identification of actions.</p><p><strong>Results: </strong>Compared to young adults, older adults showed lower sensitivity at predicting actions when they were interrupted early, but not later. At the same time, they were less affected by response bias, particularly for late-interrupted actions. Beside reduced sensitivity, older adults' response speed in predicting early-interrupted actions benefitted more than that of young adults from contextual information. Notably, contextual modulation was stronger in individuals with more intense kinesthetic sensations during motor imagery, particularly within the young group.</p><p><strong>Discussion: </strong>The results suggest that, while action prediction skills seem to reduce with aging, older adults tend to rely more heavily on contextual cues when predicting others' behavior, which may serve as a compensatory mechanism under certain conditions.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1622569"},"PeriodicalIF":4.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}