Frontiers in Aging Neuroscience最新文献

{"title":"Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer's disease: a functional near-infrared spectroscopy study.","authors":"Yuanzhi Zhao, Conglong Qiu, Ping Lin, Mei Yang, Ling Huang, Zheng Zhao, Xiangping Wu, Dongsheng Zhou","doi":"10.3389/fnagi.2024.1460853","DOIUrl":"10.3389/fnagi.2024.1460853","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown the clinical effects of repetitive transcranial magnetic stimulation (rTMS) on depression in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. The measurement of brain activation links neurobiological and functional aspects but is challenging in patients with dementia. This study investigated the influence of rTMS on cortical activation in patients with AD and depressive symptoms, measured using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task.</p><p><strong>Methods: </strong>In this randomized, double-blind study, patients with AD and depression received either active rTMS (n = 17) or sham-rTMS (n = 16). Patients received 4 weeks of bilateral standard rTMS (1 Hz rTMS delivered to the right dorsolateral prefrontal cortex (DLPFC) and 10-Hz rTMS delivered to the left DLPFC).</p><p><strong>Results: </strong>No significant changes were found in the Mini-Mental State Examination (MMSE) and Modified Barthel Index (MBI); however, significant changes were found for the 17-item Hamilton Depression Rating Scale (HAMD-17) and the depression score of the Neuropsychiatric Inventory (NPI-depression; <i>p</i> < 0.05). The results showed a decrease in the concentration of oxygenated hemoglobin, as measured with fNIRS, from baseline to week 4 in CH41 (in right DLPFC; <i>p</i> = 0.0047, FDR-corrected). There was a negative correlation between the improvement in HAMD-17 severity in these patients and reduced oxygenated hemodynamic response of CH41 (r = - 0.504, <i>p</i> = 0.039).</p><p><strong>Conclusion: </strong>The results indicated a positive effect of rTMS on depression in patients with AD. The underlying cortical changes were imaged using fNIRS. Prefrontal activation measured by fNIRS is a potential biomarker for monitoring the response of patients with depression in AD to rTMS treatment.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1460853"},"PeriodicalIF":4.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke.","authors":"Chenchen Liu, Dai Shi, Xiaoqiong Ni, Shoujiang You, Xiaofen Wu, Sheng Zhuang, Wu Cai, Liang Xu","doi":"10.3389/fnagi.2024.1492078","DOIUrl":"10.3389/fnagi.2024.1492078","url":null,"abstract":"<p><strong>Background: </strong>White matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence and strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, a maker of inflammation, and WMH and brain atrophy in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>A total of 727 AIS patients with lymphocyte count and brain magnetic resonance imaging data were enrolled. Participants were divided into four groups according to the quartiles of baseline lymphocyte counts. WMH is frequently divided into periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). WMH was defined as Fazekas scale score ≥ 3; PVH was defined as periventricular Fazekas scale ≥2; DWMH was defined as deep Fazekas scale ≥2. Brain atrophy was defined as global cortical atrophy score ≥ 1. Multivariable logistic regression models were used to assess the association between lymphocyte count and WMH and brain atrophy.</p><p><strong>Results: </strong>Among 727 AIS, 517 (71.1%), 442 (60.8%), 459 (63.1%), 583 (80.2%) had WMH, PVH, DWMH and brain atrophy, respectively. After adjustment for potential covariates, the highest quartiles of lymphocyte counts were significantly associated with lower risk of WMH (adjusted odds ratio [aOR] 0.57, 95% confidence intervals [CI] 0.32-0.99), PVH (aOR 0.52, 95% CI 0.31-0.87), DWMH (aOR 0.53 95% CI 0.32-0.90) as well as brain atrophy (aOR 0.46, 95% CI 0.23-0.92) compared with the lowest quartiles of lymphocyte counts, respectively. Furthermore, a notable inverse association was observed between continuous lymphocyte counts and WMH, PVH, DWMH, and brain atrophy. Additionally, we found that the inverse association between baseline lymphocyte count and WMH was significant only in individuals with mild stroke.</p><p><strong>Conclusion: </strong>In patients with AIS, there was an independent and inverse association between the baseline lymphocyte count and both WMH and brain atrophy.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1492078"},"PeriodicalIF":4.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study.","authors":"Ting Fu, Weiwei Zhang, Rongrong Guo, Shuang He, Saiying Yu, Huiying Wang, Yunfeng Zhang, Ying Wu","doi":"10.3389/fnagi.2024.1509846","DOIUrl":"10.3389/fnagi.2024.1509846","url":null,"abstract":"<p><strong>Background: </strong>Hypocretin-1 is a vital neurotransmitter in regulating the sleep-wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke.</p><p><strong>Methods: </strong>A total of 183 consecutively elderly patients were included in the prospective cohort study. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Cerebrospinal fluid samples were taken within 24 h of acute ischemic stroke onset. After selecting optimal predictors via univariate analysis and bootstrapped stepwise logistic regression, the predictive model was developed. The models were internally validated and evaluated comprehensively via discrimination, calibration, and clinical utility.</p><p><strong>Results: </strong>The prevalence of poor sleep (PSQI >7) was 64.5% among elderly individuals experiencing acute ischemic stroke. The study developed a predictive model using hypocretin-1, hypertension, stroke history, the National Institutes of Health Stroke score, and depression. Adding hypocretin-1 (as continuous variable) significantly improved the model performance greatly, as the area under the receiver operating characteristic curve increased from 0.799 to 0.845 (<i>p</i> < 0.001). The optimal cutoff value for hypocretin-1 was 74.94 pg/mL. Adding hypocretin-1 (as binary variable) significantly improved the model performance greatly, as the AUC increased from 0.799 to 0.857 (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Reduced cerebrospinal fluid levels of hypocretin-1 at admission were an independent poor sleep quality predictor and the model demonstrated superior performance. The combination of hypocretin-1 could offer valuable prognostic information for post-stroke sleep quality in elderly patients with acute ischemic stroke.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1509846"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis.","authors":"Jiaxuan He, Peiye Xu, Ting Xu, Haiyang Yu, Lei Wang, Rongbing Chen, Kun Zhang, Yueliang Yao, Yanyan Xie, Qinsi Yang, Wei Wu, Da Sun, Dejun Wu","doi":"10.3389/fnagi.2024.1515092","DOIUrl":"10.3389/fnagi.2024.1515092","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing a key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) in a zebrafish AD model. Zebrafish were exposed to aluminum chloride to induce AD-like pathology and then treated with HRW using a nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, and reactive oxygen species (ROS) and neutrophil fluorescence labeling were employed to assess HRW's impact. Additionally, 16S rRNA sequencing analyzed HRW's effect on gut microbiota. HRW can significantly improve cognitive impairment and depression-like behavior in zebrafish AD model, reduce Aβ deposition (<i>p</i> < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels (<i>p</i> < 0.05), reduce neuroinflammation, and reduce oxidative stress. Furthermore, HRW reduced the number of harmful bacteria linked to AD pathology by restoring the balance of microbiota in the gut. These findings suggest that HRW has potential as a therapeutic strategy for AD by targeting oxidative stress, inflammation, and gut-brain axis modulation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1515092"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11746902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential biomarkers for cerebral small vessel disease with cognitive impairment: a systematic review and meta-analysis.","authors":"Libin Liao, Weiquan Huang, Rongchao Ma, Xuan He, Moxi Su, Dujuan Sha","doi":"10.3389/fnagi.2024.1475571","DOIUrl":"10.3389/fnagi.2024.1475571","url":null,"abstract":"<p><p>Cerebral small vessel disease (CSVD) is a common factor in age-related diseases such as stroke and dementia, and about half of dementia patients worldwide are caused by CSVD. CSVD-related cognitive impairment (CSVD-CI) affects more and more elderly people, resulting in economic losses and burdens on families and society. In recent years, circulating biomarkers have made breakthroughs and played an increasingly important role in the diagnosis, progression, and prognosis of CSVD-associated cognitive impairment, and are expected to be applied to the early clinical detection, diagnosis, and treatment of patients with cerebral small vessel disease. Through a systematic review and meta-analysis, this study aimed to assess the relationship between circulating factors and cognitive impairment associated with cerebral small vessel disease, especially the possibility of becoming the potential biomarkers for diagnosis. Articles published before November 2023 were searched in four databases, PubMed, Web of Science, Embase, and Cochrane Library, to identify all relevant studies reporting circulating markers in patients with CSVD. Twenty-nine articles out of 2,911 were finalized for this study. We meta-analyzed 2 or more articles that were jointly considered to be circulating biomarkers of CSVD-CI and summarized a total of 4 possible biomarkers: homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and neurofilament protein light chain (NfL). The results revealed that patients in the CSVD-related cognitive impairment group had significantly higher levels of Hcy and hs-CRP than those in the CSVD-without cognitive impairment group, whereas there was no statistically significant difference in Lp-PLA2 and NfL between the two groups. Therefore, Hcy, hs-CRP may be considered circulating markers of cognitive impairment associated with cerebral small vessel disease.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1475571"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation for patients with walking difficulties caused by cerebral small vessel disease: a randomized controlled study.","authors":"Qiaoqiao Xu, Wenwen Yin, Xia Zhou, Shuo Wang, Sishi Chen, Jiajia Yang, Chunhua Xi, Zhongwu Sun","doi":"10.3389/fnagi.2024.1511287","DOIUrl":"10.3389/fnagi.2024.1511287","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral small vessel disease (CSVD) is a chronic systemic degenerative disease affecting small blood vessels in the brain, leading to cognitive impairments. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that applies low electrical currents to the scalp, shows promise in treating cognitive and movement disorders. However, further clinical evaluation is required to assess the long-term effects of tDCS on neuroplasticity and gait in patients with CSVD. We investigated the effects of long-term, repeated tDCS on local brain perfusion, network connectivity, cognition, and gait in patients with CSVD and gait disorders (CSVD-GD).</p><p><strong>Methods: </strong>This prospective, single-blind, multicenter, randomized controlled study enrolled 66 patients with CSVD-GD, categorized into the tDCS and Sham groups. Imaging and gait characteristic data were collected over three periods using magnetic resonance imaging and a gait analyzer, along with neuropsychological assessments.</p><p><strong>Results: </strong>Among 156 volunteers with CSVD-GD, 66 participated in this study, with 60 completing the entire process. Compared to the Sham group, the tDCS group exhibited a more pronounced increase in the cerebral blood flow to the dural cerebrospinal fluid ratio in regions such as the orbitofrontal cortex and cingulate gyrus (<i>P</i> < 0.05, FDR corrected), along with significantly greater improvements in gait speed and stride length. Tolerance to tDCS was good, with no difference in adverse reactions between the groups, except for a scalp burning sensation reported during the 1st week (24.24% and 6.06% in the tDCS and Sham groups, respectively; <i>P</i> = 0.003).</p><p><strong>Discussion: </strong>Long-term tDCS is effective and safe for improving neuroplasticity and gait cognition in patients with CSVD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1511287"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous blinking and brain health in aging: Large-scale evaluation of blink-related oscillations across the lifespan.","authors":"Sujoy Ghosh Hajra, Jed A Meltzer, Prerana Keerthi, Chloe Pappas, Allison B Sekuler, Careesa Chang Liu","doi":"10.3389/fnagi.2024.1473178","DOIUrl":"10.3389/fnagi.2024.1473178","url":null,"abstract":"<p><p>Blink-related oscillations (BROs) are newly discovered neurophysiological brainwave responses associated with spontaneous blinking, and represent environmental monitoring and awareness processes as the brain evaluates new visual information appearing after eye re-opening. BRO responses have been demonstrated in healthy young adults across multiple task states and are modulated by both task and environmental factors, but little is known about this phenomenon in aging. To address this, we undertook the first large-scale evaluation of BRO responses in healthy aging using the Cambridge Centre for Aging and Neuroscience (Cam-CAN) repository, which contains magnetoencephalography (MEG) data from a large sample (<i>N</i> = 457) of healthy adults across a broad age range (18-88) during the performance of a simple target detection task. The results showed that BRO responses were present in all age groups, and the associated effects exhibited significant age-related modulations comprising an increase in sensor-level global field power (GFP) and source-level theta and alpha spectral power within the bilateral precuneus. Additionally, the extent of cortical activations also showed an inverted-U relationship with age, consistent with neurocompensation with aging. Crucially, these age-related differences were not observed in the behavioral measures of task performance such as reaction time and accuracy, suggesting that blink-related neural responses during the target detection task are more sensitive in capturing aging-related brain function changes compared to behavioral measures alone. Together, these results suggest that BRO responses are not only present throughout the adult lifespan, but the effects can also capture brain function changes in healthy aging-thus providing a simple yet powerful avenue for evaluating brain health in aging.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1473178"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model.","authors":"Mark B Russell, Drew P Locke, Haley M Adams, Alexander R Pelley, Rojan Saghian, Alexandre S Maekawa, Darcie Stapleton, Grace V Mercer, John G Sled, Lindsay S Cahill","doi":"10.3389/fnagi.2024.1445164","DOIUrl":"10.3389/fnagi.2024.1445164","url":null,"abstract":"<p><strong>Introduction: </strong>Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (<i>dcr</i>) mouse allows investigation of early biomarkers and mechanisms of brain injury.</p><p><strong>Methods: </strong>Using high-frequency ultrasound, the common carotid arteries of female and male <i>dcr</i> and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (<i>n</i> = 6 mice/group/sex).</p><p><strong>Results: </strong>Over the disease time course, the female <i>dcr</i> mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male <i>dcr</i> mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female <i>dcr</i> mice and increased carotid artery diameter and decreased pulse wave velocity in males.</p><p><strong>Discussion: </strong>Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1445164"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection.","authors":"Gabriela Gonzalez Aleman, George D Vavougios, Carmela Tartaglia, Nalakath A Uvais, Alla Guekht, Akram A Hosseini, Vincenzina Lo Re, Catterina Ferreccio, Giovanni D'Avossa, Hernan P Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T Stavrou, Stylianos Boutlas, Konstantinos I Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Federica Avorio, Sophia Wang, Paul Edison, Yoshiki Niimi, Hamid R Sohrabi, Elizabeta B Mukaetova Ladinska, Daria Neidre, Gabriel A de Erausquin","doi":"10.3389/fnagi.2024.1432357","DOIUrl":"10.3389/fnagi.2024.1432357","url":null,"abstract":"<p><p>Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin. The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. The risk of moderate to severe impairment doubled in older adults. Moderately severe or severe impairment was significantly associated with infection diagnoses (chi-square = 26.57, <i>p</i> ≤ 0.0001) and the severity of anosmia (chi-square = 31.81, <i>p</i> ≤ 0.0001). We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. We identified the severity of acute illness and the presence of olfactory dysfunction as the primary predictors of dementia-like impairment in older adults.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1432357"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threshold effects of sleep duration and cognitive function in older adults with BMI ≥ 25 kg/m².","authors":"Kunyu Qiu, Yilei Liu, Chengwei Hu, Jie Gu, Yanyan Huang","doi":"10.3389/fnagi.2024.1529639","DOIUrl":"10.3389/fnagi.2024.1529639","url":null,"abstract":"<p><strong>Background: </strong>It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and cognitive decline remains a subject of debate. The impact of sleep duration on cognitive performance in seniors with a body mass index (BMI) ≥ 25 kg/m² is largely unknown. This makes it an intriguing subject to explore further.</p><p><strong>Methods: </strong>This study used data from the National Health and Nutrition Examination Survey (NHANES) (2011-2014) with 2,243 participants. Weighted multivariate linear regression and smooth curve fitting were employed to investigate linear and non-linear relationships. A two-part linear regression model was used to determine the threshold effects. Additionally, subgroup analysis and interaction tests were conducted.</p><p><strong>Results: </strong>Results showed that a negative association was found between sleep duration and scores in the fully adjusted model in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). A two-piecewise linear regression model was then applied to explore the threshold effect of sleep duration on cognitive performance. When sleep duration was less than 5 and 6 h per day, sleep duration was positively correlated with CERAD test scores [ß (95% CI): 2.11 (1.17, 3.05), <i>p</i> < 0.0001], AFT scores [<i>β</i> (95% CI): 0.25 (-0.17, 0.67), <i>p</i> = 0.2376], and DSST scores [ß (95% CI): 0.49 (-0.57, 1.56), <i>p</i> = 0.3654]. However, there was a threshold effect where sleep duration reached the three inflection points.</p><p><strong>Conclusion: </strong>In overweight and obese older adults, there is a clear inverted U-shaped relationship between sleep duration and cognitive function, with consistent results across different subgroups. Sleep durations of around 5-6 h may help prevent cognitive decline in older adults with a BMI ≥ 25 kg/m².</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1529639"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}