Frontiers in Aging Neuroscience最新文献

{"title":"Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts.","authors":"Wonjae Sung, Young Seo Kim, Kyu-Yong Lee, Jae-A Jung, Hojin Choi, Young Joo Lee, Seong-Ho Koh","doi":"10.3389/fnagi.2024.1507683","DOIUrl":"10.3389/fnagi.2024.1507683","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated the effect of aspirin on the subcortical SBI inflammatory processes.</p><p><strong>Methods: </strong>Consecutive patients diagnosed with subcortical SBIs without a history of acute stroke were included. The demographic and clinical data of the 26 subjects with subcortical SBIs, such as the number and location of subcortical SBIs, were reviewed. Plasma levels of macrophage migration inhibitory factor (MIF), matrix metalloproteinase-9 (MMP-9), and visfatin were measured in patients with subcortical SBIs and ten healthy participants. These biomarkers were rechecked in patients with subcortical SBI 3 months after taking aspirin (100 mg/day).</p><p><strong>Results: </strong>MIF and MMP-9 levels were significantly higher in patients with subcortical SBIs than in healthy control group (<i>p</i> = 0.031 and <i>p</i> = 0.026, respectively). Although MIF and MMP-9 did not show significant changes after taking aspirin for 3 months, the median plasma level of visfatin was significantly decreased from 1.00 ng/mL (range, 0.86-1.16 ng/mL) to 0.84 ng/mL (range, 0.77-0.91 ng/mL) (<i>p</i> = 0.002) after taking aspirin.</p><p><strong>Discussion: </strong>Inflammation could be an essential factor in the pathogenesis of subcortical SBIs, and aspirin affects several inflammation-related biomarkers.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1507683"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis.","authors":"Jinghong Zhang, Yang Li, Qiang Shi","doi":"10.3389/fnagi.2024.1502025","DOIUrl":"10.3389/fnagi.2024.1502025","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have suggested that neuromuscular junction (NMJ) denervation plays a critical role in amyotrophic lateral sclerosis (ALS). Repetitive nerve stimulation (RNS) has been used as a technique to test neuromuscular transmission, but the sensitivity and stability of its parameters have not been investigated in patients with ALS. In addition, the impact of impaired homeostasis on NMJ stability in patients with ALS remains unclear.</p><p><strong>Methods: </strong>A total of 421 patients with ALS were enrolled. Data on their clinical, biochemical and electrophysiological indicators were divided into a training set (collected from June 2019 to June 2022) and a test set (collected from July 2022 to June 2023). The coefficient of variation (CV) was used to assess the extent of variability. Stepwise regression was used in independent variable selection and model building.</p><p><strong>Results: </strong>In patients with ALS, area decrement had a higher rate of abnormal result and a lower CV than amplitude decrement. No significant difference in the rate of abnormal decrement was found when the first compound muscle action potential (CMAP) was compared with either the fourth or fifth one. Moreover, multivariate regression analysis suggests high-density lipoprotein cholesterol (HDL-C) had the greatest impact on decremental response, followed by serum uric acid (UA) and forced vital capacity (FVC). Females had a larger range of area decrement than males.</p><p><strong>Conclusion: </strong>During RNS test, assessing area decrement significantly enhances our ability to detect the impairment of neuromuscular transmission in patients with ALS. Independent factors contributing to decremental response need to be considered in drug development and clinical trials targeting NMJ in patients with ALS.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1502025"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences of subjective visual vertical perception in adults-a functional near-infrared spectroscopy study.","authors":"Jun Lu, Xiang Gong, Meng-Huan Wang, Ruo-Xin Zhao, Yu-Chen Wang, Ying-Ying Shen, Rong Cao, Guang-Xu Xu","doi":"10.3389/fnagi.2024.1449455","DOIUrl":"10.3389/fnagi.2024.1449455","url":null,"abstract":"<p><strong>Background: </strong>The perception of Subjective Visual Vertical (SVV) is crucial for postural orientation and significantly reflects an individual's postural control ability, relying on vestibular, visual, and somatic sensory inputs to assess the Earth's gravity line. The neural mechanisms and aging effects on SVV perception, however, remain unclear.</p><p><strong>Objective: </strong>This study seeks to examine aging-related changes in SVV perception and uncover its neurological underpinnings through functional near-infrared spectroscopy (fNIRS).</p><p><strong>Methods: </strong>In a comparative study of 19 young and 19 older adults, the standardized SVV task executed in Eprime 3.0 software evaluated participants' SVV orientation and uncertainty. Cortical responses were monitored via fNIRS during the task, with block averaging analysis employed to delineate the associated hemodynamic responses. The study further correlated these neuroimaging findings with behavioral measures.</p><p><strong>Results: </strong>Young individuals exhibit superior accuracy and stability in perceiving the subjective visual vertical (SVV) direction. Neuroimaging data, adjusted for multiple comparisons using the false discovery rate, reveal activation of the right supramarginal gyrus (SMG) and the left dorsolateral superior frontal gyrus (SFGdor) in both age groups during SVV tasks. However, older participants show additional activation in regions such as the bilateral postcentral gyrus (PoCG) and the right middle frontal gyrus (MFG). Lateralization studies indicate that young participants predominantly exhibit right lateralization in sensory and dorsolateral prefrontal cortices, with left lateralization in the motor cortex. In contrast, elderly participants demonstrate bilateral dominance across sensory, dorsolateral prefrontal, and motor cortices. Correlational analyses link modified SVV metrics to the activation levels of various brain regions, with negative correlations observed in both age groups, and a unique positive correlation with the left inferior frontal gyrus of the triangular part (IFGtriang) in young participants.</p><p><strong>Conclusion: </strong>Young individuals outperform the older individuals in SVV performance due to age-related differences in brain functional patterns during the execution of vertical perception judgment. Both age groups activate the right SMG and left SFGdor, but the older individuals additionally activate regions such as bilateral PoCG and right MFG. While young people exhibit right-brain dominance, the older people rely on bilateral cognitive resources, indicating bilateral dominance. Except for the left IFGtriang in the young, higher activation in brain regions correlates with better SVV performance.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1449455"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Animal models of Alzheimer's disease and other dementias: past, present, and future.","authors":"Ines Moreno-Gonzalez, Jesus Garcia-Martin, Roberta Marongiu","doi":"10.3389/fnagi.2024.1539837","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1539837","url":null,"abstract":"","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1539837"},"PeriodicalIF":4.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An EEG-based framework for automated discrimination of conversion to Alzheimer's disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study.","authors":"Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang","doi":"10.3389/fnagi.2024.1470836","DOIUrl":"10.3389/fnagi.2024.1470836","url":null,"abstract":"<p><strong>Background: </strong>As a clinical precursor to Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI) bears a considerably heightened risk of transitioning to AD compared to cognitively normal elders. Early prediction of whether aMCI will progress to AD is of paramount importance, as it can provide pivotal guidance for subsequent clinical interventions in an early and effective manner.</p><p><strong>Methods: </strong>A total of 107 aMCI cases were enrolled and their electroencephalogram (EEG) data were collected at the time of the initial diagnosis. During 18-month follow-up period, 42 individuals progressed to AD (PMCI), while 65 remained in the aMCI stage (SMCI). Spectral, nonlinear, and functional connectivity features were extracted from the EEG data, subjected to feature selection and dimensionality reduction, and then fed into various machine learning classifiers for discrimination. The performance of each model was assessed using 10-fold cross-validation and evaluated in terms of accuracy (ACC), area under the curve (AUC), sensitivity (SEN), specificity (SPE), positive predictive value (PPV), and F1-score.</p><p><strong>Results: </strong>Compared to SMCI patients, PMCI patients exhibit a trend of \"high to low\" frequency shift, decreased complexity, and a disconnection phenomenon in EEG signals. An epoch-based classification procedure, utilizing the extracted EEG features and <i>k</i>-nearest neighbor (KNN) classifier, achieved the ACC of 99.96%, AUC of 99.97%, SEN of 99.98%, SPE of 99.95%, PPV of 99.93%, and F1-score of 99.96%. Meanwhile, the subject-based classification procedure also demonstrated commendable performance, achieving an ACC of 78.37%, an AUC of 83.89%, SEN of 77.68%, SPE of 76.24%, PPV of 82.55%, and F1-score of 78.47%.</p><p><strong>Conclusion: </strong>Aiming to explore the EEG biomarkers with predictive value for AD in the early stages of aMCI, the proposed discriminant framework provided robust longitudinal evidence for the trajectory of the aMCI cases, aiding in the achievement of early diagnosis and proactive intervention.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1470836"},"PeriodicalIF":4.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic retinal vessel analysis: flickering a light into the brain.","authors":"Anna Peterfi, Ana Clara da C Pinaffi-Langley, Zsofia Szarvas, Mihaly Muranyi, Zalan Kaposzta, Cheryl Adams, Camila Bonin Pinto, Peter Mukli, Konstantin Kotliar, Andriy Yabluchanskiy","doi":"10.3389/fnagi.2024.1517368","DOIUrl":"10.3389/fnagi.2024.1517368","url":null,"abstract":"<p><strong>Introduction: </strong>Growing aging populations pose new challenges to public health as the number of people living with dementia grows in tandem. To alleviate the burden of dementia, prodromal signs of cognitive impairment must be recognized and risk factors reduced. In this context, non-invasive techniques may be used to identify early changes and monitor disease progression. Dynamic retinal vessel analysis (DVA) provides an opportunity to measure retinal vasoreactivity in a way that may be comparable to cerebral vasoreactivity, thus providing a window to the brain.</p><p><strong>Methods: </strong>We conducted a literature search on PubMed and Scopus to identify studies utilizing DVA to describe retinal vasoreactivity in central nervous system diseases and compare it with brain function and structure. We included original papers with full text in English.</p><p><strong>Results: </strong>We identified 11 studies, of which most employed a cross-sectional design (91%). Studies on cerebrovascular diseases reported that retinal vasoreactivity decreased in patient populations compared with that of healthy controls. Studies on cognitive impairment and dementia yielded mixed results, at least in part due to high population heterogeneity. There is also evidence for the association between DVA and brain and cognition parameters such as cerebral blood flow velocity, cerebral microvascular diffusivity, and cognitive function score.</p><p><strong>Discussion: </strong>The reviewed papers on DVA and brain function, despite the mixed results, have demonstrated the relationship between retinal vasoreactivity and cerebrovascular function and cognition. Heterogeneity in study populations, procedures, and analyses make comparisons difficult. Studies with larger sample size, clear description of the population and methods, and standardized DVA analysis are needed to elucidate the eye-brain connection and to enhance the translational and clinical applications of DVA.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1517368"},"PeriodicalIF":4.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of metabolic characteristics in the co-occurrence of insomnia, Alzheimer's disease, and Parkinson's disease: a Mendelian randomization study.","authors":"Chengyong Liu, Chi Wang, Jing Jiang, Yuyang Bo, Lixiu Nan, Ying Zhang, Kongxi Zhu, Xiaoqiu Wang, Xinxin Feng, Xiaoyang Lian, Shan Qin","doi":"10.3389/fnagi.2024.1436171","DOIUrl":"10.3389/fnagi.2024.1436171","url":null,"abstract":"<p><strong>Objective: </strong>There reportedly exists a significant comorbidity between insomnia and neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), indicative of a potential link to serum metabolic dysregulation.</p><p><strong>Method: </strong>To elucidate shared pathophysiological mechanisms between insomnia and AD/PD, we performed comprehensive two-sample Mendelian randomization (MR) analyses, investigating 1,400 serum metabolic characteristics for their causal relationships with the risks of insomnia, AD, widely defined AD (WDAD), and PD. We employed publicly available genetic data; the primary estimate was determined using inverse-variance weighting, supplemented by weighted median, simple mode, weighted mode, and the MR-PRESSO and MR-Egger methods to evaluate heterogeneity and pleiotropy.</p><p><strong>Results: </strong>The ratio of N-palmitoyl-sphingosine to N-palmitoyl-sphinganine is linked to higher risks of insomnia (OR = 1.137, 95% CI = 1.015-1.273, <i>p</i> = 0.026) and AD (OR = 1.090, 95% CI = 1.005-1.183, <i>p</i> = 0.037). The acetylcarnitine to propionylcarnitine ratio is a risk factor for insomnia (OR = 1.190, 95% CI = 1.003-1.370, <i>p</i> = 0.016) but has protective effects against AD (OR = 0.868, 95% CI = 0.784-0.961, <i>p</i> = 0.006) and WDAD (OR = 0.892, 95% CI = 0.817-0.973, <i>p</i> = 0.010). Glutamine conjugate of C7H12O2 levels are associated with reduced risk of insomnia (OR = 0.863, 95% CI = 0.749-0.995, <i>p</i> = 0.042) and PD (OR = 0.856, 95% CI = 0.746-0.981, <i>p</i> = 0.026).</p><p><strong>Conclusion: </strong>Our findings highlight the crucial role of serum metabolic characteristics in the comorbidity of insomnia with neurodegenerative diseases, providing valuable insights into prospective therapeutic targets and diagnostic markers.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1436171"},"PeriodicalIF":4.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep structure of short-term insomnia disorder with mild cognitive impairment in older adults and their correlation with cognitive function: a case-control study.","authors":"Jinkun Zeng, Jia Wei, Ruobing Qi","doi":"10.3389/fnagi.2024.1507285","DOIUrl":"10.3389/fnagi.2024.1507285","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to delineate the sleep architecture characteristics in older adults with short-term insomnia and mild cognitive impairment (MCI) and to explore their association with cognitive performance.</p><p><strong>Methods: </strong>Ninety elderly individuals with short-term insomnia were enrolled and stratified into two cohorts based on their Montreal Cognitive Assessment (MoCA) scores: the Short-Term Insomnia Group (STID) comprising 35 participants and the Short-Term Insomnia with Cognitive Impairment Group (STID-MCI) with 55 participants. Demographic data, Pittsburgh Sleep Quality Index (PSQI), MoCA, Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), and polysomnography (PSG) parameters were compared between groups. Correlations between MoCA scores and PSG metrics were also analyzed.</p><p><strong>Results: </strong>No significant disparities were noted between groups in terms of HAMD-17, HAMA, and PSQI scores (<i>p</i> > 0.05). However, marked differences were identified in MoCA scores and its subdomains (<i>p</i> < 0.05). Significant variations were also observed in the duration and proportion of slow-wave sleep (N3) between groups (<i>p</i> < 0.05). In STID-MCI patients, memory scores correlated positively with N3 duration and percentage (<i>p</i> < 0.05), while verbal functions and attention were positively associated with rapid eye movement (REM) sleep duration.</p><p><strong>Conclusion: </strong>This study highlights the potential of PSG in the clinical assessment of cognitive function and underscores the need for targeted interventions to improve sleep quality in this vulnerable population.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1507285"},"PeriodicalIF":4.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer's disease.","authors":"Sedef Kollarik, Dorita Bimbiryte, Aakriti Sethi, Inês Dias, Carlos G Moreira, Daniela Noain","doi":"10.3389/fnagi.2024.1519225","DOIUrl":"10.3389/fnagi.2024.1519225","url":null,"abstract":"<p><strong>Introduction: </strong>Improving sleep in murine Alzheimer's disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding the reduction in pathological hallmarks and related cognitive performance, remains poorly characterized.</p><p><strong>Methods: </strong>Here, we enhanced slow-wave activity (SWA) during sleep via sodium oxybate (SO) oral administration for 2 weeks at early (6 months old) or moderately late (11 months old) disease stages in Tg2576 mice and evaluated resulting neuropathology and behavioral performance.</p><p><strong>Results: </strong>We observed that the cognitive performance of 6-month-old Tg2576 mice significantly improved upon SO treatment, whereas no change was observed in 11-month-old mice. Histochemical assessment of amyloid plaques demonstrated that SO-treated 11-month-old Tg2576 mice had significantly less plaque burden than placebo-treated ones, whereas ELISA of insoluble protein fractions from brains of 6-month-old Tg2576 mice indicated lower Aβ-42/Aβ-40 ratio in SO-treated group vs. placebo-treated controls.</p><p><strong>Discussion: </strong>Altogether, our results suggest that SWA-dependent reduction in brain amyloidosis leads to alleviated behavioral impairment in Tg2576 mice only if administered early in the disease course, potentially highlighting the key importance of early sleep-based interventions in clinical cohorts.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1519225"},"PeriodicalIF":4.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults.","authors":"Simon Hass, Maxie Liebscher, Anni Richter, Klaus Fliessbach, Christoph Laske, Sebastian Sodenkamp, Oliver Peters, Julian Hellmann-Regen, Ersin Ersözlü, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Sandra Röske, Anja Schneider, Hartmut Schütze, Annika Spottke, Anna Esser, Stefan Teipel, Ingo Kilimann, Jens Wiltfang, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Michael Wagner, Frank Jessen, Emrah Düzel, Franka Glöckner, Björn Hendrik Schott, Miranka Wirth, Olga Klimecki","doi":"10.3389/fnagi.2024.1451850","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1451850","url":null,"abstract":"<p><strong>Background: </strong>In humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study assessed whether EE during early life (13-30 years) and midlife (30-65 years) is associated with better preserved memory-related brain activity patterns in older age.</p><p><strong>Methods: </strong>In total, 372 cognitively unimpaired older adults (aged ≥60 years old) of the DZNE-Longitudinal Study on Cognitive Impairment and Dementia (DELCODE; DRKS00007966) were investigated. EE was operationalized using items of the Lifetime of Experiences Questionnaire (LEQ), which measures the self-reported participation in a variety of leisure activities in early life and midlife. The preservation of memory-related functional brain activity was assessed using single-value scores, which relate older adults' brain activity patterns in the temporo-parieto-occipital memory network to those of young adults during visual memory encoding (FADE and SAME scores).</p><p><strong>Results: </strong>EE during early life and midlife was significantly associated with higher SAME scores during novelty processing (<i>n</i> = 372, <i>β</i> = 0.13, <i>p</i> = 0.011). Thus, older participants with higher EE showed greater similarity of functional brain activity patterns during novelty processing with young adults. This positive association was observed most strongly in participants with subjective cognitive decline (SCD, <i>n</i> = 199, <i>β</i> = 0.20, <i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>More frequent participation in a variety of leisure activities in early life and midlife is associated with more successful aging of functional brain activity patterns in the memory network of older adults, including participants at increased risk for dementia. Longitudinal studies are needed to clarify whether higher EE during life could help preserve memory network function in later life.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1451850"},"PeriodicalIF":4.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}