Frontiers in Aging Neuroscience最新文献

{"title":"Associations between cerebrospinal fluid biomarkers related to endothelial dysfunction and Alzheimer's disease.","authors":"Yang-Ke Zhu, Qiu-Jie Zhu, Lan-Yang Wang, He-Ying Hu, Xue-Jie Wang, Zi-Hao Zhang, Wei Zhang, Lan Tan, Hao Hu","doi":"10.3389/fnagi.2026.1744647","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1744647","url":null,"abstract":"<p><strong>Background: </strong>Although associations between overt vascular injury and Alzheimer's disease (AD) have been reported, the role of subclinical vascular injury in dementia pathogenesis remains unclear. Cerebrospinal fluid (CSF) biomarkers related to endothelial dysfunction may capture subclinical vascular impairment and provide insights into early AD pathogenesis.</p><p><strong>Methods: </strong>We examined associations of ten CSF biomarkers (PDGFRβ, Osteopontin, VCAM-1, E-selectin, MMP-2, MMP-10, MMP-3, MMP-12, MMP-9/TIMP-1 ratio and Periostin) with AD core biomarkers, brain volume, cognitive function, and risk of incident AD among 444 participants. Multivariable linear regression, linear mixed-effects models, Cox proportional hazards models, mediation analyses, and 3-year time-dependent ROC analyses were applied. All models were adjusted for demographic factors, <i>APOE</i> ε4 status, and vascular risk factors.</p><p><strong>Results: </strong>Seven of ten biomarkers were significantly associated with CSF tau biomarkers, whereas two biomarkers were associated with CSF Aβ₄₂. Mediation analyses suggested that CSF tau biomarkers statistically accounted for a greater proportion of the associations between MMP-10 and cognition than did Aβ₄₂. Among the biomarkers examined, MMP-10 showed the most consistent associations across AD-related outcomes, including lower CSF Aβ₄₂, higher CSF tau biomarkers, poorer cognitive performance, greater longitudinal brain atrophy, and increased risk of incident AD dementia.</p><p><strong>Conclusion: </strong>Cerebrospinal fluid biomarkers related to endothelial dysfunction and vascular injury were more consistently associated with CSF tau biomarkers than with CSF Aβ₄₂ in non-demented individuals. MMP-10 showed the most consistent pathological, cognitive, neuroimaging, and prognostic associations and provided incremental predictive information for incident AD dementia. These findings support further investigation of endothelial dysfunction-related and vascular remodeling pathways as potential correlates of AD progression.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1744647"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropeptide Y and brain ageing: an updated scoping review on the role of autophagy.","authors":"Suang Yao Cheah, Yatinesh Kumari, Nur Fatin Nabilah Mohd Sahardi, Siti Liyana Saud Gany, Nur Atiqah Haizum Abdullah, Suzana Makpol, Faizul Jaafar","doi":"10.3389/fnagi.2026.1888512","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1888512","url":null,"abstract":"<p><p>Brain ageing is a complex physiological process characterised by progressive structural and functional changes that often result in cognitive decline and reduced quality of life in the elderly. These changes are driven by multiple mechanisms, including synaptic dysfunction, oxidative stress, neuroinflammation, and impaired cellular homeostasis. Neuropeptides have emerged as important regulators of these processes. Among them, neuropeptide Y (NPY) has gained attention for its potential role in mitigating age-related brain dysfunction. However, the extent to which NPY contributes to brain ageing remains unclear. This scoping review aims to map the available evidence on the role of NPY in brain ageing, focusing on the effect of NPY on autophagy, a key mechanism involved in brain ageing. Scientific studies published between 2014 and 2026 relevant to the research topic were systematically screened and reviewed. Following a rigorous selection process, four articles that met the inclusion and exclusion criteria were included for analysis. The findings indicate that NPY levels decline in the hypothalamic arcuate nucleus in a progeroid mouse model, where restoring NPY delays several ageing phenotypes. In addition, NPY appears to mitigate brain ageing by promoting autophagy in the hypothalamus and cerebral cortex, an effect requiring both suppression of PI3K/AKT/mTOR signalling and activation of ERK1/2-MAPK. These insights may pave the way for future research into therapeutic strategies targeting NPY to combat age-related cognitive deficits and neurodegenerative diseases. However, further investigation is needed to elucidate the underlying mechanisms of NPY action, including the roles of its various receptors and interactions with other neuropeptides.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1888512"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden-dependent associations of serum sTREM2 with white matter injury and cognitive heterogeneity in cerebral small vessel disease.","authors":"Qiuju Gong, Xianfeng Yu, Shujian Chen, Ke Wan, Zhiqiang Wang, Bo Tian, Xiaoqun Zhu, Xia Zhou, Zhongwu Sun","doi":"10.3389/fnagi.2026.1937413","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1937413","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive outcomes vary among individuals with cerebral small vessel disease (CSVD), and conventional imaging markers may not fully explain this heterogeneity. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is involved in TREM2-related myeloid responses, but the clinical significance of circulating sTREM2 in CSVD remains uncertain. We investigated the associations of serum sTREM2 with CSVD burden, white matter injury, and cognitive performance across different disease burdens.</p><p><strong>Methods: </strong>Serum sTREM2 levels were measured in 171 participants, including healthy controls and individuals with low- or high-burden CSVD. Associations between serum sTREM2 and total CSVD burden, individual imaging markers, white matter hyperintensity (WMH) volume, diffusion MRI measures, and cognitive performance were examined using multivariable regression models, tract-based spatial statistics, and burden-stratified analyses.</p><p><strong>Results: </strong>Serum sTREM2 levels increased across the CSVD burden spectrum and were associated with WMH volume, whereas no significant associations were observed with lacunes, cerebral microbleeds, or enlarged perivascular spaces. Higher serum sTREM2 was associated with widespread increases in mean diffusivity across major white matter tracts, while fractional anisotropy abnormalities were limited. The association between serum sTREM2 and Montreal Cognitive Assessment (MoCA) performance differed according to CSVD burden (interaction β = 0.462, HC3 <i>P</i> = 0.027), with a positive burden-stratified association observed in high-burden CSVD. Interpretation: Serum sTREM2 exhibited a white matter-predominant association pattern across the CSVD spectrum, and its relationship with cognitive performance varied according to disease burden. These findings suggest that circulating sTREM2 may provide additional information regarding biological heterogeneity in CSVD, although its cellular origin and longitudinal significance require further investigation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1937413"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Elevated serum uric acid is associated with cognitive improvement in older American adults: a large, population-based-analysis of the NHANES database.","authors":"Rulin Geng, Yu Zhang, Miao Liu, Shengfeng Deng, Jingwen Ding, Hongfei Zhong, Qiuyun Tu","doi":"10.3389/fnagi.2026.1972629","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1972629","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnagi.2022.1024415.].</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1972629"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research architecture of RNA-binding proteins in neurodegenerative diseases: a web of science bibliometric study with PubMed record verification, 2001-2025.","authors":"Ranran Zhu, Hongyan Li","doi":"10.3389/fnagi.2026.1967205","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1967205","url":null,"abstract":"<p><strong>Background: </strong>RNA-binding proteins (RBPs) connect RNA homeostasis to proteostasis and selective neuronal vulnerability, but the organization and evolution of this cross-disease research field remain unclear.</p><p><strong>Methods: </strong>We analyzed Web of Science Core Collection (WoSCC) records published through 2025. PubMed was used only to verify records by normalized DOI or exact normalized title; PubMed metadata were not pooled with WoS data, and all bibliometric analyses used WoS fields. Publication growth, contributors, collaboration, co-citation, bibliographic coupling, and conceptual evolution were examined using bibliometrix, VOSviewer, and CiteSpace-compatible workflows. A prespecified 43-concept dictionary preserved multiword biological entities in title/abstract networks. The study characterizes a query-defined and PubMed-verified literature corpus rather than estimating the relative biological importance of individual RBPs.</p><p><strong>Results: </strong>Of 2,454 records reported by the WoS search interface, 2,450 were available in the supplied exports and 2,309 met the year criterion. PubMed record verification retained 2,160 records (93.55%) in the analysis corpus; 149 records (6.45%) were not matched. Output increased from one publication in 2001 to 213 in 2025. Within this query-defined corpus, the mapped literature was concentrated around TDP-43 pathology, TARDBP/FUS genetics, and loss of RNA-processing function. The controlled concept network resolved three macro-communities, while recent temporal signals involved LATE, cryptic exons, and RNA transport. These findings describe the retrieved and verified corpus and are not presented as a search-independent ranking of the broader RBP field.</p><p><strong>Conclusion: </strong>The maps document a WoS-derived and PubMed-verified literature corpus concentrated on TDP-43 and ALS/FTD and increasingly connected with cryptic RNA processing, condensate biology, nuclear transport, neuroimmune responses, and aging-related mixed proteinopathies. Because the corpus was conditioned by a title-level query containing named RBPs and by PubMed record verification, these patterns should not be interpreted as an unbiased ranking of RBP biology or as evidence of shared causality across diseases. Cross-disease translation should proceed through neuropathologically defined, age-stratified, and cell-type-resolved human cohorts, followed by causal perturbation and rescue in human disease models and multicenter longitudinal validation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1967205"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multicomponent exercise on global cognitive function, executive function, and brain-derived neurotrophic factors in older adults with mild cognitive impairment: a systematic review and three-level meta-analysis.","authors":"Pengfei Yang, Yongjie Liu, Yiyi Duan, Nguyen Manh Cuong, Yun Bi","doi":"10.3389/fnagi.2026.1921425","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1921425","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To systematically evaluate the effects of multicomponent exercise on global cognitive function, executive function, and brain-derived neurotrophic factor in older adults with mild cognitive impairment using a three-level meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Web of Science, Cochrane Library, Embase, EBSCOhost, PubMed, CNKI, Wanfang, and Weipu were systematically searched from inception to September 15, 2025, to identify randomized controlled trials (RCTs) examining multicomponent exercise interventions in older adults with mild cognitive impairment. Methodological quality was assessed using the PEDro scale, and the quality of evidence was evaluated using the GRADE system. Meta-analysis was conducted using a three-level random-effects model in R software, and publication bias was examined. Effect sizes were estimated using Hedges' &lt;i&gt;g&lt;/i&gt; with 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated to determine the expected range of effect sizes in future comparable studies. Funnel plots and Egger's regression test were used to assess publication bias.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 10 RCTs comprising 623 older adults with MCI from community settings, hospitals, and nursing homes were included. The interventions consisted primarily of multicomponent exercise at moderate intensity, with session durations of 30-90 min, frequencies of 2-5 sessions per week, and intervention periods of 8-48 weeks. Control groups received usual care or health education. Most studies reported no exercise-related adverse events. The mean PEDro score of the included studies was 6.0. The three-level meta-analysis revealed that multicomponent exercise significantly improved global cognitive function (&lt;i&gt;g&lt;/i&gt; = 1.063, 95% CI [0.355, 1.771], &lt;i&gt;p&lt;/i&gt; = 0.007, 95% PI [-1.141, 3.267]) and executive function (&lt;i&gt;g&lt;/i&gt; = 0.372, 95% CI [0.140, 0.604], &lt;i&gt;p&lt;/i&gt; = 0.005, 95% PI [0.140, 0.604]) in older adults with MCI. BDNF was assessed in only two studies, with conflicting findings, and its effects remain inconclusive. Exploratory subgroup analyses revealed that none of the moderator variables reached statistical significance: exercise duration [&lt;i&gt;F&lt;/i&gt;(1,9) = 0.127, &lt;i&gt;p&lt;/i&gt; = 0.730], exercise frequency [&lt;i&gt;F&lt;/i&gt;(1,10) = 3.421, &lt;i&gt;p&lt;/i&gt; = 0.094], intervention duration [&lt;i&gt;F&lt;/i&gt;(1,10) = 0.0002, &lt;i&gt;p&lt;/i&gt; = 0.988], and measurement tools [&lt;i&gt;F&lt;/i&gt;(2,9) = 0.882, &lt;i&gt;p&lt;/i&gt; = 0.447] all showed no significant moderating effects. Owing to the limited number of effect sizes in certain categories (&lt;i&gt;k&lt;/i&gt; ≤ 2), interaction tests were not performed for exercise modality, and results across groups were presented descriptively. Descriptive analyses showed that the combinations of \"aerobic + strength + balance + coordination + agility\" training (&lt;i&gt;k&lt;/i&gt; = 2, &lt;i&gt;g&lt;/i&gt; = 2.109, 95% CI [0.816, 3.402], &lt;i&gt;p&lt;/i&gt; = 0.006) and \"aerobic + strength + flexibility\" training (&lt;i&gt;k&lt;/i&gt; = 2, &lt;i&gt;g&lt;/i&gt; = 2.039, 95% CI [0.772, 3.3","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1921425"},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.","authors":"Yue Lu, Quan Zhang, Hutao Xie, Houyou Fan, Yichen Xu, Guofan Qin, Yutong Zhuang, Jiansong Huang, Anchao Yang, Yin Jiang, Jianguo Zhang","doi":"10.3389/fnagi.2026.1961905","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1961905","url":null,"abstract":"<p><strong>Objective: </strong>Visual attention deficits are common but under-recognized in Parkinson's disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients.</p><p><strong>Methods: </strong>Thirty-nine PD patients with bilateral STN-DBS perform an attentional capture task under three stimulation conditions (OFF, low-frequency, high-frequency). Patients are stratified into impaired (<i>n</i> = 21) and normal (<i>n</i> = 18) visual attention groups based on their accuracy in the AC-distractor task during OFF-stimulation, with <90% accuracy defining impairment. Behavioral accuracy and reaction time are analyzed using Bayesian mixed-effects models. P300 amplitudes and latencies are measured using electroencephalography.</p><p><strong>Results: </strong>In the impaired group, 5 Hz stimulation significantly improves accuracy in the distractor condition compared with OFF (BF > 1,000), whereas 130 Hz stimulation reduces accuracy (BF = 122.8). This behavioral pattern is paralleled by enhanced P300 amplitude and prolonged latency under 5 Hz stimulation, and suppressed P300 amplitude under 130 Hz stimulation. No significant stimulation effects are observed in the normal group.</p><p><strong>Conclusion: </strong>Theta-frequency STN-DBS selectively improves visual attention in PD with pre-existing attentional deficits, likely by enhancing top-down attentional resource allocation, while high-frequency stimulation impairs performance.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1961905"},"PeriodicalIF":5.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson's disease patients with subjective cognitive decline.","authors":"Shanzhen Wei, Mengdi Qiu, Mengyu Gong, Wenwei Zou, Jiaxin Ren, Wenchao Qiu","doi":"10.3389/fnagi.2026.1935631","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1935631","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to examine diffusion alterations indexed by the diffusion tensor image analysis along the perivascular space (DTI-ALPS) in patients with Parkinson's disease presenting with subjective cognitive decline (PD-SCD), and to investigate their associations with impairments across specific cognitive domains.</p><p><strong>Methods: </strong>This is a cross-sectional study. A total of 607 eligible participants were enrolled and categorized into three groups: healthy controls (HC), Parkinson's disease with normal cognition (PD-NC), and PD-SCD. The DTI-ALPS index was calculated as a diffusion-based metric reflecting water diffusivity along the perivascular space relative to adjacent fiber tracts. To ensure the robustness of the findings, Region of Interest (ROI) delineation was performed and validated using both manual anatomical delineation and JHU atlas-based methods. Statistical analyses included inter-group comparisons, Receiver Operating Characteristic (ROC) curves to assess predictive performance for PD-SCD, and partial correlation analyses between ALPS indices and cognitive domains.</p><p><strong>Results: </strong>The DTI-ALPS indices were significantly lower in the PD-SCD group compared to both PD-NC and HC groups, exhibiting a significant stepwise decline (HC > PD-NC > PD-SCD). ROC analysis showed that the left ALPS index (AUC = 0.6503) and the mean ALPS index (AUC = 0.6452) had modest discriminatory performance in differentiating PD-SCD from PD-NC. Partial correlation analysis revealed that ALPS indices were specifically and significantly associated with attention and working memory deficits. Notably, the side of motor symptom onset in PD did not significantly influence ALPS values. High consistency was observed between the manual and atlas-based ROI methods.</p><p><strong>Discussion: </strong>In this cross-sectional cohort, PD-SCD was associated with a lower DTI-ALPS index, and this diffusion alteration was related to attention and working-memory performance. These findings suggest that the DTI-ALPS index may serve as a potential diffusion-based marker for early cognitive risk stratification in PD; however, its precise biological basis and longitudinal significance require further investigation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1935631"},"PeriodicalIF":5.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with self- perceived speech impairment in <i>de novo</i> Parkinson's disease: a retrospective study of an international database.","authors":"Zoë Thijs, Kara Bain, Matthew Dumican","doi":"10.3389/fnagi.2026.1932141","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1932141","url":null,"abstract":"<p><strong>Introduction: </strong>People with Parkinson's disease (PwPD) may experience speech changes early in the disease process, yet it is unclear how they perceive them. Moreover, in <i>de novo</i> PD specifically, the relationship between speech, cognition, and swallowing is not well-established. Therefore, this study aimed to determine the association between self-perceived speech impairment, clinician-perceived speech impairment, cognitive impairment, and swallowing impairment in <i>de novo</i> PD.</p><p><strong>Methods: </strong>Data were obtained from the Parkinson's Progressive Markers Initiative. We included baseline visit data from 1072 <i>de novo</i> PwPD. An ordinal logistic regression was performed to determine what clinical measures were associated with self-perceived speech impairment.</p><p><strong>Results: </strong>The ordinal logistic regression found that self-perceived speech impairments were significantly associated with clinician-perceived speech impairment (Wald χ²[3] = 44.039, <i>p</i> < 0.001), self-reported swallowing impairment (Wald χ²[3] = 61.863, <i>p</i> < 0.001), cognitive impairment (Wald χ²[4] = 32.293, <i>p</i> < 0.001), and being male (Wald χ²[1] = 11.520, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This preliminary work showed potential relationships between self-perceived and clinician-perceived speech impairment, swallowing impairment, and cognitive impairment, demonstrating the multidimensional nature of self-perceived speech impairment. More research using more extensive assessment methods is needed to further elucidate these relationships in <i>de novo</i> PD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1932141"},"PeriodicalIF":5.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated plantar electrical stimulation is associated with altered lower-limb somatosensory processing in older adults: evidence from somatosensory evoked potentials.","authors":"Aoi Mase, Risa Tashiro, Kanoko Ito, Ryoji Kasanami, Ryota Sakurai, Chiaki Ohtaka, Manabu Shibasaki, Hiroki Nakata","doi":"10.3389/fnagi.2026.1939284","DOIUrl":"https://doi.org/10.3389/fnagi.2026.1939284","url":null,"abstract":"<p><strong>Introduction: </strong>Age-related declines in lower-limb somatosensory function may contribute to impaired motor control and increased fall risk in older adults. Although plantar sensory stimulation has been reported to improve postural control, its effects on neural processing remain unclear. This study investigated whether repeated plantar electrical stimulation modifies lower-limb somatosensory processing in older adults using somatosensory evoked potentials (SEPs).</p><p><strong>Methods: </strong>83 older adults aged ≥65 years were assigned to either a plantar electrical stimulation group (PES, <i>n</i> = 37) or a non-intervention control group (CON, <i>n</i> = 46). The PES group performed home-based plantar electrical stimulation for 8 weeks (30 min/session, ≥2 days/week). SEPs elicited by tibial, peroneal, and median nerve stimulation were recorded before and after the intervention. SEP latencies and amplitudes were analyzed using mixed-design ANOVA, and ANCOVA was performed for components showing baseline group differences.</p><p><strong>Results: </strong>In the PES group, P37 latency elicited by tibial nerve stimulation and P37 and N50 latencies elicited by peroneal nerve stimulation were shorter at Post than at Pre, whereas no significant changes were observed in the CON group. ANCOVA confirmed that the group effect remained significant for P37 latency during tibial and peroneal nerve stimulations after adjustment for baseline values. Significant negative correlations were observed between baseline latencies and intervention-related changes, although these findings should be interpreted cautiously because change scores include baseline values. No significant intervention effects were observed for SEP amplitudes during lower-limb stimulation, and median nerve SEPs showed no comparable latency shortening.</p><p><strong>Conclusion: </strong>Repeated plantar electrical stimulation was associated with shortened early SEP latencies elicited by lower-limb nerve stimulation. No comparable latency shortening was observed in median nerve SEPs, suggesting that the observed changes were more prominent in lower-limb than in upper-limb somatosensory processing. These findings suggest that repeated plantar electrical stimulation may be associated with changes in the temporal characteristics of lower-limb somatosensory processing in older adults. Further studies should determine whether these neurophysiological changes are associated with improvements in balance, mobility, and other functional outcomes.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"18 ","pages":"1939284"},"PeriodicalIF":5.2,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}