Frontiers in Aging Neuroscience最新文献

{"title":"Choline alphoscerate: insights between acquired certainties and future perspectives.","authors":"Giovanni Biggio, Claudio Mencacci","doi":"10.3389/fnagi.2025.1613566","DOIUrl":"10.3389/fnagi.2025.1613566","url":null,"abstract":"<p><p>While mild cognitive impairment (MCI) is a risk factor for dementia, it is currently impossible to predict which patients will go on to develop dementia or Alzheimer's disease. Given the projected global increase in dementia due to an increasingly aging population, there is an urgent need to develop pharmacological therapies to reduce symptoms of MCI, and to help delay its possible progression to dementia. Choline alphoscerate is a cholinergic precursor naturally found in the brain that has been identified as an essential nutrient and is available as a prescription drug. While the efficacy of choline alphoscerate on cognitive function is well established in patients with MCI, Alzheimer's disease, and cognitive impairment of vascular origin, emerging evidence suggests that it has neuroprotective effects against <i>β</i>-amyloid injury and may be useful as a preventive therapy against development of Alzheimer's disease in patients with MCI. Recent data also show that choline alphoscerate may be effective against non-cognitive symptoms of MCI (e.g., depression, anxiety, irritability, aggression, and apathy). Here we review pharmacological and clinical evidence regarding choline alphoscerate in order to highlight its usefulness in patients with MCI. The potential role of choline alphoscerate in promoting healthy sleep architecture is also explored.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1613566"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144949080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement in modeling of Alzheimer's disease: a comprehensive review of preclinical screening platforms.","authors":"Souvik Adak, Shivam Singh, Ridhi Jain, Abhilasha Tiwari, Binny Singh, Sumit Kumar, Ayushi Dadhwal, Avishek Chakroborty, Ashish Kumar Sharma, Ravindra Pal Singh, Rajesh Kumar Sharma","doi":"10.3389/fnagi.2025.1646551","DOIUrl":"10.3389/fnagi.2025.1646551","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a chronic and progressive neurodegenerative condition that worsens with time and causes memory loss and cognitive impairment. For prompt intervention and management of AD, early detection is essential. Screening models play a crucial role in identifying individuals at risk of developing AD before the onset of noticeable clinical symptoms. This review summarizes a wide range of <i>in vitro</i> and <i>in vivo</i> screening models currently utilized in AD research, highlighting their advantages and limitations. <i>In vitro</i> systems-such as cell lines and primary neuronal cultures-provide controlled settings to investigate cellular mechanisms and drug efficacy. In contrast, <i>in vivo</i> models, including transgenic rodents and other animals, better replicate the complex biological features of AD. Each model type comes with distinct benefits and limitations concerning clinical relevance, cost-effectiveness, and ethical challenges. By evaluating the utility and constrains of these models, this article seeks to assist researchers in choosing suitable platforms for preclinical investigations and support the advancement of improved diagnostic tools and therapeutic strategies for AD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1646551"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144949066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal vascular supply and its mediating role in systemic physiological influences on hippocampal volume.","authors":"Tae Kim, Javier Rasero, Anna L Marsland, Mark R Scudder, Tamer S Ibrahim, Peter J Gianaros","doi":"10.3389/fnagi.2025.1590242","DOIUrl":"10.3389/fnagi.2025.1590242","url":null,"abstract":"<p><strong>Background: </strong>Aging-related systemic cardiovascular changes can impair cerebrovascular circulation, contributing to hippocampal atrophy and cognitive decline. However, the mechanistic pathways by which systemic alterations may relate to hippocampal atrophy via hippocampal vascular features remain unclear.</p><p><strong>Methods: </strong>In this study, 191 participants (aged 30-59 years, 115 female) underwent 7T MRI to segment hippocampal supply vessels and hippocampal volume from T1-weighted images. Twenty-three systemic parameters related to the metabolic syndrome, autonomic function, inflammation, vascular stiffness, and endothelial function were measured at rest. Mediation analysis examined whether hippocampal vessel velocity and size mediated the relationship between systemic factors and hippocampal volume.</p><p><strong>Results: </strong>Hippocampal volume was highly associated with hippocampal supply vessel velocity, showing a pronounced right lateralized effect. Indirect associations of vessel velocity with hippocampal volume were identified for circulating vascular and intercellular adhesion molecules, heart rate variability, fasting insulin, and spontaneous baroreflex sensitivity. No significant mediated relationships were found for blood pressure, adiposity, mean heart rate, cardiac output, pre-ejection period, reactive hyperemia, pulse wave velocity, mean carotid artery intimal medial thickness, fasting glucose, lipid levels, circulating interleukin-6, hemoglobin A1C, or blood pressure variability.</p><p><strong>Conclusion: </strong>These findings highlight the role of vascular inflammation, autonomic dysfunction, and metabolic disturbances in hippocampal atrophy, with hippocampal vessel velocity serving as a key mediator. This insight advances our understanding of cerebrovascular contributions to hippocampal structural integrity and cognitive health.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1590242"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rb1 attenuates neuroflammation via activating Wnt/β-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury.","authors":"Ruo-Jing Liu, Xue Zhao, Yi-Zhen Zhu, Ling-Ling Fu, Guo Ge, Jun-de Zhu","doi":"10.3389/fnagi.2025.1555067","DOIUrl":"10.3389/fnagi.2025.1555067","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the molecular mechanism of G-Rb1 regulating microglia polarization through Wnt/β-catenin signaling pathway to alleviate cerebral ischemia-reperfusion injury in mice.</p><p><strong>Methods: </strong>C57BL/6J mouse middle cerebral artery occlusion/reperfusion (MCAO/R) model and microglia (BV2) oxygen-glucose deprivation/reoxygenation (ODG/R) model were used. The neuroprotective effect of G-Rb1 <i>in vivo</i> and <i>in vitro</i> was evaluated by measuring nerve function deficit, cerebral blood perfusion recovery, infarct volume and cell viability. Immunofluorescence, flow cytometry, Western blot and qRT-PCR were used to evaluate the effects of G-Rb1 on the Wnt/β-catenin signaling pathway and microglia phenotypic polarization mediated neuroinflammation <i>in vivo</i> and <i>in vitro</i>.</p><p><strong>Results: </strong>Compared with the Sham group, the symptoms of neurological impairment, cerebral blood perfusion, cerebral infarction volume and inflammatory reaction were increased in the IRI group. Compared with the IRI group, G-Rb1 group showed less symptoms of neurological impairment, increased cerebral blood perfusion, decreased cerebral infarction volume, increased proportion of M2-type microglia, increased release of anti-inflammatory factors, reduced inflammatory response, and up-regulated β-catenin expression while down-regulated GSK-3β expression. It was demonstrated that G-Rb1 activates the Wnt/β-catenin signaling pathway after CIRI. Compared with G-Rb1 group, G-Rb1 + XAV939 group had more neurological impairment, increased cerebral infarction volume, increased M1 microglia proportion, and increased neuroinflammation. Meanwhile, β-catenin expression decreased while GSK-3β expression increased. The results of <i>in vitro</i> experiments were similar to those of <i>in vivo</i>, which demonstrated that G-Rb1 may alter microglial polarization phenotype through Wnt/β-catenin signaling pathway and alleviate neuroinflammatory response after CIRI.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1555067"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer's disease.","authors":"Bo Kyu Choi, Yeonju Jin, Hokyung Lee, Sung-Woo Kim, Sojeong Park, Ickpyo Hong, Min Seok Baek","doi":"10.3389/fnagi.2025.1603892","DOIUrl":"10.3389/fnagi.2025.1603892","url":null,"abstract":"<p><strong>Background: </strong>The potential effect of the antiplatelet and anti-inflammatory properties of aspirin on Alzheimer's disease development, especially its role in the progression from mild cognitive impairment to Alzheimer's disease dementia, remains controversial. To evaluate the association between aspirin, use and the risk of conversion to Alzheimer's disease dementia among individuals diagnosed with mild cognitive impairment.</p><p><strong>Methods: </strong>In this retrospective population-based cohort study, we used the Korean National Health Insurance Service database to collect data on patients with mild cognitive impairment enrolled between 2013 and 2016 and followed up until 2021. In total, 508,107 patients initially diagnosed with mild cognitive impairment (192,538 with aspirin prescriptions and 315,569 without aspirin prescriptions) were enrolled. Aspirin use was assessed by extracting information from the Korean National Health Insurance Service database using aspirin prescription codes. The primary outcome was newly diagnosed Alzheimer's disease dementia. Hazard ratios and 95% confidence intervals for Alzheimer's disease were analyzed according to aspirin use using Cox proportional hazards regression analysis. Secondary outcomes included ischemic and hemorrhagic stroke risk associated with aspirin use.</p><p><strong>Results: </strong>The data of 508,107 individuals were analyzed (mean [standard deviation] age, 67.6 [10.7] years; 66.8% women and 33.2% men), and 39,318 developed Alzheimer's disease (22,572 controls and 16,746 using aspirin). The rate of conversion to Alzheimer's disease was lower in the aspirin user group, and the time to Alzheimer's disease dementia occurrence was longer than in the nonuser group. A decreased Alzheimer's disease dementia risk was found in patients using aspirin in Model 2 (adjusted hazard ratio, 0.939; 95% confidence interval, 0.920-0.959), with more pronounced effects in individuals aged ≥65 years (Model 2 adjusted hazard ratio, 0.934; 95% confidence interval, 0.914-0.955). For hemorrhagic stroke, the risk increased with aspirin use across all age groups, with the highest risk observed in younger patients (Model 2 adjusted hazard ratio, 5.082; 95% confidence interval, 4.838-5.338).</p><p><strong>Conclusion: </strong>Aspirin use was associated with reduced Alzheimer's disease risk in older patients with mild cognitive impairment. Notably, the bleeding risk associated with aspirin use should be considered, and personalized treatment should be provided.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1603892"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aging on the visuomotor control during continuous bimanual movement.","authors":"Kimia Kiani, Maya Patel, Qiushi Fu","doi":"10.3389/fnagi.2025.1525535","DOIUrl":"10.3389/fnagi.2025.1525535","url":null,"abstract":"<p><strong>Introduction: </strong>Skilled bimanual coordination is an essential component of activities of daily living that relies on complex interactions between the limbs, yet how age-related changes impact asymmetries in visuomotor control during these tasks remains largely unknown. In the present study, we examined both motor performance and visual attention distribution in non-rhythmic continuous bimanual tasks and investigated the effect of aging.</p><p><strong>Methods: </strong>Twelve right-handed young adults (YA) and twelve right-handed older adults (OA) performed a bimanual tracking task in which each hand controlled a cursor using a robotic device to track the upward movement of a horizontal target line simultaneously and independently. We assessed participants' performance in the symmetric condition, where both hands should perform the same actions to be successful. Additionally, participants performed the task in asymmetric conditions, where either a new force or a change in visuomotor gain was applied to only one hand, requiring participants to adapt by producing distinct actions with two hands. Overt visual attention was assessed by analyzing participants' gaze fixation patterns during successful task performance.</p><p><strong>Results: </strong>Our findings revealed that YA experienced greater difficulty with asymmetric visuomotor constraints than asymmetric force constraints, whereas OA showed comparable performance challenges with both types of constraints. Moreover, we found that YA distributed the gaze consistently biased to the right side despite the effect of context asymmetry on tracking errors, while OA distributed their gaze more symmetrically. Lastly, YA demonstrated asymmetrical adaptation, with improved performance in the dominant right hand under left-sided constraints, while OA showed reduced adaptation capabilities.</p><p><strong>Discussion: </strong>These findings indicate that aging is associated with a reduction in lateralized attention and diminished adaptability to asymmetric task demands during bimanual visuomotor coordination.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1525535"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics and experimental validation identify biomarkers for diagnosing Alzheimer's disease.","authors":"Hui Liu, Chenye Li, Congchen Zhai, Mei Li, Lan Ma","doi":"10.3389/fnagi.2025.1566929","DOIUrl":"10.3389/fnagi.2025.1566929","url":null,"abstract":"<p><strong>Background and purpose: </strong>Alzheimer's disease (AD) is a complex condition involving multiple mechanisms, primarily characterized by the progressive decline in cognition and memory. At present, there is no simple and reliable diagnostic method available for clinical application. Therefore, this study aims to identify potential biomarkers for AD using bioinformatics, providing new insights into its diagnosis.</p><p><strong>Methods: </strong>This study utilized the transcriptome dataset GSE63060 from the Gene Expression Omnibus (GEO) and applied bioinformatics approaches to identify candidate genes. Differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks, and machine learning techniques (LASSO, SVM-RFE, Boruta, and XGBoost) were employed on the GSE63060 dataset. Subsequently, the expression levels of the candidate genes were evaluated, and a receiver operating characteristic (ROC) curve was constructed to identify hub genes and establish a corresponding network. Finally, we focused on the common upstream transcription factor c-Myc among the hub genes and conducted clinical experiments to validate its potential. Serum samples were collected from 41 AD patients treated at the Second Affiliated Hospital of Harbin Medical University between October 2023 and November 2024, along with 41 control subjects. The c-Myc protein concentration was measured using ELISA, and a ROC curve was constructed to assess its diagnostic potential.</p><p><strong>Results: </strong>This study identified four hub genes associated with AD: RPL36AL, NDUFA1, NDUFS5, and RPS25. Additionally, the concentration of the c-Myc protein was significantly different between the AD and control groups (<i>p</i> < 0.001). The diagnostic sensitivity was 87.8%, specificity was 51.2%, and the area under the curve (AUC) value was 0.753, suggesting that c-Myc has independent diagnostic significance for AD.</p><p><strong>Conclusion: </strong>Our study demonstrates that RPL36AL, NDUFA1, NDUFS5, and RPS25 have potential as biomarkers for the diagnosis of AD. Additionally, the experiment suggests that c-Myc could serve as a promising blood biomarker for the diagnosis of AD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1566929"},"PeriodicalIF":4.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144949018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical mechanisms of repetitive transcranial magnetic stimulation in improving constipation in Parkinson's disease patients through the gut-brain axis.","authors":"Qianlan Bo, Yanmin Li, Xiayue Wang, Huijun Wang, Huimiao Liu","doi":"10.3389/fnagi.2025.1607791","DOIUrl":"10.3389/fnagi.2025.1607791","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in alleviating constipation in patients with Parkinson's disease (PD) via the gut-brain axis.</p><p><strong>Methods: </strong>Fifty-eight PD patients with constipation, admitted from May 2023 to December 2024, were randomly assigned to an rTMS treatment group or a sham rTMS control group (29 patients each). Chronic constipation severity was assessed using the Chronic Constipation Severity Score (CSS) before and 14 days after treatment. Additional measures included weekly spontaneous bowel movements (SBM), complete spontaneous bowel movements (CSBM), the Bristol Stool Scale (BSS), and serum levels of gut-brain peptides (5-HT, BDNF, VIP) and cytokines (IL-6, IFN-γ, TNF-α, IL-4, IL-10).</p><p><strong>Results: </strong>Baseline characteristics, including CSS scores, were similar between groups (<i>P</i> > 0.05). After 14 days, the study group exhibited significantly lower CSS scores compared to the control group (e.g., CSS post-treatment: study group 4.03 ± 1.01 vs. control group 6.23 ± 1.03, <i>P</i> < 0.001). Both groups showed increased SBM and CSBM frequencies; however, the study group demonstrated significantly higher counts (e.g., CSBM post-treatment: study group 4.67 ± 0.04 vs. control group 4.16 ± 0.06, <i>P</i> < 0.001). BSS scores improved in both groups, with the study group achieving significantly higher scores (<i>P</i> < 0.05). Post-treatment, the study group had significantly higher serum 5-HT (<i>P</i> < 0.001) and BDNF (<i>P</i> = 0.001) levels, and lower VIP levels (<i>P</i> = 0.041) compared to the control group. Cytokine analysis revealed significantly lower pro-inflammatory IL-6 (<i>P</i> < 0.001), IFN-γ (<i>P</i> = 0.034), TNF-α (<i>P</i> < 0.001) and higher anti-inflammatory IL-4 (<i>P</i> < 0.001), IL-10 (<i>P</i> < 0.001) levels in the study group, with corresponding Cohen's d values indicating medium to very large effect sizes.</p><p><strong>Conclusion: </strong>Repetitive transcranial magnetic stimulation effectively improves constipation symptoms in PD patients over a 14 days period. These benefits are associated with favorable modulations of gut-brain peptides and cytokine profiles, suggesting a therapeutic mechanism involving the gut-brain axis. However, direct causality and the long-term effects require further investigation.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1607791"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.","authors":"Shumin Zhao, Ranran Chen, Yi An, Yali Zhang, Cheng Ma, Ying Gao, Yanchao Lu, Fei Yang, Xue Bai, Jingjing Zhang","doi":"10.3389/fnagi.2025.1670545","DOIUrl":"10.3389/fnagi.2025.1670545","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnagi.2025.1522073.].</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1670545"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.","authors":"Xiao Fu, Yanni Shi, Hui Xu, Dongwu Xu","doi":"10.3389/fnagi.2025.1640653","DOIUrl":"10.3389/fnagi.2025.1640653","url":null,"abstract":"<p><strong>Background: </strong>Sleep deprivation (SD) exerts adverse effects on human brain. However, whether there were distinct effects of partial SD associated with gray matter changes in young and old adults, respectively, remains unclear.</p><p><strong>Methods: </strong>42 young adults and 38 old adults were enrolled in this study. All participants underwent MRI scanning, and FreeSurfer 5.3 was used to calculate cortical thickness (CT) and cortical surface area (CSA). Paired two samples <i>t</i>-tests was conducted to explore CT and CSA changes. Partial SD involved restricting total sleep time to approximately three hours, compared with baseline sleep conditions.</p><p><strong>Results: </strong>Young adults exhibited increased biopsychological response (Sickness-Q score) following partial SD compared to the rested condition, and similar trend was observed in old adults in SD. Young adults exhibited decreased CSA of left caudal middle frontal cortex and CT of entorhinal cortex (EC), but increased CSA of left temporal pole and CT of right insula after SD. However, old adults showed increased CSA and CT in widespread brain regions, including left superior frontal cortex, left isthmus cingulate cortex and right EC. While young adults showed a significant positive correlation between percent change of CSA of left EC and the biopsychological response, old adults showed a significant negative correlation between percentage change in CT of the left isthmus cingulate cortex and biopsychological response.</p><p><strong>Conclusion: </strong>Distinct effect of partial SD associated with gray matter changes were observed in young and old adults, respectively. These findings shed light on SD might affect brain structures differently in young adults and old adults.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1640653"},"PeriodicalIF":4.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}