Frontiers in Aging Neuroscience最新文献

{"title":"Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.","authors":"Jinhuan Yue, Peng Wang, Xiang-Fa Guo, Zeyi Wei, Kaiting He, Nuo Li, Xiaoling Li, Qinhong Zhang, Xiaoqing Zhou","doi":"10.3389/fnagi.2025.1547965","DOIUrl":"https://doi.org/10.3389/fnagi.2025.1547965","url":null,"abstract":"<p><p>Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1547965"},"PeriodicalIF":4.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.","authors":"Shanti Van Malderen, Melina Hehl, Stefanie Verstraelen, Robbe Breugelmans, Georg Oeltzschner, Stephan P Swinnen, Koen Cuypers","doi":"10.3389/fnagi.2025.1626417","DOIUrl":"10.3389/fnagi.2025.1626417","url":null,"abstract":"<p><strong>Introduction: </strong>The cerebellum is essential for motor control and learning, relying on structural and functional integrity. Age-related atrophy leads to Purkinje cell loss, but subtle neurochemical changes in GABA, Glx (glutamate + glutamine), and glutathione (GSH) may precede degeneration and contribute to motor decline.</p><p><strong>Methods: </strong>25 younger (YA) and 25 older adults (OA) were included in this study. Magnetic resonance spectroscopy (MRS), using the MEGA-PRESS sequence, was used to investigate how age affects GABA, Glx and GSH levels in the right cerebellar hemisphere, and their relationship with motor performance, measured using a visuomotor bimanual tracking task (BTT).</p><p><strong>Results: </strong>In line with previous work YA outperformed OA on both the simple and complex task variants of the BTT. Furthermore, YA demonstrated faster short-term motor learning as compared to OA. On the metabolic level, no significant age group differences in cerebellar GABA, Glx or GSH levels, nor any task-related modulation of GABA or Glx were observed. Additionally, neither baseline neurometabolite levels nor their modulation predicted motor performance or learning.</p><p><strong>Discussion: </strong>These results align with previous research suggesting that neurometabolic aging is region-specific, with the cerebellum potentially being more resilient due to its slower aging process. Since neither baseline nor task-related modulation of GABA, Glx, or GSH predicted motor performance or learning, cerebellar neurometabolite concentrations may not directly underlie age-related behavioral changes. Instead, volumetric decline and changes in structural and functional connectivity in the aging cerebellum may play a more significant role in motor decline as compared to neurochemical alterations. Nonetheless, it is important to consider that motor performance and learning rely on distributed brain networks-including cortical and subcortical structures-which also undergo age-related changes and may contribute to observed behavioral declines. While our findings do not support a direct role of cerebellar neurometabolite levels in age-related motor performance differences, they underscore the complexity of neurochemical aging.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1626417"},"PeriodicalIF":4.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer's disease.","authors":"Neha Singh-Reilly, Ryota Satoh, Jonathan Graff-Radford, Mary M Machulda, Val J Lowe, Keith A Josephs, Jennifer L Whitwell","doi":"10.3389/fnagi.2025.1615718","DOIUrl":"10.3389/fnagi.2025.1615718","url":null,"abstract":"<p><strong>Background: </strong>Iron is an important component in neurofibrillary tangles, is known to co-localize with tangles in Alzheimer's disease (AD) and can be measured using quantitative susceptibility mapping (QSM). However, it is unclear if iron measured using QSM is regionally related to tau in atypical presentations of AD.</p><p><strong>Methods: </strong>Forty patients with atypical AD underwent a 3 T magnetic resonance imaging (MRI) scan with a five-echo gradient echo sequence to calculate QSM, Aβ, and [¹⁸F] AV-1451 positron emission tomography (PET). The relationship between QSM and tau-PET was assessed using voxel-based regression analysis using whole brain VoxelStats and region-of-interest (ROI)-based Spearman's correlation analyses using cortical and subcortical ROIs.</p><p><strong>Results: </strong>At the voxel-level, positive correlations between tau-PET and QSM were only observed in the left caudate. At the ROI-level, a positive association was observed between tau-PET and susceptibility in the occipital lobe and a negative association was observed between substantia nigra susceptibility and occipital tau-PET uptake, although these findings did not survive correction for multiple comparisons.</p><p><strong>Discussion: </strong>Our data provides little evidence that regional tau-PET uptake is related to susceptibility changes, suggesting that iron deposition may not be directly associated with tau accumulation in atypical AD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1615718"},"PeriodicalIF":4.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research hotspots and frontiers of glymphatic system and Alzheimer's disease: a bibliometrics analysis.","authors":"Shichao Liu, Lvping Zhuang, Xiaochun Li","doi":"10.3389/fnagi.2025.1579373","DOIUrl":"10.3389/fnagi.2025.1579373","url":null,"abstract":"<p><strong>Background: </strong>As a predominant neurodegenerative disorder, Alzheimer's disease (AD) has garnered increasing attention regarding the association between its pathological mechanisms and glymphatic system (GS) dysfunction.</p><p><strong>Objective: </strong>This study employs bibliometric methods to systematically analyze the evolutionary trajectory and emerging frontiers of GS-AD research from 2010 to 2025, aiming to provide insights for clinical applications and scientific research.</p><p><strong>Methods: </strong>A total of 595 articles were selected from the Web of Science Core Collection. Knowledge mapping was constructed using tools such as CiteSpace and RStudio to analyze country/institutional collaboration networks, co-cited references, and keyword clustering.</p><p><strong>Results: </strong>Over the past decade, publication output in this field has demonstrated exponential growth. The United States maintains academic dominance, with the University of Rochester and the Nedergaard team serving as central research forces. While China ranks second in publication volume, its international influence requires further enhancement. High-frequency keyword analysis revealed three major research directions: anatomical mechanisms of the GS, (cerebrospinal fluid-interstitial fluid exchange, Aquaporin-4 polarization regulation), pathophysiological associations (amyloid-β/tau clearance, sleep-aging interactions), and clinical translational potential (diffusion tensor image analysis along the perivascular space (DTI-ALPS) imaging biomarkers, targeted intervention strategies). Co-citation analysis indicated that foundational studies by Iliff Jeffrey J and Nedergaard Maiken continue to guide the field, while recent research hotspots concentrate on glymphatic function assessment technologies and cross-disease mechanistic investigations.</p><p><strong>Conclusion: </strong>GS research is transitioning from fundamental mechanisms to clinical diagnostics and therapeutics. Future advancements necessitate the integration of multimodal imaging technologies and interdisciplinary collaboration to facilitate early AD diagnosis and therapeutic target development. This study represents the first systematic construction of a knowledge framework for this field, providing theoretical foundations for optimizing research strategies and translational pathways.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1579373"},"PeriodicalIF":4.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing changes to individual-specific brain signature with age.","authors":"Monireh Taimouri, Vikram Ravindra","doi":"10.3389/fnagi.2025.1493855","DOIUrl":"10.3389/fnagi.2025.1493855","url":null,"abstract":"<p><p>The increasing prevalence of neurodegenerative diseases in an aging population underscores the critical need for reliable biomarkers distinguishing normal aging from pathological neurodegeneration. This study leverages neuroimaging to identify age-resilient biomarkers, establishing a baseline of neural features that are relatively stable across the aging process. Our research objectives are threefold: (a) Validate a methodology using leverage scores to identify age-robust neural signatures; (b) Confirm the consistency of these features across a diverse age cohort (18-87 years); and (c) Assess the stability of individual-specific neural characteristics across multiple brain parcellations (Craddock, AAL, and HOA). Using functional connectomes data from resting-state and task-based fMRI, we found that a small subset of features consistently capture individual-specific patterns, with significant overlap (~50%) between consecutive age groups and across atlases. Our approach effectively minimized inter-subject similarity while maintaining intra-subject consistency across different cognitive tasks. The stability of these signatures throughout adulthood and their consistency across different anatomical parcellations provide new perspectives on brain aging. They highlight both the preservation of individual brain architecture and subtle age-related reorganization. These findings enhance our understanding of age-related brain changes, potentially aiding in differentiating normal cognitive decline from neurodegenerative processes.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1493855"},"PeriodicalIF":4.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal iron patterns in aging and mild cognitive impairment.","authors":"Sonja M Kagerer, Laetitia Vionnet, Jiri M G van Bergen, Rafael Meyer, Anton F Gietl, Klaas P Pruessmann, Christoph Hock, Paul G Unschuld","doi":"10.3389/fnagi.2025.1598859","DOIUrl":"10.3389/fnagi.2025.1598859","url":null,"abstract":"<p><strong>Introduction: </strong>The entorhinal cortex (EC)-hippocampus system is critical for memory and affected early in Alzheimer's disease (AD). Cognitive dysfunction in AD is linked to neuropathological changes, including non-heme iron accumulation in vulnerable brain regions. This study characterized iron distribution in the EC-hippocampus system using ultra-high field (UHF) magnetic resonance imaging (MRI) at 7 Tesla (T) in aging and mild cognitive impairment (MCI), an AD at-risk state.</p><p><strong>Methods: </strong>40 participants (mean age [SD] 69.2 [7.42] years; 12 mild cognitive impairment (MCI), 28 cognitively healthy controls (HC)) underwent UHF MRI at 7 T with turbo spin echo and quantitative susceptibility mapping (QSM). Gray matter segmentation was performed using FreeSurfer software. Intraclass correlation coefficients (ICCs) were calculated for hippocampal and EC measures.</p><p><strong>Results: </strong>ICCs for mean susceptibilities were 0.61 overall, 0.58 for HC, and 0.69 for MCI, with significant group differences between HC and MCI (Kolmogorov-Smirnov test, <i>k</i> = 0.625, <i>p</i> ≤ 0.05).</p><p><strong>Discussion: </strong>Our findings suggest a higher coherence of non-heme iron distribution in MCI. An increasingly uniform distribution of iron in MCI could reflect a clinical continuum ranging from healthy aging to pathologic brain change and cognitive disorder. This highlights the potential of non-heme iron as a biomarker for early AD co-pathology.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1598859"},"PeriodicalIF":4.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study.","authors":"Libin Liao, Weiquan Huang, Rongchao Ma, Wentong Hu, Hui Wu, Moxi Su, Dujuan Sha","doi":"10.3389/fnagi.2025.1580722","DOIUrl":"10.3389/fnagi.2025.1580722","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is the major complication of acute ischemic stroke, which is a significant health concern imposing a heavy economic burden on families and society. Studies have shown that the serum uric acid (SUA) level is correlated to clinical outcomes of stroke and neurogenerative diseases. The serum uric acid to serum creatinine ratio (SUA/SCr) is an independent risk factor for poor outcomes of acute ischemic stroke and can potentially become an effective diagnostic indicator for cognitive decline. In this study, we aimed to investigate the association between SUA/SCr and early-onset post-stroke cognitive impairment.</p><p><strong>Methods: </strong>Consecutive acute ischemic stroke patients from our hospital were enrolled between June 2023 and September 2024. All blood samples were collected within 24 h after admission, and the cognitive function of patients was assessed within 2 weeks using the Chinese version of the Montreal Cognitive Assessment (MoCA). SUA/SCr was calculated by serum uric acid (umol/L)/serum creatinine (umol/L) and was split into three layers according to tertiles. The subjects were divided into a post-stroke cognitive impairment group and a non-post-stroke cognitive impairment group based on cognitive assessment. Binary logistic regression with different models, multivariate logistic regression analysis, and receiver operating characteristic (ROC) curves were adopted to evaluate the predictive ability of SUA/SCr in early-onset post-stroke cognitive impairment.</p><p><strong>Results: </strong>The current study showed that the post-stroke cognitive impairment group had lower SUA/SCr (<i>p</i> = 0.005) and the lower tertile of SUA/SCr is associated with a higher prevalence of post-stroke cognitive impairment (<i>p</i> = 0.008). The multivariate logistic analysis indicated that SUA/SCr (OR = 0.560, 95% CI = 0.321-0.976, <i>p</i> = 0.024) was independently associated with early-onset post-stroke cognitive impairment, and the lowest tertile was independently associated with a 5.903-fold increased risk of post-stroke cognitive impairment after adjusting for confounders. The optimal cutoff value of SUA/SCr to predict post-stroke cognitive impairment was 4.874, which gave a sensitivity of 72.22% and a specificity of 63.16%.</p><p><strong>Conclusion: </strong>Our study revealed that SUA/SCr can be a potential indicator for post-stroke cognitive impairment in the early phase, a lower level of SUA/SCr upon admission was independently correlated to cognitive dysfunction after stroke.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1580722"},"PeriodicalIF":4.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.","authors":"Cheng Cheng, Huijia Yang, Lulu Tian, Yang Ni, Congcong Jia, Weidong Le, Qingshan Wang","doi":"10.3389/fnagi.2025.1612389","DOIUrl":"10.3389/fnagi.2025.1612389","url":null,"abstract":"<p><strong>Introduction: </strong>The autophagy-lysosomal pathway (ALP) dysfunction and lysosomal impairment contribute to the pathogenesis of Parkinson's disease (PD). Nuclear receptor related protein 1 (Nurr1) maintains the differentiation and maturation of dopaminergic neurons, and mutants or polymorphism in Nurr1 is associated with familial and sporadic PD. Previous studies on Nurr1 have mainly focused on the development and maintenance of midbrain dopaminergic neurons, while the potential involvement of Nurr1 in ALP regulation remains uncharacterized.</p><p><strong>Methods: </strong>Stable Nurr1 knockdown cells and inducible Nurr1 knockout mice were generated. Transcriptome sequencing and analysis was utilized to confirm the altered pathways and differentially expression genes associated with ALP. Transmission electron microscopy observation was conducted to find the ultrastructure differences between the Nurr1 knockdown cells and the controls. The expression of LC3B and the colocalization of LC3B and Lamp1 were assessed. Lysosomal acidity in the Nurr1 knockdown cells and the controls was measured. The expression of lysosomal proteins (Lamp 1/2, CTSD, and GBA) was determined <i>in vitro</i> and <i>in vivo</i> in the Nurr1-deficient models. Dual-luciferase reporter gene assay was performed to detect the transcriptional activity of GBA. The key lysosomal proteins (Lamp 1/2 and CTSD) were assessed after GBA overexpression.</p><p><strong>Results: </strong>Twenty-two terms and 45 differentially expression genes associated with ALP were identified by transcriptome analysis. Knockdown of Nurr1 induced intracellular aggregation of autophagosomes, increased endogenous expression of LC3B II and elevated colocalization of exogenous GFP-LC3B with Lamp1. Lysosome dysfunction has been implicated with lysosomal alkalization and deprived level of lysosomal marker proteins with Nurr1 deficiency. GBA was transcriptionally downregulated by Nurr1 and Nurr1 deficiency-triggered lysosomal dysfunction were attenuated by GBA overexpression in the Nurr1 knockdown cells.</p><p><strong>Discussion: </strong>Our study provided the first experimental evidence that Nurr1 deficiency induced lysosomal dysfunction by alkalizing the lumen of lysosomes and downregulating the key lysosomal protein (Lamp1, CTSD, and Lamp2) expression <i>in vivo</i> and <i>in vitro</i>. Defective lysosomal function compromised lysosomal mediated autophagic vesicle clearance. Mechanistically, Nurr1 transcriptionally regulated GBA expression, which in turn governed lysosomal marker protein homeostasis through a GBA-dependent axis. This study illuminated the involvement of Nurr1 in the ALP and the interaction between PD-related genes in the pathogenesis of PD.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1612389"},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes.","authors":"Michelle Horan, Daniel Carey, Silvin Knight, A Fagan, James F M Meaney, Rose Anne Kenny, Céline De Looze","doi":"10.3389/fnagi.2025.1466294","DOIUrl":"10.3389/fnagi.2025.1466294","url":null,"abstract":"<p><strong>Introduction: </strong>There is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of increased arterial stiffness (AS) and reduced cerebral blood flow (CBF) on hippocampal volume (HV) in a large MRI sample of community-dwelling older adults from the Irish Longitudinal Study on Ageing (TILDA).</p><p><strong>Methods: </strong>Longitudinal data from study participants for Wave 1 (2009-2011) and Wave 3 (2014-2015) were included. This included health and social information as well as a nurse-administered health assessment. Patients who had complete AS, CBF and MR-hippocampal measurements were included. Pseudo-continuous arterial spine labelling was performed to quantify whole CBF. Volumetric analysis was performed using FreeSurfer 6.0 recon-all processing pipeline.</p><p><strong>Results: </strong>395 patients met inclusion criteria. This four-year follow up longitudinal study demonstrated that (i) prolonged elevated AS (at wave 1 and wave 3), (ii) the interaction between higher AS at wave 1 and lower CBF at wave 3 and (iii) the interaction between prolonged elevated AS (at wave 1 and wave 3) and reduced CBF at wave 3 were associated with smaller HV.</p><p><strong>Conclusion: </strong>Increased arterial stiffness and reduced CBF were not independently associated with smaller HV. However, in combination, persistently elevated AS and reduced CBF is associated with smaller HV. These effects were equally exerted across all hippocampal subfields tested. Our findings suggest a lag effect in the arterial stiffness and hippocampal volume relationship. We propose that the subsequent reduction in cerebral blood flow observed with elevated arterial stiffness may be the missing link in the pathway associating arterial stiffness with hippocampal atrophy.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1466294"},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent supplementation with <i>Akkermansia muciniphila</i> and galactooligosaccharides modulates Alzheimer's disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice.","authors":"Arnas Kunevičius, Akshay Kumar Vijaya, Alessandro Atzeni, Jonas Mingaila, Ieva Šimoliūnė, Rapolas Jamontas, Emilija Keževičiūtė, Miguel Gueimonde, Rolandas Meškys, Daiva Baltriukienė, Silvia Arboleya, Aurelijus Burokas","doi":"10.3389/fnagi.2025.1617980","DOIUrl":"10.3389/fnagi.2025.1617980","url":null,"abstract":"<p><strong>Background: </strong>Bidirectional communication and mutual regulation between the gastrointestinal tract and the CNS is facilitated through the gut-brain axis. Recent studies have found reduced diversity of the gut microbiota in Alzheimer's disease (AD) patients, and animal models suggest microbial involvement in amyloid beta peptide (Aβ) accumulation. Modulation of the gut microbiota by new-generation probiotics represents a novel treatment strategy to alleviate the symptoms and slow the progression of AD.</p><p><strong>Methods: </strong>In this study, the therapeutic effect of the probiotic <i>Akkermansia muciniphila</i> and the prebiotic galactooligosaccharides (GOS) was investigated in the APP/PS1 mouse model. After 7 months of triweekly administration, we evaluated physiological parameters, glucose metabolism, and behavioral outcomes. Additionally, we assessed gut microbiota diversity and composition, short-chain fatty acid (SCFA) concentrations in the cecum, Aβ load in the hippocampus and prefrontal cortex, and microglial abundance in the hippocampus.</p><p><strong>Results: </strong><i>A. muciniphila</i> and GOS administration normalized fasting glucose levels, glucose metabolism, and intestinal transit time to wild-type levels. Furthermore, supplementation reduced anxiety, improved long-and short-term memory, and partially restored activity levels. It also regulated SCFA concentrations in the cecum, improved the richness of the gut microbiota, and normalized abundance of microglia in the hippocampus, indicating reduced neuroinflammation.</p><p><strong>Conclusion: </strong>These findings suggest that long-term administration of <i>A. muciniphila</i> and GOS effectively improves metabolic health and modulates symptoms of AD in the APP/PS1 mouse model.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1617980"},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}