{"title":"Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.","authors":"Jinhuan Yue, Peng Wang, Xiang-Fa Guo, Zeyi Wei, Kaiting He, Nuo Li, Xiaoling Li, Qinhong Zhang, Xiaoqing Zhou","doi":"10.3389/fnagi.2025.1547965","DOIUrl":null,"url":null,"abstract":"<p><p>Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1547965"},"PeriodicalIF":4.1000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271167/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2025.1547965","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia. In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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