Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE).

IF 4.5 2区 医学 Q2 GERIATRICS & GERONTOLOGY
Frontiers in Aging Neuroscience Pub Date : 2025-08-20 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1632607
Sarah Mendorf, Konstantin G Heimrich, Hannah M Mühlhammer, Tino Prell, Aline Schönenberg
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引用次数: 0

Abstract

Introduction: Previous longitudinal studies have identified numerous factors influencing quality of life (QoL) in people of older age (PoA). However, most of these studies focus on group-level trends and fail to consider individual QoL trajectories or age-specific patterns over time.

Methods: We investigated longitudinal changes in QoL among community-dwelling older adults using five waves (2010-2019) of the Survey of Health, Aging and Retirement in Europe (easySHARE). Clinically relevant changes were defined via the minimal clinically important difference (MCID). We applied linear regression and linear mixed models (LMM) to explore predictors of QoL trajectories.

Results: Descriptive analyses showed that 2481 PoA (19.7%) experienced stable QoL between waves, based on changes below the MCID threshold of 3.18 points. The remaining participants exhibited consistent improvements or declines, with 1,701 different longitudinal patterns of QoL identified across the five time points. These individual patterns were further examined using LMM. LMM showed that the random effect of ID had the strongest impact on QoL across the five waves, suggesting highly individual QoL patterns. The influence of age was less significant compared to ID and decreased significantly after the addition of covariates.

Conclusion: Our findings underscore the importance of individual-level analyses in aging research. While QoL may appear stable at the group level, individual trajectories vary considerably. This has important implications for the use of QoL as a primary endpoint in clinical trials, particularly in geriatric populations. Notably, age alone did not significantly influence QoL over time.

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社区居住老年人生活质量的年龄相关轨迹:来自欧洲健康、老龄化和退休调查(SHARE)的结果。
先前的纵向研究已经确定了许多影响老年人生活质量(QoL)的因素。然而,这些研究大多侧重于群体水平的趋势,而没有考虑个人生活质量轨迹或年龄特定模式。方法:我们使用欧洲健康、老龄化和退休调查(easySHARE)的五波(2010-2019)调查了社区居住老年人生活质量的纵向变化。临床相关变化通过最小临床重要差异(MCID)来定义。我们应用线性回归和线性混合模型(LMM)来探索生活质量轨迹的预测因子。结果:描述性分析显示,2481例PoA(19.7%)的波间生活质量稳定,变化低于MCID阈值3.18点。其余参与者表现出一致的改善或下降,在五个时间点上确定了1701种不同的生活质量纵向模式。使用LMM进一步检查了这些个体模式。LMM结果显示,ID的随机效应在5个波中对生活质量的影响最大,表明生活质量具有高度的个体特征。与ID相比,年龄的影响不显著,加入协变量后显著降低。结论:我们的发现强调了个体水平分析在衰老研究中的重要性。虽然生活质量在群体水平上似乎是稳定的,但个体的轨迹变化很大。这对于将生活质量作为临床试验的主要终点具有重要意义,特别是在老年人群中。值得注意的是,随着时间的推移,年龄本身并没有显著影响生活质量。
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来源期刊
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES
CiteScore
6.30
自引率
8.30%
发文量
1426
期刊介绍: Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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