Free Radical Biology and Medicine最新文献

{"title":"Mitochondrial Dysfunction and Impaired SREBF-Dependent Lipid Homeostasis Contribute to Radiation-Induced Endothelial Senescence","authors":"Masaki Nagane, Yuko Naya, Koya Yamashita, Masanori Tomita, Daishi Tanabu, Isshin Shiiba, Takehito Suzuki, Hibiki Tatsumi, Yi Shang, Daisuke Iizuka, Hinano Mizugaki, Hironobu Yasui, Tomoki Bo, Hironobu Murakami, Tadashi Yamashita","doi":"10.1016/j.freeradbiomed.2026.08.084","DOIUrl":"10.1016/j.freeradbiomed.2026.08.084","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Page S9"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of the Stress-Activated Kinase ASK1 Inhibitor on Mast Cell Activation","authors":"Tomohiro Otsuka, Ibuki Tomonaga, Tetsuro Kamiya, Hiroyuki Tanaka, Hirokazu Hara","doi":"10.1016/j.freeradbiomed.2026.08.092","DOIUrl":"10.1016/j.freeradbiomed.2026.08.092","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Pages S11-S12"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the Mitochondrial Antioxidant Peroxiredoxin 3 as a Novel Therapeutic Target in Diffuse Midline Glioma","authors":"Margaret Trout, Victoria Gibson, Nathaniel Shannon, Alqassem Abuarqoub, James Stafford, Brian Cunniff","doi":"10.1016/j.freeradbiomed.2026.08.076","DOIUrl":"10.1016/j.freeradbiomed.2026.08.076","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Page S6"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redox-Linked tRNA Modifications and Codon Usage Bias Shape Oncogene Expression in Cancer","authors":"Chetna Mathur, Evan Davis, Dylan Ehrbar, Peter C. Dedon, Thomas J. Begley","doi":"10.1016/j.freeradbiomed.2026.08.073","DOIUrl":"10.1016/j.freeradbiomed.2026.08.073","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Pages S5-S6"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of H2O2-Dependent Oxidation on p38 alpha-Ligand Interactions","authors":"Abhijit Mallick, Tiffany Chambers, Judith Enemundo, Robert H. Newman","doi":"10.1016/j.freeradbiomed.2026.08.122","DOIUrl":"10.1016/j.freeradbiomed.2026.08.122","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Page S20"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo1 Couples Extracellular Calcium Entry to CSE Activation and Sulfane Sulfur Production","authors":"Saima Niti, Shafiul Alam, John D. Glawe, Xinggui Shen, Gopi K. Kolluru, Christopher G. Kevil","doi":"10.1016/j.freeradbiomed.2026.08.124","DOIUrl":"10.1016/j.freeradbiomed.2026.08.124","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Page S20"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclo-octasulfur (S8) Formation Via NOX and NOS-Mediated Supersulfide Metabolism","authors":"Tsuyoshi Takata, Uladzimir Barayeu, Tetsuro Matsunaga, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Yukihiro Tsuchiya, Yasuo Watanabe, Hozumi Motohashi, Michito Yoshizawa, Hideki Sumimoto, Takaaki Akaike","doi":"10.1016/j.freeradbiomed.2026.08.127","DOIUrl":"10.1016/j.freeradbiomed.2026.08.127","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":"Page S21"},"PeriodicalIF":8.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149028676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Can nucleotide stress prevent molecular resolution of sterile inflammation?","authors":"Xie Han, Ling Wu, WeiTing Zu, Mei Zhao","doi":"10.1016/j.freeradbiomed.2026.08.029","DOIUrl":"10.1016/j.freeradbiomed.2026.08.029","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the author(s) and/or editor due to an error in the publishing process. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies-and-standards/article-withdrawal.</p>","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mitochondrial protein Timm13 promotes liver fibrosis by activating TGFβ signaling through Hsp90aa1","authors":"Xiaomin Liao ,&nbsp;Zelong Jiang ,&nbsp;Zeyuan Li ,&nbsp;Junjie Liu ,&nbsp;Weizhong Tang","doi":"10.1016/j.freeradbiomed.2026.06.005","DOIUrl":"10.1016/j.freeradbiomed.2026.06.005","url":null,"abstract":"<div><div>Liver fibrosis is a pathological consequence of chronic liver injury that is reversible but can potentially progress to serious complications. Currently, due to the incomplete elucidation of its key molecular driving mechanisms, effective targeted therapeutic approaches remain lacking in clinical practice. The mitochondrial inner membrane transporter Timm13 has been implicated in cellular stress and disease, yet its role in liver fibrosis remains unclear. This study found that Timm13 is significantly upregulated in human fibrotic liver tissue. Functional studies demonstrated that Timm13 overexpression promotes the activation, proliferation, migration, and extracellular matrix production of hepatic stellate cells (HSCs), whereas Timm13 knockdown inhibits these processes. In a carbon tetrachloride (CCl₄)-induced mouse model of liver fibrosis, Timm13 overexpression exacerbated collagen deposition and histopathological damage, whereas its knockdown exerted a protective effect. Mechanistically, Co-immunoprecipitation and proteomic analyses identified heat shock protein 90α family member 1 (Hsp90aa1) as a direct binding partner of Timm13. We further demonstrate that this interaction is critical for activating the TGFβ signaling pathway, as Hsp90aa1 silencing reverses the Timm13-driven upregulation of fibrotic markers and TGFβ1 protein levels. This indicates that Timm13 promotes fibrogenic activity by regulating TGFβ1 expression through Hsp90aa1.</div><div>Furthermore, studies indicate that Timm13 significantly induces mitochondrial dysfunction in hepatic stellate cells, manifested by reduced mitochondrial membrane potential, elevated reactive oxygen species levels, and impaired ATP synthesis. Our results defined a previously unrecognized Timm13/Hsp90aa1/TGFβ signaling axis, revealing how Timm13, through its interaction with Hsp90aa1, concurrently regulates TGFβ1 expression and integrates mitochondrial stress signals to drive the fibrogenic activity of hepatic stellate cells. This study establishes Timm13 as a potential diagnostic biomarker and therapeutic target for liver fibrosis.</div></div>","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"253 ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-199a inhibition ameliorates the amyotrophic lateral sclerosis phenotype in SOD1 mice by preserving neuromuscular junctions","authors":"Lara Rodríguez-Outeiriño ,&nbsp;Raúl Gonzalez-Ojeda ,&nbsp;Anthony J. Sannicandro ,&nbsp;María Borja-Gonzalez ,&nbsp;K. Goljanek-Whysall","doi":"10.1016/j.freeradbiomed.2026.05.055","DOIUrl":"10.1016/j.freeradbiomed.2026.05.055","url":null,"abstract":"","PeriodicalId":12407,"journal":{"name":"Free Radical Biology and Medicine","volume":"249 ","pages":"Page S11"},"PeriodicalIF":8.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}