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Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats 香蕉淀粉干预通过调节糖尿病大鼠的肠道微生物群-脑轴改善糖尿病诱导的情绪障碍
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-06-14 DOI: 10.1080/09540105.2022.2071846
Yongliang Bai, Meiguo Xin, Junming Lin, Jing Xie, Roumin Lin, Zhenshan Peng, Jingwen Guo, Weidong Bai
{"title":"Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats","authors":"Yongliang Bai, Meiguo Xin, Junming Lin, Jing Xie, Roumin Lin, Zhenshan Peng, Jingwen Guo, Weidong Bai","doi":"10.1080/09540105.2022.2071846","DOIUrl":"https://doi.org/10.1080/09540105.2022.2071846","url":null,"abstract":"ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"377 - 402"},"PeriodicalIF":3.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42046958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dietary supplemental synbiotic – yucca extract compound preparation modulates production performance, immune status and faecal microflora diversity in laying hens 饲粮添加合成丝兰提取物复合制剂对蛋鸡生产性能、免疫状态和粪便菌群多样性的影响
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-06-13 DOI: 10.1080/09540105.2022.2080187
D. Song, Weiwei Wang, Bingxu Chen, Aike Li, G. Song, Junlin Cheng, Lin Qiao, Ronghua Zhu, Y. Min
{"title":"Dietary supplemental synbiotic – yucca extract compound preparation modulates production performance, immune status and faecal microflora diversity in laying hens","authors":"D. Song, Weiwei Wang, Bingxu Chen, Aike Li, G. Song, Junlin Cheng, Lin Qiao, Ronghua Zhu, Y. Min","doi":"10.1080/09540105.2022.2080187","DOIUrl":"https://doi.org/10.1080/09540105.2022.2080187","url":null,"abstract":"ABSTRACT This research was designed to assess the influence of a synbiotic – yucca extract compound preparation (MCC) on production performance, faecal microbiota and immune in laying hens. A total of 180, 27-week-old healthy Hy-Line Brown laying hens were divided into 2 treatments with 6 replicates (15 birds/per replicates), including control group (CN), and treatment group with 3.34 g MCC/kg diet (MCC). The results revealed that supplementation of MCC in diet resulted in a greater laying rate in hens. The concentrations of serum IL-2, IL-6 and TNF-α were lower than CN group, whereas the concentrations of IgG and IL-10 in serum were higher in the MCC group. Furthermore, at the genus levels, the abundance of Romboutsia, and Helicobacter was lower, however, the abundance of Lactobacillus was higher when the hens were fed MCC. Therefore, the addition of MCC positively impacted the production performance, immune and faecal microbial diversity of laying hens.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"360 - 376"},"PeriodicalIF":3.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44842384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Sensitisation to molecular components of fungi in atopic dermatitis patients, the relation to the occurrence of food hypersensitivity reactions 特应性皮炎患者对真菌分子成分的致敏，与食物过敏反应发生的关系
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-25 DOI: 10.1080/09540105.2022.2074968
J. Čelakovská, E. Čermáková, R. Vankova, C. Andrys, J. Krejsek
{"title":"Sensitisation to molecular components of fungi in atopic dermatitis patients, the relation to the occurrence of food hypersensitivity reactions","authors":"J. Čelakovská, E. Čermáková, R. Vankova, C. Andrys, J. Krejsek","doi":"10.1080/09540105.2022.2074968","DOIUrl":"https://doi.org/10.1080/09540105.2022.2074968","url":null,"abstract":"ABSTRACT The aim of our study is the evaluation of the relation between the sensitisation to molecular components of moulds and yeast and the occurrence of food hypersensitivity reactions in atopic dermatitis patients. The food reactions were confirmed in an open exposure test (history); the sensitisation to allergen reagents (molecular components) of moulds and yeast was confirmed with ALEX2 Allergy Explorer Multiplex examination. The relation between the sensitisation to molecular components of fungi and the food hypersensitivity reactions was evaluated with the use of Fisher’s exact test. One hundred atopic dermatitis patients were included in the study (48 men and 52 women with an average age of 40.9 years). In patients with reaction to hazelnuts, walnuts, peanuts, fish and egg, the significantly higher level of specific IgE to Asp f 3, Cla h 8, Alt a 6, Alt a 1, Mala s 6 and Asp f 6 was confirmed.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"328 - 345"},"PeriodicalIF":3.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49116082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development of a highly sensitive and specific monoclonal antibody-based immunoassay for detection of okadaic acid in oysters and green mussels 基于高灵敏度和特异性单克隆抗体的免疫分析法检测牡蛎和绿贻贝中的冈田酸
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-25 DOI: 10.1080/09540105.2022.2076812
Cheng Liang, Yuxiang Ji, Jiyong Ma, Chundong Zhang, Hongwei Zhao
{"title":"Development of a highly sensitive and specific monoclonal antibody-based immunoassay for detection of okadaic acid in oysters and green mussels","authors":"Cheng Liang, Yuxiang Ji, Jiyong Ma, Chundong Zhang, Hongwei Zhao","doi":"10.1080/09540105.2022.2076812","DOIUrl":"https://doi.org/10.1080/09540105.2022.2076812","url":null,"abstract":"ABSTRACT Okadaic acid (OA), one of marine biotoxins produced by several species of dinoflagellates, can accumulate in marine animals. The consumption of OA-contaminated seafood can cause diarrhoeic shellfish poisoning. Many countries have established regulatory restriction to limit the level of OA in seafood. In the present study, we report a highly sensitive monoclonal antibody (mAb) against OA produced by a new immunogen. Two monoclonal hybridoma cell lines (M8 and M12) that producing mAb with the best sensitivity and specificity were obtained. The obtained mAb-M12 was used to develop an indirect competitive ELISA (icELISA) with 50% inhibition concentrations of 0.15 ng mL−1 and a working range of 0.02–2.74 ng mL−1. The developed icELISA was more sensitive than the previous reports. HPLC-MS confirmed the accuracy and the working range of icELISA, suggesting that the developed icELISA is suitable for the rapid detection of OA in oysters and green mussels.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"346 - 359"},"PeriodicalIF":3.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44394336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Unexpected immunoregulation effects of D-lactate, different from L-lactate 不同于L-乳酸的D-乳酸的意外免疫调节作用
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-24 DOI: 10.1080/09540105.2022.2068508
Yongheng Yan, Ruijie Xu, Xiu-xia Li, Zhijie Yao, Hao Zhang, Haitao Li, Wei Chen
{"title":"Unexpected immunoregulation effects of D-lactate, different from L-lactate","authors":"Yongheng Yan, Ruijie Xu, Xiu-xia Li, Zhijie Yao, Hao Zhang, Haitao Li, Wei Chen","doi":"10.1080/09540105.2022.2068508","DOIUrl":"https://doi.org/10.1080/09540105.2022.2068508","url":null,"abstract":"ABSTRACT With advances in the study of the human microbiome, the fact that lactate is the smallest chiral molecule in nature has drawn attention. However, there have been few comparative studies on the classification of L-lactate and D-lactate. In this study, we investigated the safety and efficacy of D-lactate as an immunomodulator of food origin. In terms of safety evaluation, both lactates were found to promote cell proliferation and repair. D-lactate was well tolerated for 30 d at doses up to 2000 mg/kg in mice. In terms of immune function evaluation, unexpectedly, D-lactate was found to enhance immunity by increasing the immune organ index, ear swelling index, lymphocyte conversion rate, haemolysis rate and macrophage phagocytosis rate and had a dose-dependent effect. D-lactate showed stronger immune regulation effects than L-lactate. This study proves the safety and the immunoregulation capacity of D-lactate and provides a mechanistic basis for the bioactivity of fermented foods.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"286 - 301"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45488406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a sensitive monoclonal antibody-based immunochromatographic strip for neomycin detection in milk 基于单克隆抗体的敏感牛奶新霉素免疫层析条的研制
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-24 DOI: 10.1080/09540105.2022.2070606
Kemeng Qin, Mingyue Ding, Chensi Zhang, Xijie Zhang, Yexuan Mao, Meng Dang, Zizhe Li, Youyi Wang, Shaohui Zhang, Yuhang Sun, Zhibin Zhang, Gaiming Zhao, Yu Li, Qian Li, Xiya Zhang
{"title":"Development of a sensitive monoclonal antibody-based immunochromatographic strip for neomycin detection in milk","authors":"Kemeng Qin, Mingyue Ding, Chensi Zhang, Xijie Zhang, Yexuan Mao, Meng Dang, Zizhe Li, Youyi Wang, Shaohui Zhang, Yuhang Sun, Zhibin Zhang, Gaiming Zhao, Yu Li, Qian Li, Xiya Zhang","doi":"10.1080/09540105.2022.2070606","DOIUrl":"https://doi.org/10.1080/09540105.2022.2070606","url":null,"abstract":"ABSTRACT To improve the detection sensitivity of neomycin (NEO) in milk, we produced a sensitive monoclonal antibody (mAb) against NEO and developed a lateral flow immunoassay based on amorphous carbon nanoparticles (ACNPs-LFA). First, we conjugated NEO to carrier protein to prepare mAbs. We obtained six mAbs: mAb 1C6, mAb 1D3, mAb 2D3, mAb 4D5, mAb 5D1, and mAb 5H1. We characterised the mAbs by indirect competitive enzyme-linked immunosorbent assay and selected the most sensitive mAb based on the half-maximal inhibitory concentration (IC50). We selected mAb 4D5 (IC50 = 0.15 ng/mL) for the development of LFA. MAb 4D5 was labelled with ACNPs (ACNPs-mAb 4D5) by electrostatic absorption. Under optimised conditions, 5.4 μg mAb 4D5 coupling with 1 mL ACNPs, NEO-OVA at concentration of 80 μg/mL, 3 μL ACNPs-mAb 4D5 were used to develop LFA. The cut-off value was 8 ng/mL. Therefore, our developed ACNPs-LFA is suitable for on-site detection of NEO residues.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"315 - 327"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47732539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Immune background state among the residents of the north, depending on nutrition type 北方居民的免疫背景状态，取决于营养类型
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-24 DOI: 10.1080/09540105.2022.2070605
Lilia Konstantinovna Dobrodeeva, V. A. Shtaborov, N. P. Geshavets
{"title":"Immune background state among the residents of the north, depending on nutrition type","authors":"Lilia Konstantinovna Dobrodeeva, V. A. Shtaborov, N. P. Geshavets","doi":"10.1080/09540105.2022.2070605","DOIUrl":"https://doi.org/10.1080/09540105.2022.2070605","url":null,"abstract":"ABSTRACT The questionnaire survey and the study of 1334 people living in the north of the European part of the Russian Federation, of which 970 are women and 364 are men, was conducted. 707 residents of the Arkhangelsk region and 627 residents of the Nenets Autonomous Okrug. The results of the questionnaire were analyzed depending on the appetite state (decreased -102 respondents, increased - 276, normal appetite – 1096, as well as dietary compliance – 124 and adherence to vegetarianism – 139). The most pronounced combined defects of immune protection (deficiency of phagocytic protection, deficiency of the content of natural killers and T-helpers) occur in people who have been eating mainly cereals and bread for a long time. Increased appetite in people over 55 years of age is associated with the frequency of chronic diseases of the gastrointestinal tract (35.7%) and increased tolerance to food antigens (52.3%).","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"302 - 314"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46448948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressurization technique: principles and impact on quality of meat and meat products 加压技术:原理及其对肉类和肉制品质量的影响
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-23 DOI: 10.1080/09540105.2022.2068507
Javeed Akhtar, Mebrhit Gebremariam Abrha
{"title":"Pressurization technique: principles and impact on quality of meat and meat products","authors":"Javeed Akhtar, Mebrhit Gebremariam Abrha","doi":"10.1080/09540105.2022.2068507","DOIUrl":"https://doi.org/10.1080/09540105.2022.2068507","url":null,"abstract":"ABSTRACT High-pressure processing as a unique technique of meat preservation is being widely used to preserve the meat and meat products by which a commercially feasible product’s production is possible to meet the consumer’s demand with no chemical preservatives and other harmful substances. Pressure treatment could have effects on colour, texture, protein denaturation, and meat microbial stability at ambient or low temperatures; it can help in minimizing the thermal exposure of the meat product to prevent the quality degradation, reduce microbial contamination and improve tenderness. This paper briefly reviews the attention of the high-pressure processing influence on meat product quality, namely texture, tenderness, colour, and microbial. The principles, HPP equipment, challenges, and future trends in high-pressure processing are also discussed.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"264 - 285"},"PeriodicalIF":3.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47951347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Chrysanthemum Zawadskii Herbich var. latilobum (Maxim.) Kitamura water extract prevents BALB/c mice lung injury from particulate matter 10 toxicity 菊花(Zawadskii Herbich var. latilobum)北村水提物对BALB/c小鼠肺损伤有预防作用
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-05-18 DOI: 10.1080/09540105.2022.2064435
W. Huang, Inhye Jeong, Bok-Kyung Han, M. J. Kim, Jiyoun Hong, S. Ahn, Wan Heo, J. Pan, Jae Kyeom Kim, Eui‐Cheol Shin, Y. J. Kim
{"title":"Chrysanthemum Zawadskii Herbich var. latilobum (Maxim.) Kitamura water extract prevents BALB/c mice lung injury from particulate matter 10 toxicity","authors":"W. Huang, Inhye Jeong, Bok-Kyung Han, M. J. Kim, Jiyoun Hong, S. Ahn, Wan Heo, J. Pan, Jae Kyeom Kim, Eui‐Cheol Shin, Y. J. Kim","doi":"10.1080/09540105.2022.2064435","DOIUrl":"https://doi.org/10.1080/09540105.2022.2064435","url":null,"abstract":"ABSTRACT Chronic exposure to airborne particulate matter (PM) causes respiratory damage in humans owing to oxidative stress and inflammation. Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (CZL) has been used in traditional medicine to treat several inflammatory diseases; however, studies on inflammatory pulmonary diseases are scarce. This study investigated the protective effects of CZL extract against PM10-induced lung injury in BALB/c mice. Cell type specific signaling pathways were explored using A549 and RAW264.7 cell lines. CZL extract noticeably attenuated PM10-induced lung injury and inflammatory cell infiltration in a mouse model. Protein markers, such as p-AKT, p-ERK, and p-NF-κB for PM10 induced lung inflammation were effectively reduced in CZL extract-treated mice and cells. Furthermore, CZL extracts considerably reduced the generation of reactive oxygen species and nitric oxide in cells. Collectively, CZL extract effectively reduced PM10-induced lung injury by suppressing pulmonary inflammation, potentially due to its anti-inflammatory and antioxidant properties.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"252 - 263"},"PeriodicalIF":3.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41824944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Environmental carbon tetrachloride exposure disrupts the liver structure and metabolic detoxification function in mice via p38MAPK/NF-κB/NLRP3 pathway 环境四氯化碳暴露通过p38MAPK/NF-κB/NLRP3途径破坏小鼠肝脏结构和代谢解毒功能
IF 3 3区 农林科学
Food and Agricultural Immunology Pub Date : 2022-04-11 DOI: 10.1080/09540105.2022.2060192
Yuanyuan Wei, Danyang Ma, Yimeng Fan, Chen Gao, Qingtao Wang, Yanmeng Yuan, Yan-nan Zhang, J. Han, Zhihui Hao
{"title":"Environmental carbon tetrachloride exposure disrupts the liver structure and metabolic detoxification function in mice via p38MAPK/NF-κB/NLRP3 pathway","authors":"Yuanyuan Wei, Danyang Ma, Yimeng Fan, Chen Gao, Qingtao Wang, Yanmeng Yuan, Yan-nan Zhang, J. Han, Zhihui Hao","doi":"10.1080/09540105.2022.2060192","DOIUrl":"https://doi.org/10.1080/09540105.2022.2060192","url":null,"abstract":"ABSTRACT We investigated the effects of carbon tetrachloride (CCl4) exposure on liver detoxification. We confirmed that 0.2%-0.8% CCl4 decreased the liver carboxylesterase (CarE), lactate dehydrogenase (LDH) activity and total protein (TP) levels, while 0.2% and 0.8% CCl4 increased the liver acetylcholine esterase (AChE) activity (P< 0.05). It was observed0.4%-0.8% CCl4 increased serum glutathione S-transferase (GST) and catalase (CAT) activity, 0.1%-0.8% CCl4 increased the level of malondialdehyde (MDA), and 0.2% CCl4 increased the level of total superoxide dismutase (T-SOD). The expression of nod-like receptor protein 3 (NLRP3), interleukin-1β (IL-1β), and tumour necrosis factor-α (TNF-α) were significantly elevated in 0.2%-0.8% CCl4 exposure (P< 0.05). The expression of p38MAPK, gasdermin D (GSDMD), and nuclear factor kappa-B kinase (IKK) was decreased in 0.1%-0.8% CCl4 exposure, while the apoptosis was not statistically different in all groups. This indicates that 0.1% CCl4 exposure could damage the liver structure and detoxification function via p38MAPK/NF-κB/NLRP3 pathway. GRAPHICAL ABSTRACT","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"235 - 251"},"PeriodicalIF":3.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46705773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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