菊花(Zawadskii Herbich var. latilobum)北村水提物对BALB/c小鼠肺损伤有预防作用

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED

Food and Agricultural Immunology Pub Date : 2022-05-18 DOI:10.1080/09540105.2022.2064435

W. Huang, Inhye Jeong, Bok-Kyung Han, M. J. Kim, Jiyoun Hong, S. Ahn, Wan Heo, J. Pan, Jae Kyeom Kim, Eui‐Cheol Shin, Y. J. Kim

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引用次数: 1

摘要

长期暴露于空气中的颗粒物(PM)会引起氧化应激和炎症，从而导致人体呼吸系统损伤。菊花(zawadskii Herbich var. latilobum)Kitamura (CZL)已在传统医学中用于治疗几种炎症性疾病;然而，关于炎症性肺部疾病的研究很少。本研究探讨了CZL提取物对pm10诱导的BALB/c小鼠肺损伤的保护作用。以A549和RAW264.7细胞系为研究对象，探索细胞类型特异性信号通路。CZL提取物明显减轻pm10诱导的小鼠肺损伤和炎症细胞浸润。pakt、p-ERK和p-NF-κB等PM10诱导的肺部炎症蛋白标志物在CZL提取物处理的小鼠和细胞中有效降低。此外，CZL提取物显著减少了细胞中活性氧和一氧化氮的产生。总的来说，CZL提取物通过抑制肺部炎症有效地减少pm10诱导的肺损伤，可能是由于其抗炎和抗氧化特性。

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Chrysanthemum Zawadskii Herbich var. latilobum (Maxim.) Kitamura water extract prevents BALB/c mice lung injury from particulate matter 10 toxicity

ABSTRACT Chronic exposure to airborne particulate matter (PM) causes respiratory damage in humans owing to oxidative stress and inflammation. Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (CZL) has been used in traditional medicine to treat several inflammatory diseases; however, studies on inflammatory pulmonary diseases are scarce. This study investigated the protective effects of CZL extract against PM10-induced lung injury in BALB/c mice. Cell type specific signaling pathways were explored using A549 and RAW264.7 cell lines. CZL extract noticeably attenuated PM10-induced lung injury and inflammatory cell infiltration in a mouse model. Protein markers, such as p-AKT, p-ERK, and p-NF-κB for PM10 induced lung inflammation were effectively reduced in CZL extract-treated mice and cells. Furthermore, CZL extracts considerably reduced the generation of reactive oxygen species and nitric oxide in cells. Collectively, CZL extract effectively reduced PM10-induced lung injury by suppressing pulmonary inflammation, potentially due to its anti-inflammatory and antioxidant properties.

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.