Food and Agricultural Immunology最新文献

Nutritional supplement Youtianli regulates Treg function and gut immunity via SCFA-producing microbiota modulation 营养补充剂有天利通过调节产生scfa的微生物群调节Treg功能和肠道免疫

3区农林科学

Food and Agricultural Immunology Pub Date : 2025-08-07 DOI: 10.1080/09540105.2025.2533244

Hexiu Yuan, Yichun Xiao, Yubo Huang, Leming Huang

{"title":"Nutritional supplement Youtianli regulates Treg function and gut immunity via SCFA-producing microbiota modulation","authors":"Hexiu Yuan, Yichun Xiao, Yubo Huang, Leming Huang","doi":"10.1080/09540105.2025.2533244","DOIUrl":"https://doi.org/10.1080/09540105.2025.2533244","url":null,"abstract":"Gut microbiota plays a vital role in immune regulation by producing short-chain fatty acids (SCFAs), which influence regulatory T cells (Tregs) and maintain immune balance. Disruptions in the SCFAs-Tregs axis contribute to immune dysregulation and inflammation. This study explores the immunomodulatory effects of the nutritional supplement Youtianli (YTL) in a juvenile mouse model of lipopolysaccharide (LPS)-induced immune dysregulation. YTL supplementation significantly reduced pro-inflammatory cytokines, restored Th17/Treg balance, and increased SCFA-producing bacteria. Metabolomic analysis confirmed upregulation of butyrate and propionate metabolism, essential for immune modulation. Fecal microbiota transplantation (FMT) demonstrated that immunoregulatory effects of YTL were microbiota-dependent. These findings suggest that YTL improves immune function by modulating gut microbiota and enhancing SCFA metabolism. This study highlights the potential of YTL as an immunoregulatory supplement and encourages further research into microbiota-targeted nutritional interventions.Schematic of the molecular mechanism by which YTL supplementation modulates treg cell function via gut microbiota and SCFAs.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tandfonline.com/doi/pdf/10.1080/09540105.2025.2533244?needAccess=true","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response 玄参磷酸化多糖通过抑制NF-κ b介导的炎症反应，减轻脂多糖（LPS）诱导的小鼠急性肺损伤

3区农林科学

Food and Agricultural Immunology Pub Date : 2024-12-19 DOI: 10.1080/09540105.2024.2442362

Lufen Huang, Anguo Wu, Jiaxue Chen, Jiamin Zhu, Xulong Qin, Jianing Mi, Bowen Wei, Jianan Wang, Yufeng Liu

{"title":"Phosphorylated polysaccharides derived from Scrophulariae Radix mitigates lipopolysaccharide (LPS)-induced acute lung injury in mice by suppressing the NF-κB-mediated inflammatory response","authors":"Lufen Huang, Anguo Wu, Jiaxue Chen, Jiamin Zhu, Xulong Qin, Jianing Mi, Bowen Wei, Jianan Wang, Yufeng Liu","doi":"10.1080/09540105.2024.2442362","DOIUrl":"https://doi.org/10.1080/09540105.2024.2442362","url":null,"abstract":"Acute lung injury (ALI) is a severe form of diffuse lung disease that poses a significant health burden in clinical settings. Numerous natural compounds derived from plants have shown effective anti-inflammatory activities with low toxicity, particularly polysaccharides, which have garnered considerable attention. This study explores key aspects of the pathogenesis of ALI and the potential mitigation effects of phosphorylated polysaccharides derived from Scrophulariae Radix (PPSR) in a lipopolysaccharide (LPS)-induced mouse model of ALI. These include alterations in the lung tissue wet/dry ratio, histopathological changes, modulation of pro-inflammatory cytokines, and inhibition of the NF-κB signalling pathway. Moreover, PPSR significantly reduced lung nitric oxide (NO) production and the expression of inducible NO synthase (iNOS) in lung tissue. The findings provide important insights into the mechanisms underlying the therapeutic effects of PPSR, emphasising its anti-inflammatory properties and its potential to alleviate the detrimental consequences of ALI.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Skin collagen peptides of Chinese giant salamander ( Andrias davidianus ) exert anti-inflammatory effects in LPS-induced RAW264.7 cells via the lincRNA-EPS/ NF-κB pathway 大鲵皮肤胶原肽通过lincRNA-EPS/ NF-κB通路对lps诱导的RAW264.7细胞发挥抗炎作用

3区农林科学

Food and Agricultural Immunology Pub Date : 2024-12-17 DOI: 10.1080/09540105.2024.2434474

Wencong Shang, Shuchai Su, Qinrong Li, Can Li

{"title":"Skin collagen peptides of Chinese giant salamander ( Andrias davidianus ) exert anti-inflammatory effects in LPS-induced RAW264.7 cells via the lincRNA-EPS/ NF-κB pathway","authors":"Wencong Shang, Shuchai Su, Qinrong Li, Can Li","doi":"10.1080/09540105.2024.2434474","DOIUrl":"https://doi.org/10.1080/09540105.2024.2434474","url":null,"abstract":"Food-derived collagen peptides have recently been reported to have immunomodulatory functions. The Chinese giant salamander (CGS) has both edible and medicinal values. In this study, we tried to verify the immunoregulatory function of CGS skin collagen peptides (CGSSCPs) on macrophages and elucidate its mechanism. CGSSCPs decreased the secretion of nitric oxide (NO) and downregulated the expression of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), chemokine (C–C motif) ligand 5 (CCL5) and (C-X-C motif) ligand 10 (CXCL10) in Lipopolysaccharide (LPS)-induced RAW264.7 cells. Moreover, CGSSCPs promoted the expression of lincRNA-EPS, and inhibited the phosphorylation of nuclear factor kappa-B (NF-κB) in LPS-induced RAW264.7 cells. Silencing lincRNA-EPS up-regulated the phosphorylation level of NF-κB and the expression of inflammatory cytokines (IL-6, IL-1β, and TNF-α) and chemokines (CCL5 and CXCL10). These suggest that CGSSCPs may regulate RAW264.7 cells by the lincRNA-EPS/NF-κB pathway, which provides a theoretical basis for the development of new anti-inflammatory drugs.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Efficacy of Ergosterol and Ergosterol peroxide in different anti-inflammatory models – a comparison study 麦角甾醇和过麦角甾醇在不同抗炎模型中的疗效比较研究

3区农林科学

Food and Agricultural Immunology Pub Date : 2024-11-24 DOI: 10.1080/09540105.2024.2423638

Luyao Li, Yuhang Zhu, Wenjing Cheng, Feiqian Di, Jiachan Zhang, Changtao Wang

{"title":"Efficacy of Ergosterol and Ergosterol peroxide in different anti-inflammatory models – a comparison study","authors":"Luyao Li, Yuhang Zhu, Wenjing Cheng, Feiqian Di, Jiachan Zhang, Changtao Wang","doi":"10.1080/09540105.2024.2423638","DOIUrl":"https://doi.org/10.1080/09540105.2024.2423638","url":null,"abstract":"Ergosterol and its peroxide with important regulatory roles in a variety of intracellular biological processes. In this study, both of the LPS- and UVA-induced human keratinocyte (HaCaT) inflammatory models were established to investigate the anti-inflammatory effects of ES and EP. The protective effects of EP and ES on UVA and LPS-induced cell damage were discussed by cell viability assays, reactive oxygen species levels, skin barrier-related proteins, anti-inflammatory factors, and expression of genes involved in related signaling pathways were analyzed. The results showed that both of ES and EP could reduce the intracellular ROS levels; inhibit IL-8 and IL-1β secretion; and had significant promotion effects on AQP3 and FLG, inhibited gene expressions of PI3K, AKt, IL-1β and IL-8 and ES and EP were not irritating according to the safety evaluation. In summary, both of ES and EP showed excellent anti-inflammatory effects and provided a degree of protection against UVA/LPS-induced inflammatory damage.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tandfonline.com/doi/pdf/10.1080/09540105.2024.2423638?needAccess=true","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anti-inflammatory activity of Staphylea bumalda leaves through inhibiting ERK1/2 and NF-κB signalling, and activating Nrf2/HO-1 signalling in LPS-stimulated RAW264.7 cells 通过抑制 LPS 刺激的 RAW264.7 细胞中的 ERK1/2 和 NF-κB 信号，以及激活 Nrf2/HO-1 信号，葡萄叶具有抗炎活性

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-09-17 DOI: 10.1080/09540105.2024.2404917

Hyeok Jin Choi, Gwang Hun Park, Jeong Won Choi, Jae Won Lee, Hae-Yun Kwon, Hye Jin Park, Jin Boo Jeong

引用次数: 0

Dietary fiber: an unmatched food component for sustainable health 膳食纤维：无与伦比的可持续健康食品成分

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-08-15 DOI: 10.1080/09540105.2024.2384420

Anjana Suresh, Shobna, Mani Salaria, Sonia Morya, Waseem Khalid, Farukh Adeem Afzal, Ammar Ahmad Khan, Saira Safdar, Muhammad Zubair Khalid, Emery Lenge Mukonzo Kasongo

引用次数: 0

α-Amylase enzyme inhibition relevant to type II diabetes by using functional yogurt with Cinnamomum verum and Stevia rebaudiana 使用含有肉桂和甜叶菊的功能性酸奶抑制与 II 型糖尿病相关的α-淀粉酶

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-08-13 DOI: 10.1080/09540105.2024.2389091

Aneela Hameed, Fartashia Ashraf, Muhammad Junaid Anwar, Adnan Amjad, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Ishtiaque Ahmad, Muhammad Shoaib Aslam, Ahmed H. El-Ghorab, Mohammed M. Ghoneim, Mohamed E. Shaker, Mohamed A. Abdelgawad, Entessar Al Jbawi

引用次数: 0

Obesity and micronutrients deficit, when and how to suplement 肥胖与微量营养素缺乏，何时以及如何补充

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-08-02 DOI: 10.1080/09540105.2024.2381725

Sebastián Pablo Chapela, Andres Luciano Nicolas Martinuzzi, Natalia Daniela Llobera, Florencia Ceriani, Victoria Gonzalez, Martha Montalvan, Ludovica Verde, Evelyn Frias-Toral

引用次数: 0

Effect of critical amino acids’ properties on potential allergenicity of Ara h 2 epitopes 关键氨基酸的特性对 Ara h 2 表位潜在过敏性的影响

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-07-21 DOI: 10.1080/09540105.2024.2373064

Zhou Xiaoya, Zhang Mengfei, Hu Changbao, Xin Li, Anshu Yang, Ping Tong, Zhihua Wu, Hongbing Chen

引用次数: 0

Analysis of microbial diversity and resistant genes among three types of pork via metagenomic and HPC-NGS 通过元基因组和 HPC-NGS 分析三种猪肉的微生物多样性和抗性基因

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2024-07-10 DOI: 10.1080/09540105.2024.2376600

Yu Zhang, Jiaxin Song, Junfei Zhou, Yingmin Jia, Aijin Ma

引用次数: 0