{"title":"香蕉淀粉干预通过调节糖尿病大鼠的肠道微生物群-脑轴改善糖尿病诱导的情绪障碍","authors":"Yongliang Bai, Meiguo Xin, Junming Lin, Jing Xie, Roumin Lin, Zhenshan Peng, Jingwen Guo, Weidong Bai","doi":"10.1080/09540105.2022.2071846","DOIUrl":null,"url":null,"abstract":"ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"377 - 402"},"PeriodicalIF":1.7000,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats\",\"authors\":\"Yongliang Bai, Meiguo Xin, Junming Lin, Jing Xie, Roumin Lin, Zhenshan Peng, Jingwen Guo, Weidong Bai\",\"doi\":\"10.1080/09540105.2022.2071846\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.\",\"PeriodicalId\":12300,\"journal\":{\"name\":\"Food and Agricultural Immunology\",\"volume\":\"33 1\",\"pages\":\"377 - 402\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food and Agricultural Immunology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1080/09540105.2022.2071846\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food and Agricultural Immunology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09540105.2022.2071846","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats
ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.
期刊介绍:
Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed.
The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on:
-Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer
-Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals
-Effects of food on the immune system
-Studies on allergy and allergic reactions
-Investigations into food allergies
-Development of allergen-free food systems
-Development of novel assay formats
-Applications of assay systems to the monitoring of food items in relation to safety and labelling
-Food quality issues, e.g. speciation, adulteration and contamination
-Comparisons between different analytical techniques
The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.