不同于L-乳酸的D-乳酸的意外免疫调节作用

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED

Food and Agricultural Immunology Pub Date : 2022-05-24 DOI:10.1080/09540105.2022.2068508

Yongheng Yan, Ruijie Xu, Xiu-xia Li, Zhijie Yao, Hao Zhang, Haitao Li, Wei Chen

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引用次数: 0

摘要

摘要随着人类微生物组研究的进展，乳酸是自然界中最小的手性分子这一事实引起了人们的关注。然而，关于L-乳酸和D-乳酸的分类的比较研究很少。在本研究中，我们研究了D-乳酸作为食品来源的免疫调节剂的安全性和有效性。在安全性评估方面，发现两种乳酸盐都能促进细胞增殖和修复。D-乳酸在小鼠中以高达2000mg/kg的剂量耐受30天。在免疫功能评估方面，出乎意料的是，发现D-乳酸通过提高免疫器官指数、耳朵肿胀指数、淋巴细胞转化率、溶血率和巨噬细胞吞噬率来增强免疫力，并具有剂量依赖性作用。D-乳酸显示出比L-乳酸更强的免疫调节作用。本研究证明了D-乳酸的安全性和免疫调节能力，为发酵食品的生物活性提供了机制依据。

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Unexpected immunoregulation effects of D-lactate, different from L-lactate

ABSTRACT With advances in the study of the human microbiome, the fact that lactate is the smallest chiral molecule in nature has drawn attention. However, there have been few comparative studies on the classification of L-lactate and D-lactate. In this study, we investigated the safety and efficacy of D-lactate as an immunomodulator of food origin. In terms of safety evaluation, both lactates were found to promote cell proliferation and repair. D-lactate was well tolerated for 30 d at doses up to 2000 mg/kg in mice. In terms of immune function evaluation, unexpectedly, D-lactate was found to enhance immunity by increasing the immune organ index, ear swelling index, lymphocyte conversion rate, haemolysis rate and macrophage phagocytosis rate and had a dose-dependent effect. D-lactate showed stronger immune regulation effects than L-lactate. This study proves the safety and the immunoregulation capacity of D-lactate and provides a mechanistic basis for the bioactivity of fermented foods.

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.