Eye and Vision最新文献

{"title":"Age-related changes in geometry and transparency of human crystalline lens revealed by optical signal discontinuity zones in swept-source OCT images.","authors":"Ashish Gupta, Daniel Ruminski, Alfonso Jimenez Villar, Raúl Duarte Toledo, Grzegorz Gondek, Barbara Pierscionek, Pablo Artal, Ireneusz Grulkowski","doi":"10.1186/s40662-023-00365-y","DOIUrl":"10.1186/s40662-023-00365-y","url":null,"abstract":"<p><strong>Background: </strong>The shape and microstructure of the human crystalline lens alter with ageing, and this has an effect on the optical properties of the eye. The aim of this study was to characterise the age-related differences in the morphology and transparency of the eye lenses of healthy subjects through the optical signal discontinuity (OSD) zones in optical coherence tomography (OCT) images. We also investigated the association of those changes with the optical quality of the eye and visual function.</p><p><strong>Methods: </strong>OCT images of the anterior segment of 49 eyes of subjects (9-78 years) were acquired, and the OSD zones (nucleus, C1-C4 cortical zones) were identified. Central thickness, curvature and optical density were measured. The eye's optical quality was evaluated by the objective scatter index (OSI). Contrast sensitivity and visual acuity tests were performed. The correlation between extracted parameters and age was assessed.</p><p><strong>Results: </strong>The increase in lens thickness with age was dominated by the thickening of the cortical zone C3 (0.0146 mm/year). The curvature radii of the anterior lens surface and both anterior and posterior nucleo-cortical interfaces decreased with age (- 0.053 mm/year, - 0.013 mm/year and - 0.006 mm/year, respectively), and no change was observed for the posterior lens radius. OCT-based densitometry revealed significant correlations with age for all zones except for C1β, and the highest increase in density was in the C2-C4 zones (R = 0.45, 0.74, 0.56, respectively, P < 0.001). Increase in OSI was associated with the degradation of visual function.</p><p><strong>Conclusions: </strong>OCT enables the identification of OSD zones of the crystalline lens. The most significant age-related changes occur in the C3 zone as it thickens with age at a faster rate and becomes more opaque than other OSD zones. The changes are associated with optical quality deterioration and reduction of visual performance. These findings contribute to a better understanding of the structure-function relationship of the ageing lens and offer insights into both pathological and aging alterations.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"10 1","pages":"46"},"PeriodicalIF":4.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of small back optic zone design on myopia control for corneal refractive therapy (CRT): a one-year prospective cohort study.","authors":"Xuewei Li, Lili Zuo, Heng Zhao, Jie Hu, Tao Tang, Kai Wang, Yan Li, Mingwei Zhao","doi":"10.1186/s40662-023-00364-z","DOIUrl":"10.1186/s40662-023-00364-z","url":null,"abstract":"<p><strong>Background: </strong>To investigate the control effect on the axial length elongation using corneal refractive therapy (CRT) with different optical zone diameters (BOZDs). We also sought to compare the difference in higher-order aberrations (HOAs), treatment zone (TZ) size and Zernike defocus coefficient with different BOZDs and seek the optimal parameter for predicting axial elongation.</p><p><strong>Methods: </strong>This prospective cohort study included 7- to 14-year-olds fitted with orthokeratology (ortho-K) lenses of 5-mm (5-mm group) or 6-mm BOZD (6-mm group). Axial length (AL), corneal topography, HOAs and Zernike defocus coefficient were obtained at baseline, and 1, 3, 6, 9 and 12 months follow-up visits. Multivariate regression analyses were used to explore the association between AL change and ocular biometric parameters. Receiver operating characteristic (ROC) curve analysis was used to determine the best diagnostic value for AL change in ocular biometric parameters.</p><p><strong>Results: </strong>In total, 301 participants completed the one-year follow-up. The mean AL change in the 5-mm group (0.13 ± 0.18 mm) was less than that in the 6-mm group (0.27 ± 0.15 mm) at the 12 months visit. The TZ size and decentration were smaller, while the Zernike defocus coefficient and HOAs were higher in the 5-mm group (all P < 0.05). Older age and smaller TZ size were protective factors against AL elongation in multiple regression. In predicting AL elongation, TZ diameter yielded an area under the ROC curve of 0.684 with a cut-off value of 3.82 mm.</p><p><strong>Conclusion: </strong>The 5-mm group showed 0.14 mm (51.8%) less axial elongation than the 6-mm group. The 5-mm BOZD produced a smaller TZ size, higher Zernike defocus coefficient and higher HOA after reshaping of the cornea. TZ size was the best predictor of AL elongation. TZ diameter less than 3.82 mm may lead to AL elongation less than 0.2 mm in one year.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"10 1","pages":"47"},"PeriodicalIF":4.2,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138175993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.","authors":"Renato Ambrósio,&nbsp;Marcella Q Salomão,&nbsp;Lorena Barros,&nbsp;João Batista R da Fonseca Filho,&nbsp;Jaime Guedes,&nbsp;Alexandre Neto,&nbsp;Aydano P Machado,&nbsp;Bernardo T Lopes,&nbsp;Nelson Sena,&nbsp;Louise Pellegrino Gomes Esporcatte","doi":"10.1186/s40662-023-00363-0","DOIUrl":"10.1186/s40662-023-00363-0","url":null,"abstract":"<p><p>Different diagnostic approaches for ectatic corneal diseases (ECD) include screening, diagnosis confirmation, classification of the ECD type, severity staging, prognostic evaluation, and clinical follow-up. The comprehensive assessment must start with a directed clinical history. However, multimodal imaging tools, including Placido-disk topography, Scheimpflug three-dimensional (3D) tomography, corneal biomechanical evaluations, and layered (or segmental) tomography with epithelial thickness by optical coherence tomography (OCT), or digital very high-frequency ultrasound (dVHF-US) serve as fundamental complementary exams for measuring different characteristics of the cornea. Also, ocular wavefront analysis, axial length measurements, corneal specular or confocal microscopy, and genetic or molecular biology tests are relevant for clinical decisions. Artificial intelligence enhances interpretation and enables combining such a plethora of data, boosting accuracy and facilitating clinical decisions. The applications of diagnostic information for individualized treatments became relevant concerning the therapeutic refractive procedures that emerged as alternatives to keratoplasty. The first paradigm shift concerns the surgical management of patients with ECD with different techniques, such as crosslinking and intrastromal corneal ring segments. A second paradigm shift involved the quest for identifying patients at higher risk of progressive iatrogenic ectasia after elective refractive corrections on the cornea. Beyond augmenting the sensitivity to detect very mild (subclinical or fruste) forms of ECD, ectasia risk assessment evolved to characterize the inherent susceptibility for ectasia development and progression. Furthermore, ectasia risk is also related to environmental factors, including eye rubbing and the relational impact of the surgical procedure on the cornea.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"10 1","pages":"45"},"PeriodicalIF":4.2,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71422118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a novel ER-stress induced myopia model in mice.","authors":"Longdan Kang,&nbsp;Shin-Ichi Ikeda,&nbsp;Yajing Yang,&nbsp;Heonuk Jeong,&nbsp;Junhan Chen,&nbsp;Yan Zhang,&nbsp;Kazuno Negishi,&nbsp;Kazuo Tsubota,&nbsp;Toshihide Kurihara","doi":"10.1186/s40662-023-00361-2","DOIUrl":"https://doi.org/10.1186/s40662-023-00361-2","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have indicated a strong correlation between endoplasmic reticulum (ER) stress and myopia and that eyedrops containing the ER stress inducer tunicamycin (Tm) can induce myopic changes in C57BL/6 J mice. Therefore, this study aimed to create a new myopia model using Tm eyedrops and to explore the mechanism of ER stress-mediated myopia development.</p><p><strong>Methods: </strong>Three-week-old C57BL/6 J mice were treated with different concentrations (0, 25, 50, and 100 μg/mL) and/or number of applications (zero, one, three, and seven) of Tm eyedrops. Refraction and axial length (AL) were measured before and one week after Tm treatment. Scleral collagen alterations were evaluated under polarised light after picrosirius red staining. ER stress-related indicators, such as the expression of collagen I and cleaved collagen were detected using Western blotting.</p><p><strong>Results: </strong>Compared with the control group, mice administered eyedrops with 50 μg/mL Tm only once showed the greatest myopic shifts in refraction and AL elongation and reduced scleral expression of collagen I. Picrosirius red staining showed a lower percentage of bundled collagen in the Tm group. Expression of ER-stress indicators increased in the Tm groups. Furthermore, optimised administration of Tm induced matrix metalloproteinase-2 (MMP2) expression in the sclera, which plays a major role in collagen degradation.</p><p><strong>Conclusions: </strong>We have demonstrated that ER stress in the sclera is involved in myopia progression. Tm eyedrops induced myopic changes, loosening of the scleral collagen and decreased expression of collagen I. This process may be associated with ER stress in the sclera, which upregulates the expression of MMP2 leading to collagen degradation.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"10 1","pages":"44"},"PeriodicalIF":4.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71422117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of total keratometry in ten intraocular lens power calculation formulas in highly myopic eyes","authors":"Ling Wei, K. Cheng, Wenwen He, Xiangjia Zhu, Yi Lu","doi":"10.1186/s40662-022-00293-3","DOIUrl":"https://doi.org/10.1186/s40662-022-00293-3","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"18 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89346458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice","authors":"Lu Du, Guang-hua Peng","doi":"10.1186/s40662-022-00292-4","DOIUrl":"https://doi.org/10.1186/s40662-022-00292-4","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"43 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74381464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ghrelin-GHSR-1a pathway inhibits high glucose-induced retinal angiogenesis in vitro by alleviating endoplasmic reticulum stress","authors":"Rong Li, Guomin Yao, Lingxiao Zhou, M. Zhang, Jin Yan","doi":"10.1186/s40662-022-00291-5","DOIUrl":"https://doi.org/10.1186/s40662-022-00291-5","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"8 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74376150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of corneal tomography using a novel swept-source optical coherence tomographer and rotating Scheimpflug system in normal and keratoconus eyes: repeatability and agreement analysis","authors":"R. Herber, J. Lenk, L. Pillunat, F. Raiskup","doi":"10.1186/s40662-022-00290-6","DOIUrl":"https://doi.org/10.1186/s40662-022-00290-6","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"41 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73400833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardizing the measurement and classification of quality of life using the Keratoconus End-Points Assessment Questionnaire (KEPAQ): the ABCDEF keratoconus classification","authors":"K. Balparda, Tatiana Herrera-Chalarca, Melissa Cano-Bustamante","doi":"10.1186/s40662-022-00288-0","DOIUrl":"https://doi.org/10.1186/s40662-022-00288-0","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"2 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77969461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-wide field imaging to assess the optic nerve and retina in Boston type I and II keratoprosthesis patients","authors":"William R. Bloom, M. Karl, S. B. Smith, Y. Shao, William Terrell, A. Tarabishy, Andrew Hendershot, Rebecca A Kuennen, Tyler D. Oostra, T. Mauger, C. Cebulla","doi":"10.1186/s40662-022-00289-z","DOIUrl":"https://doi.org/10.1186/s40662-022-00289-z","url":null,"abstract":"","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"70 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89210815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}