Eye and Vision最新文献

{"title":"Bilateral occlusive retinal vasculitis secondary to intravitreal faricimab injection: a case report and review of literature.","authors":"Yong Min Lee, Rajya Gurung, Jagjit Singh Gilhotra, Sumu Simon, Sudha Cugati","doi":"10.1186/s40662-024-00416-y","DOIUrl":"10.1186/s40662-024-00416-y","url":null,"abstract":"<p><strong>Background: </strong>This article describes a rare occurrence of bilateral retinal occlusive vasculitis secondary to intravitreal faricimab injection.</p><p><strong>Case presentation: </strong>A 72-year-old female with age-related macular degeneration presented with bilateral retinal occlusive vasculitis following intravitreal faricimab injections. The patient was treated with 3 days of intravenous methylprednisolone followed by oral prednisolone taper and topical steroid therapy. Resolution of retinal occlusive vasculitis was observed 2 months post treatment.</p><p><strong>Conclusions: </strong>Retinal occlusive vasculitis is a rare complication of intravitreal anti-vascular endothelial growth factor (anti-VEGF), particularly with faricimab injections. We also present a review of literature regarding retinal occlusive vasculitis following intravitreal anti-VEGF injections and propose further information regarding its pathophysiology.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"48"},"PeriodicalIF":4.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing an objective decision criterion for intraocular lens exchange due to homogeneous calcification: a prospective clinical analysis.","authors":"Timur M Yildirim, Grzegorz Łabuz, Nikola Henningsen, Hyeck-Soo Son, Victor A Augustin, Leoni Britz, Lizaveta Chychko, Ramin Khoramnia, Gerd U Auffarth","doi":"10.1186/s40662-024-00415-z","DOIUrl":"https://doi.org/10.1186/s40662-024-00415-z","url":null,"abstract":"<p><strong>Background: </strong>Homogeneous intraocular lens (IOL) calcification deteriorates patient's visual quality. There is a lack of functional and patient-reported data on patients with this material change undergoing IOL exchange surgery. The aim of this study was to evaluate subjective and objective outcomes following IOL exchange due to homogeneous IOL calcification to improve evidence-based patient counseling.</p><p><strong>Methods: </strong>In this prospective, non-interventional, clinical study, 53 eyes of 42 patients with homogeneous IOL calcification were included. IOL exchange was performed in 30 out of 53 eyes. Subjective symptoms using a quality-of-life questionnaire (Catquest-9SF), photic phenomena, corrected distance visual acuity (CDVA), straylight (C-Quant, Oculus, Wezlar, Germany) and contrast sensitivity with and without glare (CSV-1000, VectorVision, Houston, USA) were assessed before (T0) and at 3 to 12 months after IOL exchange (T1).</p><p><strong>Results: </strong>Preoperative CDVA and straylight did not correlate. Average halo and glare size and intensity decreased and Catquest-9SF items improved. The CDVA rose significantly from 0.16 ± 0.13 to 0.05 ± 0.10 logMAR, and contrast sensitivity increased with and without glare. The straylight value decreased statistically and clinically significant from 2.32 ± 0.34 to 1.23 ± 0.33 log(s).</p><p><strong>Conclusion: </strong>Homogeneous IOL calcification is not always associated with a pronounced reduction in visual acuity. In most cases, IOL exchange still reduces subjective complaints and improves quality of vision of affected patients. Visual acuity should not be the sole functional parameter in assessing patients with homogeneous IOL calcification as intraocular straylight and contrast sensitivity can better objectify patients' visual impairment. We recommend a straylight value above 1.56 log(s) as a cut-off when deciding on an IOL exchange surgery.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"46"},"PeriodicalIF":4.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.","authors":"Haoru Li, Nan Gao, Ruixin Li, Luobu Luodian, Jinyuan Sui, Yang Bai, Di Wu, Qing He, Yuxin Wang, Zhiqing Li, Ruihua Wei","doi":"10.1186/s40662-024-00413-1","DOIUrl":"https://doi.org/10.1186/s40662-024-00413-1","url":null,"abstract":"<p><strong>Background: </strong>To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.</p><p><strong>Methods: </strong>This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis. Logistic regression analysis and machine learning were applied to explore the risk factors for PS and its progression.</p><p><strong>Results: </strong>Patients in the PS group exhibited faster growth rates of spherical equivalent refraction (SER), axial length (AL), curvature index (CI), and posterior scleral height (PSH) as well as higher loss rates of choriocapillaris perfusion area (CCPA), choroid perfusion area (CPA) and choroidal vascularity index (CVI) compared to the NPS group (all P < 0.05). The baseline SER (B =  - 1.291, OR = 0.275, P = 0.008), baseline subfoveal scleral thickness (B =  - 1.621, OR = 0.198, P = 0.046), baseline PSH (B = 2.959, OR = 19.282, P = 0.001) and foveal CVI changes per year (B =  - 2.776, OR = 0.062, P < 0.001) were the risk factors for PS. Baseline AL (B = 0.561, OR = 1.752, P = 0.033), parafoveal choroidal thickness changes per year (B =  - 0.094, OR = 0.910, P = 0.032), foveal retinal vascular density changes per year (B = 0.104, OR = 1.110, P = 0.013) and foveal CCPA changes per year (B =  - 0.214, OR = 0.807, P = 0.038) were the risk factors for the PS progression.</p><p><strong>Conclusions: </strong>During the progression of myopia in adults, changes in the morphology of the eye's posterior pole are not limited to axial lengthening alone; there also will be a phase of compensatory lateral expansion. Baseline AL and changes in the microcirculation can be utilized to predict the progression of PS.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodopa is associated with reduced development of new-onset geographic atrophy in patients with age-related macular degeneration.","authors":"Kyle S Chan, Nitika Aggarwal, Shannon Lawson, Nick Boucher, Mathew W MacCumber, Jeremy A Lavine","doi":"10.1186/s40662-024-00412-2","DOIUrl":"10.1186/s40662-024-00412-2","url":null,"abstract":"<p><strong>Background: </strong>Geographic atrophy (GA) is a significant cause of vision loss in patients with age-related macular degeneration (AMD). Current treatments are limited to anti-complement drugs, which have limited efficacy to delay progression with significant risk of complications. Levodopa (L-DOPA) is a byproduct of melanin synthesis that is associated with reduced development of neovascular AMD. In this study, we determined if L-DOPA was associated with a reduced likelihood of new-onset GA.</p><p><strong>Methods: </strong>We performed a retrospective analysis in the Vestrum Health Retina Database. We included eyes with non-neovascular AMD without GA and 1-5 years of follow-up. Eyes were divided into two groups. Exposed to L-DOPA before or on the date of non-neovascular AMD without GA diagnosis, and eyes not exposed to L-DOPA. We extracted age, sex, AREDS2 status, dry AMD stage, smoking history, and conversion rate to GA at years 1 through 5. Propensity score matching was used to match L-DOPA and control groups. Cox proportional hazard regression, adjusting for age, sex, AMD severity, AREDS2 use, smoking status, and L-DOPA use was employed to calculate hazard ratios for new-onset GA detection.</p><p><strong>Results: </strong>We identified 112,089 control and 844 L-DOPA exposed eyes with non-neovascular AMD without GA. After propensity score matching, 2532 control and 844 L-DOPA exposed eyes remained that were well-matched for age, sex, AMD severity, AREDS2 use, and smoking status. We found that L-DOPA exposure was associated with a significantly reduced likelihood (HR = 0.68, 95% CI: 0.48-0.95, P = 0.025) of new-onset GA detection.</p><p><strong>Conclusion: </strong>L-DOPA use was associated with reduced detection of new-onset GA.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring optical coherence tomography parameters in eyes with myopic tilted disc.","authors":"Yu Qiao Zhang, Xiu Juan Zhang, Ru Yue Shen, Yuzhou Zhang, Fang Yao Tang, Simon K H Szeto, Danny Siu-Chun Ng, Ka Wai Kam, Alvin L Young, Li Jia Chen, Chi Pui Pang, Clement C Tham, Jason C Yam, Poemen P Chan","doi":"10.1186/s40662-024-00411-3","DOIUrl":"10.1186/s40662-024-00411-3","url":null,"abstract":"<p><strong>Background: </strong>To investigate the impact of optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) on different retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) segments in healthy myopic eyes.</p><p><strong>Methods: </strong>ODT and OI were measured from fundus photographs. HDT angle, peripapillary RNFL, and macular GCIPL were measured by swept-source optical coherence tomography (SS-OCT). The association between optic disc morphology and the RNFL/GCIPL thickness were evaluated, with age and axial length (AL) adjusted.</p><p><strong>Results: </strong>Among 530 healthy myopic eyes of 284 participants (mean age: 41.7 years, mean spherical equivalent: - 7.70 D, and mean AL: 26.6 mm), 335 eyes (63.2%) had temporal disc torsion (temporal group) and 195 eyes (36.8%) had nasal disc torsion (nasal group). For the nasal group, a larger OI was associated with thinner superior-to-superonasal GCIPL (β = - 7.465 to - 6.972, both P = 0.024) and temporal RNFL sectors (β = - 49.596 to - 27.748, P ≤ 0.014). For the temporal group, a larger OI was associated with thinner superior-to-nasal (β = - 50.255 to - 22.093, P ≤ 0.006) and thicker temporal RNFL sectors (β = 29.015 to 56.890, P ≤ 0.003). Additionally, a larger HDT angle was associated with thinner superior-to-nasal RNFL sectors (β = - 0.559 to - 0.242, P ≤ 0.036) and thinner superior-to-superotemporal GCIPL sectors (β = - 0.084 to - 0.069, P ≤ 0.037).</p><p><strong>Conclusions: </strong>The optic disc tortional direction was associated with the measurement of different RNFL and GCIPL sectors independent of the AL and age. These should be considered when constructing a myopic normative database.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"47"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the application of in-vivo confocal microscopy on conjunctival diseases.","authors":"Mingyi Yu, Chang Liu, Jodhbir S Mehta, Yu-Chi Liu","doi":"10.1186/s40662-024-00409-x","DOIUrl":"10.1186/s40662-024-00409-x","url":null,"abstract":"<p><p>Over the past few decades, the expanded applications of in-vivo confocal microscopy (IVCM) have greatly enhanced the knowledge of a variety of conjunctival diseases. IVCM allows non-invasively detailed observation of tarsal, palpebral and bulbar conjunctiva, from the superficial to the substantia propria at the cellular level. IVCM has been shown as a powerful tool for the assessment of morphological changes in both physiological and pathological conditions. High-resolution images of different cellular phenotypes, together with quantifiable results, open new insights into understanding the mechanisms of conjunctival diseases, as well as provide valuable and longitudinal information for the diagnosis and therapeutic evaluation. This review aims to provide an overview of the current knowledge on the applications of IVCM on conjunctival disorders, including aging changes, dry eye-related morphological changes, glaucoma and glaucoma surgery-related morphological changes, conjunctival neoplasm, pterygium, allergic conjunctivitis, trachomatous scarring, and the conjunctiva-associated lymphoid tissue (CALT) changes. In this review, we highlight the key findings of previous studies and discusses the current limitations and challenges of IVCM in assessing the structural characteristics of the conjunctiva. Furthermore, we consider possible future directions for unlocking the full potential of IVCM applications. The insights presented here will contribute to a more comprehensive understanding of the applications of IVCM in conjunctival diseases.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"43"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bilateral implantation of monofocal intraocular lenses with enhanced intermediate function targeting with - 2.00 D and emmetropia in moderate to high myopic Asian patients.","authors":"Yoo Young Jeon, Hayoung Lee, Kyu Sang Eah, Nahyun Park, Ho Seok Chung, Jae Yong Kim, Hungwon Tchah, Hun Lee","doi":"10.1186/s40662-024-00410-4","DOIUrl":"10.1186/s40662-024-00410-4","url":null,"abstract":"<p><strong>Background: </strong>To investigate the outcomes of bilateral implantation of enhanced monofocal intraocular lenses (IOLs, ICB00) with a - 2.00 diopter (D) target in patients with moderate to high myopia and to compare the clinical outcomes of a - 2.00 D binocular target with an emmetropia target in patients who underwent cataract surgery.</p><p><strong>Methods: </strong>In this retrospective study, we reviewed the medical records of patients who underwent uncomplicated phacoemulsification with ICB00 IOL implantation. Emmetropia (Group 1) and - 2.00 D (Group 2) were targeted in 60 and 20 eyes of 30 and 10 patients, respectively. Three months after surgery, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), and uncorrected near visual acuity (UNVA) were measured. Defocus curves were measured under the photopic condition by intervals of 0.50 D from + 0.50 D to - 4.00 D.</p><p><strong>Results: </strong>The postoperative binocular logMAR UDVA, UIVA, and UNVA were 0.01 ± 0.03, 0.08 ± 0.11, and 0.33 ± 0.15 in Group 1 and 0.31 ± 0.13, 0.04 ± 0.05, and 0.11 ± 0.07 in Group 2, respectively. Group 2 showed a significantly superior postoperative binocular UNVA (P = 0.027) and inferior binocular UDVA (P = 0.003) than Group 1. Binocular UIVA and CDVA did not significantly differ between the groups although UIVA was better in Group 2 than in Group 1. Near glasses were needed by 66% of Group 1 and 0% of Group 2.</p><p><strong>Conclusions: </strong>Bilateral implantation of ICB00 IOL with - 2.00 D of residual myopia is suitable for patients with moderate to high myopia to improve UDVA, UIVA, and UNVA.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"42"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual and patient reported outcomes provided by a refractive multifocal intraocular lens based on continuous transitional focus.","authors":"Jorge L Alió, Antonio Martínez-Abad, Ramón Ruiz-Mesa, Hyo Myung Kim, Javier Mendicute, Filomena J Ribeiro, Mike P Holzer, Mario Cantó-Cerdán","doi":"10.1186/s40662-024-00408-y","DOIUrl":"https://doi.org/10.1186/s40662-024-00408-y","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the quality of vision of patients implanted bilaterally with the multifocal Precizon Presbyopic intraocular lens (IOL), as well as to evaluate the visual performance provided by the lens.</p><p><strong>Setting: </strong>Vissum Miranza Alicante.</p><p><strong>Design: </strong>Prospective multicenter study.</p><p><strong>Methods: </strong>56 patients (mean age 65.0 ± 8.7 years old) underwent bilateral implantation with multifocal Precizon Presbyopic IOL. The quality of vision was assessed by a quality of vision questionnaire at 6 months after the implantation procedure, a complete eye examination was also performed including visual and refractive measurements, defocus curve and contrast sensitivity assessment. Visual and refractive variables were compared in preoperative, 3-month postoperative and 6-month postoperative visits by Wilcoxon test.</p><p><strong>Results: </strong>The quality of vision analysis showed the absence of severe glare and severe haloes in all evaluated patients. Likewise, non-symptoms of glare, haloes and starbursts were seen in 75%, 68%, and 55% of subjects, respectively. Efficacy and safety index was 1.26 and 1.42, respectively. The 6-month postoperative binocular uncorrected distance visual acuity and near uncorrected visual acuity were 0.00 ± 0.09 and 0.20 ± 0.13 logMAR, respectively. Mean spherical equivalent was 0.29 ± 0.45 D.</p><p><strong>Conclusions: </strong>The Precizon Presbyopic NVA IOL (OPHTEC BV) provides a suitable quality of vision with a low rate of disturbance photic phenomena induction, as well as an excellent visual performance at main distances of sight accomplishing the visual demands of the majority of patients.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"41"},"PeriodicalIF":4.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and genomic interactions within keratoconus susceptible patients: a nationwide registered case-control study.","authors":"Farideh Doroodgar, Fatemeh Alizadeh, Sana Niazi, Seyedeh Maryam Razavi, Nazanin Jalilian, Asaad Azarnezhad, Feizollah Niazi, Mohammad Ali Javadi, Jorge Alió Del Barrio, Shima Dehghani, Majid Moshirfar, Zisis Gatzioufas, Renato Ambrósio, Jorge L Alio","doi":"10.1186/s40662-024-00407-z","DOIUrl":"10.1186/s40662-024-00407-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between variants in the interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian population.</p><p><strong>Methods: </strong>In the case group, there were 188 KC patients diagnosed by clinical findings and corneal tomography. The control group included all 205 healthy controls with no personal or family history of eye-related, metabolic, or immune system-related disease. Using the standard salting out extraction procedure, genomic DNA was isolated from peripheral blood leukocytes. The genotypes were determined by applying agarose gel electrophoresis for the IL-1RN 86 bp VNTR and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for rs16944 and rs1143634.</p><p><strong>Results: </strong>The results showed a significant association between the IL-1β rs1143634 (rs1143634 T allele, P = 0.008) and IL-1RN 86 bp VNTR polymorphisms (LL and LS genotype, P = 0.048 and 0.012 respectively) and susceptibility to KC in the Iranian population. The genotype distributions of rs1143634 (P = 0.004) and rs2234663 (P = 0.042) significantly differed between case and control groups, with certain genotypes demonstrating a protective effect against KC. Logistic regression analysis revealed a protective effect of the IL-1RN L allele [odds ratio (OR) = 0.367, 95% confidence interval (CI): 0.240-0.562; P = 0.000] and certain haplotypes (OR = 0.628, 95% CI: 0.447-0.884; P = 0.007) against KC. However, no significant association was found for the IL-1β rs16944 polymorphism.</p><p><strong>Conclusion: </strong>This study provides evidence for an association between variants in the IL-1 gene cluster and susceptibility to KC in an Iranian population. Further research on larger and more diverse populations is warranted to validate these findings and explore the underlying mechanisms involved.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"40"},"PeriodicalIF":4.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year trends of delayed sequential bilateral cataract surgery (DSBCS) in Sweden: a register-based study.","authors":"Andreas Viberg, Tomas Bro, Anders Behndig, Maria Kugelberg, Madeleine Zetterberg, Ingela Nilsson, Mats Lundström","doi":"10.1186/s40662-024-00406-0","DOIUrl":"10.1186/s40662-024-00406-0","url":null,"abstract":"<p><strong>Purpose: </strong>To study the trend of delayed sequential bilateral cataract surgery (DSBCS) in Sweden in the past decade.</p><p><strong>Methods: </strong>This register-based cohort study utilized data from the Swedish National Cataract Register (NCR) from 2010 through 2019. Register files from patients who underwent cataract surgery in both eyes during the study period were linked using their social security numbers. Bilateral surgeries on different days were classified as DSBCS. The study investigated the association between DSBCS within 3 months and several variables with stratification and multivariate logistic regression. The following variables were used: operation year, region, private or public unit, age, sex, indication for surgery, type of intraocular lens (IOL), preoperative visual acuity, ocular comorbidity, posterior capsule rupture and perioperative difficulties.</p><p><strong>Results: </strong>During the study period, 368,106 patients underwent DSBCS, of which 62.6% (n = 230,331) had bilateral surgery within 3 months. The median time between the surgeries was 61 days (interquartile range 26-161 days), showing regional variations. Better visual acuity in the fellow eye, presence of ocular comorbidity, various perioperative events and complications were associated with longer time to surgery of the second eye. Conversely, cataract surgery in more recent years, private clinic, increasing age, anisometropia and multifocal IOL were associated with shorter timespan between surgeries.</p><p><strong>Conclusions: </strong>The majority of DSBCS were conducted within a 3-month timeframe, with the interval between surgeries decreasing throughout the study period. Several rational factors were associated with the time difference, in addition to regional variations. Many patients would probably benefit from less time between the surgeries, and we encourage a clinical practice taking the whole patient's visual function into account.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"39"},"PeriodicalIF":4.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}