Eye and Vision最新文献

{"title":"Association between alcohol and tobacco use and primary open-angle glaucoma: the Eyes of Africa study.","authors":"Oluwatobi J Hussain, Olusola Olawoye, Kelsey V Stuart, Tarela Sarimiye, Chimdi Chuka-Okosa, Ugbede Idakwo, Naa Naamuah Tagoe, Kwesi Nyan Amissah-Arthur, Kuburat O Adenrele, Nkiru Kizor-Akaraiwe, Chinedu Anthony Okeke, Akinyemi O Adedeji, Bola Adekoya, Aderonke Baiyeroju, Onoja M Akpa, Oluwole Majekodunmi, Nkechi Uche, Bernice Adegbehingbe, Adeola Onakoya, Oyetunde E Oyedepo, Chimdia Ogbonnaya, Bolajoko Abidemi Adewara, Joseph Matiya Msosavict, Akosua Badu Mensa-Bonsu, Kwaku Oppong Kwarteng, Yakubu Seidu Adam, Kwame Okyere Osei, Edem Lodoh, Benjamin Abaidoo, Raymond Toseafa, Suhanyah Okeke, Obinna Shiweobi, Steve Adebusoye, Kayode Fowobaje, Benedict Gboyega Ajayi, Adeyinka Falusi, Oluwafumbi Adeboye, Promise Okoroafor, Ifeyinwa Obianwu, Caroline Adeoti, Adedapo Adejuwon, Nathan Congdon, Anthony P Khawaja, Michael A Hauser, Tony Realini, Adeyinka Ashaye","doi":"10.1186/s40662-026-00515-y","DOIUrl":"10.1186/s40662-026-00515-y","url":null,"abstract":"<p><strong>Background: </strong>Primary open-angle glaucoma (POAG) is the most prevalent glaucoma subtype globally and has disproportionately high rates in Africa. While smoking and alcohol consumption are established risk factors for several ocular conditions, their associations with POAG remain unclear. This study examined substance use patterns among individuals with and without POAG in sub-Saharan Africa.</p><p><strong>Methods: </strong>This cross-sectional study included 9,418 participants aged ≥ 40 years (5,189 POAG cases and 4,229 controls) from the Eyes of Africa: Genetics of Blindness study conducted across Nigeria, Ghana, and Malawi between 2017 and 2023. Comprehensive ocular examinations were performed, and POAG was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology criteria. Sociodemographic data and detailed information on the use of substances including alcohol, tobacco, pharmaceutical substances, and illicit drugs, were collected through structured interviews. Chi-squared tests were used to examine the associations between variables, and multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for substance use and POAG status.</p><p><strong>Results: </strong>Alcohol consumption and tobacco smoking were strongly and independently associated with POAG (P < 0.001). Former (OR = 1.49; 95% CI: 1.33-1.66; P < 0.001) and current drinkers (OR = 1.15; 95% CI: 1.00-1.31; P = 0.04) had higher odds than never-drinkers. Lifetime heavy episodic drinking (> 2 drinks per occasion) was associated with 40% higher odds of POAG (95% CI: 1.20-1.65; P < 0.001) than having ≤ 2 drinks. Tobacco use was also independently associated with POAG among both former (OR = 1.38; 95% CI: 1.13-1.68; P = 0.002) and current smokers (OR = 1.46; 95% CI: 1.12-1.91; P = 0.005). In addition, older age, male sex, higher educational level, and unemployment (all P < 0.001) were independently associated with POAG.</p><p><strong>Conclusion: </strong>Cigarette smoking and alcohol use are significantly associated with increased risk of POAG in this African population, representing potentially modifiable risk factors. Confirmatory longitudinal studies are needed to establish causality. If validated, public health strategies for POAG prevention in Africa should incorporate substance use reduction as a key component of primary prevention.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose indices and incident glaucoma: integrated UK Biobank and Mendelian randomization study.","authors":"Jianming Xu, Yuelan Gao, Jun Yu, Zihe Xu, Yuzhou Zhang, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen","doi":"10.1186/s40662-026-00516-x","DOIUrl":"10.1186/s40662-026-00516-x","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the associations of the triglyceride-glucose (TyG) index and related adiposity-integrated indices with incident glaucoma and explore potential causal evidence using Mendelian randomization (MR).</p><p><strong>Methods: </strong>This prospective cohort study included 396,213 participants without glaucoma of European ancestry from the UK. The TyG index and four related indices, including TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and TyG-waist-to-hip ratio (TyG-WHR), were assessed. Multivariate Cox models and restricted cubic splines were used to examine the association with incident glaucoma. Associations between the corneal-compensated intraocular pressure (IOPcc) and retinal structures were assessed using regression analyses. The predictive performance was evaluated using extreme gradient boosting (XGBoost). Two-sample MR was conducted to assess the genetic association between the TyG index and glaucoma.</p><p><strong>Results: </strong>During a mean follow-up of 8.06 years, 6957 cases of incident glaucoma occurred. In fully adjusted models, higher TyG and related indices were associated with increased glaucoma risk, including TyG (hazard ratio [HR] = 1.05, 95% confidence interval [CI]: 1.02-1.08), TyG-BMI (HR = 1.20, 95% CI: 1.14-1.27), TyG-WC (HR = 1.30, 95% CI: 1.23-1.37), TyG-WHtR (HR = 1.26, 95% CI: 1.20-1.31), and TyG-WHR (HR = 1.16, 95% CI: 1.12-1.21). The TyG showed a significant non-linear U-shaped association with incident glaucoma. TyG-related indices were positively associated with IOPcc, although the effect sizes were small and inversely associated with several measurements of retinal layer thickness. The XGBoost model showed good discrimination, with TyG-WHtR contributing the strongest among the TyG-related indices (C-index = 0.851, area under the curve = 0.823). MR provided suggestive evidence for an association between genetically predicted TyG and glaucoma risk (odds ratio = 1.27, 95% CI: 1.00-1.62, P = 0.046), although sensitivity estimates were not statistically significant.</p><p><strong>Conclusions: </strong>TyG-related indices, particularly adiposity-integrated measures, were associated with a higher glaucoma risk. Systemic glucose-lipid metabolic dysfunction and central adiposity may contribute to glaucoma susceptibility. Thus, TyG-related indices may serve as low-cost adjunct indicators for glaucoma risk stratification and external validation.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal glial cell removing during internal limiting membrane peeling is associated with higher-stage idiopathic epiretinal membrane.","authors":"Denise Vogt, Christopher Schmitz, Azza Dammak, Andrea Govetto, Ricarda G Schumann, Mario R Romano, Melih Parlak, Armin Wolf","doi":"10.1186/s40662-026-00514-z","DOIUrl":"10.1186/s40662-026-00514-z","url":null,"abstract":"<p><strong>Background: </strong>Histological examination of surgically excised internal limiting membrane (ILM) specimens may provide insights into retinal tissue changes, but their relationship to retinal imaging findings remains unclear. The aim of this study was to correlate retinal imaging findings with histological evidence of retinal tissue components in surgically excised ILM specimens from eyes with idiopathic epiretinal membrane (iERM) or full-thickness macular hole (FTMH).</p><p><strong>Methods: </strong>This retrospective clinicopathological study included 42 eyes that underwent pars plana vitrectomy with membrane peeling at the Department of Ophthalmology, University Hospital Ulm, Germany, between April 2024 and May 2025: 22 eyes with iERM and 20 with FTMH. Surgically excised tissue from all eyes was examined by transmission electron microscopy (TEM), and clinical data and retinal imaging findings obtained by optical coherence tomography (OCT) were evaluated.</p><p><strong>Results: </strong>TEM confirmed the ILM in all included eyes. Intact retinal glial cells with ultrastructural features consistent with Müller cells were observed in localized areas of ILM thinning in 3 eyes with iERM but in no eyes with FTMH. Retinal cell fragments were detected in 21 eyes with iERM and 18 eyes with FTMH. Among eyes with iERM, those containing retinal glial cells had a significantly greater mean central macular thickness (CMT, 619 ± 57 µm) than those without retinal glial cells (P = 0.008); all 3 eyes had Stage 3 epiretinal membrane (ERM), ectopic inner foveal layers (EIFL), and central bouquet abnormalities (CBA). OCT findings did not differ according to retinal cell fragment size.</p><p><strong>Conclusion: </strong>Retinal glial cells adherent to the ILM were identified only in eyes with iERM and were associated with higher-stage ERM, often in areas of ILM thinning. By contrast, retinal cell fragments occurred in both iERM and FTMH. These findings suggest disease-specific differences at the vitreoretinal interface, with stronger and more complex retinal-ILM interactions in iERM that may influence ILM peeling.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense pulsed light as a multi-target intervention paradigm for refractory ocular surface diseases: a review.","authors":"Jiayi Yan, Wei Chen, Jinyang Li","doi":"10.1186/s40662-026-00510-3","DOIUrl":"https://doi.org/10.1186/s40662-026-00510-3","url":null,"abstract":"<p><p>Ocular surface diseases (OSDs) are a heterogeneous group of disorders characterized by overlapping inflammatory, vascular, microbial, neuroimmune, and meibomian gland abnormalities that contribute to the onset and persistence of ocular surface symptoms and signs. Conventional symptom-directed therapies do not adequately alleviate refractory meibomian gland dysfunction, Demodex-associated blepharitis, ocular rosacea, recurrent chalazion, and allergic conjunctivitis. Recent evidence suggests that these conditions may share convergent pathological features, including chronic inflammation, abnormal lid-margin vascularity, and microbial or parasitic imbalance. Intense pulsed light (IPL), which was initially used for vascular and inflammatory disorders in dermatology, has emerged as a potential physical therapy that acts through several proposed mechanisms in patients with selected refractory OSDs, including photothermal liquefaction of inspissated meibum, coagulation of abnormal vessels, reduction of Demodex and microbial burden, modulation of inflammatory responses, and possible effects on neuroimmune signaling; however, these mechanisms remain incompletely established. Case series and clinical studies have reported improvements in ocular symptoms, tear film stability, meibomian gland function and drainage, lid-margin inflammation, and chalazion or lesion resolution, particularly when IPL is combined with meibomian gland expression or other adjunctive therapies. However, treatment responses vary across disease phenotypes and standardized treatment parameters, long-term safety data, and high-quality randomized controlled trials remain limited. Anatomical factors, disease severity, glandular structure, and inflammatory status may also influence therapeutic outcomes. Overall, IPL therapy represents a promising but evolving treatment strategy for refractory OSDs. This review summarizes the current knowledge regarding the proposed mechanisms, clinical applications, treatment protocols, limitations, and future directions and provides updated perspectives for the rational use of IPL in OSD management.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes of trabecular micro-bypass minimally invasive glaucoma surgery devices in eyes with high myopia: a 24-month retrospective multicenter cohort study.","authors":"Bryan Chin Hou Ang, Natalie Shi Qi Wong, Aditi Kochar, Samantha Lor, Lee Ching Phang, Hla Myint Htoon, Jeremy Tan, Mitchell Lawlor, Prasanna Venkatesh Ramesh, Younhea Jung, Zhu Li Yap, Si Rui Ng, Rachel S Chong","doi":"10.1186/s40662-026-00512-1","DOIUrl":"10.1186/s40662-026-00512-1","url":null,"abstract":"<p><strong>Background: </strong>To describe outcomes of two trabecular bypass minimally invasive glaucoma surgery (MIGS) devices in highly myopic (HM) eyes with glaucoma up to 24 months postoperatively.</p><p><strong>Methods: </strong>A retrospective, observational multicenter study of HM eyes (phakic refractive spherical equivalent ≤ -6 D and/or axial length ≥ 26 mm) undergoing trabecular bypass MIGS between January 2019 and December 2023. Changes in intraocular pressure (IOP), anti-glaucoma medications and visual acuity, and rates of complications including hyphema, peripheral anterior synechiae and significant IOP elevation, defined as ≥ 30 mmHg or an increase of ≥ 6 mmHg from preoperative IOP, were recorded. IOP outcome criteria and surgical success were reported per European Glaucoma Society and American Academy of Ophthalmology (AAO) guidelines, respectively. Linear mixed models were used for continuous variables, logistic regression for categorical variables and cluster-adjusted Cox regression to compare survival between groups.</p><p><strong>Results: </strong>Two hundred and fifty-two eyes of 207 subjects across three centers were studied. One hundred and twenty-eight eyes received iStent inject and 124 received Hydrus microstent; 96.1% of iStent and 100% of Hydrus eyes underwent combined phacoemulsification. At 24 months postoperatively, ≥ 20% IOP reduction with anti-glaucoma medications (AGMs) was achieved by 35.8% (Hydrus) or 30.0% (iStent); or without AGM 13.4% (Hydrus) or 6.67% (iStent). Drop-freedom was achieved by 48.7% (Hydrus) or 38.5% (iStent). An IOP of ≤ 15 mmHg with AGM was achieved by 55.2% (Hydrus) or 63.3% (iStent); or without AGM 28.4% (Hydrus) or 21.7% (iStent). The 12-month cumulative risk of failure to maintain ≥ 20% IOP reduction with AGM was 86.7% (Hydrus) or 90.3% (iStent); or without AGM 90.1% (Hydrus) or 92.5% (iStent). Surgical success based on AAO guidelines was attained by 60.5% (Hydrus) or 53.8% (iStent) of eyes. Significant IOP elevation was the most common complication (4.84% Hydrus; 4.54% iStent), followed by hyphema (0.8% Hydrus; 4.5% iStent) at 1 month postoperatively. Outcomes did not differ significantly between the Hydrus and iStent groups.</p><p><strong>Conclusions: </strong>Both iStent inject and Hydrus microstent achieved modest IOP-lowering efficacy and low complication rates in HM eyes. Neither device exceeded the minimal clinically important difference proposed for MIGS combined with cataract surgery.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLC7A11-mediated disulfidptosis underlies the pathogenesis of proliferative diabetic retinopathy.","authors":"Bowei Yuan, Shuilian Chen, Jiayan Liu, Tingting Yang, Feng Zeng, Rui Zhang, Zhihui Xiao, Xi Chen, Jin Qiu, Cong Wei, Zhiyan Zhou, Qiutong Pan, Yamei Lu, Jing Zhuang","doi":"10.1186/s40662-026-00511-2","DOIUrl":"10.1186/s40662-026-00511-2","url":null,"abstract":"<p><strong>Background: </strong>We investigated the role of disulfidptosis, a recently identified form of cell death, in the pathogenesis of proliferative diabetic retinopathy (PDR) and explore the function of the cystine/glutamate antiporter, SLC7A11, as a key mediator and potential therapeutic target.</p><p><strong>Methods: </strong>Bioinformatic analysis was used to screen disulfidptosis-related genes from public RNA sequencing datasets, which were subsequently validated in PDR fibrovascular membranes (FVMs) and vitreous humor via immunofluorescence and western blotting analysis. Human retinal microvascular endothelial cells (HRMECs) were cultured in normal or high-glucose media, and SLC7A11 expression modulated using small interfering RNA or lentiviral overexpression. Angiogenesis was assessed via proliferation, migration, and tube formation assays. Disulfidptosis was induced via acute glucose deprivation in high-glucose-adapted HRMECs and biochemically evaluated. A streptozotocin-induced diabetic mouse model was utilized to assess SLC7A11 expression in vivo, and therapeutic efficacy was tested through weekly intravitreal lavage with glucose-free versus glucose-replete solutions.</p><p><strong>Results: </strong>Disulfidptosis-related genes, particularly SLC7A11, were significantly upregulated in PDR FVMs, predominantly localizing to the vascular endothelium. In vitro, high-glucose conditions induced SLC7A11 and vascular endothelial growth factor A expression in HRMECs, thereby promoting proliferation, migration, and tube formation. SLC7A11 knockdown abrogated these pro-angiogenic effects, whereas overexpression exacerbated them. Critically, high-glucose-adapted cells developed a profound dependency on glucose; subsequent acute glucose deprivation triggered rapid cell death, exhibiting classic disulfidptosis features (F-actin collapse), a process that could not be rescued by ferroptosis inhibitors. In the diabetic mouse model, SLC7A11 expression was similarly upregulated in the pathological retinal vasculature. Therapeutic vitreous lavage with a glucose-free solution significantly attenuated the progression of these pathological neovessels.</p><p><strong>Conclusions: </strong>Our results revealed a novel SLC7A11-mediated metabolic vulnerability in PDR. We demonstrated that exploiting this glucose dependency via localized deprivation induces disulfidptosis-like features in neovascular cells, representing a new therapeutic strategy for PDR.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative predictive factors for opaque bubble layer formation and area during small-incision lenticule extraction: predictive models based on machine learning.","authors":"Chuzhi Peng, Xi Chen, Ying Yang, Huanhuan Ren, Yuke Huang, Jin Qiu, Yan Li, Keming Yu, Jing Zhuang","doi":"10.1186/s40662-026-00509-w","DOIUrl":"10.1186/s40662-026-00509-w","url":null,"abstract":"<p><strong>Background: </strong>We aimed to develop exploratory machine learning (ML)-based predictive models for the occurrence and area of an opaque bubble layer (OBL) during small-incision lenticule extraction (SMILE) and identify associated preoperative and surgical-planning factors.</p><p><strong>Methods: </strong>This retrospective study included 216 eyes (72 with an OBL, 144 controls) that underwent SMILE at the Zhongshan Ophthalmic Center between August 2024 and August 2025, which were matched 1:2 by age and sex. Comprehensive preoperative ocular examinations were performed using a Pentacam HR camera system and standard equipment. The OBL area was quantified from intraoperative videos using ImageJ software. Fifty-four preoperative and surgical features were used to develop the ML models: 15 classification algorithms for OBL occurrence, and 19 regression algorithms for the relative OBL area. Shapley additive explanations analysis was applied for model interpretability.</p><p><strong>Results: </strong>The Extra Trees model achieved optimal performance for predicting OBL occurrence (area under the receiver operating characteristic curve = 0.885, accuracy = 0.820). The top five key factors included femtosecond laser energy, intraocular pressure, residual stromal thickness, 10-mm corneal volume, and total astigmatism, all of which showed positive correlations. For OBL area prediction, the random forest regression model performed best in the test sets (mean absolute error = 2.89%, root mean square error = 3.37%). Corneal optical density (within the central 2-mm zone of the anterior 120-μm corneal layer) and age were negatively associated with OBL area, whereas keratoconus index showed the strongest positive association.</p><p><strong>Conclusion: </strong>The ML models showed exploratory predictive ability for OBL occurrence and area during SMILE using preoperative and surgical-planning parameters. External validation and recalibration in consecutive cohorts with a natural OBL prevalence are required before clinical use.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a precision reference benchmark for corneal epithelial aberration measurements using a new hybrid device across keratoconus stages.","authors":"Yizhou Yang, Rui Ning, Siheng Li, Xinning Yang, Yiran Wang, Kexin Li, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang","doi":"10.1186/s40662-026-00508-x","DOIUrl":"10.1186/s40662-026-00508-x","url":null,"abstract":"<p><strong>Background: </strong>To establish a precision reference benchmark for corneal epithelial aberration measurements across different stages of keratoconus (KC) by evaluating the precision of a new spectral-domain optical coherence tomography-Placido disk device (MS-39; CSO).</p><p><strong>Methods: </strong>Eyes with KC were classified into forme fruste keratoconus (FFKC), mild, moderate, and severe disease stage. Three consecutive corneal epithelial aberration measurements were obtained with the MS-39 by two skilled operators. The intraobserver repeatability and interobserver reproducibility were evaluated using within-subject standard deviation (S_w), test-retest variability (TRT), and intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The prospective study enrolled 141 eyes from 141 KC subjects. Subgroups included 32 eyes with FFKC, 29 with mild, 45 with moderate, and 35 with severe KC. In the FFKC, mild, moderate, and total groups, S_w and TRT for intraobserver repeatability were ≤ 0.18 μm and ≤ 0.50 μm, respectively. ICCs were ≥ 0.884 for most parameters except trefoil and astigmatism II. The S_w and TRT for interobserver reproducibility were ≤ 0.15 μm and ≤ 0.41 μm, respectively. ICCs were ≥ 0.917 except for trefoil and astigmatism II. In the severe group, the ICCs for intraobserver repeatability and interobserver reproducibility were 0.366 to 0.904 and 0.493 to 0.908.</p><p><strong>Conclusions: </strong>The new MS-39 device demonstrated moderate-to-good precision in corneal epithelial aberration measurements for FFKC, mild, moderate and total KC. Despite the decrease associated with increasing KC severity, the potential of the device for early diagnosis and monitoring was still evident. The instrument's precision should be tailored to disease severity. Stage-specific TRT thresholds for epithelial aberration measurements were proposed for KC management.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of modified pneumatic retinopexy with transscleral subretinal fluid drainage for primary rhegmatogenous retinal detachment.","authors":"Qintuo Pan, Renwan Liu, Huirong Pan, Meiqi Liu, Jiayi Wei, Saifei Zhang, Xuting Hu, Zhaoliang Zhang, Wei Chen, Zongduan Zhang","doi":"10.1186/s40662-026-00506-z","DOIUrl":"10.1186/s40662-026-00506-z","url":null,"abstract":"<p><strong>Background: </strong>Primary rhegmatogenous retinal detachment (RRD) occurs when a retinal tear or break causes fluid from inside the eye to seep behind the retina, which pushes it away from the wall of the eye. This can cause permanent vision loss if not treated. Which of three current interventions is optimal to treat RRD has not been established. We evaluated the anatomical and visual outcomes of a modified pneumatic retinopexy (mPnR) that drains fluid from beneath the retina to treat RRD.</p><p><strong>Methods: </strong>This retrospective single-center case series included 53 consecutive eyes of 53 patients with primary RRD who met the pneumatic retinopexy versus vitrectomy trial criteria. All patients underwent mPnR that comprised transscleral subretinal fluid drainage, intravitreal air injection, and postoperative laser photocoagulation of retinal breaks. The main outcome measures were single-surgery anatomical success rates and best-corrected visual acuity (BCVA) at 3 months postoperatively.</p><p><strong>Results: </strong>The single-surgery anatomical success rate was 51 of 53 (96.23%). Three months postoperatively, the median BCVA had significantly improved from a preoperative logarithm of the minimum angle of resolution (logMAR) of 0.10 (interquartile range [IQR], 0.00-0.60) to 0.02 (IQR, 0.00-0.20) (P < 0.001). The anatomic success rate was 100% for the macula-off subgroup (n = 20), as BCVA improved from 0.75 (IQR, 0.43-1.18) to 0.20 (IQR, 0.04-0.30) logMAR (P < 0.001). Two eyes (3.77%) with recurrent detachment and one eye (1.89%) with a secondary macular epiretinal membrane required subsequent pars plana vitrectomy.</p><p><strong>Conclusions: </strong>The mPnR procedure is efficient and minimally invasive, expansile gas is not required, and preliminary safety and efficacy profiles were favorable. Therefore, mPnR offers a simplified, feasible surgical option for treating eligible patients with primary RRD.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcomes of combined phacoemulsification and goniosynechialysis in primary angle-closure glaucoma with cataracts: a multicenter prospective study.","authors":"Kun Xiong, Wuliang Li, Qingyi Liu, Shaodan Zhang, Guoxing Li, Huiyan Mao, Qiangjie Huang, Qi'ao Zhang, Rongrong Le, Yanqian Xie, JingJing Zuo, Bo Yu, Yachen Wang, Xiaoping Xu, Xiaoli Xing, Lijun Zhao, Lu Yang, Yuanbo Liang, Ningli Wang","doi":"10.1186/s40662-026-00507-y","DOIUrl":"https://doi.org/10.1186/s40662-026-00507-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to observe the safety and effectiveness of combined phacoemulsification and goniosynechialysis (PEI-GSL) in patients with primary angle-closure glaucoma (PACG) and coexisting cataracts.</p><p><strong>Methods: </strong>This multicenter prospective study enrolled 289 consecutive patients with PACG and cataracts who were treated using PEI-GSL between November 1, 2022 and March 12, 2024. All patients underwent comprehensive ocular evaluations at baseline, at 1 week, and at 1, 3, 6, and 12 months postoperatively. Complete success was defined as achieving an intraocular pressure (IOP) of 6-18 mmHg without antiglaucoma medications or reoperation. Qualified success was similarly defined but allowed antiglaucoma medications.</p><p><strong>Results: </strong>Among patients with PACG, 237 (82.0%) of 289 completed a 12-month follow-up. The baseline IOP decreased from 22.9 ± 10.2 to 14.0 ± 3.1 mmHg at 12 months, and the number of antiglaucoma medications declined from 2.08 ± 1.23 to 0.14 ± 0.52. The complete and qualified success rates were 80.6% and 88.3%, respectively. Postoperative complications occurred in 49 (17.0%) patients; while 3 (1.0%) patients underwent yttrium-aluminum-garnet (YAG) laser capsulotomy and 6 (2.1%) required glaucoma surgery. Multivariate Cox regression analysis revealed that the anterior chamber depth (P = 0.044) and axial length (P = 0.050) were positively associated with qualified success. The complete and qualified success rates among patients with advanced PACG were 78.2% and 87.9%, respectively.</p><p><strong>Conclusion: </strong>We demonstrated that PEI-GSL is an effective and safe treatment for patients with PACG and coexisting cataracts, even in advanced stages.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148790098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}