Eye and Vision最新文献

{"title":"Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population.","authors":"Yinghao Yao, Xingyong Li, Lan Wu, Jia Zhang, Yuanyuan Gui, Xiangyi Yu, Yang Zhou, Xuefei Li, Xinyu Liu, Shilai Xing, Gang An, Zhenlin Du, Hui Liu, Shasha Li, Xiaoguang Yu, Hua Chen, Jianzhong Su, Shihao Chen","doi":"10.1186/s40662-024-00421-1","DOIUrl":"https://doi.org/10.1186/s40662-024-00421-1","url":null,"abstract":"<p><strong>Background: </strong>Keratoconus (KC) is a prevalent corneal condition with a modest genetic basis. Recent studies have reported significant genetic associations in multi-ethnic cohorts. However, the situation in the Chinese population remains unknown. This study was conducted to identify novel genetic variants linked to KC and to evaluate the potential applicability of a polygenic risk model in the Han Chinese population.</p><p><strong>Methods: </strong>A total of 830 individuals diagnosed with KC and 779 controls from a Chinese cohort were enrolled and genotyped by whole-genome sequencing (WGS). Common and rare variants were respectively subjected to single variant association analysis and gene-based burden analysis. Polygenic risk score (PRS) models were developed using top single-nucleotide polymorphisms (SNPs) identified from a multi-ethnic meta-analysis and then evaluated in the Chinese cohort.</p><p><strong>Results: </strong>The characterization of germline variants entailed correction for population stratification and validation of the East Asian ancestry of the included samples via principal component analysis. For rare protein-truncating variants (PTVs) with minor allele frequency (MAF) < 5%, ZC3H11B emerged as the top prioritized gene, albeit failing to reach the significance threshold. We detected three common variants reaching genome-wide significance (P ≤ 5 × 10^-8), all of which are novel to KC. Our study validated three well known predisposition loci, COL5A1, EIF3A and FNDC3B. Additionally, a significant correlation of allelic effects was observed for suggestive SNPs between the largest multi-ethnic meta-genome-wide association study (GWAS) and our study. The PRS model, generated using top SNPs from the meta-GWAS, stratified individuals in the upper quartile, revealing up to a 2.16-fold increased risk for KC.</p><p><strong>Conclusions: </strong>Our comprehensive WGS-based GWAS in a large Chinese cohort enhances the efficiency of array-based genetic studies, revealing novel genetic associations for KC and highlighting the potential for refining clinical decision-making and early prevention strategies.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"12 1","pages":"5"},"PeriodicalIF":4.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same-session dual chromophore riboflavin/UV-A and rose bengal/green light PACK-CXL in Acanthamoeba keratitis: a case report.","authors":"Farhad Hafezi, Jürg Messerli, Emilio A Torres-Netto, Nan-Ji Lu, M Enes Aydemir, Nikki L Hafezi, Mark Hillen","doi":"10.1186/s40662-024-00420-2","DOIUrl":"10.1186/s40662-024-00420-2","url":null,"abstract":"<p><strong>Background: </strong>Acanthamoeba keratitis (AK) is the most challenging corneal infection to treat, with conventional therapies often proving ineffective. While photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) with riboflavin/UV-A has shown success in treating bacterial and fungal keratitis, and PACK-CXL with rose bengal/green light has demonstrated promise in fungal keratitis, neither approach has been shown to effectively eradicate AK. This case study explores a novel combined same-session treatment approach using both riboflavin/UV-A and rose bengal/green light in a single procedure.</p><p><strong>Case presentation: </strong>A 44-year-old patient with active AK in the left cornea, unresponsive to 10 months of conventional treatment according to American Academy of Ophthalmology (AAO) guidelines, was treated using same-session sequential PACK-CXL with riboflavin/UV-A (365 nm) irradiation (10 J/cm²) and rose bengal/green light (522 nm) irradiation (5.4 J/cm²) in a single setting. The procedure was repeated twice due to persistent signs of inflammation and infection. After three combined same-session PACK-CXL treatments, the patient's cornea converted to a quiescent scar, and symptoms of ocular pain, photophobia, epiphora, and blepharospasm resolved. Confocal microscopy revealed no detectable Acanthamoeba cysts. The patient currently awaits penetrating keratoplasty.</p><p><strong>Conclusions: </strong>The same-session combination of riboflavin/UV-A and rose bengal/green light PACK-CXL effectively treated a patient with confirmed AK that was resistant to conventional medical therapy, suggesting that using two chromophores in a single procedure may represent a future treatment alternative for AK.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"12 1","pages":"2"},"PeriodicalIF":4.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between axial elongation and corneal topography in children undergoing orthokeratology with different back optic zone diameters.","authors":"Qi Tan, Randy Kojima, Pauline Cho, Stephen J Vincent","doi":"10.1186/s40662-024-00418-w","DOIUrl":"10.1186/s40662-024-00418-w","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the associations between myopia defocus dosage (MDD), aberration coefficients (primary spherical aberration and coma), and axial elongation in children undergoing orthokeratology (ortho-k) with back optic zone diameters (BOZD) of 5 mm and 6 mm over 2 years.</p><p><strong>Methods: </strong>Data from 80 participants from two ortho-k studies were analyzed: 22 and 58 children wore lenses with 5-mm and 6-mm BOZD, respectively. Four MDD metrics were calculated from corneal topography data over a 5-mm pupil for the 1-month and 24-month visits: the circumferential, flat, steep, and volumetric MDD. Corneal primary spherical aberration and comatic aberrations were also extracted from topography data over a 5-mm pupil. Linear mixed modelling was performed to explore the associations between the MDD, corneal aberrations, and axial elongation over 2 years, while controlling for confounding factors (e.g., baseline age and sex).</p><p><strong>Results: </strong>Participants in the 5-mm BOZD group displayed less axial elongation than the 6-mm BOZD group over 2 years (0.15 ± 0.21 mm vs. 0.35 ± 0.21 mm, P < 0.001). A greater volumetric MDD was observed in the 5-mm BOZD group compared with the 6-mm BOZD group at the 1- and 24-month visits (both P < 0.001). No significant differences were observed between the two groups for the other MDD metrics or corneal aberration coefficients (all P > 0.05). Less axial elongation was associated with a greater volumetric MDD at the 1- and 24-month visits (both β = -0.01, P < 0.001 and P = 0.001), but not with any other MDD metrics or corneal aberrations (all P > 0.05).</p><p><strong>Conclusions: </strong>The volumetric MDD over a 5-mm pupil after 1 month of ortho-k lens wear was associated with axial elongation after 24 months, and may be a useful predictor of future axial elongation in children undergoing ortho-k.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"12 1","pages":"3"},"PeriodicalIF":4.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the inverted internal limiting membrane flap technique without versus with an autologous blood clot for treating macular hole-associated retinal detachment.","authors":"Ke Zhu, Yingchao Wang, Boya Lei, Ling Chen, Yanqiong Zhang, Qing Chang, Gezhi Xu, Yingqin Ni","doi":"10.1186/s40662-024-00417-x","DOIUrl":"10.1186/s40662-024-00417-x","url":null,"abstract":"<p><strong>Background: </strong>To investigate the anatomical and functional outcomes of macular hole-associated retinal detachment (MHRD) after vitrectomy using the inverted internal limiting membrane (ILM) flap technique with autologous blood clot (ABC).</p><p><strong>Methods: </strong>This retrospective observational study included 80 eyes with MHRD that underwent vitrectomy with ILM flap without (46 eyes) or with ABC (34 eyes). Fundus photography and optical coherence tomography were evaluated. The pre- and postoperative best-corrected visual acuities (BCVAs) and BCVA improvement were compared between the two groups.</p><p><strong>Results: </strong>The MH closure rates after initial surgery were similar in the ILM flap group and ILM flap with ABC group [40 (87%) vs. 29 (85%) eyes, respectively]. The proportion of eyes with hyperreflective bridging tissue (HBT) was lower in the ILM flap group than ILM flap with ABC group [13 (32%) vs. 16 (55%) eyes, P = 0.060]. The postoperative improvement in BCVA was significantly better in the ILM flap group (P = 0.027). Multiple linear regression analysis revealed that preoperative BCVA was positively associated with postoperative improvement in BCVA (β = 0.638, P = 0.000), while the ILM flap with ABC technique was negatively associated with postoperative improvement in BCVA (β =  - 0.299, P = 0.039, adjusted r² = 0.415).</p><p><strong>Conclusions: </strong>The inverted ILM flap technique alone resulted in better foveal configurations and visual outcomes than the ILM flap technique combined with ABC in patients with MHRD.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"12 1","pages":"1"},"PeriodicalIF":4.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances and current challenges in suture and sutureless scleral fixation techniques for intraocular lens: a comprehensive review.","authors":"Han Sun, Caixia Wang, Hong Wu","doi":"10.1186/s40662-024-00414-0","DOIUrl":"10.1186/s40662-024-00414-0","url":null,"abstract":"<p><p>Over the past two decades, both suture and sutureless techniques for scleral fixation of intraocular lenses have seen significant advancement, driven by improvements in methodologies and instrumentation. Despite numerous reports demonstrating the effectiveness, safety, and superiority of these techniques, each approach carries with it its own drawbacks, including an elevated risk of certain postoperative complications. This article delves into various surgical techniques for scleral fixation of posterior chamber intraocular lenses, discussing their procedural nuances, benefits, drawbacks, postoperative complications, and outcomes. Furthermore, a comparative analysis between suture and sutureless fixation methods is presented, elucidating their respective limitations and associated factors. It is hoped that this comprehensive review will offer clinicians guidance on how to individualize procedural selection and mitigate surgical risks, and thus achieve optimal visual outcomes. This review will also endeavor to provide guidance for future advancements in intraocular lens fixation techniques.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"49"},"PeriodicalIF":4.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral occlusive retinal vasculitis secondary to intravitreal faricimab injection: a case report and review of literature.","authors":"Yong Min Lee, Rajya Gurung, Jagjit Singh Gilhotra, Sumu Simon, Sudha Cugati","doi":"10.1186/s40662-024-00416-y","DOIUrl":"10.1186/s40662-024-00416-y","url":null,"abstract":"<p><strong>Background: </strong>This article describes a rare occurrence of bilateral retinal occlusive vasculitis secondary to intravitreal faricimab injection.</p><p><strong>Case presentation: </strong>A 72-year-old female with age-related macular degeneration presented with bilateral retinal occlusive vasculitis following intravitreal faricimab injections. The patient was treated with 3 days of intravenous methylprednisolone followed by oral prednisolone taper and topical steroid therapy. Resolution of retinal occlusive vasculitis was observed 2 months post treatment.</p><p><strong>Conclusions: </strong>Retinal occlusive vasculitis is a rare complication of intravitreal anti-vascular endothelial growth factor (anti-VEGF), particularly with faricimab injections. We also present a review of literature regarding retinal occlusive vasculitis following intravitreal anti-VEGF injections and propose further information regarding its pathophysiology.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"48"},"PeriodicalIF":4.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing an objective decision criterion for intraocular lens exchange due to homogeneous calcification: a prospective clinical analysis.","authors":"Timur M Yildirim, Grzegorz Łabuz, Nikola Henningsen, Hyeck-Soo Son, Victor A Augustin, Leoni Britz, Lizaveta Chychko, Ramin Khoramnia, Gerd U Auffarth","doi":"10.1186/s40662-024-00415-z","DOIUrl":"https://doi.org/10.1186/s40662-024-00415-z","url":null,"abstract":"<p><strong>Background: </strong>Homogeneous intraocular lens (IOL) calcification deteriorates patient's visual quality. There is a lack of functional and patient-reported data on patients with this material change undergoing IOL exchange surgery. The aim of this study was to evaluate subjective and objective outcomes following IOL exchange due to homogeneous IOL calcification to improve evidence-based patient counseling.</p><p><strong>Methods: </strong>In this prospective, non-interventional, clinical study, 53 eyes of 42 patients with homogeneous IOL calcification were included. IOL exchange was performed in 30 out of 53 eyes. Subjective symptoms using a quality-of-life questionnaire (Catquest-9SF), photic phenomena, corrected distance visual acuity (CDVA), straylight (C-Quant, Oculus, Wezlar, Germany) and contrast sensitivity with and without glare (CSV-1000, VectorVision, Houston, USA) were assessed before (T0) and at 3 to 12 months after IOL exchange (T1).</p><p><strong>Results: </strong>Preoperative CDVA and straylight did not correlate. Average halo and glare size and intensity decreased and Catquest-9SF items improved. The CDVA rose significantly from 0.16 ± 0.13 to 0.05 ± 0.10 logMAR, and contrast sensitivity increased with and without glare. The straylight value decreased statistically and clinically significant from 2.32 ± 0.34 to 1.23 ± 0.33 log(s).</p><p><strong>Conclusion: </strong>Homogeneous IOL calcification is not always associated with a pronounced reduction in visual acuity. In most cases, IOL exchange still reduces subjective complaints and improves quality of vision of affected patients. Visual acuity should not be the sole functional parameter in assessing patients with homogeneous IOL calcification as intraocular straylight and contrast sensitivity can better objectify patients' visual impairment. We recommend a straylight value above 1.56 log(s) as a cut-off when deciding on an IOL exchange surgery.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"46"},"PeriodicalIF":4.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.","authors":"Haoru Li, Nan Gao, Ruixin Li, Luobu Luodian, Jinyuan Sui, Yang Bai, Di Wu, Qing He, Yuxin Wang, Zhiqing Li, Ruihua Wei","doi":"10.1186/s40662-024-00413-1","DOIUrl":"https://doi.org/10.1186/s40662-024-00413-1","url":null,"abstract":"<p><strong>Background: </strong>To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.</p><p><strong>Methods: </strong>This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis. Logistic regression analysis and machine learning were applied to explore the risk factors for PS and its progression.</p><p><strong>Results: </strong>Patients in the PS group exhibited faster growth rates of spherical equivalent refraction (SER), axial length (AL), curvature index (CI), and posterior scleral height (PSH) as well as higher loss rates of choriocapillaris perfusion area (CCPA), choroid perfusion area (CPA) and choroidal vascularity index (CVI) compared to the NPS group (all P < 0.05). The baseline SER (B =  - 1.291, OR = 0.275, P = 0.008), baseline subfoveal scleral thickness (B =  - 1.621, OR = 0.198, P = 0.046), baseline PSH (B = 2.959, OR = 19.282, P = 0.001) and foveal CVI changes per year (B =  - 2.776, OR = 0.062, P < 0.001) were the risk factors for PS. Baseline AL (B = 0.561, OR = 1.752, P = 0.033), parafoveal choroidal thickness changes per year (B =  - 0.094, OR = 0.910, P = 0.032), foveal retinal vascular density changes per year (B = 0.104, OR = 1.110, P = 0.013) and foveal CCPA changes per year (B =  - 0.214, OR = 0.807, P = 0.038) were the risk factors for the PS progression.</p><p><strong>Conclusions: </strong>During the progression of myopia in adults, changes in the morphology of the eye's posterior pole are not limited to axial lengthening alone; there also will be a phase of compensatory lateral expansion. Baseline AL and changes in the microcirculation can be utilized to predict the progression of PS.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levodopa is associated with reduced development of new-onset geographic atrophy in patients with age-related macular degeneration.","authors":"Kyle S Chan, Nitika Aggarwal, Shannon Lawson, Nick Boucher, Mathew W MacCumber, Jeremy A Lavine","doi":"10.1186/s40662-024-00412-2","DOIUrl":"10.1186/s40662-024-00412-2","url":null,"abstract":"<p><strong>Background: </strong>Geographic atrophy (GA) is a significant cause of vision loss in patients with age-related macular degeneration (AMD). Current treatments are limited to anti-complement drugs, which have limited efficacy to delay progression with significant risk of complications. Levodopa (L-DOPA) is a byproduct of melanin synthesis that is associated with reduced development of neovascular AMD. In this study, we determined if L-DOPA was associated with a reduced likelihood of new-onset GA.</p><p><strong>Methods: </strong>We performed a retrospective analysis in the Vestrum Health Retina Database. We included eyes with non-neovascular AMD without GA and 1-5 years of follow-up. Eyes were divided into two groups. Exposed to L-DOPA before or on the date of non-neovascular AMD without GA diagnosis, and eyes not exposed to L-DOPA. We extracted age, sex, AREDS2 status, dry AMD stage, smoking history, and conversion rate to GA at years 1 through 5. Propensity score matching was used to match L-DOPA and control groups. Cox proportional hazard regression, adjusting for age, sex, AMD severity, AREDS2 use, smoking status, and L-DOPA use was employed to calculate hazard ratios for new-onset GA detection.</p><p><strong>Results: </strong>We identified 112,089 control and 844 L-DOPA exposed eyes with non-neovascular AMD without GA. After propensity score matching, 2532 control and 844 L-DOPA exposed eyes remained that were well-matched for age, sex, AMD severity, AREDS2 use, and smoking status. We found that L-DOPA exposure was associated with a significantly reduced likelihood (HR = 0.68, 95% CI: 0.48-0.95, P = 0.025) of new-onset GA detection.</p><p><strong>Conclusion: </strong>L-DOPA use was associated with reduced detection of new-onset GA.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring optical coherence tomography parameters in eyes with myopic tilted disc.","authors":"Yu Qiao Zhang, Xiu Juan Zhang, Ru Yue Shen, Yuzhou Zhang, Fang Yao Tang, Simon K H Szeto, Danny Siu-Chun Ng, Ka Wai Kam, Alvin L Young, Li Jia Chen, Chi Pui Pang, Clement C Tham, Jason C Yam, Poemen P Chan","doi":"10.1186/s40662-024-00411-3","DOIUrl":"10.1186/s40662-024-00411-3","url":null,"abstract":"<p><strong>Background: </strong>To investigate the impact of optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) on different retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) segments in healthy myopic eyes.</p><p><strong>Methods: </strong>ODT and OI were measured from fundus photographs. HDT angle, peripapillary RNFL, and macular GCIPL were measured by swept-source optical coherence tomography (SS-OCT). The association between optic disc morphology and the RNFL/GCIPL thickness were evaluated, with age and axial length (AL) adjusted.</p><p><strong>Results: </strong>Among 530 healthy myopic eyes of 284 participants (mean age: 41.7 years, mean spherical equivalent: - 7.70 D, and mean AL: 26.6 mm), 335 eyes (63.2%) had temporal disc torsion (temporal group) and 195 eyes (36.8%) had nasal disc torsion (nasal group). For the nasal group, a larger OI was associated with thinner superior-to-superonasal GCIPL (β = - 7.465 to - 6.972, both P = 0.024) and temporal RNFL sectors (β = - 49.596 to - 27.748, P ≤ 0.014). For the temporal group, a larger OI was associated with thinner superior-to-nasal (β = - 50.255 to - 22.093, P ≤ 0.006) and thicker temporal RNFL sectors (β = 29.015 to 56.890, P ≤ 0.003). Additionally, a larger HDT angle was associated with thinner superior-to-nasal RNFL sectors (β = - 0.559 to - 0.242, P ≤ 0.036) and thinner superior-to-superotemporal GCIPL sectors (β = - 0.084 to - 0.069, P ≤ 0.037).</p><p><strong>Conclusions: </strong>The optic disc tortional direction was associated with the measurement of different RNFL and GCIPL sectors independent of the AL and age. These should be considered when constructing a myopic normative database.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":"11 1","pages":"47"},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}