Food & Nutrition Research最新文献

{"title":"Maternal and infant serum ferritin concentrations across pregnancy and postpartum: a longitudinal study in Norway.","authors":"Synnøve Næss Sleire, Inger Aakre, Lisbeth Dahl, Tonje Eiane Aarsland, Rebekka Sandvik, Marian Kjellevold, Maria Wik Markhus","doi":"10.29219/fnr.v70.14217","DOIUrl":"10.29219/fnr.v70.14217","url":null,"abstract":"<p><strong>Introduction: </strong>Adequate iron status is particularly important during pregnancy and infancy, as iron deficiency can pose health risks to the woman, developing fetus, and future child. However, data in these population groups are scarce in Norway.</p><p><strong>Aim: </strong>To describe serum ferritin concentrations in a cohort of pregnant women in Norway, followed through the postpartum period, and their infants. Further, to examine associations between maternal and infant serum ferritin concentrations, and to assess the influence of dietary supplement use and breastfeeding status on serum ferritin levels.</p><p><strong>Methods: </strong>In this longitudinal cohort study, 137 pregnant women in Norway were enrolled and followed at gestational week 18 and 36, and at 3 and 6 months postpartum together with their infants. Infant and maternal serum ferritin concentrations were measured.</p><p><strong>Results: </strong>At gestational week 18, 14% of pregnant women were iron deficient (serum ferritin < 15 µg/L), and 44% had depleted iron stores (< 30 µg/L). By gestational week 36, the prevalence of iron deficiency had increased to 65% and depleted stores to 95%. Infant ferritin concentrations declined between 3 and 6 months of age. At 3 months, 96% of infants had sufficient iron status (≥ 50 µg/L). At 6 months, 90% remained sufficient, while 10% were iron deficient (< 15 µg/L). No associations were observed between iron status and dietary iron supplement use or breastfeeding status.</p><p><strong>Conclusion: </strong>A substantial proportion of the women were found to have iron deficiency, and depleted iron stores both during pregnancy and the postpartum period measured by serum ferritin concentrations. In contrast, the infants generally showed adequate iron status, and although serum ferritin levels declined between 3 and 6 months of age, the prevalence of iron deficiency remained low.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13325958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of diet on the modulation of gut microbiota and its neurobiological effects on cognition: a systematic review and meta-analysis.","authors":"Alexander Pabón Moreno, Edgar Fabián Manrique-Hernández, Maricel Licht-Ardila, Alexandra Hurtado-Ortiz, Melissa Melinna Gómez Arrieta, Rhonald Gómez Caballero, Sol Ochoa, Diana Carolina Tiga Loza, Silvana Teresa Tapia Paniagua, Hernan Guillermo Hernández Hincapié","doi":"10.29219/fnr.v70.13843","DOIUrl":"10.29219/fnr.v70.13843","url":null,"abstract":"<p><strong>Introduction: </strong>The gut microbiota, a key regulator of the gut-brain axis, is profoundly influenced by diet, and its modulation through dietary patterns may play a critical role in mitigating mild cognitive impairment (MCI).</p><p><strong>Objective: </strong>To evaluate whether dietary interventions modify gut microbiota composition in individuals with MCI and to determine whether these microbiota changes are associated with variations in cognitive function.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Randomized clinical trials and observational studies evaluating dietary exposures, gut microbiota, and cognitive outcomes in adults with MCI were included. Data extraction and risk-of-bias assessment were performed using standardized and validated tools. When applicable, pooled effects on cognition were estimated using random-effects models and between-study heterogeneity was quantified.</p><p><strong>Results: </strong>Of 3,029 records identified, 11 studies met the inclusion criteria (nine randomized trials and two observational studies), with a weighted mean age of 65.24 years. Gut microbiota differed between normal cognition and MCI-beneficial taxa (e.g. <i>Bifidobacterium, Faecalibacterium</i>) predominated in normal cognition, while potentially taxa more frequently reported in pro-inflammatory/dysbiosis-associated profiles (e.g. <i>Ruminococcus, Enterobacteriaceae</i>) were higher in MCI. The pooled effect showed a trend favoring dietary interventions (standardized mean difference = -0.32 (95% CI: -0.92 to 0.28)), although this did not reach statistical significance.</p><p><strong>Conclusion: </strong>This review highlights the potential role of diet in modulating gut microbiota and its impact on cognition in MCI, emphasizing the need for standardized interventions and further research to clarify the underlying mechanisms.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13325949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of SRW^® Stem on the functional properties, oxidative stress and inflammation of human umbilical cord mesenchymal stem cells.","authors":"Yoann Birling, Greg Macpherson, Jonathan Lim, Hongbin Qi, Deep Bhuyan, Julie Chen","doi":"10.29219/fnr.v70.14068","DOIUrl":"10.29219/fnr.v70.14068","url":null,"abstract":"<p><strong>Background: </strong>Global population ageing has heightened the demand for anti-ageing nutritional interventions. Science Research Wellness (SRW^®) Stem was designed by SRW^® to address this demand with ingredients that improve stem cell function, which is central to protection against age-related decline. These ingredients include mitoquinol, sea buckthorn extract, fucoidan, oleuropein, and vitamin D3.</p><p><strong>Objectives: </strong>We compared the effects of SRW^® Stem on the functions of human umbilical cord mesenchymal stem cells (hUC-MSCs) with those of mitoquinol alone, which is known to improve these functions.</p><p><strong>Design: </strong><i>In vitro</i> assays, including CCK-8 for cell viability, trypan blue exclusion, colony formation, transwell migration, adipogenic differentiation, ROS/glutathione analysis, and cytokine profiling under oxidative stress, were used to assess proliferation, migration, and differentiation capacities, as well as antioxidant and anti-inflammatory activity of the SRW^® Stem.</p><p><strong>Results: </strong>Results demonstrated that SRW^® Stem 5 and 10 μg/mL significantly (<i>P</i> < 0.05 for all) enhanced proliferation, colony formation, and migration, and promoted adipogenic differentiation in the hUC-MSCs, compared with vehicle control and mitoquinol (positive control). Under oxidative stress, SRW^® Stem significantly reduced (<i>P</i> < 0.001 for all) intracellular ROS, increased glutathione synthesis, suppressed IL-1β secretion, and restored IL-10 production in hUC-MSCs.</p><p><strong>Discussions: </strong>These findings indicated that SRW^® Stem 5 and 10 μg/mL exerts antioxidant, anti-inflammatory, and pro-regenerative effects on hUC-MSCs, outperforming mitoquinol across most parameters.</p><p><strong>Conclusions: </strong>The results highlighted the potential of SRW^® Stem as an anti-ageing intervention and a supportive agent in stem cell-based therapies. Further investigations in animal models and clinical trials are warranted to validate its efficacy.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments.","authors":"Jinwu Bai, Jixing Fan, Ruideng Wang, Shilong Su, Daole Hu, Xi He, Shan Gao, Fang Zhou","doi":"10.29219/fnr.v70.13033","DOIUrl":"10.29219/fnr.v70.13033","url":null,"abstract":"<p><p>Excessive and chronic inflammation can cause osteogenic dysfunction and disrupt the balance of the osteoimmune microenvironment, thereby increasing the risk of fracture non-union. Urolithin A (UA), a gut microbiota-derived metabolite produced from dietary sources, has been reported to inhibit RANKL-induced osteoclastogenesis and alleviate postmenopausal osteoporosis. However, the effect of UA on osteogenesis, particularly under pathogenic inflammatory conditions, remains unclear. In this study, mouse bone marrow-derived mesenchymal stromal cells (mBMSCs) were used to evaluate osteogenesis <i>in vitro</i>, and RAW 264.7 cells were used as macrophages <i>in vitro</i>. Tumour necrosis factor (TNF)-<i>α</i> was used to establish an inflammatory environment. <i>In vivo</i>, a mouse femur fracture model with local TNF-<i>α</i> injection was established, and UA or vehicle was administered by intragastric gavage. The UA showed no obvious effect on cell viability at concentrations ranging from 0 to 10 μM and had no direct effect on the osteogenic differentiation of mBMSCs. TNF-<i>α</i> treatment significantly decreased the expression of osteogenesis-related genes and proteins and inhibited calcium deposition, whereas UA reversed this inhibitory effect in a dose-dependent manner. Mechanistically, UA inhibited activation of the TNF-<i>α</i>-induced nuclear factor-<i>κ</i>B signalling pathway. Furthermore, UA reduced pro-inflammatory cytokine levels and inhibited type-1 macrophage polarisation under TNF-<i>α</i>-induced inflammatory conditions. Conditioned medium derived from RAW 264.7 cells stimulated with TNF-<i>α</i> after UA treatment promoted the osteogenic differentiation of mBMSCs. <i>In vivo</i>, local administration of TNF-<i>α</i> significantly impaired bone fracture healing in the mouse femur fracture model, whereas intragastric supplementation with UA improved fracture healing and reduced pro-inflammatory responses. Collectively, these findings demonstrated that UA alleviates osteogenic dysfunction through inhibition of the nuclear factor-<i>κ</i>B signalling pathway and regulation of macrophage-mediated inflammation under TNF-<i>α</i>-induced inflammatory conditions, thereby promoting osteogenesis and fracture healing.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effect of insulin resistance in the relationship between dietary inflammatory index and cardiovascular-kidney-metabolic syndrome stage in US adults, 2007-2018.","authors":"Ying Xiao, Hongzhao You, Tianjie Wang, Yan Zeng, Yingxuan Zhu, Rui Zhang, Dong Liu, Yanyan Zhao, Yilu Liu, Shijie You, Bokang Qiao, Jiansong Yuan, Weixian Yang","doi":"10.29219/fnr.v70.13744","DOIUrl":"10.29219/fnr.v70.13744","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome is a progressive, five-stage disease framework driven by interrelated cardiovascular, renal, and metabolic dysfunction, with chronic inflammation and insulin resistance (IR) playing key roles. The dietary inflammatory index (DII) quantifies overall dietary inflammatory potential, but its role in CKM staging remains unclear.</p><p><strong>Objective: </strong>This study aimed to evaluate the association between DII and CKM syndrome stage and to assess the potential mediating effect of IR.</p><p><strong>Design: </strong>This cross-sectional study used data from the National Health and Nutrition Examination Survey (2007-2018). DII was derived from 24-h dietary recall. CKM stages were defined by the American Heart Association criteria. IR was assessed using the triglyceride-glucose index (TyG), Metabolic Score for IR (METS-IR), and Homeostatic Model Assessment for IR (HOMA-IR). Statistical analyses were performed after accounting for the complex survey design.</p><p><strong>Results: </strong>Of the 27,635 participants, 94.08% had CKM syndrome (Stage 1 or higher). Compared with Stage 0, stepwise increases in the adjusted odds ratios for a higher DII score were observed across CKM stages (Q4 vs. Q1: 1.67 [1.31-2.15] for Stage 1; 2.11 [1.63-2.73] for Stage 2; 2.32 [1.08-4.98] for Stage 3; and 4.19 [2.65-6.63] for Stage 4). Restricted cubic splines models confirmed the positive linear association between DII and each CKM stage (all <i>P</i> _overall < 0.05; <i>P</i> _non-linear > 0.05), with increasingly steep slopes at higher stages. TyG, METS-IR, and HOMA-IR mediated 30.7, 45.0, and 25.3% of the association between DII and CKM syndrome stage, respectively.</p><p><strong>Conclusions: </strong>Pro-inflammatory diet, as indicated by a higher DII score, was positively associated with more advanced CKM syndrome stage, partly mediated by IR. The DII may serve as a practical measure of dietary inflammation in CKM management.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based <i>Melissa officinalis</i> supplement: a secondary analysis in a subpopulation.","authors":"Giuseppe Mazzola, Mariangela Rondanelli, Alessandro Lazzarotti, Paola Misiano, Giovanna Petrangolini, Simone Perna","doi":"10.29219/fnr.v70.14023","DOIUrl":"10.29219/fnr.v70.14023","url":null,"abstract":"<p><strong>Background: </strong>Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, as indicated by altered salivary cortisol secretion, has been linked to poor sleep quality, mood disturbances, and emotional distress. In the principal clinical trial, 3 weeks of Melissa phospholipids' supplementation was associated with significant improvements in sleep quality and mood outcomes.</p><p><strong>Objective: </strong>This study aimed to evaluate salivary cortisol dynamics in a subpopulation supplemented with <i>Melissa officinalis</i> extract formulated in phospholipids for 3 weeks.</p><p><strong>Design: </strong>This secondary analysis evaluated a predefined subgroup (<i>n</i> = 12) receiving 400 mg/day of Melissa phospholipids for 3 weeks. Salivary cortisol was collected at 3 timepoints at baseline (T0), week 1 (T1), and week 3 (T2), and quantified by high-sensitivity enzyme-linked immunosorbent assay (ELISA). Associations between cortisol levels and psychometric outcomes were also assessed.</p><p><strong>Results: </strong>Mean salivary cortisol levels decreased progressively over the 3-week supplementation period, with a significant main effect of time (<i>P</i> < 0.001). Significant correlations (<i>P</i> < 0.05) were also observed between psychometric domains, including PSQI, DASS-21 depression and stress, PANAS, WEMWBS, and WHOQoL-BREF scores, indicating consistent improvements in sleep quality, mood, and perceived well-being.</p><p><strong>Discussion and conclusions: </strong>This secondary analysis provides preliminary evidence that Melissa phospholipids supplementation, is associated with a significant modulation of HPA axis activity, characterized by a reduction in daily salivary cortisol levels, in adults with poor sleep quality and emotional distress.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating home-delivered meal service programs for obesity: a randomized controlled approach.","authors":"Merve Çapaş, Aylin Ayaz","doi":"10.29219/fnr.v70.12024","DOIUrl":"10.29219/fnr.v70.12024","url":null,"abstract":"<p><strong>Background: </strong>Though a healthy diet is the most effective solution for obesity, it is hindered by two main barriers: difficulty in accessing or preparing healthy meals and lack of portion control knowledge.</p><p><strong>Objective: </strong>This study compared two different medical nutrition therapies (home-delivered diet meal service [HDMS] combined with dietary counseling and dietary counseling solely) in terms of anthropometric measurements, biochemical parameters and eating behaviors in women with overweight or obesity who participated in a weight loss program.</p><p><strong>Design: </strong>A non-randomized, controlled, parallel-group intervention study was conducted with 60 women aged 25-45 years, having a Body Mass Index (BMI) of 25-35 kg/m², representing individuals with overweight and class I obesity. Participants were divided into two groups: an intervention group receiving HDMS combined with dietary counseling (<i>n</i> = 30) and a control group receiving dietary counseling solely (<i>n</i> = 30). Anthropometric measurements, bioelectrical impedance analysis (BIA), and dietary and physical activity records were monitored throughout the 8-week intervention, while comprehensive assessments including biochemical parameters (fasting blood glucose, homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile), resting metabolic rate (RMR) (FITMATE), and eating behaviors assessed using the Three-Factor Eating Questionnaire (TFEQ) were conducted at baseline, week 4, and week 8.</p><p><strong>Results: </strong>Both groups showed significant reductions over time in body weight, BMI, waist circumference, hip circumference, body fat percentage, RMR, blood glucose, lipid parameters, and blood pressure values (<i>P</i> < 0.001). Although greater reductions were observed in the HDMS group, the differences between groups were not statistically significant (<i>P</i> > 0.05). When considering the group-time interaction, changes in waist circumference (<i>P</i> < 0.001), hip circumference (<i>P</i> < 0.05), RMR (<i>P</i> < 0.05), fasting blood glucose (<i>P</i> < 0.05), low-density lipoprotein (LDL), cholesterol (<i>P</i> < 0.05), and systolic blood pressure (<i>P</i> < 0.05) were found to be significant in the HDMS group. In addition, when examining eating behaviors, statistically significant changes were observed in the intervention group for both time effects and behavior outcomes. Uncontrolled eating and emotional eating behaviors decreased, while cognitive restraint increased (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Both interventions improved anthropometric and metabolic parameters, with greater reductions observed in the HDMS group; however, the differences between groups were not statistically significant. HDMS may be considered a practical approach to support weight management.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Gochujang</i> elicits anti-cancer effects via distinct molecular mechanisms across different gastrointestinal cancer cell types.","authors":"Chan-Ho Park, Eun-Bi Seo, Su-Bin Lee, Anna Han","doi":"10.29219/fnr.v70.13691","DOIUrl":"10.29219/fnr.v70.13691","url":null,"abstract":"<p><p>Gastrointestinal (GI) cancers, including gastric, hepatic, and pancreatic cancers, account for a substantial proportion of cancer-related global morbidity and mortality. Dietary habits and bioactive food components significantly influence cancer initiation and progression. As a representative Korean traditional fermented food (KTFF), <i>Gochujang</i> exhibits multiple health benefits, including anti-mutagenic effects; however, its detailed cellular and molecular mechanisms of anti-cancer effects across different GI cancer cell types remain unclear. The radical scavenging activity of <i>Gochujang</i> extract (GE) was ABTS: 2.86-31.84% and DPPH: 7.95-52.79%. In addition, total phenolic and flavonoid contents of GE were 6.94 ± 0.23 mg GAE/g and 9.28 ± 0.72 mg RE/g, respectively. GE markedly inhibited cell viability, migration, and colony formation in all GI cancer cell lines, including gastric cancer (AGS and SNU-668), hepatic cancer (HepG2 and Hep3B), and pancreatic cancer (MIA PaCa-2). Furthermore, GE markedly reduced the expression of cell proliferation-related proteins and changed the levels of apoptosis-involved proteins in AGS, Hep3B, and MIA PaCa-2 cells, indicating its multifaceted anti-cancer activity. Interestingly, GE significantly altered the expression of antioxidant enzymes and increased reactive oxygen species (ROS) production in gastric and hepatic cancer cells, but these effects of GE were not observed in pancreatic cancer cells. In conclusion, these findings demonstrate that <i>Gochujang</i> exerts comprehensive anti-cancer effects across gastric, hepatic, and pancreatic cancer cells through the coordinated inhibition of proliferation-, migration-, and survival-related mechanisms, while additionally regulating ROS metabolism in a distinctly cell type-specific manner.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFTA2 reduced colorectal cancer ferroptosis promoting metastasis through regulating EMT transition by degradation of Nrf2.","authors":"Jian Huang, Guihua Wei, Shengxun Mao","doi":"10.29219/fnr.v70.13267","DOIUrl":"10.29219/fnr.v70.13267","url":null,"abstract":"<p><p>Colon cancer is a common malignancy of the digestive system, tumor disease, and its prevalence in China shows a consistently increasing trend. This study aimed to investigate the role of surfactant associated 2 (SFTA2) in colorectal cancer (CRC) and its molecular mechanism involving ferroptosis. Colon cancer tissues were obtained from patients and normal volunteers from our hospital, and a mouse model of CRC was established using azoxymethane (AOM)/dextran sulfate sodium (DSS) induction. SFTA2 expression was significantly up-regulated at both the messenger RNA (mRNA) and protein levels in CRC tissues and cell lines. Patients with high SFTA2 expression exhibited a shorter survival time compared to those with low SFTA2 expression. SFTA2 was found to be expressed in cancer cells of CRC patients, associated with key signaling molecules. Sh-SFTA2 reduced cancer proliferation in the mice model of CRC. SFTA2 up-regulation promoted cell proliferation of CRC. SFTA2 down-regulation promoted cell proliferation of CRC. SFTA2 up-regulation reduced oxidative stress and ferroptosis of CRC. SFTA2 up-regulation reduced ferroptosis of CRC through mitochondrial damage-tricarboxylic acid cycle (TAC). SFTA2 down-regulation suppressed nuclear factor erythroid 2-related factor 2 (Nrf2) expression in the model of CRC. SFTA2 up-regulation reduced Nrf2 ubiquitination in the model of CRC. Nrf2 reversed the effects of si-SFTA2 on ferroptosis of CRC. Furthermore, SFTA2 down-regulation suppressed Nrf2 expression, while SFTA2 up-regulation decreased Nrf2 ubiquitination in the CRC model. Nrf2 was shown to reverse the pro-ferroptotic effects of si-SFTA2, indicating that SFTA2 activates the Nrf2 pathway by inhibiting its ubiquitination, thereby reducing mitochondrial damage and TCA cycle disruption in CRC. SFTA2 induced the Nrf2 pathway to reduce mitochondrial damage-TAC of the CRC model through the inhibition of Nrf2 ubiquitination. SFTA2 is thus a potentiallyeffective therapeutic strategy for patients with CRC or other cancers.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":"13267"},"PeriodicalIF":4.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary acid load with diabetes and glucose metabolism index in Chinese adults: a cross-sectional study.","authors":"Shengqi Jia, Yuqin Shi, Xiang Ma, Qiuyin Chen, Weijia Huang, Yulan Zeng, Ping Wang","doi":"10.29219/fnr.v70.13470","DOIUrl":"10.29219/fnr.v70.13470","url":null,"abstract":"<p><strong>Background: </strong>Dietary acid load (DAL) has been proven to be associated with hypertension, chronic kidney disease, gout, and the prevalence of type 2 diabetes in several countries. However, its relationship with the prevalence of prediabetes and diabetes in the Chinese population, as well as with fasting blood glucose, fasting insulin levels, and insulin resistance-related indicators, remains unclear.</p><p><strong>Method: </strong>This is a cross-sectional study based on the China Health and Nutrition Survey (CHNS), which uses Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) to assess DAL. Logistic regression was employed to analyze the relationship between DAL and prediabetes as well as diabetes. Linear regression was used to examine the associations between DAL and fasting blood glucose, fasting insulin levels, estimated glucose disposal rate (eGDR), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and the TyG index in the affected population. Restricted cubic spline (RCS) curves were utilized to explore potential nonlinear relationships, and mediation analysis was conducted to investigate the mediating role of insulin resistance in the effects of DAL on fasting blood glucose and insulin. Finally, the findings were validated and compared using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Results: </strong>Higher PRAL (odds ratio [OR]: 1.004, 95% confidence interval [CI]: 1.002-1.006) and NEAP (OR: 1.009, 95% CI: 1.005-1.012) were associated with an increased prevalence of diabetes and prediabetes. Elevated levels of PRAL and NEAP were also correlated with higher fasting blood glucose levels and a lower eGDR. Moreover, eGDR played a significant mediating role in the effect of DAL on fasting blood glucose (PRAL: 69.74%, <i>P</i> = 0.048; NEAP: 65.75%, <i>P</i> = 0.004). However, this phenomenon was not significant in the US population, indicating differences between Chinese and American populations.</p><p><strong>Conclusion: </strong>High DAL is significantly associated with an increased prevalence of diabetes and prediabetes in the Chinese population, and it influences fasting blood glucose levels in affected individuals by reducing the eGDR. These findings highlight the clinical importance of regulating acid-producing diets to help manage blood glucose levels in individuals with diabetes.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"70 ","pages":"13470"},"PeriodicalIF":4.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}