Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database.

IF 3.5 4区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food & Nutrition Research Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.29219/fnr.v68.10338

Xiaolei Zhang, Jiangwen Wu, Ting Wu, Liwen Guo, Ruiping Zhang, Xin Jin

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引用次数: 0

Abstract

Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach.

Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables.

Results: A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines (P < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991-0.998, P = 0.001), never smokers (OR: 0.991, 95% CI: 0.985-0.997, P = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987-0.999, P = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines.

Conclusion: We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines.

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25-羟基维生素D与严重头痛或偏头痛的相关性：来自NHANES数据库的证据。

目的：本研究的目的是阐明25-羟基维生素D （25(OH)D）与严重头痛或偏头痛的发生之间的相关性，采用横断面分析方法。方法：利用2001年至2004年间进行的全国健康与营养检查调查（NHANES）的数据，对7661名参与者进行了为期两个周期的横断面调查。采用加权逻辑回归方法建立了两个变量之间的关系模型。通过分层分析进行亚组分析，调整混杂因素，探讨25(OH)D与严重头痛或偏头痛之间的关系。最后，利用有限三次样条回归（RCS）分析了各变量之间的非线性关系。结果：共有7661名参与者被纳入本研究，严重头痛或偏头痛的总体患病率为1576 / 7661（22.3%）。所有模型的结果一致表明血清25(OH)D水平与严重头痛或偏头痛的风险呈显著负相关（P < 0.05）。分层分析显示，在女性人群（优势比[OR]: 0.995, 95% CI: 0.991-0.998, P = 0.001）、从不吸烟者（OR: 0.991, 95% CI: 0.985-0.997, P = 0.003）和不饮酒者（OR: 0.993, 95% CI: 0.987-0.999, P = 0.022）中，严重头痛或偏头痛的风险随着血清25(OH)D浓度的增加而降低。RCS结果显示血清25(OH)D水平与严重头痛或偏头痛的风险呈线性关系。结论：我们发现血清25(OH)D水平与严重头痛或偏头痛患病率呈负相关，特别是在女性、非吸烟者和非高血压个体中。需要进一步的临床研究来证实这些发现，建立因果关系，并探索偏头痛的潜在预防和治疗机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food & Nutrition Research FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS

CiteScore

5.20

自引率

9.10%

发文量

审稿时长

14 weeks

期刊介绍： Food & Nutrition Research is a peer-reviewed journal that presents the latest scientific research in various fields focusing on human nutrition. The journal publishes both quantitative and qualitative research papers. Through an Open Access publishing model, Food & Nutrition Research opens an important forum for researchers from academic and private arenas to exchange the latest results from research on human nutrition in a broad sense, both original papers and reviews, including: * Associations and effects of foods and nutrients on health * Dietary patterns and health * Molecular nutrition * Health claims on foods * Nutrition and cognitive functions * Nutritional effects of food composition and processing * Nutrition in developing countries * Animal and in vitro models with clear relevance for human nutrition * Nutrition and the Environment * Food and Nutrition Education * Nutrition and Economics Research papers on food chemistry (focus on chemical composition and analysis of foods) are generally not considered eligible, unless the results have a clear impact on human nutrition. The journal focuses on the different aspects of nutrition for people involved in nutrition research such as Dentists, Dieticians, Medical doctors, Nutritionists, Teachers, Journalists and Manufacturers in the food and pharmaceutical industries.