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Blood circulation effect of fermented citrus bioconversion product (FCBP) in EA.hy926 endothelial cells and high-fat diet-fed mouse model. 发酵柑橘生物转化产物(FCBP)对 EA.hy926 内皮细胞和高脂饮食喂养小鼠模型的血液循环影响。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10682
Eun-Chae Cho, Hyuck Se Kwon, Na Young Lee, Hyun Jeong Oh, Yean-Jung Choi
{"title":"Blood circulation effect of fermented citrus bioconversion product (FCBP) in EA.hy926 endothelial cells and high-fat diet-fed mouse model.","authors":"Eun-Chae Cho, Hyuck Se Kwon, Na Young Lee, Hyun Jeong Oh, Yean-Jung Choi","doi":"10.29219/fnr.v68.10682","DOIUrl":"https://doi.org/10.29219/fnr.v68.10682","url":null,"abstract":"<p><strong>Background: </strong>The escalating global burden of cardiovascular diseases, largely driven by unhealthy lifestyle choices and dietary patterns, has intensified the search for effective and safe interventions. With current treatments often marred by significant side effects, the exploration of natural compounds such as flavonoids presents a compelling alternative.</p><p><strong>Objective: </strong>This study investigated the effects of fermented citrus bioconversion product (FCBP), a fermented citrus bioflavonoid, on various markers of cardiovascular health in the context of a high-fat diet.</p><p><strong>Design: </strong><i>In vivo</i>, a high-fat diet-induced mouse model was used to assess the effects of FCBP on body weight, serum nitric oxide (NO) levels, activated partial thromboplastin time (aPTT), phosphatidylserine (PS) exposure on red blood cells, and the expression of inflammatory markers Intercellular Adhesion Molecule (ICAM)-1 and Vascular Cell Adhesion Molecule (VCAM)-1 in the thoracic aorta. <i>In vitro</i>, EA.hy926 endothelial cells were used to evaluate the compound's effects on cell viability, NO production, endothelial nitric oxide synthase (eNOS) expression, and cell adhesion molecule (CAM) levels to further understand the mechanisms behind the <i>in vivo</i> findings.</p><p><strong>Results: </strong><i>In vivo</i>, FCBP supplementation led to a dose-dependent reduction in weight gain, a significant decrease in serum NO levels at 10 mg/kg, and reduced ICAM-1 and VCAM-1 expressions in the thoracic aorta, indicating anti-inflammatory properties. PS exposure on red blood cells was also reduced, suggesting decreased procoagulant activity, while aPTT remained unchanged. <i>In vitro</i>, FCBP was non-cytotoxic to endothelial cells, showed a trend toward increased NO production and eNOS expression, and reduced the expression of ICAM-1 and VCAM-1, supporting its potential anti-inflammatory effects.</p><p><strong>Conclusions: </strong>FCBP demonstrates potential as a bioactive compound for managing cardiovascular health by reducing inflammation, mitigating weight gain, and influencing blood circulation-related parameters under high-fat diet conditions. Further studies, including diverse models and human trials, are warranted to elucidate its mechanisms and compare its efficacy with established cardiovascular therapeutics.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating environmental sustainability into food-based dietary guidelines in the Nordic countries. 在北欧国家将环境可持续性纳入以食物为基础的膳食指南。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10792
Ellen Trolle, Jelena Meinilä, Hanna Eneroth, Helle Margrete Meltzer, Inga Þórsdóttir, Thorhallur Halldorsson, Maijaliisa Erkkola
{"title":"Integrating environmental sustainability into food-based dietary guidelines in the Nordic countries.","authors":"Ellen Trolle, Jelena Meinilä, Hanna Eneroth, Helle Margrete Meltzer, Inga Þórsdóttir, Thorhallur Halldorsson, Maijaliisa Erkkola","doi":"10.29219/fnr.v68.10792","DOIUrl":"https://doi.org/10.29219/fnr.v68.10792","url":null,"abstract":"<p><p>The overall aim of this paper was to provide background knowledge to the Nordic Nutrition Recommendations 2023 Committee for integrating environmental sustainability in a framework for national Food-Based Dietary Guidelines (FBDG) within the Nordics and Baltics. Additionally, this paper aims to give an overview of recent Nordic scientific literature on environmental impact of foods and dietary patterns and of the FBDG of the Nordics. Finally, we suggest methods for developing national sustainable FBDG. Nordic and Baltic studies on sustainability of diets were searched in August 2022 and complemented with additional relevant literature. The studies show that current diets are far from environmentally sustainable, exceeding planetary boundaries for most impact categories; meat and dairy products being the largest contributors to dietary greenhouse gas emissions (GHGEs) and land use. Scenario, modelling, optimisation and intervention studies confirm the potential of shifting towards more plant-based diets to improve overall diet quality in terms of both health and environmental sustainability. Such diets comprised of vegetables, fruits, legumes, potatoes, whole grain and refined cereal products, nuts, seeds and vegetable oils, with animal foods in moderate or limited amounts. The FBDG in the Nordics promotes more plant-based diets than the current average diet but could improve from further integration of environmental sustainability. To form basis for sustainable FBDG dietary modelling at the national level, prioritising health outcomes and nutritional adequacy is essential. Second, integrating environmental sustainability involves estimating the impact of food choices and amounts on GHGE, land and water use, eutrophication and biodiversity loss. Exploring positive and negative implications of fortified foods and supplementation in relation to nutrient intake, health and environmental sustainability may be needed. Implementing dietary transition requires solutions beyond FBDG to ensure affordability, acceptability and ease of adaption.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gochujang suppresses cell survival and changes reactive oxygen species metabolism in colorectal cancer cells. 五味子能抑制结直肠癌细胞的存活并改变其活性氧代谢。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10844
Eun-Bi Seo, So-Min Oh, Anna Han
{"title":"<i>Gochujang</i> suppresses cell survival and changes reactive oxygen species metabolism in colorectal cancer cells.","authors":"Eun-Bi Seo, So-Min Oh, Anna Han","doi":"10.29219/fnr.v68.10844","DOIUrl":"https://doi.org/10.29219/fnr.v68.10844","url":null,"abstract":"<p><p>There is a significant global increase in colorectal cancer (CRC) among young adults. <i>Gochujang</i>, one of the signature Korean traditional fermented foods, contains various bioactive compounds and has multiple health-beneficial effects, including anticancer effects; however, the detailed cellular and molecular mechanisms of its anticancer outcomes are not fully understood. The objective of the present study was to investigate the detailed underlying anticancer mechanisms of <i>Gochujang</i> in CRC cells. <i>Gochujang</i> was extracted with 80% ethanol, and total polyphenol contents (9.9 ± 1.63 mgGAE/g) and total flavonoid contents (0.14 ± 0.07 mgQE/g) of <i>Gochujang</i> extract (GE) were evaluated. GE significantly suppressed cell viability, migration, and colony formation in CRC cells. Also, GE increased the cell cycle arrest-related protein p21 level, whereas it decreased cell cycle progression-associated proteins, such as p-Rb. Moreover, GE markedly elevated the levels of proapoptotic proteins (e.g. Bim and c-PARP), while it downregulated antiapoptotic protein expressions (e.g. Bcl-2 and Bcl-xL). GE also altered the expression of the autophagy-involved proteins. Furthermore, GE strongly reduced the expression of major antioxidant enzymes and increased the reactive oxygen species (ROS) generation in CRC cells, causing an imbalance of ROS metabolism. In conclusion, this study demonstrated that <i>Gochujang</i> exerts anticancer effects in CRC cells by inhibiting cell proliferation, increasing cell death, and interrupting ROS metabolism.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-derived extracellular vesicles from obese mice suppressed splenocyte-mediated pancreatic cancer cell death. 肥胖小鼠脂肪组织衍生的细胞外囊泡抑制脾细胞介导的胰腺癌细胞死亡
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10545
Inae Jeong, Shinjung Park, Jinbum Park, Ok-Kyung Kim
{"title":"Adipose tissue-derived extracellular vesicles from obese mice suppressed splenocyte-mediated pancreatic cancer cell death.","authors":"Inae Jeong, Shinjung Park, Jinbum Park, Ok-Kyung Kim","doi":"10.29219/fnr.v68.10545","DOIUrl":"https://doi.org/10.29219/fnr.v68.10545","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a risk factor for pancreatic cancer and negatively contributes to the immune system. However, the mechanisms by which obesity mediates these actions are still poorly understood. Recent studies have demonstrated that extracellular vesicles (EVs) are key mediators of communication between cells and may influence various aspects of cancer progression.</p><p><strong>Objectives: </strong>We aim to explore the influence of EVs derived from adipose tissue of obese mice on cytokine production within the interactions between cancer cells and immune cells.</p><p><strong>Design: </strong>We isolated EVs from the adipose tissue of both C57BL6/J mice and <i>Ob/Ob</i> mice. Subsequently, we treated EVs with Panc02 cells, the murine ductal pancreatic cancer cell line, which were co-cultured with splenocytes. Viability and SMAD4 gene expression were examined in Panc02 cells, and cytokine concentrations of IL-6, IL-4, IL-12, and IL-12p70 were measured in the cultured medium.</p><p><strong>Results: </strong>Interestingly, we observed a significant reduction in splenocyte-mediated Panc02 cell death when treated with EVs derived from the adipose tissue of <i>Ob/Ob</i> mice, compared to those from C57BL6/J mice. Additionally, EVs from <i>Ob/Ob</i> mice-derived adipose tissue significantly increased the levels of IL-4, IL-2, and IL-12p70 in the culture media of Panc02 cells co-cultured with splenocytes, compared to EVs from C57BL6/J mice-derived adipose tissue.</p><p><strong>Conclusion: </strong>Adipose tissue-derived EVs from obese mice suppressed splenocyte-mediated Panc02 cell death and upregulated IL-4, IL-2, and IL-12p70 in cultured medium.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responses to the updated Nutri-Score algorithms in Norway: A qualitative study among food system actors in the NewTools-project. 挪威对更新的营养评分算法的反应:对新工具项目中食品系统参与者的定性研究。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10254
Mari Mohn Paulsen, Bente Øvrebø, Anne Lene Løvhaug, Kaja Lund-Iversen, Lene Frost Andersen, Arnfinn Helleve, Marianne Hope Abel
{"title":"Responses to the updated Nutri-Score algorithms in Norway: A qualitative study among food system actors in the NewTools-project.","authors":"Mari Mohn Paulsen, Bente Øvrebø, Anne Lene Løvhaug, Kaja Lund-Iversen, Lene Frost Andersen, Arnfinn Helleve, Marianne Hope Abel","doi":"10.29219/fnr.v68.10254","DOIUrl":"https://doi.org/10.29219/fnr.v68.10254","url":null,"abstract":"<p><strong>Background: </strong>Nutri-Score is a front-of-pack label grading foods and beverages from A to E indicating nutritional quality based on the foods' favorable and unfavorable components, and a contender in the ongoing debate on the possible implementation of a harmonized mandatory front-of-pack nutrition label in the European Union. NewTools is a research project on scoring systems for foods involving 28 partners representing actors involved in the Norwegian food system.</p><p><strong>Objective: </strong>This study aimed to explore views reported by Norwegian food system actors on the advantages and disadvantages with the updated Nutri-Score algorithms for food and beverages (2022-2023). This included Nutri-Score's performance in ranking foods according to the national food-based dietary guidelines and to the nutritional challenges in Norway.</p><p><strong>Design: </strong>A total of 28 project partners and 15 other food system stakeholders following the NewTools-project were invited to provide responses on the Nutri-Score algorithms and their application on foods and beverages in the Norwegian food composition table. Thirteen written responses were received and analyzed with qualitative content analysis.</p><p><strong>Results: </strong>The responses to the updated Nutri-Score varied in content, reflecting mainly concerns. Examples of perceived concerns included excessive penalty of salt content; insufficient differentiation based on fat content in meat, sausages, cheese, and milk; and several unreasonable comparisons across food categories. They also expressed a concern that Nutri-Score may stimulate to increased food processing, and some reported inconsistencies between Nutri-Score's classification of foods and national nutrition guidelines and policies.</p><p><strong>Discussion and conclusion: </strong>Several concerns with the updated Nutri-Score algorithms were raised, including the weighting of specific nutrients, unfair outcomes when comparing across food categories, and inconsistencies with established Norwegian nutrition guidelines and policies. The results should be interpreted with caution, as some perspectives from the Norwegian food system may be missing.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of freeze-dried Baiyedancong-Oolong tea aqueous extract containing bioactive compounds on the activities of CYP450 enzymes, the transport capabilities of P-gp and OATs, and transcription levels in mice. 含有生物活性化合物的冻干白茶-乌龙茶水提取物对小鼠体内 CYP450 酶活性、P-gp 和 OATs 转运能力以及转录水平的影响。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10605
Miaogao Zhang, Zhenguo Qiu
{"title":"The impact of freeze-dried Baiyedancong-Oolong tea aqueous extract containing bioactive compounds on the activities of CYP450 enzymes, the transport capabilities of P-gp and OATs, and transcription levels in mice.","authors":"Miaogao Zhang, Zhenguo Qiu","doi":"10.29219/fnr.v68.10605","DOIUrl":"https://doi.org/10.29219/fnr.v68.10605","url":null,"abstract":"<p><p>In this study, (-)-epigallocatechin gallate (EGCG) and caffeine extracted from freeze-dried autumn Baiyedancong Oolong tea (FBOT) were orally administered to mice for 7 consecutive days to explore the effects of BOT and its bioactive compounds on the activities and transcription levels of CYP450 enzymes, intestinal effluence transporter P-gp, and renal ingestion Organic Anion Transporters (OATs). Concurrently, EGCG and caffeine enhanced the activities of CYP3A, CYP2E1, and CYP2C37 in the liver of mice, while impairing the transport capabilities of P-gp and OATs. Reduced levels of MDR1 encoding P-gp transcription in the small intestine and renal OAT1 and OAT3 revealed that transcription was involved in the regulation of CYP450, P-gp, and OATs. The reduced transcription level of liver CYP2E1 suggested that CYP2E1 activity may have been elevated due to alternative mechanisms, but not through transcription. The absorption, metabolism, and excretion of drugs may be influenced by the daily consumption or high-dose administration of BOT and its related products, in which EGCG and caffeine may make great contributions.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the anti-obesity effects of kimchi through enhanced thermogenesis in differentiated T37i brown adipocytes. 通过增强分化的 T37i 棕色脂肪细胞的产热,探索泡菜的抗肥胖作用。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10738
Ye-Rang Yun, Ji-Eun Lee, Seongsoo Lee, Sung Wook Hong
{"title":"Exploring the anti-obesity effects of kimchi through enhanced thermogenesis in differentiated T37i brown adipocytes.","authors":"Ye-Rang Yun, Ji-Eun Lee, Seongsoo Lee, Sung Wook Hong","doi":"10.29219/fnr.v68.10738","DOIUrl":"10.29219/fnr.v68.10738","url":null,"abstract":"<p><strong>Background: </strong>Previous research has demonstrated the anti-obesity effects of kimchi in 3T3-L1 adipocytes and mice with diet-induced obesity by assessing the expression of obesity-associated genes. Additionally, recent studies have identified mechanisms involving thermogenesis that support these effects.</p><p><strong>Objective: </strong>This study aims to further investigate the anti-obesity properties of kimchi, focusing on its impact on thermogenic activity in differentiated T37i brown adipocytes.</p><p><strong>Design: </strong>The study first evaluated the antioxidant potential of kimchi using total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Optimal differentiation conditions for T37i adipocytes were established before proceeding with evaluations of cell viability, intracellular triglyceride (TG) content, lipid accumulation, and the expression of genes and proteins related to obesity and thermogenesis.</p><p><strong>Results: </strong>Kimchi maintained over 90% cell viability in T37i adipocytes at concentrations up to 1,000 μg/mL. Efficient differentiation of T37i preadipocytes was achieved using a medium containing 10% calf serum, 2 nM 3,3',5-triiodo-L-thyronin (T3), and 100 nM insulin. Kimchi significantly reduced intracellular TG levels and lipid accumulation, compared to the control group, and enhanced the expression of genes and proteins related to thermogenesis while reducing the expression of obesity-related genes.</p><p><strong>Discussion: </strong>The findings suggest that kimchi exerts its anti-obesity effects by modulating thermogenic and obesity-related pathways in brown adipocytes, which may be partially attributed to its antioxidant properties.</p><p><strong>Conclusions: </strong>Kimchi shows promise as a preventive measure against obesity by influencing metabolic pathways associated with both obesity and thermogenesis in T37i brown adipocytes.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Healthy Eating Index-2015 and prostate enlargement: A cross-sectional study of the National and Nutrition Examination Survey 2001-2008. 2015年健康饮食指数与前列腺增生之间的关系:2001-2008年全国营养调查横断面研究。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10828
Xing-Peng Di, Chi Yuan, Xin Wei
{"title":"Association between Healthy Eating Index-2015 and prostate enlargement: A cross-sectional study of the National and Nutrition Examination Survey 2001-2008.","authors":"Xing-Peng Di, Chi Yuan, Xin Wei","doi":"10.29219/fnr.v68.10828","DOIUrl":"10.29219/fnr.v68.10828","url":null,"abstract":"<p><strong>Background: </strong>Benign prostate hyperplasia (BPH) occurs in elder men globally with high prevalence. Human diet and lifestyle aroused great attention in the prevalence of BPH. Prostate enlargement (PE) is a major symptom of BPH.</p><p><strong>Objectives: </strong>To elaborate the effect of total diet quality for adults from the United States, we investigated the association between Health Eating Index (HEI)-2015 and the risk of PE in adults from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>This cross-sectional study was conducted based on NHANES 2001-2008. Participants who reported a PE history were included. We conducted a logistic regression analysis to investigate the association between HEI-2015 and PE.</p><p><strong>Results: </strong>A total of 4,866 male participants aged 40 and above were enrolled. Compared with Q1 of HEI-2015, no significant differences were found in adjusted models. Higher vegetables intake (Odds ratio [OR] = 1.073; 95% confidence interval [95%CI] 1.015 to 1.134, <i>P</i> = 0.02) and higher total dairy intake (OR = 1.034; 95%CI 1.009 to 1.061, <i>P</i> = 0.01) were significantly related with higher risk of PE.</p><p><strong>Conclusions: </strong>There was no significant difference between HEI-2015 and PE after full adjustment. Total vegetables and dairy product might be associated with higher risk of PE and needed further validation.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproducibility and comparison of a digital food frequency questionnaire (DIGIKOST-FFQ) assessing adherence to national diet and lifestyle recommendations. 数字化食物频率问卷(DIGIKOST-FFQ)的可重复性和对比性,评估国家饮食和生活方式建议的遵守情况。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10366
Markus Dines Knudsen, Monica Hauger Carlsen, Anette Hjartåker, Rune Blomhoff, Hege Berg Henriksen
{"title":"Reproducibility and comparison of a digital food frequency questionnaire (DIGIKOST-FFQ) assessing adherence to national diet and lifestyle recommendations.","authors":"Markus Dines Knudsen, Monica Hauger Carlsen, Anette Hjartåker, Rune Blomhoff, Hege Berg Henriksen","doi":"10.29219/fnr.v68.10366","DOIUrl":"10.29219/fnr.v68.10366","url":null,"abstract":"<p><strong>Background: </strong>We have developed a digital semi-quantitative food frequency and lifestyle questionnaire, the DIGIKOST-FFQ, based on the validated paper-based NORDIET-FFQ.</p><p><strong>Objective: </strong>The study aims to investigate the reproducibility of the DIGIKOST-FFQ and to compare the DIGIKOST-FFQ against the NORDIET-FFQ for the adjusted questions for intakes of fruits, vegetables, whole grains, fish, meat, and dairy products.</p><p><strong>Design: </strong>Participants were recruited from May to September 2021 through a random sample from the National Population Register and advertisements on Facebook in Norway. In the reproducibility study, the DIGIKOST-FFQ was completed twice by the participants, 1-2 months apart. In the comparison study, the DIGIKOST-FFQ was completed 1-2 months prior to the NORDIET-FFQ.</p><p><strong>Results: </strong>In the reproducibility study, 317 individuals were included. For 12 out of 16 food groups there were no significant differences in intake estimations between the first and second DIGIKOST-FFQ administrations. A small but significant median difference was observed for fruits (6 g/day) and vegetables (24 g/day). Correlations were satisfactory for all items (<i>r</i> = 0.60-1.00), and in the cross-classification 85% of the participants were classified into the same or adjacent quartile for all items. The comparison study included 81 individuals. Compared to the NORDIET-FFQ a significant median difference was observed for fruits 29 g/day, vegetables 36 g/day, whole grains -10 g/day, and red meat -11 g/day, but not for fish, processed meat, or dairy products.</p><p><strong>Conclusion: </strong>The DIGIKOST-FFQ was able to reproduce diet and lifestyle at the group level. An intended difference for the food groups where questions had been adjusted, was observed between DIGIKOST-FFQ and NORDIET-FFQ in the comparison study.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"68 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brazil nut (Bertholletia excelsa) and metformin abrogate cardiac complication in fructose/STZ-induced type 2 diabetic rats by attenuating oxidative stress and modulating the MAPK-mTOR/NFkB/IL-10 signaling pathways. 巴西坚果(Bertholletia excelsa)和二甲双胍通过减轻氧化应激和调节 MAPK-mTOR/NFkB/IL-10 信号通路,减轻果糖/STZ 诱导的 2 型糖尿病大鼠的心脏并发症。
IF 3.5 4区 医学
Food & Nutrition Research Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.29219/fnr.v68.10749
Zhenzuo Li, Baolan Wang, Dongfang Bai, Li Zhang
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