Andrew A Nicholson, Sandhya Narikuzhy, Jakub Wolf, Mina Pichtikova, Magdalena Siegel, James Mirabelli, Taylor Hatchard, Niki Hosseini-Kamkar, Ella Bawagan, Sophia L Roth, Christina Mutschler, Ruth A Lanius, Fardous Hosseiny, Kristen Eckstrand, Brigitte Lueger-Schuster
{"title":"Identity in turmoil: Investigating the morally injurious dimensions of minority stress.","authors":"Andrew A Nicholson, Sandhya Narikuzhy, Jakub Wolf, Mina Pichtikova, Magdalena Siegel, James Mirabelli, Taylor Hatchard, Niki Hosseini-Kamkar, Ella Bawagan, Sophia L Roth, Christina Mutschler, Ruth A Lanius, Fardous Hosseiny, Kristen Eckstrand, Brigitte Lueger-Schuster","doi":"10.1080/20008066.2025.2479396","DOIUrl":"10.1080/20008066.2025.2479396","url":null,"abstract":"<p><p><b>Background</b>: Sexual and gender minorities (SGMs) are at an increased risk for developing mental health disorders due to their socially stigmatized identities. Minority stress (i.e. discrimination, identity nondisclosure, internalized stigma) has been shown to impact mental health outcomes among SGMs. Both distal and proximal minority stressors may serve as potentially morally injurious events (PMIEs), which may lead to moral injury and trauma/stressor-related symptoms. Critically, minority stress-related moral injury among SGMs has never before been explored using a mixed-methods approach.<b>Methods</b>: Thirty-seven SGM participants with diverse minority identities participated in the study. Using a convergent parallel mixed-methods design, we conducted semi-structured qualitative interviews, performed clinical assessments, and administered a comprehensive battery of quantitative measures. Here, we modified the Moral Injury Event Scale (MIES) for use with SGMs. Qualitative themes were extracted and then converged with MIES scores to investigate differential thematic presentations based on the quantitative intensity of SGM-related PMIEs.<b>Results</b>: Data analysis indicated four core themes related to moral injury among SGMs: shame (internalizing stigma), guilt, betrayal/loss of trust, and attachment injuries (rejection, altered sense-of-self, and social cognition). The qualitative presentation of these themes differed depending on MIES severity. Attachment injuries emerged as a unique core feature of moral injury among SGMs, whereby the remaining core themes align with previous moral injury research. Furthermore, quantitative analyses revealed that the level of exposure to and intensity of minority stress-related PMIEs was positively associated with hazardous alcohol use and trauma-related symptoms.<b>Conclusions</b>: This is the first mixed-methods study to investigate minority stressors as PMIEs, highlighting how these experiences may contribute to symptoms of moral injury among SGMs. Moral injury may serve as a valuable framework for better understanding trauma-related symptoms and mental health disparities among SGMs. These findings have the potential to inform novel treatment interventions aimed at addressing mental health burdens among SGMs.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2479396"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Wang Fung, Ming Yu Claudia Wong, Grace Wing Ka Ho, Mark Shevlin, Anson Kai Chun Chau, Stanley Kam Ki Lam, Janet Yuen-Ha Wong, Shan-Yan Huang
{"title":"Investigating ICD-11 adjustment disorder among college students in Taiwan using the Chinese version of the International Adjustment Disorder Questionnaire.","authors":"Hong Wang Fung, Ming Yu Claudia Wong, Grace Wing Ka Ho, Mark Shevlin, Anson Kai Chun Chau, Stanley Kam Ki Lam, Janet Yuen-Ha Wong, Shan-Yan Huang","doi":"10.1080/20008066.2025.2528306","DOIUrl":"10.1080/20008066.2025.2528306","url":null,"abstract":"<p><p><b>Background:</b> The 11th edition of the International Classification of Diseases has redefined adjustment disorder and the International Adjustment Disorder Questionnaire (IADQ) was developed to assess the symptoms and diagnostic criteria. The present study is the first to investigate ICD-11 adjustment disorder using the IADQ in the East Asian context.<b>Methods:</b> We administered standardized self-report measures, including the Chinese version of the IADQ, to a sample of 766 college students in Taiwan, of whom 265 (34.6%) endorsed at least one psychosocial stressor.<b>Results:</b> The two-factor structure of the IADQ reported in previous studies was replicated. The reliability of the two IADQ subscales were high (α = .935 to .948), and they were highly correlated with symptoms of depression, anxiety, and complex PTSD (r<sub>s</sub> = .69 to .79, <i>p</i> < .001), demonstrating concurrent validity. In this sample, 5.4% of participants met the diagnostic criteria for ICD-11 adjustment disorder. When participants with probable depression (PHQ-9 ≥ 15) were excluded as per the ICD-11 exclusion rules, 15 participants (1.96%) had probable ICD-11 adjustment disorder.<b>Conclusions:</b> The findings suggest that ICD-11 adjustment disorder can be reliably and validly assessed using the IADQ in the Chinese context. Future studies can use the IADQ to further research the disorder in diverse clinical and nonclinical settings.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2528306"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madoka Niwa, Tomoko Kato, Yosuke Suga, Rieko Otomo, Mayumi Sugawara, Mie Matsui, Toshiko Kamo, Hiroaki Hori, Yoshiharu Kim
{"title":"Neurocognitive functioning over the course of STAIR Narrative Therapy for ICD-11 complex PTSD.","authors":"Madoka Niwa, Tomoko Kato, Yosuke Suga, Rieko Otomo, Mayumi Sugawara, Mie Matsui, Toshiko Kamo, Hiroaki Hori, Yoshiharu Kim","doi":"10.1080/20008066.2025.2523079","DOIUrl":"10.1080/20008066.2025.2523079","url":null,"abstract":"<p><p><b>Background:</b> Posttraumatic stress disorder (PTSD) has been associated with impairments in neurocognitive functions, particularly in memory, attention, and executive function. These problems can interfere with the individual's daily functioning and recovery. Given the different symptom features and potentially different neural profiles between ICD-11 complex PTSD (CPTSD) and PTSD, neurocognitive dysfunction is considered an even more serious problem in CPTSD. Still, no studies have directly examined whether neurocognitive deficits in CPTSD can improve over the course of treatment.<b>Objective:</b> This study examined whether neurocognitive functioning changes over the course of Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (SNT) by analyzing data from a pilot study of women with CPTSD related to childhood abuse.<b>Methods:</b> Thirteen women aged 21-46 years (<i>M</i> = 29.6 years) with childhood-abuse-related ICD-11 CPTSD were enrolled in this study. The International Trauma Interview was administered to diagnose CPTSD and assess its severity. Neurocognitive functions were evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) pretreatment, immediately posttreatment, and three months after treatment.<b>Results:</b> Among the RBANS scores, immediate memory and global cognitive scores significantly improved three months after treatment compared to pretreatment. No significant improvements over time were observed in scores for other cognitive domains, including visuospatial construction, attention, language, and delayed memory.<b>Conclusions:</b> These preliminary results suggest that SNT can improve immediate memory and global cognitive functioning as well as CPTSD symptoms. Further research is needed to verify these findings and understand neurobiological mechanisms underlying the effect of SNT on neurocognitive functioning.<b>Trial registration number:</b> UMIN000030889.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2523079"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monika M Stojek, Marta Łukowska, Jagoda Różycka, Maryla Sokołowska, Joanna Zielińska, Ari Nowacki, Roksana Duszkiewicz, Anna Psurek, Vasiliki Michopoulos
{"title":"Systemic inflammation and metabolic syndrome components in threshold/subthreshold posttraumatic stress disorder and food addiction in a Polish community sample.","authors":"Monika M Stojek, Marta Łukowska, Jagoda Różycka, Maryla Sokołowska, Joanna Zielińska, Ari Nowacki, Roksana Duszkiewicz, Anna Psurek, Vasiliki Michopoulos","doi":"10.1080/20008066.2025.2478792","DOIUrl":"10.1080/20008066.2025.2478792","url":null,"abstract":"<p><p><b>Background:</b> Posttraumatic stress disorder (PTSD) is associated with metabolic syndrome and various addictive behaviours. Food addiction (FA) is associated with obesity, and individuals with PTSD have higher rates of FA than those without. It is unclear whether addictive-like eating patterns contribute to the metabolic dysfunction in PTSD.<b>Objective:</b> We examined the relative contributions of PTSD, FA, and sex - as well as their interactive effects - to the systemic inflammation (CRP) and metabolic syndrome components (MetS: waist circumference, glucose, triglycerides, HDL cholesterol, insulin) in a general population of the Upper Silesia region in Poland.<b>Method:</b> <i>N</i> = 187 participants (52.7% women) completed Yale Food Addiction Scale 2.0 (FA symptoms count), Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) semi-structured interview (PTSD or other trauma and stressor-related disorder (OTSR) diagnosis presence), anthropometric assessment, and phlebotomy in a fasted state.<b>Results:</b> A series of hierarchical linear regressions indicated that greater number of FA symptoms had a significant effect on greater waist circumference, while PTSD/OTSR diagnosis had a significant effect on higher insulin levels. Sex did not moderate these relationships.<b>Conclusions:</b> It appears that dysregulated eating patterns are associated with greater abdominal obesity, but not with metabolic dysfunction. PTSD/OTSR, but not FA, contributes to greater insulin levels. The average metabolic indices were within normal limits reflecting a non-clinical nature of the sample. Future longitudinal studies should examine whether detection of and intervention for PTSD/OTSR symptoms may be a strategy for preventing progression of metabolic dysfunction.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2478792"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyunsan Cho, June Christoph Kang, Hee-Jin Park, Yoon Hee Park, Yeo Eun Park, Intae Hwang, Hyo Jin Kang
{"title":"The impact of intimate partner violence on facial emotion recognition among Korean baby boomers.","authors":"Hyunsan Cho, June Christoph Kang, Hee-Jin Park, Yoon Hee Park, Yeo Eun Park, Intae Hwang, Hyo Jin Kang","doi":"10.1080/20008066.2025.2474890","DOIUrl":"10.1080/20008066.2025.2474890","url":null,"abstract":"<p><p><b>ABSTRACT</b><b>Background:</b> Intimate partner violence (IPV) can have lasting psychological and cognitive effects, potentially impairing facial emotion recognition (FER). This study examines the accuracy of FER among IPV survivors compared to individuals without IPV experience within the Korean baby boomer generation, aged 60-69, exploring the relationship between IPV, post-traumatic stress disorder (PTSD) symptoms, and FER abilities.<b>Objective:</b> To assess whether IPV impacts FER accuracy and intensity and to investigate whether symptoms of PTSD moderate this relationship.<b>Method:</b> The study included 80 participants, with 31 % identified as IPV survivors. A self-administered survey collected information on lifetime experiences of physical, emotional, and sexual abuse, as well as assessments for PTSD symptoms. Participants completed the Korean Montreal Cognitive Assessment (K-MOCA) and performed 70 FER tasks to evaluate accuracy and intensity of facial emotions. Logistic regressions were used to analyse the relationship between IPV, PTSD symptoms, and FER performance.<b>Results:</b> IPV survivors demonstrated 0.64 times lower accuracy in recognizing overall facial emotions, including anger, sadness, surprise, and neutral expressions Additionally, IPV survivors exhibited significantly lower intensity scores for overall facial expressions. Significant interaction terms between IPV and PTSD symptoms indicate that PTSD symptoms moderate the effect of IPV on the FER, as well as neutral and sad facial expressions.<b>Conclusions:</b> IPV can disrupt one's ability to recognize facial emotions, and PTSD symptoms may moderate this impairment. This highlights the potential benefits of assisting IPV survivors with emotion recognition as part of their recovery process, which could enhance both social connections and their safety.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2474890"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charlotte Williamson, Walter Busuttil, Amos Simms, Laura Palmer, Sharon A M Stevelink, Marie-Louise Sharp
{"title":"'Man up and get on with it': a qualitative exploration of UK ex-serving personnel's experiences of seeking help for self-harm and suicidal behaviours.","authors":"Charlotte Williamson, Walter Busuttil, Amos Simms, Laura Palmer, Sharon A M Stevelink, Marie-Louise Sharp","doi":"10.1080/20008066.2025.2480990","DOIUrl":"10.1080/20008066.2025.2480990","url":null,"abstract":"<p><p><b>Background:</b> A substantial proportion of UK military personnel experiencing mental health problems do not seek professional support. Although the promotion of help-seeking is a key suicide prevention strategy, little is known about help-seeking for self-harm and suicidal behaviours among the UK Armed Forces.<b>Objective:</b> This study aimed to explore UK ex-serving personnel's experiences of seeking help for self-harm, suicidal ideation, and suicide attempts.<b>Method:</b> Participants were recruited via an existing longitudinal cohort study exploring the health and well-being of the UK Armed Forces. A subgroup of ex-serving personnel reporting lifetime self-harm and/or suicidal behaviours was invited to participate in semi-structured interviews and 15 individuals participated, representing help-seekers/non-help-seekers and formal/informal support. Interviews were analysed using reflexive thematic analysis.<b>Results:</b> Five distinct but related and interacting themes were developed: (1) military mindset; (2) stigma; (3) fear of consequences; (4) access to and awareness of support; and (5) facilitators to help-seeking.<b>Conclusions:</b> Help-seeking decisions and experiences were influenced by several barriers and facilitators. Providing an environment where military populations feel willing and able to access support for self-harm and suicidal behaviours could lessen the impact on their health and well-being and ultimately save lives.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2480990"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicola Cogan, Liza Morton, John Campbell, Linda Irvine Fitzpatrick, Danielle Lamb, Johannes De Kock, Alisha Ali, David Young, Stephen Porges
{"title":"Neuroception of psychological safety scale (NPSS): validation with a UK based adult community sample.","authors":"Nicola Cogan, Liza Morton, John Campbell, Linda Irvine Fitzpatrick, Danielle Lamb, Johannes De Kock, Alisha Ali, David Young, Stephen Porges","doi":"10.1080/20008066.2025.2490329","DOIUrl":"https://doi.org/10.1080/20008066.2025.2490329","url":null,"abstract":"<p><p><b>Background:</b> Psychological safety plays a vital role in rest, recovery, and fostering social connections. However, a history of trauma can predispose individuals to perceive heightened levels of threat and danger. Research suggests that a lack of psychological safety may be a defining biopsychosocial characteristic of posttraumatic stress disorder (PTSD). Persistent feelings of threat and danger are associated with a lack of psychological safety and may be predictive of PTSD. Our pioneering work reported on the development of the neuroception of psychological safety (NPSS), rooted in polyvagal theory, and consists of social engagement, compassion, and body sensations dimensions. Understanding more about the dimensionality of the NPSS and further establishing its psychometric properties was our priority.<b>Objective:</b> Our current research aimed to validate and test the reliability and dimensionality of the NPSS, using a large community sample (<i>n</i> = 2035) of adult residents in the UK<b>Method</b>: We examined the internal and test-retest reliability, convergent, discriminant, and concurrent validity as well as dimensionality of the NPSS.<b>Results:</b> The 3-factor structure of the NPSS was replicated with regard to the absolute fit indices. Internal consistencies ranged from acceptable to excellent across the NPSS's subscales. Providing support for the validity of the NPSS, scores were predictably related to team psychological safety, wellbeing, post-traumatic stress, burnout, body awareness, and personality, with effect sizes typically in the high to medium range. Scores on the NPSS were found to show good test-retest reliability.<b>Conclusions:</b> This study demonstrates the validity, reliability and dimensionality of the NPSS with an adult sample. Further work is underway to support and enhance understandings of psychological safety with diverse clinical populations impacted by trauma. The NPSS has applicability across a range of health and social care contexts, such as shaping new approaches to evaluating trauma treatments and enhancing trauma informed care.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2490329"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marianne Skogbrott Birkeland, Camilla Blestad, Ane-Marthe Solheim Skar, Filip K Arnberg, Tine K Jensen
{"title":"Development and pilot-testing of an app to complement trauma-focused cognitive behavioral therapy for adolescents.","authors":"Marianne Skogbrott Birkeland, Camilla Blestad, Ane-Marthe Solheim Skar, Filip K Arnberg, Tine K Jensen","doi":"10.1080/20008066.2025.2481703","DOIUrl":"https://doi.org/10.1080/20008066.2025.2481703","url":null,"abstract":"<p><p><b>Background:</b> Apps have the potential to support psychological treatments by providing psychoeducation, increasing homework compliance, and generalizing therapeutic skills outside of sessions. However, there are few apps developed to support specific evidence-based treatment for PTSD for adolescents.<b>Objective:</b> This paper shares experiences developing an app to complement Trauma-Focused Cognitive Behavioral Therapy (TF-CBT). It also describes adolescents' and therapists' perceived usefulness and the potential effect of the app 'My everyday life' on posttraumatic stress symptoms (PTSS).<b>Methods:</b> We did a needs assessment with adolescents, therapists, and TF-CBT trainers, followed by programming and beta-testing. We carried out a mixed methods study of 59 adolescent patients (aged 13-18 years) and their therapists. Using a triangulation design, we combined quantitative data on app use and changes in PTSS with qualitative data from interviews with 10 adolescents and 10 therapists who described their experiences with the app.<b>Results:</b> The app includes psychoeducation, mental health self-monitoring, coping tools, and goal-setting functionality. The most used features were psychoeducation and breathing exercises. Few therapists actively used the monitoring progress feature. Both adolescents and therapists found the app beneficial for everyday use, though some therapists were unsure about how to integrate it with TF-CBT. Adolescents reported significant PTSS improvement during TF-CBT with the app as a complement. Adolescents with post-treatment data (<i>n</i> = 13) did not report significantly different PTSD improvement compared to adolescents without access to app, but the study lacked power to draw strong conclusions.<b>Conclusions:</b> The app 'My everyday life' can be useful for adolescents receiving TF-CBT. The therapists may benefit from clearer guidelines on how to integrate apps with evidence-based treatments. Digital tools are a promising avenue for supporting the implementation of evidence-based treatment.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2481703"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study.","authors":"Zheng Zhang, Yating Wang, Jiazheng Li, Hao Ren, Xinglian Wang, Haitang Qiu, Huirong Luo, Xueqian Wang, Junyao Li, Renqin Hu, Yanwei Guo, Jinglan Tan, Chenggang Jiang, Qinghua Luo","doi":"10.1080/20008066.2024.2383127","DOIUrl":"https://doi.org/10.1080/20008066.2024.2383127","url":null,"abstract":"<p><p><b>Background:</b> Prior research indicates a potential connection between childhood maltreatment and asthma. In response, we designed a Mendelian Randomization (MR) study to further investigate this association.<b>Methods:</b> Utilizing the MR approach, we leveraged Genome-Wide Association Studies (GWAS) data from the UK Biobank (UKB). Our primary outcome was asthma, analyzed through GWAS datasets termed AsthmaUKB and AsthmaIEU, sourced from two distinct studies. Additionally, we conducted stratified analyses focusing on pediatric asthma and adult asthma to address different asthma phenotypes. The causal impact of childhood maltreatment (CM) on asthma was assessed using inverse-variance weighted (IVW) methods, MR-Egger, and MR-PRESSO tests, thereby enhancing the robustness and generalizability of our findings.<b>Results:</b> The IVW analyses identified significant associations between CM and increased risks for AsthmaUKB (<i>OR</i> = 1.59, 95% <i>CI</i> = 1.23-2.05, <i>p</i> < .001), AsthmaIEU (<i>OR</i> = 1.04, 95% <i>CI </i>= 1.02-1.06, <i>p</i> < .001), pediatric asthma (<i>OR</i> = 1.72, 95% <i>CI</i> = 1.26-2.35, <i>p</i> = .001), and adult asthma (<i>OR</i> = 1.71, 95% <i>CI</i> = 1.17-2.48, <i>p</i> = .005). The MR-Egger and MR-PRESSO results confirmed the absence of pleiotropy, reinforcing our causal inferences. Although Cochran's <i>Q</i> test indicated some heterogeneity among asthma subtypes (<i>p</i> > .05), the robustness of the IVW results remains reliable.<b>Conclusions:</b> Our findings suggest a potential causal relationship between CM and various asthma phenotypes, as validated through rigorous Mendelian randomization analyses. These results emphasize the importance of considering CM in asthma prevention and intervention strategies and lay the groundwork for further investigation into how early-life adversities may predispose individuals to asthma, contributing to a deeper understanding of its etiological pathways.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2383127"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irma Hein, Maj Gigengack, Cedric Sachser, Ramón Lindauer
{"title":"Accuracy of the Pediatric Emotional Distress Scale - Early Screener to predict the risk for developing PTSD in young children after accidental injury.","authors":"Irma Hein, Maj Gigengack, Cedric Sachser, Ramón Lindauer","doi":"10.1080/20008066.2025.2494364","DOIUrl":"https://doi.org/10.1080/20008066.2025.2494364","url":null,"abstract":"<p><p>Early identification of posttraumatic stress disorder (PTSD) in children is important to prevent chronic symptoms and long-term negative consequences. However, PTSD often goes unrecognized in the emergency setting of hospitals and screening methods for young children are lacking.</p><p><p>To evaluate the accuracy of an early screening tool for PTSD in a sample of young children (0-7 years) after unintentional injury.</p><p><p>The Pediatric Emotional Distress Scale - Early Screener (PEDS-ES) was administered to parents of children referred to the Emergency Department within 7 days post-accident (<i>n</i> = 82), and a validated interview for PTSD was administered 3 months after the accident as criterion measure: the Diagnostic Infant and Preschool Assessment (DIPA). Diagnostic accuracy of the PEDS-ES was inspected using area under the curve analyses including sensitivity, specificity, Positive and Negative Predictive Value.</p><p><p>After three months PTSD diagnosis was established in 21% of the children. Use of the PEDS-ES within 7 days after the injury showed fair accuracy with AUC = .727. Sensitivity (0.65) and specificity (0.73) for the suggested cutoff of 8 were moderate for predicting PTSD diagnosis 3 months after the injury. The examination of cutoff values that achieve enhanced sensitivity in a screening context - where sensitivity is prioritized - while maintaining a high level of specificity suggests that a lower cutoff of around 6 points may serve as a more sensitive (sensitivity: 0.82; specificity: 0.56) valid alternative cutoff score.</p><p><p>The PEDS-ES allows for successful early screening of risk for traumatic stress symptoms in young children after single accidental injury. It enables early identification of individuals who are at risk for developing PTSD and need further monitoring of symptoms, diagnostic assessment and treatment.</p>","PeriodicalId":12055,"journal":{"name":"European Journal of Psychotraumatology","volume":"16 1","pages":"2494364"},"PeriodicalIF":4.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}