European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Bilateral vestibulopathy in Alexander disease type II- a case report.","authors":"Jan Bernhard Hofmann, Matthias Gautschi, Anja Vossenkaul, Marisa Blanquet, Tatiana Bremova-Ertl","doi":"10.1007/s00405-025-09416-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09416-7","url":null,"abstract":"<p><strong>Introduction: </strong>Alexander disease (AxD) is rare leukodystrophy caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. Astrocyte dysfunction leads to myelinization disturbances and white matter damage, resulting in distinct neurological symptoms and neuroradiological findings.</p><p><strong>Case report: </strong>Our patient, a 46-year old male, showed typical symptoms of AxD, including myoclonus of the soft palate, nystagmus, and cerebellar ataxia, as well as typical radiological findings found in AxD. The results of a device-based vestibular examination, including a video head-impulse test, showed a bilaterally decreased gain of vestibulo-ocular reflex of all semicircular canals suggestive of a bilateral vestibulopathy (BVP), a novel aspect of AxD. Symptomatic treatment of cerebellar ataxia and BVP with 4-aminopyridine (4-AP) led to an improvement of several device-examined vestibular parameters, but without subjective improvements in balance.</p><p><strong>Conclusion: </strong>This case report describes BVP in a patient suffering from AxD, a novel phenotype of the disease. In leukodystrophies, such as AxD, central vestibular symptoms should be assessed early on to evaluate the potential use of 4-AP.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of tympanoplasty with persistent air-bone gap in adults with chronic otitis media: hearing, health care utilization and quality of life.","authors":"Susan Arndt, Olivier Deguine, Jérôme Nevoux, Serafin Sánchez, Miray-Su Yılmaz Topçuoğlu, Christiane D'hondt, Håkan Hua, Ray Lin, Xabier Altuna","doi":"10.1007/s00405-025-09421-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09421-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate long-term hearing outcomes, healthcare utilization, and health-related quality of life (HRQoL) in adults with chronic otitis media (COM) who underwent primary tympanoplasty (PT) but were left with a significant air-bone gap (25-30 dB).</p><p><strong>Methods: </strong>A retrospective medical chart review was conducted to assess the standard of care for COM patients across three European countries, analyzing hearing data, healthcare utilization, and demographics. Additionally, HRQoL and hearing disability were assessed prospectively using questionnaires. Sixty-nine adults diagnosed with COM who underwent PT between 2010 and 2016 were included.</p><p><strong>Results: </strong>Average hearing outcomes showed minimal to no improvement, with a substantial number of patients experiencing moderate to severe hearing loss post-PT. Many continued to rely on rehabilitative technologies, with bone conduction hearing device (BCHD) users reporting higher consistent use compared to conventional hearing aid users. Participants required an average of 7.6 healthcare visits with a mean follow-up time of 7.64 years after PT, underscoring the ongoing burden on healthcare systems. Impaired hearing negatively impacted both general and disease-specific HRQoL.</p><p><strong>Conclusion: </strong>Managing COM remains challenging due to the variability in surgical outcomes, particularly regarding hearing restoration. The high post-PT healthcare utilization and persistent HRQoL impairments caused by impaired hearing highlight the need for more effective rehabilitative strategies such as conventional hearing aids and BCHD.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical and structural response in patients with tall cell papillary thyroid cancer: a dual centre retrospective study : Early Recurrence in Tall Cell PTC.","authors":"Louis Britten-Jones, Spinder Samra, David Goltsman, Gideon Sandler, Matti L Gild, Christian M Girgis","doi":"10.1007/s00405-025-09426-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09426-5","url":null,"abstract":"<p><strong>Purpose: </strong>Tall cell papillary thyroid cancer (tcPTC) is traditionally considered to be an aggressive subtype of differentiated thyroid cancer, although its independent prognostic value is unclear. To investigate the independent prognostic value of tall cell morphology a tcPTC cohort was compared with a classical PTC (cPTC) cohort.</p><p><strong>Methods: </strong>A retrospective longitudinal study was performed using a cohort of tcPTC patients treated at Royal North Shore Hospital and Westmead Hospital in Sydney, Australia, and a cohort of cPTC patients treated at Westmead Hospital. Clinicopathological tumour characteristics and treatment pathways were analysed. Thyroglobulin and thyroglobulin antibody levels and further neck surgeries in the two years post thyroidectomy were used as a surrogate marker for early disease recurrence.</p><p><strong>Results: </strong>Presentation and treatment were analysed for 51 tcPTC patients and a comparator group of 365 cPTC patients. On univariate analysis, tcPTC was found to present at an older age (53.6 years v 46.4 years, p < 0.01), with greater rates of positive surgical margins (31.37% v 16.44%, p < 0.05), and greater rates of microscopic (47.06% v 22.74%, p < 0.001) and gross extrathyroidal extension (15.69% v 6.30%, p < 0.05). Longitudinal analysis was conducted for 236 patients (n = 24 for tcPTC, n = 212 for cPTC). Multivariate analysis found no difference in the odds of developing early recurrence between the tcPTC cohort and the cPTC cohort (OR = 0.65, p > 0.1).</p><p><strong>Conclusion: </strong>tcPTC is associated with more aggressive features compared with cPTC. Tall cell morphology was not found to be an independent predictor of early recurrence.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of filter-based and software-based image enhancement systems for endoscopic swallowing diagnostics: a head-to-head study.","authors":"Almut C Niessen, Julia Glinzer, Jana Zang, Christina Pflug","doi":"10.1007/s00405-025-09413-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09413-w","url":null,"abstract":"<p><strong>Purpose: </strong>Flexible endoscopic evaluation of swallowing (FEES) is a gold standard for diagnosing swallowing disorders. This study investigates two image enhancement technologies usable in FEES-hardware filtering (Narrow Band Imaging, NBI^®) and software filtering (Professional Image Enhancement Technology, PIET^®)-to assess their effectiveness in improving the visibility of food dyes.</p><p><strong>Methods: </strong>This Head-to-head study compared NBI^® and PIET^® by creating 190 videos showcasing food dyes diluted from 1:10 to 1:100,000, tested in the oral cavities of four volunteers. Four raters evaluated the maximum visible dilution for both systems across all colors. Sixteen snippets representing eight colors (red, yellow, blue, green, purple, orange, black, and white) at a 1:10 dilution were analyzed by 14 raters, including two with no prior FEES experience, all blinded to the filtering method.</p><p><strong>Results: </strong>The study used a point system to assess subjective image quality, color intensity, and contrast to the mucosa. Both systems produced similar hues for yellow and red and their secondary colors. PIET was preferred for red and purple, while NBI was favored for yellow, green, and orange. For blue, black, and white (all showing no intensification), PIET was nearly unanimously chosen. Raters agreed 100% on the maximum visible dilution, showing no significant difference between systems; both enhanced visibility tenfold.</p><p><strong>Conclusions: </strong>Both image enhancement systems improved the visibility of specific food dyes effectively. Each method has distinct advantages. The choice between them depends on personal preference and available systems.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ear-canal lavage for curing noninvasive otomycosis: A randomized controlled trial.","authors":"Jia Zhang, Yusheng Du, Lihua Tang, Fan Song, Guoliang Wang, Xingyu Mei, Lili Hou, Zelin Cui, Zhenghua Zhu","doi":"10.1007/s00405-025-09418-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09418-5","url":null,"abstract":"<p><strong>Objective: </strong>Fungal infection of the external auditory canal, otomycosis, is generally a superficial, but sometimes stubborn mycotic infection that rarely involves the middle ear. We designed a randomized, controlled cohort study to analyse the treatment effect of ear canal lavage on otomycosis.</p><p><strong>Methods: </strong>The clinical patients were divided into two groups: an irrigation group and an irrigation + local drug treatment control group. The patients were followed up once a month for three months.</p><p><strong>Results: </strong>From January 2022 to December 2023, a total of 102 patients treated for otomycosis were enrolled, and 98 of the patients were followed up for three months. 22 of the 98 patients (22.45%) had no or minor symptoms. Common symptoms such as pruritus, pain, hearing impairment, etc., presented solely or in combination. Our fungal culture results revealed that, in 83 patients (84.69%), the otomycotic pathogen was Aspergillus, in 3 patients (3.06%) it was Penicillium, in 2 patients (2.04%) it was Candida species, and in the remaining 13 patients (13.27%) it was negative. There were 3 patients (3.06%) with a mixture of fungal culture reports. In the lavage group, 48 (48/52, 92.30%) patients were cured with initial treatment after three months of follow-up, two (2/52, 3.85%) patients were cured after one month but were lost to follow-up after three months, and two (2/52, 3.85%) patients failed after initial treatment, received topical miconazole ointment treatment and were eventually cured. In the irrigation + local drug control group, 48 (48/50, 96.00%) subjects responded to initial treatment without recurrent disease after three months; 2 (2/50, 4.00%) subjects were lost to follow-up. According to Fisher's exact test, there was no significant difference in treatment efficiency between the two groups (P = 0.258).</p><p><strong>Conclusion: </strong>This study demonstrated that the diagnosis of otomycosis requires vigilance from clinicians given its nonspecific or minor symptoms. Both ear canal rinses and local antifungal creams are effective, and sequential treatment via both methods is reasonable.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten years of stapes surgery in France (2013-2022). About 35368 procedures.","authors":"Rémi Hervochon, Diane Picard, Yann Nguyen, Ghizlene Lahlou, Georges Lamas, Frédéric Tankere","doi":"10.1007/s00405-025-09399-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09399-5","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of otosclerosis appears to have been declining since the late 1970s. We conducted a retrospective nationwide study to assess the evolution of the annual number of stapes surgeries and to analyze the changes in technical practices, specifically comparing laser techniques to cold instruments.</p><p><strong>Methods: </strong>We examined the French national dataset from the \"Programme de Médicalisation des Systèmes d'Information\" (PMSI). Within this national database, we collected data on the number of stapes surgical procedures performed using cold instruments and laser technology from 2013 to 2022 in France.</p><p><strong>Results: </strong>The total number of stapes surgeries has decreased each year, dropping from 4,268 procedures in 2013 to 3,007 procedures in 2022, which represents a decline of 29.5% over a decade. On average, 162 fewer procedures were performed each year compared to the previous year. The use of laser technology increased from 42% of cases in 2013 to 61% of cases in 2022. Laser techniques were more commonly employed in university hospitals and private non-profit clinics than in general hospitals and private clinics.</p><p><strong>Conclusion: </strong>The number of stapes surgeries is decreasing linearly and consistently, raising concerns regarding the training of young surgeons. Furthermore, laser techniques are gradually replacing cold instruments in clinical practice.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Styloid process before Watt Weems Eagle. An Italian story.","authors":"Ruggero Campisi, Alberto Caranti, Luca Cerritelli, Francesco Maria Galassi, Felice Antonio Rasulo, Stefano Pelucchi, Claudio Vicini","doi":"10.1007/s00405-025-09225-y","DOIUrl":"10.1007/s00405-025-09225-y","url":null,"abstract":"<p><strong>Purpose: </strong>The article provides an intriguing overview with tangible historical references, accompanied by photographic material, delving into the historical context of Eagle syndrome.. It ambitiously aims to shed light on the origins of the surgeon's reflections regarding the anatomy of the styloid process. Indeed, ever since the first original article by Watt Weems Eagle, these reflections have been attributed to Pietro Marchetti (Padua, 1589-1673), an Italian surgeon, anatomist, and physician. However, it appears they should be attributed to his son, Domenico De Marchetti (Padua, 1626 - 1688).</p><p><strong>Methods: </strong>The original book \"ANATOMIA-cui responsiones ad Riolanum anatomicum Parisiensem in ipsius animaduersionibus contra Veslingium additae sunt\", (Padua-ed. 1654, first edition in 1652),written by Domenico De Marchetti was examined.The Latin text was analyzed adopting a philologico-clinical approach and related to contemporary medical and anatomical knowledge [18,19].</p><p><strong>Results: </strong>The study highlights Marchetti's meticulous analysis of the hyoid bone and its associated structures, revealing the multifaceted nature of the styloid process. Noteworthy is Marchetti's observation regarding the styloid process's connection with the hyoid bone's horns during cadaver dissections, hinting at the calcification of the stylohyoid ligament, a key factor in Eagle syndrome. Marchetti's insights during cadaver dissection are evocative both regarding the hypothesis of stylohyoid ligament calcification and concerning the concept of styloid process growth throughout a person's life.</p><p><strong>Conclusions: </strong>Marchetti's observations provide the first evidence of the continuous evolution of the styloid process throughout life and represent a valuable contribution to understanding the etiology of Eagle's Syndrome.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2655-2661"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in otorhinolaryngology: current trends and application areas.","authors":"Emre Demir, Burak Numan Uğurlu, Gülay Aktar Uğurlu, Gülçin Aydoğdu","doi":"10.1007/s00405-025-09272-5","DOIUrl":"10.1007/s00405-025-09272-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to perform a bibliometric analysis of scientific research on the use of artificial intelligence (AI) in the field of Otorhinolaryngology (ORL), with a specific focus on identifying emerging AI trend topics within this discipline.</p><p><strong>Methods: </strong>A total of 498 articles on AI in ORL, published between 1982 and 2024, were retrieved from the Web of Science database. Various bibliometric techniques, including trend keyword analysis and factor analysis, were applied to analyze the data.</p><p><strong>Results: </strong>The most prolific journal was the European Archives of Oto-Rhino-Laryngology (n = 67). The USA (n = 200) and China (n = 61) were the most productive countries in AI-related ORL research. The most productive institutions were Harvard University / Harvard Medical School (n = 71). The leading authors in this field were Lechien JR. (n = 18) and Rameau A. (n = 17). The most frequently used keywords in the AI research were cochlear implant, head and neck cancer, magnetic resonance imaging (MRI), hearing loss, patient education, diagnosis, radiomics, surgery, hearing aids, laryngology ve otitis media. Recent trends in otorhinolaryngology research reflect a dynamic focus, progressing from hearing-related technologies such as hearing aids and cochlear implants in earlier years, to diagnostic innovations like audiometry, psychoacoustics, and narrow band imaging. The emphasis has recently shifted toward advanced applications of MRI, radiomics, and computed tomography (CT) for conditions such as head and neck cancer, chronic rhinosinusitis, laryngology, and otitis media. Additionally, increasing attention has been given to patient education, quality of life, and prognosis, underscoring a holistic approach to diagnosis, surgery, and treatment in otorhinolaryngology.</p><p><strong>Conclusion: </strong>AI has significantly impacted the field of ORL, especially in diagnostic imaging and therapeutic planning. With advancements in MRI and CT-based technologies, AI has proven to enhance disease detection and management. The future of AI in ORL suggests a promising path toward improving clinical decision-making, patient care, and healthcare efficiency.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2697-2707"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT for responding to patient inquiries about otosclerosis: correspondence.","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.1007/s00405-025-09210-5","DOIUrl":"10.1007/s00405-025-09210-5","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2785-2786"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising diagnostics for hard-of-hearing infants: factors associated with successful MRI scanning without general anaesthesia.","authors":"Marlise D van der Veen, Ithri Kaman, Bas Jasperse, Thadé Goderie, Fenna A Ebbens, K Mariam Slot, Marjo S van der Knaap, Paul Merkus","doi":"10.1007/s00405-024-09118-6","DOIUrl":"10.1007/s00405-024-09118-6","url":null,"abstract":"<p><strong>Purpose: </strong>Scanning during infancy is often required in otology, preferably without general anaesthesia. This study aims to determine the success rate of MRI of the head without general anaesthesia for infants, and to identify predictors for a successful scan.</p><p><strong>Methods: </strong>Data was extracted from the electronic patient file for patients who received MRI of the head without general anaesthesia between 01-01-2019 and 31-12-2022 at an age younger than 6 months. Each MRI-session was dichotomised into success (i.e., of sufficient quality to answer the clinical question) or failure, and success percentages were calculated. A logistic regression analysis was performed to determine the association between success and variables of interest, which were selected based on interviews with medical specialists.</p><p><strong>Results: </strong>Eighty-seven patients were included, showing an overall success rate of 75.9% for MRI of the head without anaesthesia. Success rates for MRI brain were higher than for MRI cerebellopontine angle (CPA), respectively 91.2% and 66.0% (p = 0.013). For MRI CPA the odds of success decreased for infants aged 3-5 months, compared to infants under 3 months (respectively 48.1% and 84.6%, p = 0.009). For MRI CPA the success percentage was lower for boys (51.9%) than for girls (80.8%, p = 0.039). Time of day and hearing loss showed no significant effect on the success rate.</p><p><strong>Conclusion: </strong>Obtaining MRI of the head without anaesthesia for infants under six months is feasible. For MRI CPA the success rate is higher for infants scanned at a younger age, as well as for female infants compared to male infants.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2321-2329"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}