European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Nasal cytological evidence of chronic inflammation in the olfactory cleft in post-viral olfactory dysfunction.","authors":"Gianluca Velletrani, Denise Fiorelli, Beatrice Francavilla, Marzia Nuccetelli, Sergio Bernardini, Simonetta Masieri, Stefano Di Girolamo","doi":"10.1007/s00405-025-09302-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09302-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated nasal cytological alterations in patients with persistent post-viral olfactory dysfunction. The primary objective was to evaluate the role of immune dysregulation and chronic local inflammation within the nasal mucosa in sustaining long-term olfactory impairment.</p><p><strong>Methods: </strong>An observational case-control study was conducted at the Otorhinolaryngology Department of the University of Rome Tor Vergata. Thirty-six patients with persistent olfactory dysfunction were compared to two control groups: one comprised subjects recovered from SARS-CoV-2 infection without olfactory impairment, and the other included individuals without a history of COVID-19 or olfactory dysfunction. Psychophysical olfactory function was assessed using the TDI (Threshold, Discrimination, and Identification) test. Nasal cytology samples were obtained via nasal brushing at the level of the olfactory cleft and stained using the May-Grunwald-Giemsa technique. Cellular alterations were evaluated using a semiquantitative grading system.</p><p><strong>Results: </strong>Patients with persistent olfactory dysfunction exhibited increased lymphocytes and neutrophils compared to both control groups, indicating ongoing local inflammation. Ciliocytophthoria was notably present in a significant portion of the olfactory dysfunction group, while absent or minimally present in controls. Eosinophils and mast cells were rare across all groups.</p><p><strong>Conclusion: </strong>Persistent post-viral olfactory dysfunction is associated with sustained immune activation and epithelial damage localized to the olfactory cleft. Elevated lymphocytes, neutrophils, and ciliocytophthoria emphasize the role of chronic inflammation in the pathogenesis of prolonged olfactory deficits. These findings highlight the potential utility of targeted therapies to modulate immune responses and promote olfactory recovery in affected patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of pre-operative ultrasonic depth of invasion (DOI) with histopathological depth of invasion (DOI) in gingivobuccal sulcus squamous cell carcinoma with neck nodal metastasis.","authors":"Akshay A Byadgi, Venkatesh Anehosur, Kaveri Hallikeri, Niranjan Kumar","doi":"10.1007/s00405-025-09326-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09326-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Head and neck carcinomas have the highest incidence among other carcinomas in the several regions of the country with trends still rising in the third population. The tumor mass is not planar but rather grows three-dimensionally, so surgeons should have the knowledge of the third dimension, which is the depth of invasion (DOI). Nowadays advanced techniques have been introduced to measure the preoperative depth of invasion of the primary tumor, i.e., ultrasonography (USG) scans. Ultrasonography (USG) scan is still considered a preoperative gold standard to measure DOI because of its advantages of radiation-free imaging and excellent tumor visualization, economical, non-invasive, and real-time images that can be obtained spontaneously. The primary objective of the study was to evaluate and compare pre-operative ultrasonic depth of invasion (DOI) with histopathological DOI in gingivobuccal sulcus squamous cell carcinoma with neck nodal metastasis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methodology: &lt;/strong&gt;This is a single-center prospective study including 51 patients reporting to our unit from November 2019 to November 2021 who were subjected to surgery. Preoperative USG evaluation of lesion was performed on all patients which recorded DOI.Similarly, postoperatively, all the resected specimens were examined for the histopathological DOI.The value obtained preoperatively from USG examinations was then compared with histopathological DOI postoperatively. Correlation coefficient analysis was studied using a scatter diagram by Karl Pearson and a dependent t-pair test. A chi-square with Yates's correction test was used to study the statistical association between USG DOI and lymph node metastasis (LNM).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 51 patients were included in the study of which 40(78.4%) were male patients and 11(21.6%) were female patients. DOI measured preoperatively from the USG scan in these cases ranged from 6 mm to 37 mm with an average of 19.41 mm. Histopathological DOI measured in all these patients ranged from 1.3 mm to 16 mm with an average of 7.26 mm. A statistical significance was noted between preoperatively measured DOI from the USG scan and postoperatively (histologically) measured DOI with a p-value of 0.0316. Cervical lymph node metastasis was USG positive in 15 (29.41%) patients out of 51 patients. Chi-square test with Yates's correction = 0.2721, P = 0.6020, noted association between the USG DOI and the occurrence of the cervical lymph node metastasis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;DOI is clearly a potentially useful and objectively measurable prognostic tool. USG imaging studies are used preoperatively to locate the extension of the lesion proper and to measure the area of the deepest invasion of the tumour. Preoperatively, DOI data obtained helps the surgeon to plan 3-dimensional clearance of the disease. Although USG scans lack in early detection of bone invasion in gingivo buccal sulcus","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comment on oral phenylephrine use in sinonasal pathologies.","authors":"Syed Ahmed Shahzaeem Hussain, Muhammad Talha, Muhammad Faizan Tariq","doi":"10.1007/s00405-025-09348-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09348-2","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participant valued appearance of bone conduction devices: a comparison between percutaneous and transcutaneous systems.","authors":"Hidde K Krijnen, Tjerk W Aukema, Myrthe K S Hol","doi":"10.1007/s00405-025-09335-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09335-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether the appearance of percutaneous bone conduction devices (perBCDs) or active transcutaneous bone conduction devices (atBCDs) is preferred by BCD-users and non-users. The second aim is to examine the degree to which the appearance of a device matters in comparison to other BCD traits, and whether certain participant characteristics predict this.</p><p><strong>Methods: </strong>An online questionnaire was designed and administered to BCD-users and non-users (i.e., persons with no experience using a BCD). Pair-wise comparisons showing pictures of the latest generation perBCD and atBCD sound processors and implant sites were anonymously provided to participants, who could indicate their preference. Sum scores were calculated ranging from - 2 (strong preference for perBCD) to 2 (strong preference for atBCD). Means for the total score as well as sub scores of pictures showing either sound processor or implant site were calculated. Statements were presented in which the appearance of the device was weighed against other traits such as better hearing.</p><p><strong>Results: </strong>The study population consisted of 102 BCD-users and 105 non-users. An overall preference for perBCD sound processors was observed (mean score - 0.50 (95% CI: -0.63, -0.37). BCD-users had no preference for implant sites whilst non-users preferred atBCDs (-0.03 (-0.27, 0.21) and 0.60 (0.40, 0.80) respectively, p < 0.01). Most participants found better hearing more important than having an appealing device (n = 150, 73.0%).</p><p><strong>Conclusions: </strong>PerBCD sound processors were preferred over atBCD sound processors by both BCD-users and non-users. Functionality seems to be more important than the appearance of the device.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGR2 activates the TGF-β/Smad signaling pathway to promote epithelial-mesenchymal transition, invasion, and metastasis in nasopharyngeal carcinoma.","authors":"Hui Jin, Gengtian Liang, Wenxia Huang, Zhen Wang, Longjun Wu, Yaping Li","doi":"10.1007/s00405-025-09328-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09328-6","url":null,"abstract":"<p><strong>Background: </strong>Anterior gradient 2 protein (AGR2) is associated with tumorigenesis and metastasis in different cancers. However, its role in nasopharyngeal carcinoma (NPC) remains unknown. This study aimed to explore the effect of AGR2 on epithelial-mesenchymal transition (EMT) in NPC and its underlying mechanisms.</p><p><strong>Methods: </strong>AGR2 expression was analyzed in cancerous and para-cancerous tissues from ten NPC patients using RT-qPCR. Western blotting was used to determine the AGR2 protein levels in two NPC cell lines and a nasopharyngeal epithelial cell line. AGR2 was overexpressed or knocked out in NPC cells and its effects on cell viability, migration, invasion, and EMT markers were evaluated in vitro.</p><p><strong>Result: </strong>AGR2 expression was significantly higher in NPC tissues compared to adjacent normal tissues. Similarly, NPC cell lines exhibited increased AGR2 levels compared to the nasopharyngeal epithelial cell line. AGR2 knockout significantly reduced cell viability, migration, and invasion. It also decreased N-cadherin protein levels while increasing E-cadherin, α-SMA, and vimentin expression. Conversely, AGR2 overexpression produced the opposite effects. Furthermore, AGR2 deletion inactivated the TGF-β/Smad signaling pathway.</p><p><strong>Conclusion: </strong>AGR2 promotes tumor progression and EMT in NPC through activation of the TGF-β/Smad signaling pathway. These findings suggest that AGR2 may serve as a potential biomarker and therapeutic target for NPC.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of irradiated mucosa using confocal laser endomicroscopy in the upper aerodigestive tract.","authors":"Lisa Thesing, Matti Sievert, Bharat Akhanda Panuganti, Marc Aubreville, Till Meyer, Flurin Müller-Diesing, Agmal Scherzad, Stephan Hackenberg, Miguel Goncalves","doi":"10.1007/s00405-025-09318-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09318-8","url":null,"abstract":"<p><strong>Purpose: </strong>Confocal laser endomicroscopy (CLE) enables a real time in-vivo optical biopsy of the upper aerodigestive tract. Previous studies demonstrated its potential in identifying malignant tissue, but none examined mucosa treated with radiotherapy. This study characterizes the appearance of irradiated mucosa using CLE.</p><p><strong>Methods: </strong>We recorded 58 CLE sequences (860 s, 6,884 frames) in 10 patients previously treated with radiotherapy for upper aerodigestive tract tumors. A corresponding tissue biopsy (formalin-fixed, H&E stained) was taken as the reference standard for each sequence. We analyzed each sequence regarding differences from normal mucosa and characterized irradiated mucosa in CLE.</p><p><strong>Results: </strong>Irradiated mucosa in CLE exhibits irregular tissue architecture. Radiation induces DNA damage, apoptosis, and tissue inflammation, leading to hyperkeratotic and fibrotic tissue. Consequently, CLE showed a wider range of cellular morphologic and tissue structural aberrancies, in comparison to normal, non-irradiated mucosa. In addition to regular honeycomb-like patterns, the tissue displayed uneven, blurry, and cell-rich areas. Irradiated mucosa appears more irregular and variable in CLE than radiation-naïve mucosa.</p><p><strong>Conclusion: </strong>Irradiated mucosa can be differentiated from healthy tissue using CLE, but its higher baseline morphological variability may mimic malignancy. Further research is needed to clarify its impact on tumor detection and refine existing scoring systems.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implant benefits over time in adult patients with Single Sided Deafness.","authors":"Cuda Domenico, Pizzol Erica, Laborai Andrea, Salsi Daria, Sara Ghiselli","doi":"10.1007/s00405-025-09298-9","DOIUrl":"https://doi.org/10.1007/s00405-025-09298-9","url":null,"abstract":"<p><strong>Purpose: </strong>Recently, the indications for Cochlear Implant (CI) have also been extended to subjects with Single Sided Deafness (SSD) in order to restore binaural hearing. The primary objective of this study was to investigate the advantages of CI following one year of usage in SSD subjects. Secondarily we want to assess the long-term stability of the CI.</p><p><strong>Methods: </strong>57 participants performed speech audiometry in noise and localization test. For each was also evaluated subjective hearing profile (with Speech Spatial and Qualities_SSQ questionnaire) and the impact of tinnitus (with the Tinnitus Handicap Inventory_THI questionnaire).</p><p><strong>Results: </strong>After one year of CI usage, we observed a significant improvement in speech in noise, in sound localization abilities, in the Speech (p-value 0.001) and Spatial (p-value 0.001) subscales of the SSQ questionnaire and in THI questionnaire (p-value 0.001). The improvements in speech in noise and localization abilities and the reduction of the SSQ and THI questionnaires scores were maintained over time. Only eight participants did not fully utilize the CI.</p><p><strong>Conclusion: </strong>CI in SSD represents an effective method for improving speech recognition in noisy environments, restoring sound localization abilities, reducing tinnitus and improve subjective listening skills.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical liability in France: analysis of claims in otorhinolaryngology.","authors":"Florent Carsuzaa, Valentin Favier, Alexia Delbreil, Adeline Ranger, François Arnault, Xavier Dufour, Stéphane Tringali, Maxime Fieux","doi":"10.1007/s00405-025-09316-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09316-w","url":null,"abstract":"<p><strong>Introduction: </strong>Claims against surgeons have increased considerably in Europe and North America. Ear nose and throat (ENT) physicians appears to be little affected by civil, administrative, criminal or disciplinary claims. Our objective was to conduct a comprehensive review of claims pertaining to ENT physicians in France.</p><p><strong>Methods: </strong>A retrospective study including criminal, civil, administrative, and disciplinary claims against French ENT physicians between 2010 and 2023 was conducted. All claims against ENT physicians related to medical malpractice, over-invoicing and non-professional human behavior were included. The French legal system is structured around four main jurisdictions: criminal, civil, administrative, and disciplinary. Descriptive analyses of claims were made according to the four jurisdictions, the jurisdictional court involved, the type of malpractice, the outcome (conviction or dismissal), the type of sentence and the reasons for convictions.</p><p><strong>Results: </strong>Among 2688 claims screened, 88 claims (3%) were related to ENT procedures. Claims most frequently concerned medical malpractices (70%, 62/88), with otology (23%, 20/88) as first subspecialty followed by rhinology (20%, 18/88), over-invoicing issues (21%, 18/88), and non-professional human behaviors (9%, 8/88). Among all claims, 67% (59/88) resulted in a conviction and concerned medical malpractice in 59% (35/59), over-invoicing issues in 29% (17/59) of cases, and non-professional human behavior in 10% (6/59).</p><p><strong>Conclusion: </strong>Criminal, civil, administrative, and disciplinary claims against ENT physicians frequently result in convictions. ENT physicians must be vigilant regarding the information they provide to patients, their surgical indications, and compliance to the established procedures validated by learned societies.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesteatoma aggressiveness in paediatric vs. adult patients: a comparative analysis of molecular markers with MERI and EAONO/JS staging.","authors":"M Karthikeyan, Vishudh Mohan, Purvi Purohit, Vidhu Sharma, Kapil Soni, Bikram Choudhury, Mithu Banerjee, Poonam Elhence, Amit Goyal","doi":"10.1007/s00405-025-09322-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09322-y","url":null,"abstract":"<p><strong>Purpose: </strong>Cholesteatoma is characterized by the abnormal growth of keratinizing squamous epithelium in the middle ear. Although both pediatric and adult populations are affected, differences in the molecular mechanisms underlying cholesteatoma between these age groups are not fully understood. miRNA-21 and IL-6 have been implicated in various inflammatory and proliferative processes, and their roles in cholesteatoma pathogenesis among different age groups warrant detailed investigation. Research objective -Compare the expression levels of miRNA-21 and IL-6 genes in pediatric versus adult cholesteatoma tissues to elucidate potential age-related molecular differences.</p><p><strong>Methods: </strong>Tissue samples were collected from 30 patients (15 in Pediatric group and 15 in Adult group) undergoing surgical treatment for cholesteatoma. Preoperative MERI scores and Quantitative real-time PCR (qRT-PCR) was employed to measure the expression levels of miRNA-21 and IL-6. Statistical analyses were conducted to compare the expression profiles between the two groups.</p><p><strong>Results: </strong>The results revealed a significantly higher expression of miRNA-21 and IL-6 in pediatric cholesteatoma compared to adult cholesteatoma. These findings suggest distinct molecular pathways may be involved in the pathogenesis of cholesteatoma in different age groups.</p><p><strong>Conclusion: </strong>The differential expression of miRNA-21 and IL-6 between pediatric and adult cholesteatoma underscores the potential for age-specific therapeutic targets. Increased miRNA-21 and IL-6 gene expression in pediatric cases may indicate a more pronounced role in tissue proliferation and inflammation. Further research is necessary to explore the clinical implications and potential for targeted treatments based on these molecular differences.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between abdominal visceral fat and laryngopharyngeal reflux in patients with obstructive sleep apnea.","authors":"Xiangrong Cao, Yanru Duan, Yibo Hao, Zhe Wang, Chenhai Zheng, Zhiming Zhang, Jie Qin, Dahai Wu","doi":"10.1007/s00405-025-09320-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09320-0","url":null,"abstract":"<p><strong>Purpose: </strong>To research the correlation between abdominal visceral fat and laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>This study included 72 OSA patients, and the correlation between abdominal visceral fat and the severity of LPR was analyzed after abdominal visceral fat area (VFA) was measured according to body composition analysis and reflux symptom index (RSI) score was completed. Finally, in order to further clarify the effect of VFA on LPR, multiple linear regression analysis was performed on the collected related parameters.</p><p><strong>Results: </strong>Partial correlation analysis showed that the VFA was positively correlated with the RSI score (r = 0.502, p < 0.001) after controlling for apnea-hypopnea index (AHI), body mass index (BMI), lowest oxygen saturation (LSO₂), age, and sex. The multiple linear regression analysis indicated that VFA and AHI were the factors influencing LPR (t = 4.678, p < 0.001; t = 3.164, p = 0.002).</p><p><strong>Conclusion: </strong>Our study found that VFA was associated with RSI score in OSA patients, but BMI didn't show an independent correlation with RSI score. This indicated that we should pay attention to the effect of abdominal visceral fat on LPR in OSA patients, and more experiments are needed in the future to clarify the relationship between the two.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}