European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Development of an extratracheal device for pulmonary function assessment in laryngectomized patients.","authors":"Carlos Eduardo Molinari Nardi, Mario Augusto Ferrari de Castro, Daniel A Ribeiro, Luiz Paulo Kowalski, Rogério Aparecido Dedivitis","doi":"10.1007/s00405-025-09415-8","DOIUrl":"10.1007/s00405-025-09415-8","url":null,"abstract":"<p><strong>Purpose: </strong>Pulmonary function assessment in laryngectomized patients is challenging due to technical difficulties in performing spirometry. Existing methods have limitations, including potential air leakage and patient discomfort. The purpose of this study was to develop a simple, comfortable extratracheal device for accurate pulmonary function assessment in laryngectomized patients.</p><p><strong>Methods: </strong>We designed a silicone extratracheal device with a central connector for spirometer attachment and an adhesive layer for secure skin fixation. Ten laryngectomized patients underwent spirometry using the device. Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and FEV1/FVC ratio were measured and compared to predicted values.</p><p><strong>Results: </strong>The extratracheal device was validated after performing successful spirometric tests in 10 laryngectomized patients, maintaining the necessary air seal to ensure the accuracy of the results, with no air leakage. Pulmonologists evaluating the device found it to be technically adequate for report generation.</p><p><strong>Conclusion: </strong>The developed extratracheal device has proven to be reliable and effective for assessing pulmonary function in laryngectomized patients, potentially serving as a valuable tool for regular pulmonary function monitoring in this population.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3771-3776"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of surgeon experience on the incidence of tip fold-over with slim preformed cochlear implant electrodes.","authors":"Esther Knörle, Caterina Vazzana, Timo Stöver, Silke Helbig","doi":"10.1007/s00405-025-09235-w","DOIUrl":"10.1007/s00405-025-09235-w","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether increasing experience with implantation of a thin preformed electrode array for perimodiolar insertion reduces the incidence of tip fold-over (TFO).</p><p><strong>Methods: </strong>The retrospective study included 100 patients who received a cochlear implant (CI) with the Slim Modiolar (SM) electrode array (Cochlear, Sydney, Australia) at a university CI centre between November 2015 and December 2022. Postoperative radiological imaging was performed to verify electrode position. Surgical reports and radiological images were reviewed and the incidence of TFO was analyzed for three experienced CI surgeons. In addition, the incidence of intraoperative measurements showing evidence of electrode malposition and the mean duration of surgery over time were documented.</p><p><strong>Results: </strong>129 SM implantations in 100 patients were included. In seven cases (5.4%) TFO was radiologically detected and successfully revised. In eight cases (6.2%), electrophysiological measurements indicated misplacement and the position was corrected during the same surgery. For one surgeon, five out of 67 implantations (7.5%) were affected by TFO, with the frequency of this complication decreasing over time. The average surgery time for all surgeons was 122.2 (± 44.2) minutes, with two surgeons showing a decrease over time.</p><p><strong>Conclusion: </strong>The results show a tendency that the SM electrodes can be implanted with a lower complication rate and faster over time. Therefore, it can be assumed that the implantation of the SM electrode requires a certain amount of practice, even for experienced surgeons. As intraoperative electrophysiological measurements detected 71.4% of all radiologically confirmed TFOs, their use is highly recommended.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3449-3456"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of postoperative outcomes of cochlear implantation in hearing impaired patients: auditory-verbal and spatial hearing abilities.","authors":"Xiyu Quan, Jun Ying, Wei Lu, Du Wu, Chenghua Tian","doi":"10.1007/s00405-025-09237-8","DOIUrl":"10.1007/s00405-025-09237-8","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effects of cochlear implantation on auditory-verbal and spatial-auditory abilities of hearing-impaired children.</p><p><strong>Methods: </strong>A total of 406 hearing-impaired patients, ranging from 1 to 13 years, were categorized into six groups: 1-3 years (7), 3-5 years (34 ), 5-7 years (62), 7-9 years (94 ), 9-11 years (138 ), and 11-13 years (71 ) groups. Auditory-verbal ability and speech-space hearing quality were assessed using the Categories of Auditory Performance (CAP), the Speech Intelligibility Rating (SIR), and the Chinese version of the Speech, Spatial, and Other Qualities of Hearing Scale-Parental (SSQ-P). The auditory and speech abilities of cochlear implant patients at 1-3, 3-5, 5-7, 7-9, 9-11, and 11-13 years after start-up were compared.</p><p><strong>Results: </strong>A longer duration of cochlear implant use within 1-9 years of start-up was associated with higher hearing ability and speech intelligibility scores of the hearing impaired patients (p < 0.001). The dimensions of speech perception and auditory quality in the SSQ-P questionnaire were also significantly improved (p < 0.001). Auditory ability, speech intelligibility, and speech-spatial hearing quality of hearing-impaired patients showed a decreasing trend within 9-13 years of start-up. Auditory ability affects speech perception and speech function affects 2 dimensions of speech perception and hearing quality.</p><p><strong>Conclusions: </strong>Children with cochlear implants showed a significant improvement in auditory-verbal ability up to 9 years after start-up. Therefore, cochlear implantation has significantly improved auditory speech and spatial hearing abilities in children with hearing loss, and it is suggested that 9 years after implantation can be an important reference stage for whether to proceed with device renewal.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3457-3464"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of sensorineural hearing loss and its relation to Optical Coherence Tomography Angiography findings in Behcet's disease.","authors":"Maha S I Abdelrahman, Mohamed G A Saleh, Maha Abdelgaber A Aly, Shaimaa Salah","doi":"10.1007/s00405-025-09280-5","DOIUrl":"10.1007/s00405-025-09280-5","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to analyze auditory involvement in patients with Behcet's disease and its association with Optical Coherence Tomography Angiography findings and disease manifestations.</p><p><strong>Methods: </strong>This study included 54 eyes and 68 ears of 34 adults with Behcet's disease in comparison to 30 eyes and 60 ears of healthy controls. Clinical, laboratory and ophthalmological evaluation including Optical Coherence Tomography Angiography was done. Audiological assessment included otoscopic examination, immitancemetry and pure tone and speech audiometry.</p><p><strong>Results: </strong>Sensorineural hearing loss was observed in 32.35% of the studied cases. Behcet's disease patients showed significantly higher average hearing level and significant reduction of retinal vessel density compared to controls. Patients with sensorineural hearing loss demonstrated significantly lower central retinal capillary vessel density and higher neuro-Behcet's disease incidence in comparison to those without hearing loss (p-value = 0.039 and 0.024, respectively), which was confirmed by univariate regression analysis. After entering significant factors into the multivariate model, neuro-BD was identified as the most significant single predictor of sensorineural hearing loss in BD (p-value = 0.003).</p><p><strong>Conclusions: </strong>The association between sensorineural hearing loss and central retinal vessel density reduction and neuro- Behcet's disease should be considered in Behcet's disease.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3571-3578"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive thermal ablation techniques for neck lipomas: RFA vs. MWA.","authors":"Pi-Ling Chiang, Johnson Chia-Shen Yang, Chih-Chi Chou, Wei-Che Lin","doi":"10.1007/s00405-025-09398-6","DOIUrl":"10.1007/s00405-025-09398-6","url":null,"abstract":"<p><p>Lipomas, common benign tumors, may cause discomfort and cosmetic concerns. Radiofrequency ablation (RFA) and microwave ablation (MWA) is a minimally invasive treatment gaining popularity. This report examines the efficacy of RFA and MWA in treating neck lipomas. Two cases of RFA and MWA for neck lipomas were evaluated over 6 months. RFA achieved 53% volume reduction with partial ablation, while MWA resulted in remarkable reductions (81%, 86%, and 90% at 1, 3, and 6 months). Thermal ablation techniques are possibly used for managing lipomas. MWA is a more effective and safer minimally invasive option for treating neck lipomas compared to RFA, offering significant volume reduction and potential for broader clinical application.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3801-3805"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally advanced maxillary sinus cancer fed from the internal carotid artery.","authors":"Tatsuhiko Yamada, Masashi Kuroki, Hirofumi Shibata, Shoma Nagata, Hiroshi Kawada, Hiroki Kato, Akira Ohkoshi, Ikuho Kojima, Ryota Iinuma, Hiroshi Okuda, Yukio Katori, Masayuki Matsuo, Takenori Ogawa","doi":"10.1007/s00405-025-09343-7","DOIUrl":"10.1007/s00405-025-09343-7","url":null,"abstract":"<p><strong>Objective: </strong>Superselective intra-arterial infusion of cisplatin and concomitant radiation therapy (RADPLAT) is one of the effective treatments for advanced maxillary sinus cancer, and prospective trials have been conducted. However, treatment of cases with intraorbital infiltration or skull base infiltration that are fed from the internal carotid artery (ICA) may be problematic. In this study, we investigated the frequency, treatment, and prognosis of locally advanced maxillary sinus cancer fed from the ICA.</p><p><strong>Method: </strong>This study included patients with locally advanced maxillary sinus cancer (clinical T4a or T4b) who underwent RADPLAT only via external carotid artery from January 2008 to January 2024.</p><p><strong>Result: </strong>Nineteen of 44 cases were fed from the ICA (43.2%). Three-year overall survival (OS), three-year progression-free survival (PFS), and three-year local control rate (LCR) of all cases were 69.8%, 47.5%, and 61.8%, respectively. The three-year OS, PFS and LCR were equivalent between cases with or without feeding from the ICA.</p><p><strong>Conclusion: </strong>This study revealed the frequency and prognosis of locally advanced maxillary sinus cancer fed from the ICA. The prognosis was equivalent between cases with or without feeding from the ICA; therefore, it would be considered important to determine the tumor volume for each feeding blood vessel and assess the areas of dual perfusion.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3723-3728"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submandibular sialolithiasis treatment: a comparative pilot prospective study of holmium: YAG laser and pneumatic lithotripsy techniques.","authors":"Necdet Özçelik, Husam Vehbi, Elvin Alaskarov","doi":"10.1007/s00405-025-09309-9","DOIUrl":"10.1007/s00405-025-09309-9","url":null,"abstract":"<p><strong>Objective: </strong>Sialendoscopy is a minimally invasive technique employed to diagnose and treat obstructions in the major salivary glands.Holmium: YAG Laser Lithotripsy (HLL) and Intraductal Pneumatic Lithotripsy (IPL) are increasingly utilized for stone fragmentation; however, comparative studies are still limited. This study aims to prospectively compare the outcomes of HLL and IPL in cases of submandibular sialolithiasis.</p><p><strong>Materials and methods: </strong>Fifty patients diagnosed with submandibular sialolithiasis were randomly assigned to two groups for treatment with either HLL or IPL. Demographics, stone size and location, operative times, and complications were meticulously documented. Preoperative imaging with ultrasound and computed tomography identified stone parameters. Follow-up assessments occurred at 1 week, 3 months, and 6 months post-treatment, which included a 3-month ultrasound to evaluate for residual stones and assess ductal evaluation.</p><p><strong>Results: </strong>No significant differences between the groups concerning demographics, stone size, or location (p > 0.05). However, the IPL group demonstrated shorter operative times for distal and mid-duct stones (p < 0.05). The stone-free rates were 92% in the HLL group and 96% in the IPL group. The HLL group exhibited higher rates of mucosal laceration and ductal perforation, while the IPL group showed a greater potential for stone migration. Postoperative symptom resolution was achieved in both groups. Additionally, quality of life (QOL) scores, assessed using the SF-36 questionnaire, showed significant improvement at 6 months postoperatively in both groups, with no statistically significant differences between them.</p><p><strong>Conclusion: </strong>Both HLL and IPL are effective treatments for submandibular sialolithiasis. IPL is associated with shorter operative times, especially for distal and mid-duct stones, while the complication rates for both methods remain within acceptable limits.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3689-3697"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of miRNA in laryngeal squamous cell carcinoma progression: a retrospective study.","authors":"Nejmiye Akkuş, Elif Kaya Çelik, Suleyman Ozdemir, Emrah Sapmaz","doi":"10.1007/s00405-025-09306-y","DOIUrl":"10.1007/s00405-025-09306-y","url":null,"abstract":"<p><strong>Objective: </strong>MicroRNAs (miRNAs) have emerged as promising biomarkers for diagnosis and prognosis in laryngeal squamous cell carcinoma (LSCC). This study investigates the expression patterns of specific cancer-associated miRNAs in early and advanced stage LSCC to evaluate their potential role in disease progression.</p><p><strong>Methods: </strong>The expression levels of miRNA-21, miRNA-802, miRNA-29 and miRNA-9 were analysed in formalin-fixed paraffin-embedded (FFPE) tissues from 44 LSCC patients (20 early stage, 24 advanced stage) using quantitative multiplex RT-PCR. Tissue samples were analysed retrospectively.</p><p><strong>Results: </strong>The expression level of hsa-miR-9a expression was significantly upregulated (5.2-fold) in advanced stage patients compared to the early stage group (p = 0.0088). Similarly, hsa-miR-802a showed significantly higher expression (9.2-fold) in advanced stage patients compared to early stage patients (p = 0.005). No significant differences in miRNA-21 and miRNA-29 expression levels were observed between the groups.</p><p><strong>Conclusion: </strong>As a result of the study, elevated miRNA levels in advanced stage patients can be used in targeted therapy and evaluated as a treatment option in LSCC patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3683-3688"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.","authors":"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö","doi":"10.1007/s00405-025-09251-w","DOIUrl":"10.1007/s00405-025-09251-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).</p><p><strong>Materials and methods: </strong>This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.</p><p><strong>Results: </strong>EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.</p><p><strong>Conclusions: </strong>Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3513-3521"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and safety of repositioning maneuvers for posterior semicircular canal BPPV (benign paroxysmal positional vertigo) in elderly over 80 years of age.","authors":"Luigi Califano, Iacopo Cangiano, Alessandro Nobile, Roberto Teggi","doi":"10.1007/s00405-025-09234-x","DOIUrl":"10.1007/s00405-025-09234-x","url":null,"abstract":"<p><strong>Purpose: </strong>Balance problems in the elderly are a major social concern, primarily due to the risk of falls. One of the reasons of fast worsening of stability and therefore falling is represented by acute BPPV. Treatment through repositioning maneuvers could significantly reduce the risk of further falls of the patients treated with. The physical ability of older individuals to be treated with maneuvers is a topic of debate due to possible joint stiffness and less compliance with movements. There are few previous studies focusing on the practicality and effectiveness of physical therapy for BPPV in people over 80 years.</p><p><strong>Methods: </strong>We conducted a retrospective study collecting data on 517 patients to assess the feasibility, effectiveness, safety and the number of therapeutic maneuvers necessary to get therapeutic success when treating individuals over 80 years compared to those aged between 18 and 64.</p><p><strong>Results: </strong>We found no difference in terms of number of maneuvers needed to get therapeutic success between the two groups. As for the therapeutic maneuver no difference in success and feasibility of execution was found between Semont and Epley maneuvers which proved equally effective in the two groups.</p><p><strong>Conclusion: </strong>Our data are not inconsistent with the hypothesis that repositioning maneuvers for posterior canal BPPV are feasible and demonstrated a good efficacy in all elderly people. This could encourage the diagnosis and treatment of BPPV also for the purpose of reducing the risk of falls in the elderly.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3443-3447"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}