European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Angiofibroma arising from the olfactory epithelium.","authors":"Fabio Portella Gazmenga, Mariana Dalbo Contrera Toro, Fabio Lau, Luciana Schultz, Eulalia Sakano","doi":"10.1007/s00405-025-09386-w","DOIUrl":"10.1007/s00405-025-09386-w","url":null,"abstract":"<p><strong>Background: </strong>Angiofibromas are rare benign vascular tumors, with juvenile nasopharyngeal angiofibroma (JNA) being the most common clinical presentation. Even more rarely, histologically similar tumors can develop outside of nasopharynx, known as extranasopharyngeal angiofibromas (ENAs), and are considered distinct entities owing to their unique clinical features.</p><p><strong>Clinical case: </strong>A 42-year-old man presented with a 12-month history of epistaxis and right nasal obstruction. Computed Tomography and Magnetic Resonance Imaging of the face revealed expansile solid lesion centered within the right nasal cavity, without involvement of sphenopalatine foramen. During endoscopic endonasal surgery to resect the tumor, its insertion into the olfactory epithelium was identified, at the transition between the nasal septum and the roof of the nasal cavity, in the most posterior portion of the olfactory fossa. Histopathological analysis and immunohistochemical study confirmed the diagnosis of angiofibroma.</p><p><strong>Discussion: </strong>ENAs affect all age groups, including women, are generally less vascularized and grow more rapidly than JNAs. ENAs are typically diagnosed in early stages and are less locally aggressive; furthermore, complete surgical resection is generally feasible for ENAs and the associated recurrence rate is low.</p><p><strong>Conclusion: </strong>Although rare, angiofibromas should be considered in the differential diagnosis of vascularized tumors outside the nasopharynx, irrespective of patient's sex or age.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3795-3799"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Helicobacter pylori have a role in the pathogenesis of otitis media with effusion, or is it a fallacy??","authors":"Ayse Yasemin Gunduz, Mahmut Tayyar Kalcioglu, Serdal Celik, Oguz Ari, Riza Durmaz","doi":"10.1007/s00405-025-09277-0","DOIUrl":"10.1007/s00405-025-09277-0","url":null,"abstract":"<p><strong>Purpose: </strong>Helicobacter pylori, causing chronic systemic infection, may colonize in middle ear milieu and conduce to effusion collection. Many investigations on relationship between pathogenesis of otitis media with effusion (OME) and Helicobacter pylori yielded conflicting results. We investigated Helicobacter pylori presence in effusion and adenoid samples of children having OME and in middle ear and adenoid samples of children with healthy middle ears to elucidate its role on OME pathogenesis.</p><p><strong>Methods: </strong>This prospective case-control study included 300 patients aged 1-12 years. One-hundred effusion samples collected from 100 children undergoing ventilation tube insertion and adenoidectomy due to chronic OME and adenoid hypertrophy formed study group, and 100 adenoid samples collected from adenoids of these children formed Group-1. One-hundred healthy-looking middle ear irrigation solutions collected from 100 children undergoing cochlear implantation formed Group-2. One-hundred adenoid samples collected from 100 children having no effusion and only undergoing adenoidectomy formed Group-3. After DNA isolation of samples, Helicobacter pylori 16 S rRNA and 23 S rRNA gene for clarithromycin-resistance were investigated by real time-polymerase chain reaction (Rt-PCR).</p><p><strong>Results: </strong>The median age of 300 children was 5, and 179 were boys and 121 were girls. Helicobacter pylori was detected by Rt-PCR in none (%0) of the 400 samples (200 middle ear, 200 adenoid).</p><p><strong>Conclusion: </strong>In this largest sample-size study utilizing updated molecular methods to date, negative results indicate that Helicobacter pylori does not play role as an active pathogen in polymicrobiality of OME, and adenoids do not serve as a reservoir for Helicobacter pylori in this process.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3561-3569"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of notched music therapy vs conventional music therapy for chronic subjective tinnitus patients: a systematic review and meta-analysis.","authors":"Wen Jiang, Yun Zheng, Cheng Zheng, Rouxian Chen, Bin Li","doi":"10.1007/s00405-025-09260-9","DOIUrl":"10.1007/s00405-025-09260-9","url":null,"abstract":"<p><strong>Purpose: </strong>The etiology and mechanism of chronic subjective tinnitus (CST) are still unclear, thus there is no specific treatment yet. The notched music therapy (NMT) has been found to relieve patients' tinnitus symptoms, but its efficacy is still controversial. This study aims to resolve the controversy through meta pooling method.</p><p><strong>Methods: </strong>By searching Embase, Pubmed, Elsevier, WOS, CNKI, and CBM (China Biology Medicine disc) databases, relevant literature on \"notch music therapy\" and \"tinnitus\" was obtained, and suitable clinical controlled trials were screened. Cochrane ROB v2.0 was used to assess the risk of literature bias, and the efficacy after treatment was evaluated by pooling the effect size of tinnitus handicap inventory (THI) and visual analog scale (VAS) between intervention group and control group.</p><p><strong>Results: </strong>A total of 14 randomized controlled trial studies were included for quantitative analysis, with a total of 793 CST patients participating, including 395 patients in the intervention group and 398 patients in the control group. Among them, five studies were evaluated as biased with \"some concerns of risk\". The meta-analysis results showed a pooling effect size of THI score of patients after 3 months of treatment (MD = - 8.62, 95% CI (- 17.01, - 0.23), Z = - 2.01, P = 0.044) and VAS score of tinnitus after 3 months of treatment (MD = - 1.13, 95% CI (- 2.49, - 0.11), Z = - 2.14, P = 0.003) between NMT and conventional music therapy (CMT). Heterogeneity investigation and regression analysis found that notch frequency range, publication year, and patient age were not specific factors affecting the merged results. The sensitivity analysis results showed that the comprehensive effect size was stable and reliable, with no significant publication bias (P > 0.05).</p><p><strong>Conclusion: </strong>Compared to traditional music therapy, notched music therapy can significantly reduce the scores of the tinnitus disability scale and tinnitus loudness score for patients after treatment. It is a good non-pharmacological treatment that is worthy of clinical promotion.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3431-3442"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-melanoma skin cancer of the external auditory canal: long-term outcomes of a tertiary head and neck unit.","authors":"Eleanor Apthorp, Rebecca Lam, Rupert Obholzer, Jean-Pierre Jeannon, Richard Oakley, Aleix Rovira","doi":"10.1007/s00405-025-09274-3","DOIUrl":"10.1007/s00405-025-09274-3","url":null,"abstract":"<p><strong>Purpose: </strong>External auditory canal (EAC) skin cancer is often diagnosed at advanced stages, leading to poor survival outcomes. Our study aims to describe disease characteristics, treatments and outcomes of patients with EAC cancer, increasing understanding of the management of this rare disease.</p><p><strong>Methods: </strong>Retrospective, observational study including patients with non-melanoma EAC skin cancer treated at Guy's and St Thomas' Head and Neck Unit from 2012 to 2021, with follow-up until October 2023. Patient with EAC or auricular primaries extending into the EAC were included. Demographic, histopathological, and surgical data were obtained from electronic records.</p><p><strong>Results: </strong>Thirty-eight patients were included, 86.8% treated with curative intent. The median follow-up was 49.9 months. One, three, and five-year overall survival for patients treated curatively were 100%, 96.9% and 75.3%, respectively, versus 40.0%, 0.0% and 0.0% for palliative. 68.4% had advanced disease (Pittsburgh staging, III: 18.4%, IV: 50.0%). 39.5% were treated after recurrent or persistent disease. Histological subtypes included squamous cell carcinoma (60.5%), basal cell carcinoma (26.3%) and others (13.2%). Among those treated surgically (n = 31), 74.2% underwent lateral temporal bone resection and 29.0% wide local excision. 83.9% had parotidectomy, neck dissection or both. 51.6% received post-operative radiotherapy/chemoradiotherapy. Advanced stage was significantly associated with reduced overall survival (p = 0.05) but not disease-free survival (p = 0.25). No primary site features, regional metastasis (p = 0.63), direct parotid invasion (p = 0.71) or age (p = 0.15) significantly impacted survival.</p><p><strong>Conclusion: </strong>According to the good outcomes reported, this study suggests lowering the threshold for radical treatment may improve outcomes for patients with potentially poor prognostic features.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3657-3667"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of peroperative ultrasound used by the surgeon in parathyroidectomy on operation time.","authors":"Mehmet Turan Cicek, Mehmet Aslan, Cigdem Firat Koca","doi":"10.1007/s00405-025-09319-7","DOIUrl":"10.1007/s00405-025-09319-7","url":null,"abstract":"<p><strong>Purpose: </strong>One of the endocrine conditions that endocrinologists see the most frequently is primary hyperparathyroidism, which is brought on by a parathyroid adenoma. Minimally invasive parathyroidectomy (MIP) has become the first line of treatment for primary hyperparathyroidism due to solitary parathyroid adenoma. Surgeon-performed ultrasonography (SUS), which has been found to be extremely accurate in localizing aberrant glands, has been employed preoperatively to augment the sensitivity of high-resolution ultrasonography (hUS).</p><p><strong>Methods: </strong>Two groups were randomly created from cases that underwent parathyroid surgery. In the first group, surgery was performed on 31 patients, taking into account the ultrasound results reported by radiology and the Technetium-99 m sestamibi scintigraphy results interpreted by the nuclear medicine clinic. In addition to the ultrasound results reported by radiology and the scintigraphy results interpreted by the nuclear medicine clinic, surgery was performed on 18 patients in the second group, that the surgeon applied ultrasound to them before the operation and separately evaluating the location of the parathyroid adenoma. Surgery time, hospital stay, pre and postoperative calcium and parathormon values were compared between the two groups.</p><p><strong>Results: </strong>When groups 1 and 2 were compared in terms of surgical time and hospital stay, there was a statistically significant difference between the two groups (p < 0.05). In Group 2, the duration of operation and hospital stay was significantly shortened. There was no statistically significant difference between the groups in terms of pre- and postoperative calcium and parathormone values (p > 0.05).</p><p><strong>Conclusions: </strong>We believe that the time required for surgery after a radiologist and surgeon performing ultrasonography is less than that required for surgery after radiologist performed ultrasonography demonstrating the efficacy of the surgery plus a radiologist and surgeon performing ultrasonography combination. We determined that the surgery time was statistically shorter in patients who underwent a radiologist and surgeon performing ultrasonography.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3699-3706"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is ductoplasty required following transoral sialolithotomy? - A case series.","authors":"Katie Holland, Jinnee U J Lee, Olga Gomeniouk, Grant S Owen, Richard Raad, Mihir Bhayani","doi":"10.1007/s00405-025-09324-w","DOIUrl":"10.1007/s00405-025-09324-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine if there was a difference in postoperative outcomes and complications between patients who underwent traditional two-layer closure (ductoplasty and floor of mouth) after Wharton's duct sialolithatomy during hybrid sialendoscopy compared to those who underwent single layer closure of only the floor of mouth.</p><p><strong>Methods: </strong>Retrospective case series of a single surgeon's patients who underwent hybrid sialendoscopy at an urban tertiary care hospital. Demographic, preoperative, intraoperative, and postoperative information was collected from patients who underwent hybrid sialendoscopy with transoral sialolithotomy of Wharton's duct from 2020 to 2023. Data included salivary glands explored, intraoperative complications, ductal repair, postoperative complications, and recurrence of salivary symptoms.</p><p><strong>Results: </strong>32 patients underwent hybrid sialendoscopy. Of those, 28.1% (n = 9) underwent traditional two-layer closure, and in 71.9% (n = 23) had single layer closure. 2.6% (n = 1) had a postoperative infection. There were no immediate postoperative complications reported in those with single layer closure. There was no statistical difference in postoperative complications between the two groups (p = 0.10). In patients with follow up, 86.7% of (n = 13) patients had documented salivary flow through the natural papilla after one layer closure compared to 80% (n = 4) in the two-layer group. There was no significant difference between the groups (p = 0.72).</p><p><strong>Conclusions: </strong>The results of this study support that single layer closure without ductoplasty after hybrid sialendoscopy allows for ductal recanalization and may produce the same postoperative outcomes as traditional two-layer closure while increasing operative efficiency.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3707-3713"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ramsay-hunt-syndrome associated with unilateral parotitis following COVID-19 vaccine: a case report.","authors":"Masood Soltanipur, Hossein Yarmohammadi, Seyed Fatah Mahdavi Anari, Mohammadreza Karimi Nemch, Amirmahdi Taromiha, Seyed Davar Siadat","doi":"10.1007/s00405-025-09330-y","DOIUrl":"10.1007/s00405-025-09330-y","url":null,"abstract":"<p><strong>Background: </strong>Varicella-zoster-virus (VZV) reactivation is a recognized complication following COVID-19 vaccination; however, Ramsay-hunt-syndrome (RHS) rarely has been reported.</p><p><strong>Case presentation: </strong>This case presents a 36-year-old immunocompetent man with features of RHS three weeks following the second dose of the BBIBP-CorV (Sinopharm) vaccine. Interestingly, he developed acute unilateral parotitis on his left side and the ultrasonography showed a 55*44*18 mm parotid gland with decreased parenchymal echogenicity. He was treated with valacyclovir, and after seven days he was discharged. Also, his parotitis was resolved by day 29 following the presentation of the first symptoms with no further complications.</p><p><strong>Conclusion: </strong>The possibility of VZV reactivation after COVID-19 vaccination is an important point and it should be noted that this reactivation might present in unusual clinical scenarios.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3783-3788"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining a minimum nodal yield for neck dissection in mucosal head and neck squamous cell carcinoma, a systematic review.","authors":"Sara Bassani, Paolo Tesauro, Daniele Monzani, Gabriele Molteni","doi":"10.1007/s00405-025-09250-x","DOIUrl":"10.1007/s00405-025-09250-x","url":null,"abstract":"<p><strong>Background: </strong>Analysis of existing literature on lymph node yield (LNY) in neck dissection (ND) for head and neck squamous cell carcinomas (HNSCC) used as a prognostic factor and an indication of treatment adequacy.</p><p><strong>Methods: </strong>PubMed, EMBASE and Web of Science databases were systematically searched from January 2010 to June 2023. Inclusion criteria encompassed studies on mucosal HNSCC patients undergoing ND with data on LNY and its association with survival outcomes. The quality assessment followed the REMARK guidelines.</p><p><strong>Results: </strong>Among 29 included studies, minimum LNY tresholds associated with improved survival outcomes ranged from 10 to 36.5 nodes. The heterogeneity in subsite involvement and cN0/cN + status constituted a challenge in establishing a consensus cutoff. The review highlights the need for standardized surgical techniques and pathological assessments to ensure data comparability.</p><p><strong>Conclusions: </strong>LNY is a prognostic indicator and could reflect ND quality in HNSCC.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3405-3413"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric oxygen therapy and corticosteroids as combined treatment for acute acoustic trauma.","authors":"Yoni E Gutkovich, Maayan Manheim, Rina Veler, Amit Geva, Dror Tal","doi":"10.1007/s00405-025-09246-7","DOIUrl":"10.1007/s00405-025-09246-7","url":null,"abstract":"<p><strong>Purpose: </strong>Acute acoustic trauma (AAT) is a sudden sensorineural hearing loss (SNHL) due to exposure to high intensity impulse noise. There are no acceptable treatment guidelines, although several studies showed steroids could be effective in restoring hearing levels. A recent report suggested that steroids combined with hyperbaric oxygen therapy (HBOT) are a superior regiment for AAT. The purpose of the current study is to investigate the effectiveness of steroids and HBOT for AAT treatment.</p><p><strong>Methods: </strong>the medical records 90 patients (118 ears) afflicted with AAT and treated with steroids and HBOT were retrospectively reviewed. Inclusion criteria were sensorineural hearing loss of at least 30 dB at the high frequency range (> 3,000 Hz) following exposure to intense sound. Patients who started treatment within 7 days were classified as \"Early treatment\" group whereas patients who started treatment ≥ 8 days after AAT were classified as \"Late treatment\".</p><p><strong>Results: </strong>The high frequency (3-8 kHz) Pure Tone Average (hPTA) of the entire study population (n = 118) was 40.26 ± 15.42 dB pretreatment vs. 24.99 ± 15.83 dB post treatment (Wilcoxon matched-pairs test, P < 0.0001). Pre-treatment hPTA was not statistically different between early and late study groups, 39.87 ± 16.00 vs. 40.86 ± 14.35 dB in the early vs. late group, respectively (ANOVA, F[3,232] = 22.574, P > 0.05). The post-treatment hPTA on the other hand, was significantly lower in the early vs. late treatment groups (21.93 ± 15.38 vs.31.19 ± 15.09 dB, respectively; ANOVA, F[3,232] = 22.574, P < 0.05).</p><p><strong>Conclusion: </strong>Combination treatment with corticosteroids and HBOT is highly beneficial in improving hearing outcomes following AAT, when initiated within 7 days. This study was retrospectively registered on July 19th 2020 and assigned the identifier number NCT04482998.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3489-3497"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should infranotch T4b oral cavity cancer be downstage to T4a category?","authors":"Remo Accorona, Pietro Perotti, Armando De Virgilio","doi":"10.1007/s00405-025-09395-9","DOIUrl":"10.1007/s00405-025-09395-9","url":null,"abstract":"<p><strong>Purpose: </strong>This comment aims to discuss the reliability of a radical resection of T4b oral squamous cell carcinomas with masticatory space involvement as well as analyze data in the literature on the oncologic outcomes compared to T4a.</p><p><strong>Methods: </strong>Clinical review of the scientific literature with focus on oral squamous cell carcinomas with masticatory space involvement.</p><p><strong>Results: </strong>The clinical review comprised 10 studies. The masticatory space is subdivided into infra- and supra-notch spaces according to the plane passing through the mandibular notch. En-bloc resection with compartmental approach demonstrated similar outcomes for infra-notch T4b oral cancers and T4a category.</p><p><strong>Conclusion: </strong>En-bloc compartmental resection of the masticatory space provides the best chances of margins control. Surgery should be considered the first line treatment option for this \"borderline operable\" category of cancers. Comparable survival outcomes between T4a and infra-notch T4b pushed several authors to suggest the downstaging the masticatory space involvement in oral cancer to T4a category.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3777-3780"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}