European Archives of Oto-Rhino-Laryngology最新文献

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Health-related quality of life in patients after endoscopic or microscopic cholesteatoma surgery. 内窥镜或显微镜胆脂瘤手术后患者的健康相关生活质量。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2024-11-27 DOI: 10.1007/s00405-024-09097-8
Yannik Raemy, David Bächinger, Nicole Peter, Christof Roosli
{"title":"Health-related quality of life in patients after endoscopic or microscopic cholesteatoma surgery.","authors":"Yannik Raemy, David Bächinger, Nicole Peter, Christof Roosli","doi":"10.1007/s00405-024-09097-8","DOIUrl":"10.1007/s00405-024-09097-8","url":null,"abstract":"<p><strong>Purpose: </strong>Different surgical techniques exist for treating cholesteatoma, such as microscopical or transcanal endoscopic ear surgery (TEES). This study aimed to compare these two techniques, focusing on quality of life.</p><p><strong>Methods: </strong>This retrospective single-center study included 188 patients with cholesteatoma. The primary outcome was the assessment of health-related quality of life (HRQoL) using the Zurich Chronic Middle Ear Inventory (ZCMEI-21) preoperatively, 3 and 12 months postoperatively with regard to surgical technique and intraoperative staging of the cholesteatoma (ChOLE classification). Secondary outcomes included hearing pure tone average of 0.5, 1, 2 and 4 kHz (PTA<sub>4</sub>), complications assessed 3 months postoperatively as well as recidivism within the follow-up time of 1 year postoperatively.</p><p><strong>Results: </strong>A total of 28 patients underwent TEES and 160 microscopic ear surgery. The ZCMEI-21 total scores preoperatively were not significantly different between the two groups. An improvement in QoL one year postoperatively was observed in both groups to a comparable extent. The ZCMEI-21 decreased significantly (p < 0.01) in both groups. In the TEES group, the cholesteatoma tended to be smaller (lower ChOLE score), PTA<sub>4</sub> was better and complication rate comparable. The number of recidivisms was lower for the TEES group (1 [3.6%] vs. 31 [19.4%]).</p><p><strong>Conclusion: </strong>TEES is a valuable alternative to the traditional microscopic technique, at least for small cholesteatoma, which leads to a comparable improvement in HRQoL as the microscopic technique. The better postoperative hearing and lower rate of recidivism in the TEES group may be related to the smaller extent of the cholesteatoma.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2275-2283"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of inflammatory markers in the diagnosis of complicated rhinosinusitis in children. 炎症标志物在儿童复杂鼻窦炎诊断中的作用。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1007/s00405-025-09278-z
Agah Yeniceri, Melih Cayonu
{"title":"Outcomes of inflammatory markers in the diagnosis of complicated rhinosinusitis in children.","authors":"Agah Yeniceri, Melih Cayonu","doi":"10.1007/s00405-025-09278-z","DOIUrl":"10.1007/s00405-025-09278-z","url":null,"abstract":"<p><strong>Purpose: </strong>Acute rhinosinusitis (ARS) is a common pediatric disorder. When complications occur, it can lead to various morbidities. Therefore, easily accessible and inexpensive markers are needed to predict the development of complications, treatment, and clinical course of acute rhinosinusitis. We aimed to investigate the predictive ability of the various inflammatory markers in pediatric complicated ARS patients.</p><p><strong>Methods: </strong>The data of 79 pediatric patients with complicated ARS and 116 pediatric patients with uncomplicated ARS were analyzed retrospectively. The complete blood count and C-reactive protein (CRP) test results at the time of diagnosis were recorded. Also, a receiver operating characteristic (ROC) analysis was performed.</p><p><strong>Results: </strong>The complicated ARS group consisted of 65 (82.3%) patients with preseptal cellulitis, 4 (5.1%) with orbital cellulitis, 5 (6.3%) with subperiosteal abscess, and 5 (6.3%) with orbital abscess complications. At the time of initial diagnosis, there was a significant difference in WBC, NLR, CRP, %LUC, SII and SIRI values between complicated ARS and uncomplicated ARS patient groups (p < 0.05). In terms of predictive power, the area under the curve (AUC) was 0.805 (95% confidence interval (CI) 0.74-0.87, p < 0.001) for CRP, 0.62 (95% confidence interval (CI) 0.54-0.7, p = 0.004) for systemic immune-inflammatory index (SII) and 0.67 (95% confidence interval (CI) 0.6-0.75, p < 0.001) for systemic inflammatory response index (SIRI).</p><p><strong>Conclusion: </strong>In conclusion, our study shows that inflammatory markers can be helpful in the evaluation of pediatric rhinosinusitis patients. CRP, SII and SIRI were adequate markers of inflammation to predict the development of complications in patients with pediatric rhinosinusitis.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2381-2387"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of irradiated mucosa using confocal laser endomicroscopy in the upper aerodigestive tract. 上气消化道共聚焦激光内镜对辐照粘膜的观察。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1007/s00405-025-09318-8
Lisa Thesing, Matti Sievert, Bharat Akhanda Panuganti, Marc Aubreville, Till Meyer, Flurin Müller-Diesing, Agmal Scherzad, Stephan Hackenberg, Miguel Goncalves
{"title":"Characterization of irradiated mucosa using confocal laser endomicroscopy in the upper aerodigestive tract.","authors":"Lisa Thesing, Matti Sievert, Bharat Akhanda Panuganti, Marc Aubreville, Till Meyer, Flurin Müller-Diesing, Agmal Scherzad, Stephan Hackenberg, Miguel Goncalves","doi":"10.1007/s00405-025-09318-8","DOIUrl":"10.1007/s00405-025-09318-8","url":null,"abstract":"<p><strong>Purpose: </strong>Confocal laser endomicroscopy (CLE) enables a real time in-vivo optical biopsy of the upper aerodigestive tract. Previous studies demonstrated its potential in identifying malignant tissue, but none examined mucosa treated with radiotherapy. This study characterizes the appearance of irradiated mucosa using CLE.</p><p><strong>Methods: </strong>We recorded 58 CLE sequences (860 s, 6,884 frames) in 10 patients previously treated with radiotherapy for upper aerodigestive tract tumors. A corresponding tissue biopsy (formalin-fixed, H&E stained) was taken as the reference standard for each sequence. We analyzed each sequence regarding differences from normal mucosa and characterized irradiated mucosa in CLE.</p><p><strong>Results: </strong>Irradiated mucosa in CLE exhibits irregular tissue architecture. Radiation induces DNA damage, apoptosis, and tissue inflammation, leading to hyperkeratotic and fibrotic tissue. Consequently, CLE showed a wider range of cellular morphologic and tissue structural aberrancies, in comparison to normal, non-irradiated mucosa. In addition to regular honeycomb-like patterns, the tissue displayed uneven, blurry, and cell-rich areas. Irradiated mucosa appears more irregular and variable in CLE than radiation-naïve mucosa.</p><p><strong>Conclusion: </strong>Irradiated mucosa can be differentiated from healthy tissue using CLE, but its higher baseline morphological variability may mimic malignancy. Further research is needed to clarify its impact on tumor detection and refine existing scoring systems.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2507-2514"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How I do it: Modified operation technique for MR Conditional OSIA 3: anterior based flap for covering the implant. 我怎么做:改良的手术技术为MR条件OSIA 3:前基皮瓣覆盖种植体。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-01-19 DOI: 10.1007/s00405-025-09202-5
Ioana T Brill, Stefan Dazert
{"title":"How I do it: Modified operation technique for MR Conditional OSIA 3: anterior based flap for covering the implant.","authors":"Ioana T Brill, Stefan Dazert","doi":"10.1007/s00405-025-09202-5","DOIUrl":"10.1007/s00405-025-09202-5","url":null,"abstract":"<p><strong>Background: </strong>The new OSIA3 is 1.5 T and 3 T MR-Conditional. Skin related issues are the most common complications. Performing MRI, the implant is exposed to magnetic torque forces, thus creating more tension over the incision lines.</p><p><strong>Methods: </strong>We present a modified surgical technique for implanting OSI300 step-by-step. We prefer an anterior based muscle-periosteal flap to cover the implant as an integral part of the procedure.</p><p><strong>Conclusion: </strong>The anterior based muscle-periosteal flap and performing a 3-layer-suture appears to be a safe method that does not permit skin-tension directly over the implant and may help preventing implant extrusion especially with the new OSI300.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2767-2770"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balloon-assisted placement of rib graft in endoscopic posterior cricoid split; a new technique. 内窥镜下环状后裂术中球囊辅助放置肋骨移植物一项新技术。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-01-25 DOI: 10.1007/s00405-025-09220-3
Abdullah Sindi, Luluh Alsughayer, Abdulrahman Almutairi, Zahra Almoume, Nasser Almutairi, Waleed Alshareef, Ahmed Al-Ammar
{"title":"Balloon-assisted placement of rib graft in endoscopic posterior cricoid split; a new technique.","authors":"Abdullah Sindi, Luluh Alsughayer, Abdulrahman Almutairi, Zahra Almoume, Nasser Almutairi, Waleed Alshareef, Ahmed Al-Ammar","doi":"10.1007/s00405-025-09220-3","DOIUrl":"10.1007/s00405-025-09220-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the outcomes of balloon-assisted rib graft placement with traditional graft placement in Endoscopic Posterior Cricoid Split with Rib Graft Placement (EPCS/RG).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 23 patients who underwent EPCS/RG by a single senior surgeon at King Saud University Medical City from 2017 to 2024. Data were collected on demographics, surgical approach, and operative time. Statistical analyses included Mann-Whitney U tests for continuous variables and Fisher's exact test for categorical variables, with significance set at p-value < 0.05. Univariate binary regression was reported as Odds Ratio (OR) with 95% Confidence Interval (CI).</p><p><strong>Results: </strong>Of the 23 cases, 16 (69.5%) utilized the balloon-assisted technique. Age ranged from 8 months to 19 years (median age 10 years). Older age was significantly associated with the balloon-assisted technique (OR 1.627, p-value 0.022). Balloon-assisted cases demonstrated longer split lengths and graft widths, though data limitations hindered definitive conclusions. Tracheostomy was avoided in 65.2% of cases. The operative duration averaged 240 min, showing no significant difference between balloon-assisted or the standard techniques (OR 1.015, CI 0.993-1.038, p-value 0.177).</p><p><strong>Conclusion: </strong>Balloon-assisted rib graft placement in EPCS/RG facilitates surgical approach, particularly in older patients. It does not extend operative duration, offering a promising advancement in airway surgery.</p><p><strong>Level of evidence: </strong>Level 3.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2649-2654"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientometric analysis of trends in research in laryngopharyngeal reflux. 喉咽反流研究趋势的科学计量学分析。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1007/s00405-025-09381-1
Dhanshree R Gunjawate, Rohit Ravi
{"title":"Scientometric analysis of trends in research in laryngopharyngeal reflux.","authors":"Dhanshree R Gunjawate, Rohit Ravi","doi":"10.1007/s00405-025-09381-1","DOIUrl":"10.1007/s00405-025-09381-1","url":null,"abstract":"<p><strong>Objective: </strong>Scientometric analysis helps to understand the research trends and identify top contributors, publishers, trends, and research topics. Laryngopharyngeal reflux has been a topic of interest in research and clinical practice. The literature on laryngopharyngeal reflux is evolving and a scientometric analysis will help us understand the trends better. The present study aimed to analyze published data to identify trends, top contributors, top institutions and countries, growth of publications, keywords and keyword co-occurrence.</p><p><strong>Methods: </strong>The present study aims to analyze the evolution of Laryngopharyngeal reflux research using a scientometric analysis approach for publications from the Scopus database using keywords related to laryngopharyngeal reflux. Documents related to laryngopharyngeal reflux were identified for further analysis. Microsoft Excel and VosViewer were used to perform bibliometric analysis.</p><p><strong>Results: </strong>A total of 7,327 hits were obtained, and after applying filter, 5637 studies were retained for further analysis. The results revealed an increase in publications on LPR, which surged after the early 2000s. The Unites States had the maximum research output, and the Journal of Voice had the highest number of publications. The keyword co-occurrence analysis helped identify five research themes on laryngopharyngeal reflux.</p><p><strong>Conclusion: </strong>The findings reveal a rising trend in laryngopharyngeal reflux, especially in recent years. The presence of international collaborations and a high volume of research will help bridge gaps, enable capacity building and improve understanding of LPR.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2525-2532"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vestibular electrode position stability over time. 前庭电极位置随时间的稳定性。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2024-11-28 DOI: 10.1007/s00405-024-09098-7
Elke Loos, Benjamin Volpe, Bernd L Vermorken, Stan C J van Boxel, Elke M J Devocht, Joost J A Stultiens, Alida A Postma, Nils Guinand, Angelica Pérez-Fornos, Christian Desloovere, Nicolas Verhaert, Raymond van de Berg
{"title":"Vestibular electrode position stability over time.","authors":"Elke Loos, Benjamin Volpe, Bernd L Vermorken, Stan C J van Boxel, Elke M J Devocht, Joost J A Stultiens, Alida A Postma, Nils Guinand, Angelica Pérez-Fornos, Christian Desloovere, Nicolas Verhaert, Raymond van de Berg","doi":"10.1007/s00405-024-09098-7","DOIUrl":"10.1007/s00405-024-09098-7","url":null,"abstract":"<p><strong>Objectives: </strong>In vestibular implants (VI), the electrode position is thought to be important for optimal neural activation. The objective of this study was to evaluate the stability of the vestibular electrode position over time.</p><p><strong>Methods: </strong>Seven patients implanted with a VI were followed for one year. When possible, the fenestrations of the semicircular canals were kept very small (approximately 0.8 mm) to stabilize the electrode lead. Additionally, the electrodes were fixed at their fenestration sites using bone cement. A temporal bone CT scan was performed intraoperatively, and one week and one year postoperatively. In one patient reliable analysis of the intraoperative CT scan was not possible due to a technical error. A displacement of the vestibular electrodes of more than 0.5 mm was considered significant.</p><p><strong>Results: </strong>Fourteen out of 18 electrodes did not show a significant displacement between the intraoperative scan and the first postoperative scan. In the remaining four electrodes, a displacement of ≥ 0.5 mm occurred (mean 0.54 mm, range 0.50-0.58 mm). These four electrodes were found in the two first implanted patients. In both cases, the intraoperative CT scan had a slice thickness of 0.5 mm and showed severe scattering. This might imply that the measured displacement was (partially) related to a higher measurement error. None of the vestibular electrodes migrated outside of the ampulla. No displacement was observed in any of the vestibular electrodes between the first postoperative scan and the one-year follow-up scan.</p><p><strong>Conclusion: </strong>The current surgical technique seems to securely stabilize the vestibular VI electrodes over time.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2285-2292"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gender-related volumetric side asymmetries in sphenoid sinuses and their clinical significance. 蝶窦体积侧不对称的性别特征及其临床意义。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2024-12-07 DOI: 10.1007/s00405-024-09134-6
Bulent Ozdemir, Serdar Durmaz, Ayhan Kanat, Tugba Yemis, Cihangir Ozdemir, Fatma Beyazal Celiker
{"title":"The gender-related volumetric side asymmetries in sphenoid sinuses and their clinical significance.","authors":"Bulent Ozdemir, Serdar Durmaz, Ayhan Kanat, Tugba Yemis, Cihangir Ozdemir, Fatma Beyazal Celiker","doi":"10.1007/s00405-024-09134-6","DOIUrl":"10.1007/s00405-024-09134-6","url":null,"abstract":"<p><strong>Background: </strong>The sphenoid sinus (SS) is important in neurosurgical practice because it is surrounded by numerous critical neurovascular structures. Using helical computerized tomography (CT) scanning, we investigated the gender-related volumetric asymmetric nature of the SS.</p><p><strong>Materials and methods: </strong>CT scans of SS of 49 (21 females, 28 males) patients admitted to the hospital between 1 October 2018 and 1 June 2019 were analyzed retrospectively. The volumes of SSs were calculated using a secondary reconstruction tool.</p><p><strong>Results: </strong>The mean age was 33,81 for females, 41,107 and in males patients which was not statistically significant. The mean right and left SS volume was 3,03 cm<sup>3</sup> and 3,.57cm<sup>3</sup> in females, but 4,28cm<sup>3</sup> and 4,70cm<sup>3</sup> in males, respectively. The difference in side asymmetry between men and women was statistically significant (p < 0.05).</p><p><strong>Conclusion: </strong>In this study, the gender-related side differences of the SS have been the first time reported in this study. The reason for this gender-related asymmetric size of the SSs may be related to the pneumatization process.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2567-2570"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-related decrease of odorant sensitivity for a selection of nine diverse molecules. 九种不同分子的气味敏感性随年龄的下降。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-02-24 DOI: 10.1007/s00405-025-09254-7
Agnieszka Sabiniewicz, Malaika Krause, Thomas Hummel
{"title":"Age-related decrease of odorant sensitivity for a selection of nine diverse molecules.","authors":"Agnieszka Sabiniewicz, Malaika Krause, Thomas Hummel","doi":"10.1007/s00405-025-09254-7","DOIUrl":"10.1007/s00405-025-09254-7","url":null,"abstract":"<p><strong>Purpose: </strong>The ability to smell is known to decrease with age. Still, several studies demonstrate that age-related deterioration is not the inevitable fate of each individual but rather depends on \"successful aging\" and odorant properties. Based on these notions, in the present prospective study, we aimed to investigate odor thresholds in younger and older adults in response to an extended list of various odorants.</p><p><strong>Methods: </strong>In 58 participants (31% ≥ 50 years old), we assessed thresholds for nine odorants.</p><p><strong>Results: </strong>General Linear Mixed Model (GLMM) revealed that, independently of the odor context, younger adults had higher odor sensitivity compared to older ones. Furthermore, while molecular weight did not differentiate thresholds of older and younger adults, it impacted odor thresholds regardless of age, with higher sensitivity noted for lightweight molecules.</p><p><strong>Conclusion: </strong>In conclusion, based on the present findings, odor thresholds decrease with age, with a pronounced effect for molecules with higher weight. Previous studies suggest that the decline in olfactory function is more significant for certain molecules. However, the current results indicate that this may be an odorant-specific phenomenon, as we did not observe this behavior in our study, which included a selection of nine diverse molecules.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2663-2668"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of home discharge rates following total (pharyngo-)laryngectomy after implementation of a city-hospital network. 城市医院网络实施全(咽)喉切除术后家庭出院率的评估。
IF 1.9 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.1007/s00405-025-09354-4
Ismaël Ouzzine, Stéphane Gargula, Ralph Haddad, Stéphane Fabriès, Laure Santini, Pauline Paris, Alexia Mattei, Justin Michel, Nicolas Fakhry
{"title":"Evaluation of home discharge rates following total (pharyngo-)laryngectomy after implementation of a city-hospital network.","authors":"Ismaël Ouzzine, Stéphane Gargula, Ralph Haddad, Stéphane Fabriès, Laure Santini, Pauline Paris, Alexia Mattei, Justin Michel, Nicolas Fakhry","doi":"10.1007/s00405-025-09354-4","DOIUrl":"10.1007/s00405-025-09354-4","url":null,"abstract":"<p><strong>Introduction: </strong>In 2017, an innovative partnership was established between the ENT department of La Conception Hospital in Marseille and a city-hospital network (ILHUP) to facilitate early discharge after total laryngectomy (TL) and total pharyngo-laryngectomy (TPL). The main objective was to compare the home discharge rate versus transfer to a rehabilitation facility before and after implementation of this partnership.</p><p><strong>Methods: </strong>This single-center retrospective study included 205 patients who underwent TL/TPL between January 2012 and December 2023, divided into two groups: group 1 (n = 93) and group 2 (n = 112) before and after implementation of the city-hospital network.</p><p><strong>Results: </strong>The home discharge rate in Group 2 was significantly higher than in Group 1 (55.4% vs. 40.9%, p = 0.039). Within group 2, mean length of hospital stay (23.8 vs. 26.12 days, p = 0.295) and two-month readmission rate (4.8% vs. 10%, p = 0.321) were similar between patients discharged home and those transferred to rehabilitation facilities. Multivariate analysis showed that implementation of the city-hospital network partnership was the only factor independently associated with an increased home discharge rate (p = 0.018).</p><p><strong>Conclusion: </strong>Implementation of a partnership with a city-hospital network significantly increased the home discharge rate after total (pharyngo-) laryngectomy without compromising patient safety.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2515-2523"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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