European Archives of Oto-Rhino-Laryngology最新文献

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Prevalence and risk factors for underlying vestibular weakness in cochlear implant candidates. 人工耳蜗候选者潜在前庭虚弱的患病率和危险因素。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-07 DOI: 10.1007/s00405-025-09361-5
Allison Reeder, Rema Shah, Joseph Canner, Eric Schneider, Eugenia Vining, John F Kveton, Nofrat Schwartz
{"title":"Prevalence and risk factors for underlying vestibular weakness in cochlear implant candidates.","authors":"Allison Reeder, Rema Shah, Joseph Canner, Eric Schneider, Eugenia Vining, John F Kveton, Nofrat Schwartz","doi":"10.1007/s00405-025-09361-5","DOIUrl":"10.1007/s00405-025-09361-5","url":null,"abstract":"<p><strong>Objective: </strong>To describe the baseline vestibular function in cochlear implant candidates and identify demographic and audiologic risk factors for vestibular dysfunction.</p><p><strong>Study design: </strong>Retrospective cohort study (2012-2022) of the CI candidate population.</p><p><strong>Setting: </strong>Neurotology practice at large academic hospital.</p><p><strong>Methods: </strong>All patients evaluated for CI underwent routine preoperative vestibular evaluation, irrespective of symptoms. Preoperative audiologic data was also analyzed.</p><p><strong>Results: </strong>Of a total of 180 preoperative VNGs obtained, 39.4% demonstrated preoperative vestibular weakness as determined on caloric testing. Of these, 26.8% had evidence of bilateral weakness, 60.5% unilateral weakness ipsilateral to the worse hearing ear and 12.7% contralateral weakness. Demographic variables such as age, gender, BMI and medical comorbidities including diabetes, hypertension, hyperlipidemia were not found to be associated with a higher risk of vestibular weakness. Patients with vestibular weakness had significantly poorer low tone hearing. Hearing loss at 250 Hz was the strongest prognostic factor for risk of vestibular weakness. Using a cutoff of 45dB at 250 Hz as an indicator for obtaining preoperative VNG was found to have a sensitivity of 92.9% and specificity of 37.9% for identifying vestibular weakness.</p><p><strong>Conclusions: </strong>Traditional CI candidates have a high prevalence of preoperative vestibular weakness. Audiologic data and specifically severity of hearing loss in the low frequencies may be a useful indicator of vestibular weakness and thus help guide which patients should undergo preoperative VNG. We propose the cutoff point of 45dB at 250 Hz as an indicator of higher risk for vestibular weakness and recommend preoperative VNG testing for this population prior to surgery.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4505-4512"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative success of different graft types in pediatric laryngotracheal reconstruction: a systematic review and meta-analysis. 不同移植类型在小儿喉气管重建中的比较成功:系统回顾和荟萃分析。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-25 DOI: 10.1007/s00405-025-09358-0
Mohammed A Awadh, Abdulsalam Alqutub, Mohammad A Alzahrani, Naif Mozahim, Sarah M AlSharif, Abeer Z Malebari, Talal Al-Khatib
{"title":"Comparative success of different graft types in pediatric laryngotracheal reconstruction: a systematic review and meta-analysis.","authors":"Mohammed A Awadh, Abdulsalam Alqutub, Mohammad A Alzahrani, Naif Mozahim, Sarah M AlSharif, Abeer Z Malebari, Talal Al-Khatib","doi":"10.1007/s00405-025-09358-0","DOIUrl":"10.1007/s00405-025-09358-0","url":null,"abstract":"<p><strong>Background: </strong>Laryngotracheal stenosis (LTS) results from abnormal airway narrowing, primarily caused by iatrogenic injuries like prolonged intubation. It leads to respiratory distress and vocal complications, requiring interventions ranging from endoscopic procedures to open surgeries like laryngotracheal reconstruction (LTR) with autologous grafts. Pediatric patients pose unique challenges due to smaller airways but may have better healing outcomes. This review aims to synthesize evidence on the success and operative parameters of different grafts in pediatric LTR to guide clinical decision-making and improve patient outcomes.</p><p><strong>Methods: </strong>We retrieved relevant articles from PubMed, Scopus, Web of Science, and the Cochrane Library up to August 2024. Two independent authors extracted data from eligible studies, including baseline information, success rate, need for extra procedures, time to stent removal, and time to decannulation. All analyses were undertaken using RevMan v5.4.</p><p><strong>Results: </strong>We collected 1,201 records from four databases after excluding 788 duplicates. After screening titles and abstracts, 108 records were assessed for eligibility, resulting in 86 included articles. Of these, 64 had enough data for analysis. The overall success rate for LTR was 89% for costal grafts, 86% for thyroid grafts, and 85% for auricular grafts, with no significant differences between graft types. A third of cases required additional procedures. Time to stent removal averaged 7.85 days for single-stage LTR and 62.86 days for double-stage LTR. Decannulation took 198.29 days. Complications included respiratory issues like atelectasis and pneumonia, graft-related problems, infections, and wound complications. Donor site complications and deaths were rare but occurred due to respiratory arrest, pneumothorax, and tracheotomy tube obstruction.</p><p><strong>Conclusion: </strong>Costal, thyroid, and auricular grafts are comparable and show similar success rates in pediatric LTR. Optimizing perioperative management is crucial for reducing complications. Future research should standardize postoperative care and address patient pathology heterogeneity to improve outcomes.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4417-4442"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of vestibular rehabilitation therapy on quality of life and cognitive function in individuals with chronic dizziness or vertigo. 前庭康复治疗对慢性头晕或眩晕患者生活质量和认知功能的影响
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-07 DOI: 10.1007/s00405-025-09382-0
Anupriya Ebenezer, Kaushlendra Kumar, Mohan Kumar Kalaiah, Deviprasad Dosemane, M Ramiz Malik
{"title":"Impact of vestibular rehabilitation therapy on quality of life and cognitive function in individuals with chronic dizziness or vertigo.","authors":"Anupriya Ebenezer, Kaushlendra Kumar, Mohan Kumar Kalaiah, Deviprasad Dosemane, M Ramiz Malik","doi":"10.1007/s00405-025-09382-0","DOIUrl":"10.1007/s00405-025-09382-0","url":null,"abstract":"<p><strong>Purpose: </strong>Dizziness and vertigo are among the most frequently reported complaints among patients across various medical and healthcare specialties. Studies have revealed that they are associated with cognitive impairments, particularly in older adults. While vestibular rehabilitation therapy (VRT) alleviates physical symptoms, its effects on cognitive function remain underexplored. Hence, this study aims to assess the impact of VRT on the quality of life and cognitive performance of individuals with chronic dizziness or vertigo.</p><p><strong>Methods: </strong>This was a randomized control trial in which 60 participants experienced chronic dizziness or vertigo. The participants were assigned to either the medication-only group receiving betahistine or the VRT + medication group receiving VRT combined with betahistine. Quality of life was measured via the Dizziness Handicap Inventory (DHI). Cognitive performance was assessed via a digit span test, task-switching test, and recording of P300 response.</p><p><strong>Results: </strong>The VRT + Medication group showed significant improvements in cognitive performance, particularly in the digit span and task-switching tests, with reduced P300 response latency and increased amplitude. No significant cognitive changes were observed in the medication-only group. Both groups showed improvement in quality of life, with a greater reduction in DHI scores observed in the VRT + Medication group.</p><p><strong>Conclusion: </strong>VRT combined with medication significantly improves cognitive function and quality of life in individuals with chronic dizziness or vertigo. These findings suggest that VRT not only addresses physical symptoms but also enhances cognitive performance, highlighting its potential as a comprehensive therapeutic approach.</p><p><strong>Trial registration: </strong>The study protocol was registered in the Clinical Trial Registry of India (CTRI number: CTRI/2020/03/023934).</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4563-4572"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of postoperative sucralfate in adults following tonsillectomy and sleep surgery: a systematic review. 成人扁桃体切除和睡眠手术后硫糖钠的作用:一项系统综述。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-03-28 DOI: 10.1007/s00405-025-09311-1
Lauren R McCray, Erin E Briggs, Jaimin J Patel, Shaun A Nguyen, Noah Parker
{"title":"The role of postoperative sucralfate in adults following tonsillectomy and sleep surgery: a systematic review.","authors":"Lauren R McCray, Erin E Briggs, Jaimin J Patel, Shaun A Nguyen, Noah Parker","doi":"10.1007/s00405-025-09311-1","DOIUrl":"10.1007/s00405-025-09311-1","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the efficacy of topical sucralfate on postoperative recovery following oropharyngeal surgery in adults using pain scales, analgesic use, and various self-reported measures.</p><p><strong>Methods: </strong>CINAHL, Cochrane Library, PubMed, and SCOPUS databases were searched from inception through July 3, 2024. Randomized controlled trials related to topical sucralfate following oropharyngeal surgery in patients at least 18 years old were included. Study protocols for clinical trials, abstracts, and non-English language articles were excluded. Two authors extracted data, and disagreements were resolved with a third party if needed. Risk of bias was assessed according to Risk of Bias 2 (RoB 2) tool. Results of included studies and a narrative summary of our findings are presented through descriptive statistics (frequency (%) for categorical variables and mean (range) for continuous variables).</p><p><strong>Results: </strong>Four studies (n = 185) pertaining to topical sucralfate and post-operative outcomes in an adult population were included. The sucralfate group had a mean age of 40.08 vs. 37.50 for the control group. The sucralfate group had a significantly higher reduction in pain scores than the control group. The sucralfate group also had statistically significant improvements in otalgia, strength, diet tolerance, and reduction in analgesic use compared to the control group in two of the four studies.</p><p><strong>Conclusions: </strong>Oropharyngeal surgery is commonly performed in adults despite having a morbid recovery process. The literature shows promising results with the use of sucralfate in the reduction of post-operative pain in adults; however, further investigation is warranted given the limited scope of the literature.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4391-4398"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic management of traumatic facial palsy: a systematic review. 外伤性面瘫的治疗管理:系统回顾。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-26 DOI: 10.1007/s00405-025-09367-z
Alice Ottavi, Anna Cozzi, Fabiana Allevi, Christian Calvo-Henriquez, Carlos Chiesa-Estomba, Giovanni Felisati, Jerome R Lechien, Antonino Maniaci, Miguel Mayo-Yáñez, Giancarlo Pecorari, Giuseppe Riva, Luigi Angelo Vaira, Alberto Maria Saibene, Anastasia Urbanelli
{"title":"Therapeutic management of traumatic facial palsy: a systematic review.","authors":"Alice Ottavi, Anna Cozzi, Fabiana Allevi, Christian Calvo-Henriquez, Carlos Chiesa-Estomba, Giovanni Felisati, Jerome R Lechien, Antonino Maniaci, Miguel Mayo-Yáñez, Giancarlo Pecorari, Giuseppe Riva, Luigi Angelo Vaira, Alberto Maria Saibene, Anastasia Urbanelli","doi":"10.1007/s00405-025-09367-z","DOIUrl":"10.1007/s00405-025-09367-z","url":null,"abstract":"<p><strong>Purpose: </strong>Trauma is a common cause of facial nerve palsy, accounting for 3% of all cases. While many facial palsies resolve with medical treatment, some require surgical intervention. This systematic review aimed to determine the best therapeutic strategy for traumatic facial palsy.</p><p><strong>Methods: </strong>We reviewed eligible articles for patient demographics, pre-treatment assessment, parameters of selected treatment, type of treatment, outcomes, and post-treatment assessment.</p><p><strong>Results: </strong>Among 135 unique citations, 32 studies were considered eligible, reporting treatment data for 2079 patients. Most studies (n = 30) were case series. The main proposed therapeutic strategies were medical, surgical, or a combination of both. For almost all the selected studies, the House-Brackmann (HB) scale was used to estimate the severity of facial palsy.</p><p><strong>Conclusion: </strong>Based on the existing literature, a standardized guideline for the treatment of traumatic facial palsy is not well delineated, due to the extreme heterogeneity of available therapeutic choices and the lack of standardized patient stratification.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4443-4454"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ear-canal lavage for curing noninvasive otomycosis: A randomized controlled trial. 耳道灌洗治疗无创耳真菌病:一项随机对照试验。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-05-03 DOI: 10.1007/s00405-025-09418-5
Jia Zhang, Yusheng Du, Lihua Tang, Fan Song, Guoliang Wang, Xingyu Mei, Lili Hou, Zelin Cui, Zhenghua Zhu
{"title":"Ear-canal lavage for curing noninvasive otomycosis: A randomized controlled trial.","authors":"Jia Zhang, Yusheng Du, Lihua Tang, Fan Song, Guoliang Wang, Xingyu Mei, Lili Hou, Zelin Cui, Zhenghua Zhu","doi":"10.1007/s00405-025-09418-5","DOIUrl":"10.1007/s00405-025-09418-5","url":null,"abstract":"<p><strong>Objective: </strong>Fungal infection of the external auditory canal, otomycosis, is generally a superficial, but sometimes stubborn mycotic infection that rarely involves the middle ear. We designed a randomized, controlled cohort study to analyse the treatment effect of ear canal lavage on otomycosis.</p><p><strong>Methods: </strong>The clinical patients were divided into two groups: an irrigation group and an irrigation + local drug treatment control group. The patients were followed up once a month for three months.</p><p><strong>Results: </strong>From January 2022 to December 2023, a total of 102 patients treated for otomycosis were enrolled, and 98 of the patients were followed up for three months. 22 of the 98 patients (22.45%) had no or minor symptoms. Common symptoms such as pruritus, pain, hearing impairment, etc., presented solely or in combination. Our fungal culture results revealed that, in 83 patients (84.69%), the otomycotic pathogen was Aspergillus, in 3 patients (3.06%) it was Penicillium, in 2 patients (2.04%) it was Candida species, and in the remaining 13 patients (13.27%) it was negative. There were 3 patients (3.06%) with a mixture of fungal culture reports. In the lavage group, 48 (48/52, 92.30%) patients were cured with initial treatment after three months of follow-up, two (2/52, 3.85%) patients were cured after one month but were lost to follow-up after three months, and two (2/52, 3.85%) patients failed after initial treatment, received topical miconazole ointment treatment and were eventually cured. In the irrigation + local drug control group, 48 (48/50, 96.00%) subjects responded to initial treatment without recurrent disease after three months; 2 (2/50, 4.00%) subjects were lost to follow-up. According to Fisher's exact test, there was no significant difference in treatment efficiency between the two groups (P = 0.258).</p><p><strong>Conclusion: </strong>This study demonstrated that the diagnosis of otomycosis requires vigilance from clinicians given its nonspecific or minor symptoms. Both ear canal rinses and local antifungal creams are effective, and sequential treatment via both methods is reasonable.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4645-4652"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of breathing training on swallowing function in patients with neurogenic dysphagia: a systematic review and meta-analysis. 呼吸训练对神经源性吞咽困难患者吞咽功能的影响:系统回顾和荟萃分析。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1007/s00405-025-09368-y
Xiaoke Li, Jing Zhang, Yongkang Zhu, Chengfengyi Yang, Libing Tan, Yue Yang
{"title":"The effect of breathing training on swallowing function in patients with neurogenic dysphagia: a systematic review and meta-analysis.","authors":"Xiaoke Li, Jing Zhang, Yongkang Zhu, Chengfengyi Yang, Libing Tan, Yue Yang","doi":"10.1007/s00405-025-09368-y","DOIUrl":"10.1007/s00405-025-09368-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to systematically review various breathing training methods for patients with neurogenic dysphagia, and assess their clinical efficacy to improve swallowing function in individuals with neurological disorders such as stroke.</p><p><strong>Methods: </strong>Relevant studies were retrieved from nine databases (PubMed, Embase, Web of Science, The Cochrane Library, CINAHL, CNKI, Wanfang, China Science and Technology Journal Database, and China Biomedical Literature Database). Articles included in the review were published from the date of establishment of each database up to January 2024. Eleven randomized control trials (RCTs) and five quasi-experimental studies that met the inclusion criteria were included in this systematic review. Data and information were extracted independently by two reviewers, with disagreements resolved through consensus with a third coauthor. The primary outcome assessed was swallow function occurrence. The quality of the included studies was evaluated using the Cochrane risk of bias assessment tool and the JBI quality assessment tool.</p><p><strong>Results: </strong>The meta-analysis results showed that expiratory muscle strength training can improve swallowing function (standard mean deviation = -0.89, 95% confidence interval [-1.23, -0.55], Z = 5.11, P < 0.01).</p><p><strong>Conclusion: </strong>This paper categorized and summarized specific respiratory muscle groups targeted in different breathing training methods, providing guidance for clinicians in designing personalized regimens. The study showed that expiratory muscles strength training is the main method for improving respiratory strength and coordination between swallowing and breathing, reducing the risk of aspiration. More research is needed to assess the effectiveness of independent breathing training.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4455-4466"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
circ_0006168 expression serves as a potential biomarker of acquired middle ear cholesteatoma. Circ_0006168表达可作为获得性中耳胆脂瘤的潜在生物标志物。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1007/s00405-025-09391-z
Chen Liu, Bo Ning, Bing Liu, Liangjun Cheng, Huachao Li, Mei Ma
{"title":"circ_0006168 expression serves as a potential biomarker of acquired middle ear cholesteatoma.","authors":"Chen Liu, Bo Ning, Bing Liu, Liangjun Cheng, Huachao Li, Mei Ma","doi":"10.1007/s00405-025-09391-z","DOIUrl":"10.1007/s00405-025-09391-z","url":null,"abstract":"<p><strong>Objective: </strong>Acquired middle ear cholesteatomas (AMECs) is a pathological condition characterized by abnormal epithelial cell proliferation in the middle ear, often resulting from retraction pocket and epithelial migration theories. The aim of this study was to find the abnormal expressed circular RNAs (circ_RNAs) in AMECs and explore their role in the inflammatory response of AMECs.</p><p><strong>Methods: </strong>Thirty-two AMECs patients and 32 healthy volunteers were recruited. Expression levels of circ_RNAs and inflammatory genes were quantified via reverse transcription quantitative polymerase chain reaction. Concentrations of inflammatory cytokines in human AMECs or normal post-auricular skin samples were measured using enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Results showed that circ_0006168 was higher expressed in AMECs. Receiver operating characteristic (ROC) curve analysis indicated that circ_0006168 might serve as a sensitive biomarker for diagnosing AMECs. Besides, AMECs samples showed increased inflammatory cytokines concentrations. Thirty-two AMECs patients were divided into the High (N = 17) and Low (N = 15) groups according to the expression of circ_0006168. The High group patients had more tinnitus and severe hearing loss than the Low group.</p><p><strong>Conclusion: </strong>In summary, our findings suggested that circ_0006168 exacerbated inflammatory responses in AMECs, suggesting that circ_0006168 might be a potential biomarker in AMECs.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4607-4614"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The challenge of diagnosing intracranial pressure elevations as an otolaryngologist. 作为耳鼻喉科医生诊断颅内压升高的挑战。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-03-28 DOI: 10.1007/s00405-025-09333-9
Michelle S Klausner, Gerard J Gianoli, Patricia Johnson, Bulent Mamikoglu
{"title":"The challenge of diagnosing intracranial pressure elevations as an otolaryngologist.","authors":"Michelle S Klausner, Gerard J Gianoli, Patricia Johnson, Bulent Mamikoglu","doi":"10.1007/s00405-025-09333-9","DOIUrl":"10.1007/s00405-025-09333-9","url":null,"abstract":"<p><strong>Purpose: </strong>This article addresses the complex clinical scenario where patients present to otolaryngologists with symptoms typically ascribed to chronic rhinosinusitis (CRS) or migraines which may in fact stem from elevations in intracranial pressure. We aim to clarify the diagnostic challenges and emphasize the importance of considering elevated intracranial pressure (eICP) as its symptoms overlap with both CRS and migraines.</p><p><strong>Methods: </strong>This narrative review synthesizes clinical experiences and literature to discuss the differential diagnoses involving CRS, facial pain/pressure, migraines, and eICP. Key discussion points include symptomatology of eICP and its management in otolaryngological practice.</p><p><strong>Results: </strong>Patients presenting with symptoms of CRS or migraine may exhibit overlapping signs that makes diagnosis challenging. Patients with symptoms of facial pain and pressure, or other findings such as ear fullness, muffled hearing, and tinnitus, that do not resolve with conventional topical intranasal therapies or migraine management should be worked up for eICP.</p><p><strong>Conclusion: </strong>The overlap in clinical presentations among patients with concern for CRS, migraines, and ICP elevations poses a diagnostic challenge. It is crucial for otolaryngologists and neurologists to collaborate closely to ensure accurate diagnoses and appropriate management. Enhanced awareness and understanding of the broader spectrum of symptoms associated with eICP can prevent misdiagnosis and promote better patient outcomes.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"4399-4406"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long-term outcome of Meniere's disease patients following sac and shunt operation assessed by Hydrops MRI. 用Hydrops MRI评估梅尼埃病患者囊和分流术后的长期预后。
IF 2.2 3区 医学
European Archives of Oto-Rhino-Laryngology Pub Date : 2025-09-01 Epub Date: 2025-04-12 DOI: 10.1007/s00405-025-09379-9
Hong-Yu Yan, Yu-Fen Wang, Yi-Ho Young
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