European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Morphological studies of labyrinthine tissue in patients affected with Meniere's disease and vestibular schwannoma following labyrinthectomy.","authors":"Ankit Ajmera, Nikeith John, Adrienne Morey, Nigel Biggs, Sean Flanagan, Peter Earls, Daniel Brown, Payal Mukherjee","doi":"10.1007/s00405-024-09160-4","DOIUrl":"10.1007/s00405-024-09160-4","url":null,"abstract":"<p><strong>Background: </strong>Meniere's disease (MD) is a disabling disease of the inner ear, having a substantial effect on a patient's quality of life. While various postulations regarding its aetiology exists, due to the difficulty with accessing inner ear tissue, there have been limited histological studies in patients with active MD.</p><p><strong>Methods: </strong>Tissue was collected during labyrinthectomy from 8 patients with intractable MD who had failed medical therapy (22 samples), and 9 patients undergoing translabyrinthine resection of vestibular schwannoma (19 samples). 20 additional samples were obtained from 2 cadavers without a history of inner ear disease. Samples were assessed with routine histology and a panel of immunohistochemical markers to assess any differences between the groups.</p><p><strong>Results: </strong>No MD samples demonstrated significant inflammatory infiltrate, evidence of denervation of the sensory epithelium, fibrosis, or thickening of blood vessel wall stroma. Novel findings included confirmation that no lymphatic channels of usual type were present and that the subepithelial stromal cells are strongly positive for S100, suggesting possible perineurial origin. There were no consistent differences in expression of Claudin or Aquaporin between the MD and VS patient samples.</p><p><strong>Conclusion: </strong>This is one of the largest comparative histological study utilising operative samples from inner ear of living donors with active intractable MD and control patients with VS. There were no significant morphological differences between the two groups, suggesting that the aetiology lies elsewhere within the vestibular system. Examination of endolymphatic sac tissue is therefore a priority for future work.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2911-2920"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-AI collaboration for ultrasound diagnosis of thyroid nodules: a clinical trial.","authors":"Axel Bukhave Edström, Fatemeh Makouei, Kasper Wennervaldt, Anne Fog Lomholt, Mikkel Kaltoft, Jacob Melchiors, Gitte Bjørn Hvilsom, Magne Bech, Martin Tolsgaard, Tobias Todsen","doi":"10.1007/s00405-025-09236-9","DOIUrl":"10.1007/s00405-025-09236-9","url":null,"abstract":"<p><strong>Purpose: </strong>This clinical trial examined how the articifial intelligence (AI)-based diagnostics system S-Detect for Thyroid influences the ultrasound diagnostic work-up of thyroid ultrasound (US) performed by different US users in clinical practice and how different US users influences the diagnostic accuracy of S-Detect.</p><p><strong>Methods: </strong>We conducted a clinical trial with 20 participants, including medical students, US novice physicians, and US experienced physicians. Five patients with thyroid nodules (one malignant and four benign) volunteered to undergo a thyroid US scan performed by all 20 participants using the same US systems with S-Detect installed. Participants performed a focused thyroid US on each patient case and made a nodule classification according to the European Thyroid Imaging Reporting And Data System (EU-TIRADS). They then performed a S-Detect analysis of the same nodule and were asked to re-evaluate their EU-TIRADS reporting. From the EU-TIRADS assessments by participants, we derived a biopsy recommendation outcome of whether fine needle aspiration biopsy (FNAB) was recommended.</p><p><strong>Results: </strong>The mean diagnostic accuracy for S-Detect was 71.3% (range 40-100%) among all participants, with no significant difference between the groups (p = 0.31). The accuracy of our biopsy recommendation outcome was 69.8% before and 69.2% after AI for all participants (p = 0.75).</p><p><strong>Conclusion: </strong>In this trial, we did not find S-Detect to improve the thyroid diagnostic work-up in clinical practice among novice and intermediate ultrasound operators. However, the operator had a substantial impact on the AI-generated ultrasound diagnosis, with a variation in diagnostic accuracy from 40 to 100%, despite the same patients and ultrasound machines being used in the trial.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3221-3231"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlatıon between PET-CT uptake values and pathologıcaly features ın head and neck cancer.","authors":"Atakan Sarıgül, Vahit Mutlu","doi":"10.1007/s00405-025-09228-9","DOIUrl":"10.1007/s00405-025-09228-9","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the correlation between SUV-Max values and pathological outcomes in head and neck squamous cell carcinoma (HNSCC) and determine the predictive power of SUV-Max for disease prognosis.</p><p><strong>Data sources: </strong>Retrospective analysis of medical records and PET-CT imaging results from patients diagnosed with HNSCC at our institution between 2014 and 2023.</p><p><strong>Review methods: </strong>Examination of SUV-Max values from F18-FDG PET-CT scans and their association with pathological findings such as perineural invasion, lymphovascular invasion, and neck lymph node metastasis. Statistical analysis was conducted to establish cutoff values and assess the significance of correlations.</p><p><strong>Results: </strong>Our study identified significant cutoff values for PET-CT SUV-Max that correlate with the pathological features of head and neck cancer. For primary tumors, a SUV-Max cutoff of 14.71 predicted neck metastasis with a sensitivity of 67.6% and specificity of 64.2%, demonstrating moderate diagnostic accuracy with an AUC of 0.648. Perineural invasion was optimally predicted at a cutoff of 13.28, with a sensitivity of 74%, specificity of 67.3%, and an AUC of 0.728. Similarly, a cutoff of 13.28 for lymphovascular invasion yielded a sensitivity and specificity of 63%, with an AUC of 0.628. Additionally, neck lymph node metastasis was effectively assessed with a SUV-Max cutoff of 2.74, achieving a sensitivity of 62.2%, specificity of 67%, and an AUC of 0.694. These cutoff values highlight the potential of SUV-Max in enhancing diagnostic precision for both primary tumors and lymph node assessments in head and neck oncology.</p><p><strong>Conclusion: </strong>SUV-Max values from PET-CT scans are significant predictors of pathological outcomes in HNSCC, aiding in the stratification of patient prognosis and guiding clinical decision-making.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3211-3220"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging artificial intelligence in next generation sequencing for head & neck cancer: opportunities and challenges.","authors":"Carlos M Chiesa-Estomba, Antonino Maniaci, Luigi Angelo Vaira, Jerome R Lechien","doi":"10.1007/s00405-025-09256-5","DOIUrl":"10.1007/s00405-025-09256-5","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3379-3380"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous regression of adenoid hypertrophy in adults after nasal surgery.","authors":"Filippo Cascio, Ferdinando Stagno d'Alcontres, Daria Costanzo, Francesco Gazia","doi":"10.1007/s00405-025-09341-9","DOIUrl":"10.1007/s00405-025-09341-9","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to analyse the possible spontaneous regression of severe adenoid hypertrophy in patients who performed nasal surgery.</p><p><strong>Methods: </strong>Following the inclusion criteria, 83 adult patients were retrospective selected. These patients were characterized by adenoid hypertrophy from second to fourth grade before performing septoplasty andbilateral or monolateral reduction of hypertrophy of the turbinates and/or endoscopical sinus surgery (ESS).</p><p><strong>Results: </strong>Adenoid hypertrophy (grade 2-3-4) can be noted in 6.8% (83/1220) of patients who performed nasal surgery. Regarding the grade of hypertrophy before and after surgery, a clear decrease in adenoid size was obtained after nasal surgery (p < 0.001), without performing adenoidectomy, after at least one year of follow-up.</p><p><strong>Conclusion: </strong>Spontaneous regression of severe adenoid hypertrophy was observed in all patients who performed nasal surgery. Avoid adenoidectomy during nasal surgery should be a great advantage for patients, eliminating the possibility of complications such as bleeding and uncontrolled scars.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3335-3338"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scarless chondrolaryngoplasty combined with a surgical reshaping of the lower face through a single transoral approach for transgender patients.","authors":"Ralph Haddad, Antoine Giovanni, Hugo Frandjian","doi":"10.1007/s00405-025-09323-x","DOIUrl":"10.1007/s00405-025-09323-x","url":null,"abstract":"<p><strong>Background: </strong>Chondrolaryngoplasty, one of the most visible gender affirmation surgeries, is traditionally performed through a cervical approach, leaving a residual visible cervical scar.</p><p><strong>Method: </strong>We proposed a scarless technique for chondrolaryngoplasty done through a transoral incision used for concomitant genioplasty and gonioplasty, with satisfying results on the first 15 patients.</p><p><strong>Conclusion: </strong>The combination of these interventions through a single transoral incision was safe and feasible, helping transgender male-to-female patients reduce the number of interventions needed. It avoided a visible cervical scar that can constitute a constant reminder of the transition process.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3375-3378"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating round window niche visibility in cochlear implantation: anatomical insights and electrode insertion strategies.","authors":"Yesim Karagoz, Cigdem Kalaycik Ertugay, Direnç Özlem Aksoy, Ozdes Mahmutoglu, Abdullah Soydan Mahmutoglu","doi":"10.1007/s00405-024-09162-2","DOIUrl":"10.1007/s00405-024-09162-2","url":null,"abstract":"<p><strong>Purpose: </strong>Cochlear implantation (CI) surgery is essential for restoring hearing in individuals with severe sensorineural hearing loss. Accurate placement of the electrode within the cochlea is essential for successful auditory outcomes and minimizing complications. This study aims to analyze the relationship between the round window niche (RWN) alignment, its visibility during surgery, and the impact on surgical techniques and outcomes.</p><p><strong>Methods: </strong>A retrospective study was conducted, examining high-resolution computed tomography (CT) scans of the temporal bone from 103 patients who underwent CI. RWN visibility was assessed using the St. Thomas Hospital (STH) classification. Anatomical parameters such as the angles of RWN alignment relative to the lateral semicircular canal (LSCC) plane and the distances to the facial nerve were measured and recorded.</p><p><strong>Results: </strong>The analysis revealed that RWN alignment angles did not significantly correlate with RWN visibility. However, specific anatomical distances, such as the anteroposterior distance between the round window membrane (RWM) and the facial nerve, were significantly associated with improved RWN visibility.</p><p><strong>Conclusion: </strong>Preoperative knowledge of RWN anatomy, particularly its relationship with the facial nerve, can reduce the complexity of CI surgery. Understanding these anatomical variations is essential for optimizing surgical outcomes. Future research should explore additional cochlear axis orientations to enhance surgical techniques and improve visibility assessments during CI procedures.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2927-2937"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pain management strategies in acute infectious otologic conditions: a national survey of ENT trainees.","authors":"Yotam Heilig, Karin Stoliar, Daniel Yafit, Sabri El-Saied, Aviad Sapir","doi":"10.1007/s00405-025-09289-w","DOIUrl":"10.1007/s00405-025-09289-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess pain management strategies employed by otolaryngology residents for acute otologic conditions, evaluate their perceptions of pain management both generally and specifically for these conditions, and understand the pain management training and education they received during residency.</p><p><strong>Methods: </strong>A national, cross-sectional web-based survey was conducted among otolaryngology residents across all training levels. The survey opened with a theoretical patient encounter where participants provided discharge recommendations, unaware that pain management considerations were the primary outcome of interest. Responses were examined for pain management strategies. additional questions assessed residents' knowledge, attitudes, and practices in managing acute pain in otologic conditions, focusing on identifying gaps in clinical confidence,training and effectiveness.</p><p><strong>Results: </strong>42/45 (93%) ENT residents participated. Among respondents (n = 28), acknowledged pain in the discharge note, while (n = 14) did not. For those acknowledging pain (n = 22), advised \"as-needed\" medications without specification whereas only (n = 5) mentioned specific medications. One participant recommended around-the-clock analgesia. Pain training in residency for acute infectious otologic conditions was rated as sufficient by only (n = 16) of the respondents, with (n = 32) reporting no formal pain management education during residency. Familiarity with analgesic terms was limited, with (n = 21) being completely unfamiliar. A strong need for formal acute pain management training was expressed by (n = 37) of participants.</p><p><strong>Conclusion: </strong>There are critical areas for improvement in pain management education and practices among ENT residents. Addressing these gaps through standardized training programs and clearer clinical guidelines can lead to better pain management in patients with acute otologic conditions.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3261-3266"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for predicting tongue collapse in DISE based on UACT findings in OSA patients.","authors":"Shiming Wang, Yamin Liu, Yinv Dong, Yanqing Ye, Jingmeng Zhou, Wen Peng, Huaihong Chen","doi":"10.1007/s00405-025-09420-x","DOIUrl":"10.1007/s00405-025-09420-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the correlation between DISE and upper airway CT (UACT) in OSA patients and to establish and validate a predictive model for tongue base (TB) collapse in the upper airway of OSA patients.</p><p><strong>Methods: </strong>From October 2014 to March 2022, a total of 117 OSA patients diagnosed by polysomnography were enrolled. Three-dimensional CT measurements of the upper airway were conducted, and preoperative DISE examinations were performed. Surgical plans were determined based on VOTE scoring. We used logistic regression analysis to identify key predictors of tongue base (TB) collapse in patients with obstructive sleep apnea (OSA). Subsequently, a predictive model was constructed and validated using the R language.</p><p><strong>Results: </strong>Through univariate logistic regression analysis, distances between bilateral tonsils (BT), thickness of parapharyngeal space (PPS), thickness of lateral pharyngeal walls (LPW), distance from tongue to posterior pharyngeal wall (PAS), and transverse diameter of the epiglottis (TEP) (P ≤ 0.1) were included in the multivariate logistic regression analysis. Multivariate analysis revealed that the thickness of LPW (P < 0.05) and TEP (P < 0.001) were significant predictive factors for TB collapse in the predictive model. A nomogram model was created for predicting TB obstruction based on these factors, exhibiting an AUC of 0.729 (95% CI: 0.619 ~ 0.914). The internal validation of the model resulted in an AUC of 0.804 (95% CI: 0.688 ~ 0.878) within the validation population.</p><p><strong>Conclusion: </strong>A significant correlation between TB obstruction observed under DISE and LPW (P < 0.05) and TEP as measured in UACT scans among OSA patients. Based on this, a predictive nomogram model for TB obstruction during DISE demonstrates good performance.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3123-3131"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracorporeal lithotripsy of salivary stones: in vitro comparison of different methods.","authors":"Cathrin Schulze, Kruthika Thangavelu, Francesca Gehrt, Robert Schatton, Christian Keil, Hendrik Heers, Nermin H Abozenah, Boris A Stuck, Urban Geisthoff","doi":"10.1007/s00405-025-09268-1","DOIUrl":"10.1007/s00405-025-09268-1","url":null,"abstract":"<p><strong>Purpose: </strong>Intracorporeal lithotripsy is a gland-preserving treatment option for sialolithiasis. Laser lithotripsy (LL) and pneumatic lithotripsy (PL) are the only two methods currently approved, the latter being no longer available. Electrokinetic lithotripsy (EKL) is a promising alternative used for the treatment of ureteral stones. The aim of this study is to compare efficacy and therapeutical safety of EKL with LL and PL.</p><p><strong>Methods: </strong>StoneBreaker^® (PL), Lithotron EL 27 Compact (EKL) and Ho:YAG laser Auriga (LL) were assessed using in vitro setups with human salivary stones, casted and tumbled stones. Efficacy was measured by the number of impulses and time taken until fragmentation. Parameters for therapeutical safety were number of impulses until perforation, propulsion, duct widening, number of tears and tear length.</p><p><strong>Results: </strong>Efficacy of EKL was higher than LL but lower than PL. The fragmentation of casted stones took 01:50 ± 00:28 min with PL, 02:49 ± 00:37 min with EKL and 05:12 ± 00:58 min with LL (Mann-Whitney-U test p < 0.01). LL caused the lowest propulsion (0.0 ± 0 cm, n = 20); the highest propulsion was observed for PL (3.5 ± 0.7 cm, n = 20). In the gelatin setup, LL induced the most extensive damage (damage index: 5.9 ± 2.9, n = 15). LL was the fastest to cause perforation in the parotid duct (1 ± 0 impulses until perforation, n = 10).</p><p><strong>Conclusion: </strong>Efficacy and safety of EKL are between those of LL and PL. Therefore, clinical testing of EKL seems to be justified.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3233-3244"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}