European Archives of Oto-Rhino-Laryngology最新文献

{"title":"Lymphomas of the submandibular gland: a nationwide cohort study.","authors":"Fahd Al-Shahrestani, Ahmed Ehsan Al-Khafaf, Zain Asheer, Jelena Jelicic, Iman Chanchiri, Catharina E Blocher, Anne Kathrine Aalling Sørensen, Lars Møller Pedersen, Lise Mette Rahbek Gjerdrum, Steffen Heegaard, Preben Homøe","doi":"10.1007/s00405-024-09008-x","DOIUrl":"10.1007/s00405-024-09008-x","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the epidemiology, incidence, and survival outcomes associated with lymphomas of the submandibular gland (SMG) and examines the influence of autoimmune diseases on these parameters.</p><p><strong>Methods: </strong>This retrospective nationwide cohort study analysed data from patients diagnosed with SMG lymphomas in Denmark between 2000 and 2020. Information was extracted from medical records, the National Pathology Register, and the Danish Lymphoma Database. Survival analyses were conducted using Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models, focusing on lymphoma subtypes and autoimmune diseases.</p><p><strong>Results: </strong>The cohort consisted of 101 patients with a lymphoma diagnosis and involvement of the SMG. Large B-cell lymphoma (LBCL) was diagnosed in 33 cases (32.7%), follicular lymphoma (FL) in 29 cases (28.7%), extranodal marginal zone lymphoma (EMZL) in 27 cases (26.7%), and 12 cases (11.9%) with other subtypes. EMZL had a significantly longer overall survival (OS) compared to other subtypes, with a median OS of 12.4 years (95% CI 11.2-12.4) vs. 8.4 years (95% CI 6.0-12.2). EMZL and FL showed favourable 5-year OS rates of 95% and 89%, respectively. LBCL had a 5-year OS rate of 65%. Age over 60 significantly negatively impacted OS. Traditional poor prognostic indicators did not significantly affect OS. A notable association between EMZL and autoimmune diseases was observed, particularly with Sjögren's syndrome, indicated by an increased relative risk of 2.67 (CI 95% 0.45-16.01).</p><p><strong>Conclusions: </strong>Lymphomas of the SMG are rare and have ambiguous clinical presentations. This study provides novel epidemiological, clinical, and prognostic information.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2021-2031"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival analysis of laryngeal squamous cell cancer, considering different treatment modalities and other factors influencing survival - a monocentric retrospective investigation.","authors":"Gábor Dénes Répássy, András Molnár, Stefani Maihoub, Dóra Hargas, László Tamás","doi":"10.1007/s00405-025-09229-8","DOIUrl":"10.1007/s00405-025-09229-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the factors affecting laryngeal cancer survival.</p><p><strong>Methods: </strong>This study retrospectively analysed laryngeal cancer types, treatment options, and potential factors influencing survival.</p><p><strong>Results: </strong>77 patients (26.27%) had supraglottic laryngeal cancer, 209 (70.13%) had glottic laryngeal cancer, and 7 (3.6%) had subglottic laryngeal cancer. Common comorbidities such as type 2 diabetes mellitus, chronic obstructive pulmonary disease, and coronary disease were observed in 13.65%, 11.9%, and 22.18% of the patients, respectively. Smoking was detected in 88.05% of the patients, while 56.3% reported regular alcohol consumption. The study found that hemilaryngectomy and supraglottic horizontal resection led to significantly longer survival compared to other treatment options (i.e., total laryngectomy, supracricoid horizontal partial laryngectomy, transoral laser cordectomy, chemoradiation, chemotherapy, and radiotherapy), p = 0.000*. Glottic cancers tend to have longer survival when considering laryngeal cancer locations; however, this difference was statistically insignificant (p = 0.640). Statistical comparisons showed significantly longer survival rates for surgical treatments in stages 1 (p = 0.007*) and 4 (p = 0.007*). Factors such as coronary artery disease, higher ECOG performance status, advanced 'N' stages, and higher tumour grades were found to significantly worsen survival, as determined by a Cox proportional hazards model.</p><p><strong>Conclusion: </strong>The study revealed that factors such as coronary disease, patients' functionality, 'N' stages, and tumour grade significantly impacted survival rates. Furthermore, the study found that supraglottic horizontal resection and hemilaryngectomy resulted in the longest survival. Surgical methods were associated with significantly longer survival rates in disease stages 1 and 4.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"1989-2000"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the quality and readability of ChatGPT-generated patient-facing medical information in rhinology.","authors":"Alexander Z Fazilat, Camille Brenac, Danae Kawamoto-Duran, Charlotte E Berry, Jennifer Alyono, Michael T Chang, David T Liu, Zara M Patel, Stéphane Tringali, Derrick C Wan, Maxime Fieux","doi":"10.1007/s00405-024-09180-0","DOIUrl":"10.1007/s00405-024-09180-0","url":null,"abstract":"<p><strong>Purpose: </strong>The artificial intelligence (AI) chatbot ChatGPT has become a major tool for generating responses in healthcare. This study assessed ChatGPT's ability to generate French preoperative patient-facing medical information (PFI) in rhinology at a comparable level to material provided by an academic source, the French Society of Otorhinolaryngology (Société Française d'Otorhinolaryngologie et Chirurgie Cervico-Faciale, SFORL).</p><p><strong>Methods: </strong>ChatGPT and SFORL French preoperative PFI in rhinology were compared by analyzing responses to 16 questions regarding common rhinology procedures: ethmoidectomy, sphenoidotomy, septoplasty, and endonasal dacryocystorhinostomy. Twenty rhinologists assessed the clarity, comprehensiveness, accuracy, and overall quality of the information, while 24 nonmedical individuals analyzed the clarity and overall quality. Six readability formulas were used to compare readability scores.</p><p><strong>Results: </strong>Among rhinologists, no significant difference was found between ChatGPT and SFORL regarding clarity (7.61 ± 0.36 vs. 7.53 ± 0.28; p = 0.485), comprehensiveness (7.32 ± 0.77 vs. 7.58 ± 0.50; p = 0.872), and accuracy (inaccuracies: 60% vs. 40%; p = 0.228), respectively. Non-medical individuals scored the clarity of ChatGPT significantly higher than that of the SFORL (8.16 ± 1.16 vs. 6.32 ± 1.33; p < 0.0001). The non-medical individuals chose ChatGPT as the most informative source significantly more often than rhinologists (62.8% vs. 39.7%, p < 0.001).</p><p><strong>Conclusion: </strong>ChatGPT-generated French preoperative PFI in rhinology was comparable to SFORL-provided PFI regarding clarity, comprehensiveness, accuracy, readability, and overall quality. This study highlights ChatGPT's potential to increase accessibility to high quality PFI and suggests its use by physicians as a complement to academic resources written by learned societies such as the SFORL.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"1911-1920"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Test and retest reliability of objective screening tests in neonatal hearing screening program in developing countries.","authors":"Meghana Mohan B, Chandni Jain","doi":"10.1007/s00405-024-09085-y","DOIUrl":"10.1007/s00405-024-09085-y","url":null,"abstract":"<p><strong>Background: </strong>Our study aimed to assess the reliability of screening tests in healthy newborns across diverse hospital environments and neonatal intensive care unit (NICU) infants hospitalized for over 5 days, particularly within the framework of hearing screening in developing countries.</p><p><strong>Method: </strong>The study comprised 100 neonates in each group: G1 (healthy infants in government general wards), G2 (healthy infants in private special wards), and G3 (infants in NICU for over 5 days). Intra-session (within 5 min) and inter-session (within a month) otoacoustic emissions (OAE) and automated auditory brainstem responses (AABR) recordings were conducted and the reliability of each test was evaluated across sessions and groups.</p><p><strong>Results: </strong>The weighted Kappa results showed poor within-session reliability of OAEs in G1 and G3, while G2 exhibited good reliability. AABR intra-session reliability was consistently good across all three groups. The inter-session reliability of OAEs remained poor in G1 and G3 but better in G2. Significantly, the inter-session reliability for AABR decreased in G1 and G3, with Chi-square analysis revealing a notable referral discrepancy between the initial and final assessments. Such a disparity was absent in G2, where reliability remained high.</p><p><strong>Discussion: </strong>The study highlights the compromised reliability of OAEs in noisy environments, while AABR maintains good reliability under similar conditions. Additionally, AABR shows poorer reliability when conducted within a specific early timeframe, emphasizing the importance of screening after this period. This issue does not affect OAE, but OAE is limited in detecting mild conductive components. The study highlights the poor reliability of AABRs in the NICU group, attributing this to the potential for improved thresholds over time within this group.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"1843-1851"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with late-onset hearing loss in children with congenital cytomegalovirus: a systematic review.","authors":"María Fernández-Rueda, Christian Calvo-Henriquez, Rafael Fernández-Liesa, Alfredo García-Fernández, Roberto Pedrero-Tomé, Daniel Blázquez-Gamero, Joaquín De Vergas Guiterrez","doi":"10.1007/s00405-024-09013-0","DOIUrl":"10.1007/s00405-024-09013-0","url":null,"abstract":"<p><strong>Purpose: </strong>To search for existing evidence of prognostic factors related to the development of late-onset hearing loss (LOHL) in infants with congenital cytomegalovirus (cCMV).</p><p><strong>Methods: </strong>A PRISMA systematic review was performed, with the PubMed, Embase, and Web of Science databases searched from inception through to December 2023; after the application of inclusion and exclusion criteria a total of 9 papers were included in this review. PROSPERO registration number CRD42024492244.</p><p><strong>Results: </strong>9 studies encompassing a total of 292 children with late-onset hearing loss were included. A total of 12 risk factors were identified in the literature, with 6 found to be statistically significant. Late-onset hearing loss was more frequently reported in children with symptomatic than asymptomatic cCMV. Moreover, in asymptomatic cCMV cases, elevated DNAemia and salivary viral load were associated with late-onset hearing loss. Additionally, first-trimester seroconversion was identified as a risk factor for late- onset hearing loss. Further, gestational age < 37 weeks and low birth weight were found to correlate with late-onset hearing loss. Remarkably, only one study documented a relationship between late-onset hearing loss and ultrasonographic abnormalities.</p><p><strong>Conclusions: </strong>Although six statistically significant risk factors have been identified, the available evidence is limited and inconsistent, preventing the establishment of reliable neonatal and maternal parameters to predict the development of LOHL in patients with CMV. There are few studies addressing this topic, and those available exhibit a low level of evidence and heterogeneous designs. More studies should be done.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"1659-1676"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Five-year long-term functional and quality of life outcomes in total glossectomy survivors.","authors":"Aparajith Sathish Kumar, Waleed Ahmad, Aiman Irfan, Shree Rath","doi":"10.1007/s00405-024-09149-z","DOIUrl":"10.1007/s00405-024-09149-z","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2179-2180"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing quality of life and rehabilitation outcomes in total glossectomy survivors.","authors":"Anil Kumar, Abhinav Thaduri, Hemant Nemade, Jonathan T Gondi, Sravankumar Chava, Pratheek Raj, Uma Neelap, Pardhasaradhi Akalankam, Rukmangatham Tm, L M Chandra Sekara Rao S","doi":"10.1007/s00405-024-09201-y","DOIUrl":"10.1007/s00405-024-09201-y","url":null,"abstract":"","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2181-2182"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of internet resources and artificial intelligence on information on myringotomy tubes.","authors":"Melissa Papuc, Patrick Scheffler","doi":"10.1007/s00405-024-09148-0","DOIUrl":"10.1007/s00405-024-09148-0","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the quality and readability of patient education materials on myringotomy tubes from artificial intelligence and Google search.</p><p><strong>Methods: </strong>Three questions were posed to ChatGPT and Google Gemini addressing \"Condition,\" \"Investigation,\" and \"Treatment\" domains. Google was queried for \"Ear tubes,\" \"Myringotomy and tubes,\" and \"Tympanostomy tubes.\" Text quality was assessed using the DISCERN instrument. Readability was assessed using the Flesch-Kincaid Grade Level, Flesch-Kincaid Reading Ease scores, and the Fry Readability Graph.</p><p><strong>Results: </strong>The average DISCERN score for websites was 52 (SD = 13.1, Median = 55.5), out of 80. The mean Flesch-Kincaid Reading Grade Level was 8 (SD = 3, Median = 7.1), and the mean Flesch-Kincaid Reading Ease score was 55 (SD = 12.3, Median = 57.7). ChatGPT and Google Gemini's \"Condition\" responses each had DISCERN scores of 46, Flesch-Kincaid Grade Levels of 13.1 and 9.5, and Reading Ease scores of 41 and 61. For \"Investigation,\" DISCERN scores were 46 (ChatGPT) and 66 (Google Gemini), Grade Levels were 13.9 and 12.4, and Reading Ease scores were 38.9 and 34.9. For \"Treatment,\" ChatGPT and Google Gemini had DISCERN scores of 45 and 34, Grade Levels of 15.7 and 9.8, and Reading Ease scores of 36.2 and 53.9.</p><p><strong>Conclusion: </strong>Sites and artificial intelligence providing patient education material regarding myringotomy tubes are of \"fair\" quality but have readability levels above the recommended 6th grade level. Google search results were superior to artificial intelligence in readability.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2149-2153"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a nomogram for predicting cervical lymph node metastasis in tall cell variant of papillary thyroid carcinoma.","authors":"Xunyi Lin, Lan Fang, Ming Li, Jianwu Yin, Chao Yang, Yanting Chen","doi":"10.1007/s00405-024-09050-9","DOIUrl":"10.1007/s00405-024-09050-9","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the risk factors associated with the occurrence of cervical lymph node metastasis (LNM) in patients with tall cell variant of papillary thyroid carcinoma (TCV-PTC) and to establish a nomogram.</p><p><strong>Methods: </strong>Clinical data of 727 patients with TCV-PTC from SEER database were obtained, and they were randomly divided into the training group (n = 508) and validation group (n = 219). The clinicopathological characteristics were analyzed by logistic regression, including age, marital status, race, gender, tumor size(cm), T stage, M stage, bilaterality, capsular invasion, extrathyroidal extension (ETE), vascular invasion and multifocality. The C-index, calibration curves, and DCA were utilized to validate the model from the differentiation and calibration of the nomogram, respectively.</p><p><strong>Results: </strong>Tumor size, extrathyroidal extension, and multifocality were independent risk factors for the development of LNM in patients with TCV-PTC (P < 0.05). In the training and validation groups, the C-index of internal validation of the nomogram were 0.727 (95% CI: 0.571-0.785) and 0.712 (95%CI: 0.700-0.714). The calibration curves indicated that the model was in good agreement, and the DCA indicated that the nomogram model had good clinical utility.</p><p><strong>Conclusion: </strong>Tumor size, extrathyroidal extension, and multifocality are independent risk factors for developing LNM in TCV-PTC. The nomogram model can predict the risk of developing LNM in TCV-PTC patients and provide clinical guidance.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"2087-2094"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing skull base defect repair: leveraging the reused nasoseptal flap as a reliable material.","authors":"Yu-Wen Huang, Wei-Hsin Wang, Ming-Ying Lan","doi":"10.1007/s00405-025-09213-2","DOIUrl":"10.1007/s00405-025-09213-2","url":null,"abstract":"<p><strong>Purpose: </strong>The escalating number of endoscopic skull base procedures necessitates exploring additional materials to reduce postoperative cerebrospinal fluid (CSF) leaks in revision or staged surgeries. This study evaluates the effectiveness of reused nasoseptal flaps (NSFs) in such clinical scenarios.</p><p><strong>Methods: </strong>A retrospective review was conducted on patients who previously underwent surgery involving NSFs and later had revision or secondary skull base surgeries via endoscopic endonasal approaches (EEAs) at a tertiary medical center. Patients were divided into two groups: one with reused NSFs and the other without. Demographics, intraoperative CSF leaks, reconstruction materials, postoperative morbidity, and time to complete mucoepithelialization of the defect were analyzed.</p><p><strong>Results: </strong>The study included 20 patients with prior NSF usage who underwent secondary EEAs. Thirteen cases utilized reused NSFs alone or with inlay fat or fascia lata, while the remaining seven employed other materials. Pathology type disparity was significant (p = 0.031). Reused NSF demonstrated a 100% success rate in reducing CSF leaks. The average time for mucoepithelization was 61 days (SD = 34 days).</p><p><strong>Conclusions: </strong>Reusing NSF in revision or staged surgeries is a reliable technique for skull base repair, potentially reducing nasal morbidity and obviating the need for harvesting other vascular flaps.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"1921-1927"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}