内淋巴积液损害梅尼埃病患者腹腔内注射钆混合地塞米松的内耳吸收和分布。

IF 2.2 3区 医学 Q2 OTORHINOLARYNGOLOGY
Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö
{"title":"内淋巴积液损害梅尼埃病患者腹腔内注射钆混合地塞米松的内耳吸收和分布。","authors":"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö","doi":"10.1007/s00405-025-09251-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).</p><p><strong>Materials and methods: </strong>This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.</p><p><strong>Results: </strong>EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.</p><p><strong>Conclusions: </strong>Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3513-3521"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.\",\"authors\":\"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö\",\"doi\":\"10.1007/s00405-025-09251-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).</p><p><strong>Materials and methods: </strong>This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.</p><p><strong>Results: </strong>EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.</p><p><strong>Conclusions: </strong>Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.</p>\",\"PeriodicalId\":11952,\"journal\":{\"name\":\"European Archives of Oto-Rhino-Laryngology\",\"volume\":\" \",\"pages\":\"3513-3521\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Archives of Oto-Rhino-Laryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00405-025-09251-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Oto-Rhino-Laryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00405-025-09251-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:探讨内淋巴水肿(EH)对梅尼埃病(MD)患者内耳鼓内钆进入的影响。材料和方法:本研究纳入了166例MD患者。颅腔内注射地塞米松和20倍稀释Gd-DTPA后24 h行MRI检查。选择耳蜗和前庭中增强最强的感兴趣区域计算信号强度比(SIR),代表传输速度。测定前庭淋巴周围增强区Gd-DTPA分布体积。结果:77.7%的患者检出EH,其中63例确诊MD中60例检出EH, 103例疑似MD中51例检出EH。76.1%的患者存在不同程度的前庭EH,而17.5%的患者表现为内淋巴屏障受损。68.7%的患者出现不同程度的耳蜗EH,其中34.9%位于耳尖;12.7%内淋巴屏障受损。耳蜗症状的严重程度和MD的分期与EH的存在显著相关。前庭SIR与前庭EH呈负相关。前庭淋巴周围增强面积与EH和MD分期呈负相关。结论:钆从中耳进入内耳的转运和内耳分布体积与EH呈负相关,在晚期MD患者中EH受损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.

Purpose: To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).

Materials and methods: This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.

Results: EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.

Conclusions: Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
5.30
自引率
7.70%
发文量
537
审稿时长
2-4 weeks
期刊介绍: Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信