{"title":"内淋巴积液损害梅尼埃病患者腹腔内注射钆混合地塞米松的内耳吸收和分布。","authors":"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö","doi":"10.1007/s00405-025-09251-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).</p><p><strong>Materials and methods: </strong>This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.</p><p><strong>Results: </strong>EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.</p><p><strong>Conclusions: </strong>Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"3513-3521"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.\",\"authors\":\"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö\",\"doi\":\"10.1007/s00405-025-09251-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).</p><p><strong>Materials and methods: </strong>This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.</p><p><strong>Results: </strong>EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.</p><p><strong>Conclusions: </strong>Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.</p>\",\"PeriodicalId\":11952,\"journal\":{\"name\":\"European Archives of Oto-Rhino-Laryngology\",\"volume\":\" \",\"pages\":\"3513-3521\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Archives of Oto-Rhino-Laryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00405-025-09251-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Oto-Rhino-Laryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00405-025-09251-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.
Purpose: To investigate how endolymphatic hydrops (EH) affects the entry of intratympanic gadolinium in the inner ear of patients with Meniere's disease (MD).
Materials and methods: This study included 166 MD patients. MRI was performed 24 h after intratympanic injection of dexamethasone and 20-fold diluted Gd-DTPA. The region of interest with the strongest enhancement in the cochlea and vestibule was selected to calculate the signal intensity ratio (SIR), representing transport speed. The enhancement area in the vestibular perilymph, indicating the distribution volume of Gd-DTPA, was measured.
Results: EH was detected in 77.7% of patients, specifically in 60 out of 63 definite MD cases and 51 out of 103 probable MD cases. Vestibular EH with various grades was present in 76.1% of patients, whereas 17.5% exhibited impaired barriers of endolymph. Cochlear EH with various grades was observed in 68.7% of patients, and 34.9% located at the apex; 12.7% had impaired barriers of endolymph. The severity of cochlear symptoms and the stage of MD significantly correlated with the presence of EH. The vestibular SIR inversely correlated with vestibular EH. The enhancement area of the vestibular perilymph inversely correlated with EH and the stage of MD.
Conclusions: Gadolinium transport from the middle ear into the inner ear and the distribution volume in the inner ear inversely correlated with EH, which is compromised in more advanced stages MD patients.
期刊介绍:
Official Journal of
European Union of Medical Specialists – ORL Section and Board
Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery
"European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level.
European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.