Locally advanced maxillary sinus cancer fed from the internal carotid artery.

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2025-03-28 DOI:10.1007/s00405-025-09343-7

Tatsuhiko Yamada, Masashi Kuroki, Hirofumi Shibata, Shoma Nagata, Hiroshi Kawada, Hiroki Kato, Akira Ohkoshi, Ikuho Kojima, Ryota Iinuma, Hiroshi Okuda, Yukio Katori, Masayuki Matsuo, Takenori Ogawa

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引用次数: 0

Abstract

Objective: Superselective intra-arterial infusion of cisplatin and concomitant radiation therapy (RADPLAT) is one of the effective treatments for advanced maxillary sinus cancer, and prospective trials have been conducted. However, treatment of cases with intraorbital infiltration or skull base infiltration that are fed from the internal carotid artery (ICA) may be problematic. In this study, we investigated the frequency, treatment, and prognosis of locally advanced maxillary sinus cancer fed from the ICA.

Method: This study included patients with locally advanced maxillary sinus cancer (clinical T4a or T4b) who underwent RADPLAT only via external carotid artery from January 2008 to January 2024.

Result: Nineteen of 44 cases were fed from the ICA (43.2%). Three-year overall survival (OS), three-year progression-free survival (PFS), and three-year local control rate (LCR) of all cases were 69.8%, 47.5%, and 61.8%, respectively. The three-year OS, PFS and LCR were equivalent between cases with or without feeding from the ICA.

Conclusion: This study revealed the frequency and prognosis of locally advanced maxillary sinus cancer fed from the ICA. The prognosis was equivalent between cases with or without feeding from the ICA; therefore, it would be considered important to determine the tumor volume for each feeding blood vessel and assess the areas of dual perfusion.

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局部晚期上颌窦癌源自颈内动脉。

目的：顺铂超选择性动脉灌注联合放射治疗（RADPLAT）是晚期上颌窦癌的有效治疗方法之一，并进行了前瞻性试验。然而，眼眶内浸润或颅底浸润由颈内动脉（ICA）供血的病例的治疗可能是有问题的。在这项研究中，我们调查了局部晚期上颌窦癌的频率、治疗和预后。方法：本研究纳入2008年1月至2024年1月仅经颈外动脉行RADPLAT的局部晚期上颌窦癌（临床T4a或T4b）患者。结果：44例患者中有19例（43.2%）采用ICA喂养。所有病例的3年总生存期（OS）、3年无进展生存期（PFS）和3年局部控制率（LCR）分别为69.8%、47.5%和61.8%。3年OS、PFS和LCR在使用或不使用ICA喂养的病例之间相等。结论：本研究揭示了局部晚期上颌窦癌的发生率和预后。有或没有从ICA喂养的病例预后相同；因此，确定每条供血血管的肿瘤体积和评估双灌注区域是很重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.