European Journal of Medical Research最新文献

{"title":"Serum Vitamin C concentrations are inversely related to biological aging: a population-based cross-sectional study.","authors":"Ying Zhang, Fang Gong, Ai-Hua Zhang, Guan-Wu Wang, Yun Liu, Teng Li","doi":"10.1186/s40001-025-03150-w","DOIUrl":"10.1186/s40001-025-03150-w","url":null,"abstract":"<p><strong>Background and objective: </strong>Vitamin C (Vit C), which has antioxidant properties, may reduce oxidative stress and delay aging. However, the relationship between Vit C and biological aging is poorly established. Therefore, we aimed to investigate the association between serum Vit C (S-vit C) concentrations and phenotypic age acceleration (PhenoAgeAccel), an indicator of biological aging.</p><p><strong>Methods: </strong>The present study utilized a cross-sectional design using NHANES-retrieved data from 10,118 participants aged 20-79. Weighted linear regression models alongside restricted cubic spline analysis were deployed to determine the association. A two-piecewise linear regression model and a log-likelihood ratio test were utilized to assess the potential threshold effect. Using the subgroup analyses, we explored variations in association across different subgroups while utilizing the sensitivity analyses to validate the strength of the outcomes.</p><p><strong>Results: </strong>S-vit C concentrations were inversely related to PhenoAgeAccel. Participants in the highest quartile of S-vit C levels showed significantly reduced PhenoAgeAccel compared to those in the lowest quartile. A nonlinear relationship was identified between S-vit C levels and PhenoAgeAccel, characterized by an inflection point at 1.46 mg/dL. Beyond this threshold, further increases in S-vit C concentrations did not result in statistically significant reductions in PhenoAgeAccel. The results of subgroup analyses showcased that the inverse association was more substantial among older adults and individuals with hypertension or diabetes. The sensitivity analyses validated the strength of the outcomes.</p><p><strong>Conclusions: </strong>S-vit C levels exhibit an inverse association with biological aging, particularly in older individuals and those with chronic conditions, highlighting the potential role of Vit C in healthy aging.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"864"},"PeriodicalIF":3.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dual roles of T cells and keratinocytes in seborrheic dermatitis: a narrative review.","authors":"Yangfan Xu, Xiaoliang Tong","doi":"10.1186/s40001-025-03005-4","DOIUrl":"10.1186/s40001-025-03005-4","url":null,"abstract":"<p><p>Seborrheic dermatitis (SD) is a recurrent inflammatory skin disease primarily affects sebaceous gland-rich areas, particularly the scalp. Its characteristic clinical manifestations including dandruff, greasy crusting, and pruritus. These recurrent symptoms frequently impose significant psychological distress on patients. SD is classically associated with sebum secretion, Malassezia colonization, and individual susceptibility, whereas the critical roles of keratinocyte barrier dysfunction and T cell-mediated inflammation also constitute components in disease progression. In this review, we elucidate the mechanistic interplay between keratinocytes and T cells in SD development, proposing that their functional imbalance serves as a key driver of pathogenesis. We also systematically evaluate relevant therapies targeting keratinocytes and T cells, aiming to offer novel insights into SD pathophysiology and treatment.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"853"},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and female infertility: insights from a cross-sectional study.","authors":"Jingyang Wang, Ye Wang, Yue Niu, Jingzhi Wang, Lianyao Shi, Yanjun Guo, Yuyuan Zhang, Xin Zhou, Shufang Song","doi":"10.1186/s40001-025-03084-3","DOIUrl":"10.1186/s40001-025-03084-3","url":null,"abstract":"<p><strong>Background: </strong>Infertility in women of reproductive age is a major worldwide health problem. Oxidative stress, inflammatory responses, and dysregulation of lipid metabolism are among the factors that contribute to female infertility. The ratio of serum uric acid to high-density lipoprotein cholesterol (UHR), a novel composite biomarker that reflects oxidative stress and lipid metabolism, has not been extensively studied in relation to female infertility. This study aims to explore the associations between UHR levels and female infertility.</p><p><strong>Methods: </strong>This cross-sectional study focused on females aged 18-44 years in the National Health and Nutrition Examination Survey from 2013 to 2018. The association between UHR and infertility was assessed by weighted multivariable logistic regression. Restricted cubic spline (RCS) analysis was employed to analyze the presence of nonlinear relationships between UHR and infertility. Stratified analyses were conducted to investigate the interactions between UHR and infertility in subgroups.</p><p><strong>Results: </strong>Of the included 3087 women, 357 (11.56%) were recognized with infertility. When UHR was continuous, elevated UHR levels showed a positive association with infertility risk after comprehensive adjustment for confounding factors [odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.02-1.12]. Compared with the lowest UHR level (UHR ≤ 6.14), women with the highest UHR level (UHR > 10.49) had higher odds of infertility (OR = 1.80, 95% CI: 1.03-3.14). A linear relationship was found between UHR and infertility in the RCS analysis. Stratified analyses did not discover any interactions between UHR and infertility in selected subgroups, including age group, educational level, body mass index category, marital status, diabetes, hypertension, hyperlipidemia, and menstrual cycle regularity (all p values for interaction were > 0.05).</p><p><strong>Conclusions: </strong>The findings demonstrated significant linear associations between elevated UHR levels and increased odds of female infertility. UHR may serve as a potential biomarker for infertility that requires validation. Future studies should remedy the cross-sectional limitations of this study.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"854"},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting ANGPTL4 improves Treg/Th17 cell imbalance and alleviates inflammation in allergic rhinitis by suppressing the Notch signaling pathway.","authors":"Xiuli Han, He Li, Yu Sun, Yuming Wang","doi":"10.1186/s40001-025-03049-6","DOIUrl":"10.1186/s40001-025-03049-6","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the effect of angiopoietin-like 4 (ANGPTL4) on allergic rhinitis (AR) and explores the underlying mechanisms.</p><p><strong>Methods: </strong>A mouse model of AR was generated through ovalbumin (OVA) challenge. The numbers of nasal rubbing and sneezing were counted and scored. Histological staining was conducted to analyze pathological alterations and inflammation in the mouse nasal mucosa. Inflammatory cytokines in serum and nasal lavage fluid (NALF) samples were analyzed using ELISA kits. Populations of regulatory T cells (Tregs) and Th17 cells in NALF or lymph nodes were analyzed using flow cytometry. Mice with AR were administered short hairpin (sh) RNAs targeting ANGPTL4. The effect of Notch pathway in AR severity was analyzed by gain- and loss-of-function assays.</p><p><strong>Results: </strong>The consistent OVA challenge led to significant AR-like symptoms in mice, along with increased Notch signaling activation. Inhibiting this pathway using γ-secretase inhibitor (DAPT) markedly reduced the AR scores and alleviated inflammatory infiltration by improving Treg/Th17 cell balance. ANGPTL4 silencing significantly mitigated AR-related symptoms, Treg/Th17 cell imbalance, and inflammatory cascades in mice by inactivating the Notch signaling pathway. However, these alleviating effects of ANGPTL4 silencing on mice were negated by the administration of valproic acid, an agonist of the Notch signaling.</p><p><strong>Conclusion: </strong>This paper provides evidence that the ANGPTL4 knockdown shows significant therapeutic effects on AR by improving the Treg/Th17 cell balancing, effects achieved, at least in part, by blocking the Notch signaling pathway.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"851"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of BMI on pregnancy outcomes in PCOS patients undergoing ultralong GnRH-a protocol with blastocyst transfer.","authors":"Weijue Su, Lei Zhang, Jing Cheng, Yanghua Fu, Junzhao Zhao, Haoying Chen","doi":"10.1186/s40001-025-03123-z","DOIUrl":"10.1186/s40001-025-03123-z","url":null,"abstract":"<p><strong>Background: </strong>Approximately 50% of the women with polycystic ovary syndrome (PCOS) are overweight or obese and obesity can significantly impair reproductive function. This study aimed to investigate the association between body mass index (BMI) and embryonical/clinical outcomes in PCOS patients undergoing ultralong gonadotrophin-releasing hormone agonist (GnRH-a) protocol and to establish evidence-based management strategies for obese women with PCOS.</p><p><strong>Method: </strong>A total of 1704 PCOS patients aged 20-42 years were treated with an ultralong GnRH-a protocol during a single oocyte retrieval cycle, followed by blastocyst transfer between 2016 and 2023. Participants were stratified according to BMI criteria into four groups: underweight (n = 125), normal weight (n = 845), overweight (n = 517) and obese (n = 217). Baseline characteristic and reproductive outcomes were compared across BMI categories.</p><p><strong>Results: </strong>PCOS patients with obesity exhibited a significant reduction in both the number of retrieved oocytes and mature oocytes. In fresh blastocyst transfer cycles, no statistical differences in live birth rates were observed across the four BMI groups (p = 0.246). However, in frozen-thawed blastocyst transfer cycles, the obese group had the lowest live birth rate among all BMI categories. Multivariate logistic regression analysis identified several key predictors of live birth. The number of high-quality blastocysts transferred was a dominant favorable factor (OR = 1.480, 95% CI 1.251-1.751). Conversely, obesity independently predicted a reduced likelihood of live birth (OR = 0.437, 95% CI 0.298-0.641). Further analysis of cumulative live birth outcomes in a complete oocyte retrieval cycle confirmed that obesity remained a negative predictor (OR = 0.438, 95% CI 0.312-0.615), while the number of high-quality blastocysts transferred (OR = 1.269, 95% CI 1.132-1.423) and a shorter duration of infertility (OR = 0.927, 95% CI 0.885-0.972) were associated with improved success rates.</p><p><strong>Conclusions: </strong>PCOS patients with obesity presented poorer embryonical and clinical outcomes. Obesity emerged as a significant independent predictor of nonlive birth in both frozen-thawed blastocyst transfer cycles and complete in vitro fertilization (IVF) cycles. This study underscores the clinical importance of incorporating pre-IVF interventions, particularly weight management strategies, for obese PCOS patients to optimize reproductive outcomes.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"849"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratified cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): impact of varying metabolic risk factor burden.","authors":"Maha Elsabaawy, Mohamed Torkey, Mai Magdy, Madiha Naguib","doi":"10.1186/s40001-025-03151-9","DOIUrl":"10.1186/s40001-025-03151-9","url":null,"abstract":"<p><strong>Background: </strong>Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a spectrum of hepatic disorders that are closely linked to metabolic risk factors. This study aimed to investigate the stratified cardiovascular risk in patients with MASLD based on varying metabolic risk burdens.</p><p><strong>Methods: </strong>In a cross-sectional analysis, 357 patients with MASLD were classified into three subtypes based on the number of metabolic conditions used for diagnosis: subtype 1 with one metabolic risk factor (n = 110), subtype 2 with two (n = 161), and subtype 3 with three risk factors (n = 86). Clinical parameters, liver enzymes, lipid profiles, and 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) were compared among subtypes.</p><p><strong>Results: </strong>The prevalence of diabetes and hypertension increased significantly across subtypes, with subtype 3 showing the highest burden of cardiovascular risk factors (100% diabetes, 43% hypertension). Cardiovascular risk was elevated in subtype 3 (mean ASCVD 0.112 ± 0.108, p < 0.001). Multivariate analysis identified subtype 3 (OR = 7.812, 95% CI 1.980-30.819, p = 0.003), men sex (OR = 33.549, 95% CI 11.814-95.269, p < 0.001), and age (OR = 1.171, 95% CI 1.116-1.229, p < 0.001) as independent predictors of intermediate to high cardiovascular risk.</p><p><strong>Conclusion: </strong>The metabolic burden in patients with MASLD significantly stratified cardiovascular risk. Patients with the highest metabolic dysfunction are at increased risk of cardiovascular events, underscoring the need for targeted cardiovascular prevention strategies.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"847"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NGAL knockdown alleviated CSE-induced cellular senescence and reduced MMP2 and MMP9 expression in alveolar macrophages through the PI3K/Akt pathway.","authors":"Yujie Wang, Chengji Jin, Yu Zheng, Jing Wang","doi":"10.1186/s40001-025-03222-x","DOIUrl":"10.1186/s40001-025-03222-x","url":null,"abstract":"<p><strong>Background: </strong>The accumulation of senescent cells has been identified as a key factor in the progression of emphysema. This study aimed to explore the role of neutrophil gelatinase-associated lipocalin (NGAL), a known mediator of COPD, in CSE-induced senescent alveolar macrophages.</p><p><strong>Methods: </strong>NGAL and cellular senescence markers expression were quantified in the lungs of COPD patients. Meanwhile, double-immunofluorescence staining was used to detect NGAL levels in alveolar macrophages of COPD lung tissues. Using a cigarette smoke exposure (CSE)-induced cellular senescence model in MH-S cells. Effects of CSE on NGAL secretion in MH-S cells was assessed by ELISA. Western blotting analysis and SA-β-galactosidase staining were employed to measure cellular senescence markers. NGAL siRNA was used to knockdown NGAL expression. In addition, CCK8 was used to evaluate cell viability and proliferation of MH-S cells. The activation status of the PI3K/Akt pathway was determined by Western blotting.</p><p><strong>Results: </strong>NGAL was elevated in alveolar macrophages from COPD patients compared with healthy controls. In vitro, exposure to CSE induced senescence in MH-S cells and concurrently increased NGAL secretion. Notably, NGAL knockdown attenuated CSE-induced senescence in MH-S cells via the PI3K/Akt pathway. Furthermore, NGAL downregulation significantly reversed CSE-suppressed MH-S cells proliferation and reduced MMP2 and MMP9 expression in senescent MH-S cells.</p><p><strong>Conclusions: </strong>These findings indicate that CSE upregulates NGAL in alveolar macrophages, thereby driving cellular senescence and MMP production through PI3K/Akt pathway.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"850"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in healthcare and medicine: clinical applications, therapeutic advances, and future perspectives.","authors":"Yosri A Fahim, Ibrahim W Hasani, Samer Kabba, Waleed Mahmoud Ragab","doi":"10.1186/s40001-025-03196-w","DOIUrl":"10.1186/s40001-025-03196-w","url":null,"abstract":"<p><p>Healthcare systems worldwide face growing challenges, including rising costs, workforce shortages, and disparities in access and quality, particularly in low- and middle-income countries. Artificial intelligence (AI) has emerged as a transformative tool capable of addressing these issues by enhancing diagnostics, treatment planning, patient monitoring, and healthcare efficiency. AI's role in modern medicine spans disease detection, personalized care, drug discovery, predictive analytics, telemedicine, and wearable health technologies. Leveraging machine learning and deep learning, AI can analyze complex data sets, including electronic health records, medical imaging, and genomic profiles, to identify patterns, predict disease progression, and recommend optimized treatment strategies. AI also has the potential to promote equity by enabling cost-effective, resource-efficient solutions in low-resource and remote settings, such as mobile diagnostics, wearable biosensors, and lightweight algorithms. Successful deployment requires addressing critical challenges, including data privacy, algorithmic bias, model interpretability, regulatory oversight, and maintaining human clinical oversight. Emphasizing scalable, ethical, and evidence-driven implementation, key strategies include clinician training in AI literacy, adoption of resource efficient tools, global collaboration, and robust regulatory frameworks to ensure transparency, safety, and accountability. By complementing rather than replacing healthcare professionals, AI can reduce errors, optimize resources, improve patient outcomes, and expand access to quality care. This review emphasizes the responsible integration of AI as a powerful catalyst for innovation, sustainability, and equity in healthcare delivery worldwide.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"848"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of anti-osteoporotic treatments on hyperlipidemia risk in osteoporosis patients: evidence from a population-based retrospective cohort study.","authors":"Hui-Hsia Hsieh, Ni Tien, Cheng-Li Lin, Wai-Huen Wong, Wan-Yi Lee, Chi-Hua Chen, Fuu-Jen Tsai, Bang-Jau You, Yi-Jen Fang, Yun-Ping Lim","doi":"10.1186/s40001-025-03130-0","DOIUrl":"10.1186/s40001-025-03130-0","url":null,"abstract":"<p><strong>Background: </strong>In this population-based retrospective cohort study, we investigated the relationship between osteoporosis and the risk of hyperlipidemia, the main risk factor for cardiovascular disease (CVD). Despite extensive research on both conditions, the association between osteoporosis and hyperlipidemia remains unclear, particularly in Asian populations.</p><p><strong>Methods: </strong>Using information from Taiwan's Longitudinal Generation Tracking Database, we conducted a retrospective population-based cohort study spanning 2000-2021. Patients in the comparison cohort were chosen at random and frequency-matched in a 1:1 ratio based on age, sex, month, and year of the index date. Both cohorts were monitored from the index date until a new diagnosis of hyperlipidemia was established. Data on baseline characteristics, comorbidities, and prescription of anti-osteoporotic treatment (AOTs) were gathered.</p><p><strong>Results: </strong>The osteoporosis cohort consisted of 67,628 patients aged ≤ 34 years or older, diagnosed with osteoporosis, and without a history of hyperlipidemia. With a mean follow-up of 8.81 years and 9.78 years, respectively, the total incidence of hyperlipidemia was 36.7 (per 1000 person-years) for the osteoporosis cohort and 28.4 for the comparison cohort, after controlling for age, sex, and comorbidities. Without treatment, the hazard ratio (HR) for developing hyperlipidemia was 1.58 (95% confidence interval [CI], 1.54-1.62) for the osteoporosis cohort compared with the comparison cohort. The risk of hyperlipidemia was considerably reduced in patients with osteoporosis who received most types of AOTs [adjusted HR, ≤ 0.31] compared with those who did not receive any of these AOTs.</p><p><strong>Conclusion: </strong>Our findings suggest a significant association between osteoporosis and increased risk of hyperlipidemia in Asian populations, and highlight the potential protective role of AOTs against hyperlipidemia. These insights could inform clinical strategies to manage patients with osteoporosis and mitigate their risk of CVD.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"852"},"PeriodicalIF":3.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between H. pylori infection and cognitive deterioration: a systematic review and meta-analysis.","authors":"Mahmoud M Elhady, Abdelrahman Zidan, Eslam Mohammed Rabea, Heidi Sherif Farouk, Moustafa Z Elattar, Manar Adel, Mariam Abdulkhaliq Khalil, Amira A Aboali, Marwa Abdel Aziz Zeid, Mohamed A Shaltout, Alzahraa M Abdel-Daim, Asmaa Gomaa Alwarraqi, Hazem AbuEl-Enien, Mohamed Sayed Zaazouee","doi":"10.1186/s40001-025-03160-8","DOIUrl":"10.1186/s40001-025-03160-8","url":null,"abstract":"<p><strong>Background: </strong>The association between cognitive decline and Helicobacter pylori (H. pylori) infection remains controversial, with some evidence suggesting that H. pylori eradication may slow the progression of the disease. This meta-analysis aims to investigate the bidirectional relationship between H. pylori and cognitive decline.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, the Cochrane Library, and Scopus for double-arm studies that reported either the prevalence of cognitive decline in individuals with H. pylori-positive status or the prevalence of H. pylori infection in patients with cognitive decline. A random-effects meta-analysis was conducted using Comprehensive Meta-Analysis software to pool the odds ratios from the included studies. Study quality was assessed using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Our search identified 1,240 records, with 16 studies meeting the inclusion criteria. Meta-analysis showed that patients with H. pylori had a significantly higher risk of cognitive decline (OR = 1.338, 95% CI 1.046-1.713), with the strongest association seen in studies grouping cognitive dysfunction and dementia (OR: 3.190, 95% CI 1.853-5.490). However, the risk of Alzheimer's disease was insignificant. Cognitive decline cohorts showed a significantly higher prevalence of H. pylori (OR = 1.5, 95% CI 1.131-1.989), with a significant association with Alzheimer's disease (OR: 1.630, 95% CI 1.064-2.497), but not with dementia or cognitive dysfunction. The association varied across study designs, with cross-sectional studies showing no association in both analyses. Heterogeneity was substantial (I² > 70% in most analyses), highlighting variability in the findings.</p><p><strong>Conclusion: </strong>This meta-analysis indicates a bidirectional association between H. pylori and cognitive decline. While H. pylori infection increased the overall risk of cognitive decline, no significant link was found with Alzheimer's disease. Conversely, Alzheimer's disease patients had a higher prevalence of H. pylori infection. High heterogeneity underscores the need for further well-designed studies to clarify this relationship.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"846"},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}