European Journal of Medical Research最新文献

{"title":"Association between crystalline lens thickness and intermittent exotropia in children: a cross-sectional observational clinical study.","authors":"Jingxin Li, Xiangxiang Liu, Jie Hao, Fengchao Zhou, Huixin Li, Yiyang Zhao, Yumeng Wang, Lei Li, Jing Fu","doi":"10.1186/s40001-025-02644-x","DOIUrl":"https://doi.org/10.1186/s40001-025-02644-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between crystalline lens thickness (LT) and subtypes of intermittent exotropia (IXT) in children, focusing on ocular biometry and accommodation characteristics.</p><p><strong>Methods: </strong>This cross-sectional study included 501 children aged from 8 to 12 years: 122 with orthophoria (Group A) and 379 with IXT, which were further categorized into basic type (Group B, n = 254), convergence insufficiency (CI) type (Group C, n = 92), and divergence excess (DE) type (Group D, n = 33). Evaluation of strabismus was measured after diagnostic occlusion. Cycloplegic refraction and assessments of accommodation and convergence functions were performed. All children were examined with Lenstar LS-900 with fixation at non-accommodative target monocularly and ocular biometric parameters including axial length (AL), mean keratometry (Km), central corneal thickness (CCT), LT and aqueous depth (AD) were recorded. Regression analyses were performed to evaluate associations among groups.</p><p><strong>Results: </strong>The basic type was the most prevalent IXT subtype (67.0%), followed by CI (24.3%) and DE (8.7%). The CI group exhibited greater binocular LT (P = .002) and lower accommodative convergence-to-accommodation (AC/A) ratio compared to the basic type (P = 0.016). Compared to orthophoric controls, the basic IXT group showed greater accommodative amplitude (AMP) (P = 0.004), reduced accommodation lag (P = 0.006), and more distant near point of convergence (NPC) (P < 0.001). Both univariate and multivariate logistic regression analyses indicated that the CI IXT was associated with greater LT (P = 0.006) and lower AC/A ratio (P = 0.007) compared to basic IXT. Basic IXT was correlated with greater AMP (P < 0.001), reduced lag of accommodation (P = 0.002) and more distant NPC (P = 0.003) compared to controls.</p><p><strong>Conclusions: </strong>Increased LT and lower AC/A ratio were significantly associated with the CI subtype of IXT in children. The basic type is characterized by greater AMP, reduced accommodation lag, and more distant NPC compared to orthophoric controls. These findings could serve as valuable clinical markers for managing IXT, and contribute to a deeper understanding of the pathophysiology of types of IXT.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"389"},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a problem, intervention, control, and outcomes (PICO)-based perioperative blood management plan developed for patients undergoing long-segment lumbar spine posterior surgery.","authors":"Hong Gao, Ting-Ting Wang, Qin Xuan, Guan-Hua Xu, Hai-Yan Gu","doi":"10.1186/s40001-025-02656-7","DOIUrl":"https://doi.org/10.1186/s40001-025-02656-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to develop and evaluate the effectiveness of a perioperative blood management plan based on the problem, intervention, control, and outcomes (PICO) model for long-segment lumbar spine posterior surgery.</p><p><strong>Methods: </strong>In this retrospective study, 51 patients who needed long-segment posterior lumbar spine surgery at the Second Affiliated Hospital of Nantong University Department of Spinal Surgery from July 2020 to June 2022 were included in the control group, while 51 patients who needed long-segment posterior lumbar spine surgery from July 2021 to June 2022 were selected as the observation group. Patients in the control group received conventional blood management, while those in the observation group were additionally administered an evidence-based perioperative blood management plan. We compared the intervention outcomes in both the groups.</p><p><strong>Results: </strong>Patients in the observation group demonstrated significantly higher postoperative hemoglobin levels and hematocrit at various time points compared to those in the control group (P < 0.05). Intraoperative blood loss, postoperative drainage volume, and average volume of allogeneic blood transfused per recipient, as well as the number and frequency of allogeneic blood transfusions, were significantly lower in the observation group (P < 0.05). The duration of surgical drain placement and postoperative hospital stay were notably shorter in the observation group (P < 0.05). The two groups did not differ significantly in the incidence of postoperative venous thromboembolism (VTE) (P > 0.05).</p><p><strong>Conclusion: </strong>The implementation of a perioperative blood management plan was effective in reducing the total blood loss and transfusion volume in the perioperative period, improving hemoglobin and hematocrit levels, facilitating earlier removal of surgical drains, and accelerating patient discharge.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"388"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation for transthoracic echocardiography in children with Down syndrome: a propensity score-weighted retrospective cohort study.","authors":"Jie Hu, Lu Wang, Bing Xue, Ying Zhang, Ruidong Zhang","doi":"10.1186/s40001-025-02641-0","DOIUrl":"https://doi.org/10.1186/s40001-025-02641-0","url":null,"abstract":"<p><strong>Background: </strong>Transthoracic echocardiography can be performed under sedation in children with Down syndrome who have neurological or behavioral problems. This study aimed to compare the efficacy and safety of intranasal dexmedetomidine and oral chloral hydrate in children with Down syndrome who are undergoing transthoracic echocardiography.</p><p><strong>Methods: </strong>This retrospective cohort study reviewed the electronic medical records of patients with Down syndrome who underwent transthoracic echocardiography under oral chloral hydrate or intranasal dexmedetomidine sedation between June 2014 and September 2021. The patients were divided into oral chloral hydrate and intranasal dexmedetomidine groups according to the main agents used for sedation. The primary endpoint was the outcome of single-dose sedative agents, and the groups were compared using a propensity score weighting analysis.</p><p><strong>Results: </strong>In total, 149 patients (chloral hydrate group, n = 75; dexmedetomidine group, n = 74) were included in the final analysis. After propensity score weighting, 150 and 148 patients were included in the chloral hydrate and dexmedetomidine groups, respectively. The success rate of the initial sedative medication was significantly higher in the dexmedetomidine group than in the chloral hydrate group (89.1% vs. 80.7%, p = 0.0412) after adjustment for propensity score weighting. The success rate of the final sedative medication was higher in the dexmedetomidine group than in the chloral hydrate group (before propensity score weighting, 98.7% vs. 86.7%; after propensity score weighting, 98.5% vs. 86.8%; both p values < 0.01). Before and after propensity score weighting, the incidence of bradycardia during sleep was significantly higher in the dexmedetomidine group than in the chloral hydrate group. Sedation with dexmedetomidine or chloral hydrate was not associated with severe oxygen desaturation in children with Down syndrome.</p><p><strong>Conclusions: </strong>Compared with oral 50 mg/kg chloral hydrate, the use of a single intranasal dose of 2 μg/kg dexmedetomidine was related to a significantly higher success rate of sedation without increasing severe hypoxic events in children with Down syndrome undergoing transthoracic echocardiography, except for the incidence of bradycardia.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"387"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of machine learning and deep learning in musculoskeletal medicine: a narrative review.","authors":"Martina Feierabend, Julius Michael Wolfgart, Maximilian Praster, Marina Danalache, Filippo Migliorini, Ulf Krister Hofmann","doi":"10.1186/s40001-025-02511-9","DOIUrl":"10.1186/s40001-025-02511-9","url":null,"abstract":"<p><p>Artificial intelligence (AI), with its technologies such as machine perception, robotics, natural language processing, expert systems, and machine learning (ML) with its subset deep learning, have transformed patient care and administration in all fields of modern medicine. For many clinicians, however, the nature, scope, and resulting possibilities of ML and deep learning might not yet be fully clear. This narrative review provides an overview of the application of ML and deep learning in musculoskeletal medicine. It first introduces the concept of AI and machine learning and its associated fields. Different machine concepts such as supervised, unsupervised and reinforcement learning will then be presented with current applications and clinical perspective. Finally deep learning applications will be discussed. With significant improvements over the last decade, ML and its subset deep learning today offer potent tools for numerous applications to implement in clinical practice. While initial setup costs are high, these investments can reduce workload and cost globally. At the same time, many challenges remain, such as standardisation in data labelling and often insufficient validity of the obtained results. In addition, legal aspects still will have to be clarified. Until good analyses and predictions are obtained by an ML tool, patience in training and suitable data sets are required. Awareness of the strengths of ML and the limitations that lie within it will help put this technique to good use.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"386"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear associations between renal perfusion pressure indexes and AKI incidence and recovery rate.","authors":"Xinyuan Ding, Guolong Cai, Shangzhong Chen, Lihong Zhu, Chengcheng Zheng, Qian Li, Qin Li, Qingdong Jia, Yanfei Shen","doi":"10.1186/s40001-025-02582-8","DOIUrl":"https://doi.org/10.1186/s40001-025-02582-8","url":null,"abstract":"<p><strong>Background: </strong>Renal perfusion pressure plays a crucial role in the pathophysiology of acute kidney injury (AKI). While multiple methods are available for calculating renal perfusion pressure, the optimal calculation approach and its true correlation with AKI remain uncertain. This study aims to investigate the nonlinear relationship between various perfusion pressure indices and AKI, clarifying the connection between perfusion pressure, AKI onset, and recovery.</p><p><strong>Methods: </strong>Three renal perfusion pressure indices were calculated: MAP-CVP, MAP-Plateau pressure, and MAP-CVP-Plateau pressure. Restricted cubic spline (RCS) analysis was used to examine the association between these perfusion indices and AKI incidence. The relationship between MAP-CVP-Plateau pressure and both AKI occurrence and recovery rate was further assessed through linear spline function and categorical analysis.</p><p><strong>Results: </strong>A total of 8,848 ICU patients were included in the study, with an overall AKI incidence of 40%. RCS analysis revealed nonlinear relationships between the three perfusion indices and AKI incidence, each demonstrating different thresholds. ROC analysis indicated that MAP-CVP-Plateau pressure (cutoff value of 55) had the highest predictive value and was thus selected as the primary perfusion index. In the linear spline analysis, a high MAP-CVP-Plateau pressure was significantly associated with a reduced AKI risk when MAP-CVP-Plateau pressure was < 55 (OR 0.95, 95% CI 0.94-0.96, p < 0.01), while this association reversed when MAP-CVP-Plateau pressure exceeded 55 (OR 1.02, 95% CI 1.01-1.03, p < 0.01). For AKI recovery, a high MAP-CVP-Plateau pressure was significantly associated with a higher recovery rate when MAP-CVP-Plateau pressure was < 55 (OR 1.02, 95% CI 1.01-1.04, p < 0.01). However, when MAP-CVP-Plateau pressure was > 55, an elevated MAP-CVP-Plateau pressure was associated with a lower AKI recovery rate (OR 0.96, 95% CI 0.94-0.98, p < 0.01). The categorical analysis results for AKI incidence and recovery were consistent with the nonlinear relationship identified in the RCS analysis.</p><p><strong>Conclusions: </strong>This study underscores the critical role of perfusion pressure, particularly MAP-CVP-Plateau pressure, in AKI pathophysiology. Both low and high MAP-CVP-Plateau pressure levels were associated with increased AKI incidence and decreased recovery rates in critically ill patients.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"383"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analytic research and review of the literature on practice of artificial intelligence in healthcare.","authors":"Salma Mizna, Suraj Arora, Priyanka Saluja, Gotam Das, Waled Abdulmalek Alanesi","doi":"10.1186/s40001-025-02603-6","DOIUrl":"https://doi.org/10.1186/s40001-025-02603-6","url":null,"abstract":"<p><p>Artificial intelligence (AI) has transformed healthcare, particularly in robot-assisted surgery, rehabilitation, medical imaging and diagnostics, virtual patient care, medical research and drug discovery, patient engagement and adherence, and administrative applications. AI enhances pre-operative planning, intraoperative guidance, and post-operative outcomes in robotic surgery. In rehabilitation, AI enables personalized programs, physical therapy using robotics, and in real time monitoring and feedback mechanisms. The integration of AI with emerging technologies like augmented reality, virtual reality, and the Internet of Things holds promise for broader healthcare applications. However, AI adoption faces technical challenges related to data quality and bias, ethical and privacy concerns, regulatory and legal considerations, and issues of cost and accessibility. Future trends include advances in AI algorithms and robotics, integration with emerging technologies, and the potential for wider applications in healthcare and rehabilitation. Addressing ethical and security considerations is crucial for the successful integration of AI in healthcare while upholding patient safety and legal standards. Overcoming regulatory, ethical, and trust-based challenges with effective governance will be critical to the full realization of AI potential in healthcare artificial intelligence (AI)-driven healthcare solutions powered by IoT can enable in real time patient monitoring, enhancing early diagnosis and chronic illness management. AI applications in AR/VR can transform medical education by allowing healthcare professionals to practice intricate procedures in a safe environment. Wearable technology with AI-driven analytics can offer personalized health insights, facilitating proactive interventions and improved patient outcomes. Adopting these innovations can foster progress, enhance patient care, and boost overall healthcare efficiency. Future studies should refine these cross-disciplinary applications, ensure their smooth incorporation into current healthcare systems, and tackle potential ethical and security issues.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"382"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing the length of hospital stay for patients undergoing primary total knee arthroplasty by application of enhanced recovery after surgery (ERAS) pathway: a multicenter, prospective, randomized controlled trial.","authors":"Chenxi Liao, Xingning Lai, Jie Zhong, Wencong Zeng, Jiannan Zhang, Wanxin Deng, Jiayun Shu, Haobo Zhong, Liangyu Cai, Ren Liao","doi":"10.1186/s40001-025-02647-8","DOIUrl":"https://doi.org/10.1186/s40001-025-02647-8","url":null,"abstract":"<p><strong>Background: </strong>The proportion of elderly patients undergoing Total knee arthroplasty (TKA) is growing. Optimizing and accelerating postoperative recovery for TKA patients is critical in clinical practice. Enhanced Recovery After Surgery (ERAS) is a protocol involving a series of evidence-based perioperative optimization strategies to minimize surgical stress and expedite recovery, and a multidisciplinary ERAS pathway was established jointly by anesthesiologists and orthopedic surgeons in this study. The authors hypothesized that application of the ERAS pathway can reduce the length of hospital stay (LOS) for patients undergoing primary TKA.</p><p><strong>Materials and methods: </strong>This multicenter, prospective, randomized controlled trial was conducted from February 1, 2021 to January 31, 2023, and included patients undergoing elective primary TKA. 320 patients were randomly assigned to either the ERAS group (practice according to the ERAS pathway) or the control group (without ERAS pathway implementation) in a 1:1 ratio. The primary outcome was the total LOS in hospital.</p><p><strong>Results: </strong>LOS in the ERAS group was 5.92 ± 1.16 days, significantly shorter than the 8.17 ± 1.76 days in the control group (p < 0.001). Postoperative LOS and time to independent ambulation were significantly shorter in the ERAS group compared to the control group (p < 0.001). On postoperative day 1, significantly less participants reported pain both in rest and during mobilization in the ERAS group than the control group (p < 0.001). The incidences of thirst and postoperative nausea and vomiting (PONV) was significantly reduced in the ERAS group compared to the control group (16.8% vs. 88.6%, and 2.6% vs. 24.7%, respectively, p < 0.001). No perioperative deaths or reoperations within 30 days occurred in either group.</p><p><strong>Conclusion: </strong>The application of an ERAS pathway for primary TKA significantly reduces LOS, alleviates postoperative pain, and lowers the incidence of adverse events compared to perioperative management without ERAS pathway implementation.</p><p><strong>Trial registration: </strong>The National Institutes of Health Clinical Trials Registry, NCT03517098. Registered on April 24, 2018.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"385"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery.","authors":"Shanshan Yan, Yongnan Wang, Yingye Feng, Yujuan Guo, Huang Tang, Hongyi Gao","doi":"10.1186/s40001-025-02631-2","DOIUrl":"https://doi.org/10.1186/s40001-025-02631-2","url":null,"abstract":"<p><strong>Objectives: </strong>A critical measure to reduce the risk of ipsilateral breast tumor recurrence after breast-conserving surgery (BCS) for patients with early invasive breast cancer (BC) is ensuring negative margins through frozen section intraoperative margin assessment (FSIMA).This study aims to evaluate the influencing factors and prognosis associated with positive initial margins in FSIMA.</p><p><strong>Methods: </strong>The clinical data of 436 BC patients treated with BCS were retrospectively analyzed, and long-term follow-up outcomes were evaluated.</p><p><strong>Results: </strong>Among the 436 patients, approximately 90.8% (396/436) underwent successful BCS, while 71.8% (313/436) exhibited initial negative margins based on FSIMA. A total of 123 patients (28.2%) had positive initial margins, following additional excisions in some cases, 89 patients achieved negative margins. Univariate and multivariate analyses revealed significant differences between the positive and negative margin groups in tumor diameter, distance from the tumor to the nipple, and axillary lymph node metastasis (P < 0.05). No significant differences were observed in disease-free survival or overall survival between the two groups (P > 0.05).</p><p><strong>Conclusions: </strong>The findings suggest that tumor diameter, the distance between the tumor and nipple, and axillary lymph node metastasis may influence the determination of positive initial margins in FSIMA. Positive initial margins do not appear to influence disease-free survival (DFS) or overall survival (OS) among BC patients treated with BCS.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"384"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pelvic floor muscle combined with pulmonary rehabilitation training on lung function in elderly patients after surgery for intertrochanteric fractures of the femur: a randomized controlled trial.","authors":"Dongqi Ji, Yanxin Fu, Liang Wu, Chunyan Tian, Shasha Jin","doi":"10.1186/s40001-025-02610-7","DOIUrl":"https://doi.org/10.1186/s40001-025-02610-7","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of pelvic floor muscle (PFM) combined with pulmonary rehabilitation training on diaphragm function and lung function in elderly patients with intertrochanteric fracture.</p><p><strong>Methods: </strong>This study was conducted by a randomized controlled single-blind method, 50 elderly patients with intertrochanteric fracture in Beijing Xiaotangshan Hospital were selected and divided into the combined training group (Experimental group, n = 25) and the lung function training group (Control group, n = 25) by the random number table method. Patients in the combined training group received pelvic floor muscle training combined with lung rehabilitation training, and patients in the lung function training group received lung rehabilitation training. Forced vital capacity (FVC), forced expiratory volume in the first second/FVC (FEV1/FVC) and peak expiratory flow (PEF) were evaluated before and after intervention to analyze the improvement of lung function. Diaphragm thickening fraction (DTF) and diaphragm excursion (DE) were used to observe the improvement of diaphragm function.</p><p><strong>Results: </strong>After 4 weeks of intervention, there were significant differences in lung function and diaphragm function between the two groups compared with the improvement before the intervention, but patients in the combined training group had more significant improvements in FVC, FEV1/FVC, PEF, DTF, and DE.</p><p><strong>Conclusion: </strong>Pelvic floor muscle combined with lung function training can improve the diaphragm function more significantly in elderly patients with intertrochanteric fracture after operation, and thus affect the lung function of patients.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"381"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration.","authors":"Yunhao Cai, Jiahao Liu, Renwei Han, Zizhao Ma, Kaihang Yu, Ping Wu, Xiaokun Li, Zhouguang Wang, Jian Wang","doi":"10.1186/s40001-025-02552-0","DOIUrl":"https://doi.org/10.1186/s40001-025-02552-0","url":null,"abstract":"<p><strong>Background: </strong>The search for effective drugs that promote regeneration after peripheral nerve injury (PNI) has received widespread attention, but little attention has been paid to the potential secondary damage to nerves during neurosurgical procedures. CHUANG BI FU Biologic Protein Sponge (CHUANG BI FU) is a composite biological sponge loaded with basic fibroblast growth factor (bFGF) that has been effectively applied to clinical wounds, but has never been used for repairing peripheral nerves.</p><p><strong>Methods: </strong>This study used a 3.5-mm nerve defect model in mice, and wrap CHUANG BI FU around the nerve defect site, connecting the distal and proximal ends of the damaged nerve without suturing the nerve. The repair function of the nerve by the wound was tested by detecting mouse footprints, electrophysiology, NF200 staining, CD31 staining, and gastrocnemius muscle Masson staining.</p><p><strong>Results: </strong>It was found that CHUANG BI FU can promote axonal elongation, promote neuromuscular reinnervation function, and promote angiogenesis of regenerating nerves, thereby achieving the function of promoting damaged nerve regeneration. And through cellular level research, it was found that CHUANG BI FU may promote vascular regeneration through the PI3 K-AKT pathway.</p><p><strong>Conclusions: </strong>Using CHUANG BI FU to repair peripheral nerves can promote vascular regeneration through the PI3 K-AKT pathway and it can greatly reduce the technical difficulty and operation time required by surgical operators.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"380"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}