European Journal of Medical Research最新文献

{"title":"The influencing factors of cognitive dysfunction in patients after cardiac surgery and the construction of a nomogram prediction model.","authors":"Ani Zhao, Yanchun Peng, Lingyu Lin, Liangwan Chen, Yanjuan Lin","doi":"10.1186/s40001-025-02949-x","DOIUrl":"https://doi.org/10.1186/s40001-025-02949-x","url":null,"abstract":"<p><strong>Background: </strong>Early detection of cognitive dysfunction (POCD) in patients undergoing cardiac surgery may help improve the prognosis and quality of life. Identifying risk factors and clinically relevant factors is critical for prevention and treatment.</p><p><strong>Methods: </strong>This study retrospectively selected 305 patients admitted to the cardiac surgery Department of Union Hospital Affiliated with Fujian Medical University from January 2024 to July 2024 as the study objects. The cognitive function of the patients was assessed by the Montreal Cognitive Assessment Scale (MOCA) before and on the 6th day after surgery, and the patients were divided into a cognitive dysfunction group and a non-cognitive dysfunction group. Logistic regression was used to analyze the risk factors of POCD in patients undergoing cardiac surgery. R software was used to construct the nomogram model of POCD in heart patients.</p><p><strong>Results: </strong>Logistic regression model was used to screen the included variables, and the final results showed age (OR = 2.670, 95%CI 1.675-4.255, P < 0.001), white blood cell count (OR = 1.155, 95%CI 1.050-1.271, P = 0.009), lymphocytes (OR = 2.200, 95%CI 1.512-3.200, P < 0.001), and hemoglobin (OR = 1.020, 95%CI 1.009-1.032, P < 0.001) were independent risk factors for POCD on day 6 in patients undergoing cardiac surgery. The predicted value of the calibration curve of POCD on the 6th day of cardiac surgery was consistent with the actual value, and the Hosmer-Lemeshow goodness-of-fit test (χ² = 8.73, P = 0.36 > 0.05) showed good consistency. The area under the ROC curve is 0.80, with a good differentiation and decision curve.</p><p><strong>Conclusions: </strong>Age, white blood cell count, lymphocyte, and hemoglobin are independent risk factors for POCD on day 6 of cardiac surgery. The nomogram prediction model constructed in this study has good predictive ability.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"925"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of surgery and CPAP on cardiovascular health in patients with obstructive sleep apnea.","authors":"Nai-Chen Shih, Chien-Han Tsao, Yu-Hsun Wang, James Cheng-Chung Wei","doi":"10.1186/s40001-025-03132-y","DOIUrl":"https://doi.org/10.1186/s40001-025-03132-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess and compare the risks of cardiovascular disease and mortality in individuals with obstructive sleep apnea (OSA) undergoing treatment with either continuous positive airway pressure (CPAP) or upper airway surgery (UAS).</p><p><strong>Methods: </strong>Using the TriNetX database, we identified 1,477,746 OSA patients between 2014 and 2019. In total 3638 matched pairs of patients were selected, based on their propensity scores, with one group having received UAS and the other having received CPAP therapy. The Cox proportional hazards models were used to compare the risk of major adverse cardiovascular events (MACEs) between the two groups. Subgroup analyses based on age, sex, race, and BMI categories were conducted to validate the findings.</p><p><strong>Results: </strong>After propensity score matching, the UAS group had significantly lower risks of all-cause mortality (HR 0.45; 95% CI 0.33-0.59) and MACEs (HR 0.61; 95% CI 0.49-0.75) compared to the CPAP group. Subgroup analyses revealed that both male and female patients treated with UAS were associated with lower risks of all-cause mortality and MACEs. White individuals and those with BMI < 30 or ≥ 30, with age < 65 in the UAS group, consistently exhibited lower risks of all-cause mortality and MACEs.</p><p><strong>Conclusions: </strong>Patients with OSA receiving UAS were associated with lower risks of all-cause mortality and MACEs compared to those on CPAP. Subgroup analyses revealed variations in benefits, with lower risks of mortality and MACEs observed across different genders, age groups, racial backgrounds, and BMI categories within the UAS-treated population.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"923"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in diagnostic techniques for eosinophilic esophagitis: a systematic review of emerging noninvasive methods.","authors":"Abdulrhman Khaled Al Abdulqader","doi":"10.1186/s40001-025-02989-3","DOIUrl":"https://doi.org/10.1186/s40001-025-02989-3","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease characterized by esophageal dysfunction and eosinophilic inflammation. Traditional diagnostic methods rely on endoscopy with biopsy, which is invasive and resource-intensive. The recent advancements have focused on developing noninvasive and minimally invasive diagnostic tools to improve patient experience and facilitate disease monitoring.</p><p><strong>Objective: </strong>This systematic review aims to evaluate emerging noninvasive diagnostic techniques for EoE, including biomarkers, esophageal string tests (EST), and advanced imaging modalities, and their potential to complement or replace conventional diagnostic methods.</p><p><strong>Methods: </strong>A systematic search was conducted in major databases, including PubMed, Embase, and Cochrane Library, to identify studies investigating noninvasive diagnostic approaches for EoE. Inclusion criteria focused on original research and clinical trials evaluating diagnostic accuracy, patient acceptability, and clinical utility. Data on diagnostic methods, outcomes, and limitations were extracted and analyzed.</p><p><strong>Results: </strong>Emerging diagnostic methods, such as blood and urine biomarkers (e.g., EDN, ECP, eotaxin-3), EST, and advanced imaging (e.g., optical coherence tomography, EndoFLIP), demonstrated comparable sensitivity and specificity to endoscopic biopsy in detecting EoE. These tools offer advantages in reducing procedural burden, enabling dynamic disease monitoring, and enhancing patient adherence. However, challenges include variability in diagnostic thresholds and limited large-scale validation.</p><p><strong>Conclusion: </strong>Noninvasive diagnostic tools for EoE hold promise in transforming clinical practice by reducing reliance on invasive endoscopy. Further research is needed to standardize protocols and validate these methods for routine use.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"924"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway.","authors":"Zhiying Xu, Wei Shi, Jialun Ren, Qifei Zou, Mingming Fan, Yiran Li, Dong Jiang","doi":"10.1186/s40001-025-03047-8","DOIUrl":"10.1186/s40001-025-03047-8","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments.</p><p><strong>Methods: </strong>Differentially expressed genes (DEGs) in the cancer genome atlas (TCGA)-liver hepatocellular carcinoma (LIHC) and GSE101685 data sets were analyzed using the \"limma\" tool in R. Weighted Gene Co-expression Network Analysis (WGCNA) identified the key turquoise module. Bioinformatics analyzed the prognostic significance and expression of CCDC137. Functional analyses assessed the effects of CCDC137 on cell behavior and tumor growth. The connection between CCDC137 and DGCR8 and their impact on the AKT/mTOR signaling pathway and glycolysis were also examined.</p><p><strong>Results: </strong>A total of 670 overlapping DEGs were identified, and CCDC137, located within the turquoise module, was found to be significantly associated with HCC. CCDC137 was upregulated in HCC, correlating with worse prognostic outcomes. Experimental validation demonstrated that CCDC137 knockdown significantly reduced HCC cell proliferation, migration, invasion, and tumor growth. Mechanistically, CCDC137 may promote aerobic glycolysis through modulation of the AKT/mTOR signaling pathway, potentially mediated via its interaction with DGCR8.</p><p><strong>Conclusions: </strong>These findings suggest that the CCDC137/DGCR8 axis may contribute to HCC progression by regulating cellular metabolism through the AKT/mTOR pathway. Targeting this regulatory network may offer a promising direction for future therapeutic exploration in HCC.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"922"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of albumin-corrected anion gap in severe chronic kidney disease with sepsis: association with mortality and clinical outcomes.","authors":"Decai Wang, Ruizi Shi, Tao Wang, Han Li, Jianjun Wang","doi":"10.1186/s40001-025-03140-y","DOIUrl":"10.1186/s40001-025-03140-y","url":null,"abstract":"<p><strong>Objective: </strong>Albumin-corrected anion gap (ACAG) has emerged as a prognostic biomarker for critically ill patients. The mortality risk in patients with chronic kidney disease (CKD) complicated by sepsis is markedly increased Due to immune dysfunction, chronic inflammation, and metabolic disturbances. This study sought to investigate the associations between ACAG levels and mortality outcomes, including ICU, in-hospital, 14-day, 28-day, and 90-day mortality, in critically ill patients with CKD and sepsis.</p><p><strong>Methods: </strong>A total of 3459 critically ill patients with CKD and sepsis who were admitted to the ICU at Beth Israel Deaconess Medical Center were included in the analysis. These patients were categorized into two groups-lower and higher ACAG-based on the determined optimal threshold. Multivariate Cox proportional hazards models were employed to examine the associations between ACAG and ICU mortality, in-hospital mortality, as well as 14-, 28-, and 90-day mortality. The receiver operating characteristic (ROC) curve was used to evaluate the predictive ability, sensitivity, specificity, and area under the curve of ACAG for short-term and long-term mortality after admission in this specific patient population. Additionally, restricted cubic spline (RCS) analysis was conducted to explore the potential dose-response relationship between ACAG and these mortality outcomes. Subgroup analyses were conducted to assess how patient characteristics affect the prognostic value of ACAG.</p><p><strong>Results: </strong>Compared with the lower ACAG group (n = 2482), the higher ACAG group (n = 977) exhibited significantly higher ICU mortality, in-hospital mortality, and 14-, 28-, and 90-day mortality. Multivariate Cox regression analysis revealed that elevated ACAG levels were independently Linked to a higher risk of ICU mortality, in-hospital mortality, as well as 14-, 28-, and 90-day mortality rates. RCS analysis identified significant Linear relationships between ACAG levels and the risk of ICU death, in-hospital mortality, as well as mortality at 14, 28, and 90 days. ROC curve analysis indicated that ACAG had superior predictive ability for prognosis in this patient population compared to anion gap. The results of the subgroup analyses indicated that there were no statistically significant interactions between ACAG and most specific patient subgroup.</p><p><strong>Conclusion: </strong>ACAG serves as an independent prognostic marker for critically ill patients suffering from CKD and sepsis. As an easily accessible and cost-effective biomarker, ACAG can aid in the early identification of high-risk patients, optimize patient management, and improve patient outcomes.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"920"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective mechanism of taurine deoxycholic acid (TCDCA) through LPAR1 regulation in Buga syndrome.","authors":"Zeyu Guan, XiaoGao Wang, Ran Lu, Chao Xu, Erchang Zhu, Shiyuan Chen","doi":"10.1186/s40001-025-02945-1","DOIUrl":"10.1186/s40001-025-02945-1","url":null,"abstract":"<p><p>The etiology of Budd-Chiari syndrome (BCS), an uncommon but clinically significant condition, remains unclear. Therefore, this study investigates how taurodeoxycholic acid (TCDCA) influences human umbilical vein endothelial cells (HUVECs) in BCS. Following TCDCA treatment, the proliferation, apoptosis, migration, inflammatory response, and angiogenesis of HUVECs were examined, along with the levels of cAMP. Transcriptomic sequencing was further performed. Silencing LPAR1 in HUVECs was performed to explore its functional role. The results revealed significantly higher LPAR1 levels in HUVECs compared to controls. Silencing LPAR1 inhibited cell proliferation, migration, inflammation, and angiogenesis, while promoting apoptosis and increasing cAMP levels. Clinical samples from BCS patients showed significant upregulation of LPAR1, supporting our in vitro findings. Our findings suggest that TCDCA plays a pivotal role in BCS by regulating LPAR1.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"918"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study.","authors":"Shuangzhe Yao, Binbin Peng, Wenqin Liu, Jie Yang, Yangyang Hui, Chao Sun","doi":"10.1186/s40001-025-03121-1","DOIUrl":"10.1186/s40001-025-03121-1","url":null,"abstract":"<p><strong>Background: </strong>Liver cirrhosis, particularly in its decompensated stage, is associated with significant complications, including sleep disturbances. The relationship between sleep quality and muscle abnormality in patients with cirrhosis remains elusive. This study aimed to investigate the association between the Pittsburgh Sleep Quality Index (PSQI)-defined sleep disturbances and skeletal muscle abnormalities, including sarcopenia and myosteatosis, in a cohort of patients with decompensated cirrhosis.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of 505 adult patients with decompensated cirrhosis, excluding those with malignancy, acute-on-chronic liver failure, severe hepatic encephalopathy, or incomplete data. Muscle status was determined by the skeletal muscle index (SMI) and intramuscular adipose tissue content (IMAC) on computed tomography (CT), respectively.</p><p><strong>Results: </strong>The median PSQI score was significantly higher in patients with coexistent sarcopenia and myosteatosis compared to those with no or isolated muscle abnormality (P < 0.001). Multivariate analysis revealed that concomitant muscle abnormalities (OR: 3.48, P = 0.029) and body mass index (BMI) (OR: 0.95, P = 0.040) as independent predictors of poor sleep quality. Additionally, in the subgroup with preserved liver function and younger age, the differences in PSQI score across various states of skeletal muscle are more pronounced.</p><p><strong>Conclusion: </strong>Skeletal muscle abnormalities are an independent risk factor for sleep disturbances in cirrhotic patients, highlighting the need for targeted interventions to mitigate muscle abnormalities and potentially enhance sleep quality in this vulnerable population.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"917"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoster-associated pain: pretreatment time interval is inversely associated with pulsed radiofrequency effectiveness in a retrospective mono-institutional analysis.","authors":"Xuejiao Guo, Yunze Li, Xuliang Wang, Zhiying Feng","doi":"10.1186/s40001-025-02963-z","DOIUrl":"10.1186/s40001-025-02963-z","url":null,"abstract":"<p><strong>Background: </strong>Pulsed radiofrequency (PRF) is an effective treatment for herpes zoster-associated pain (ZAP), the optimal time to perform the PRF treatment remains unclear. This study aimed to explore this relationship and determine the optimal timing for PRF intervention.</p><p><strong>Methods: </strong>This research conduct a single-center retrospective cohort study in China. 303 patients who received PRF treatment for ZAP were followed up for 3 months. The primary endpoints were numerical rating scale (NRS) score and NRS reduction rate. Multiple assessment scales were used to evaluate pain and symptoms. Cox regression analysis and restricted cubic spline analysis were performed to examine the relationship between pre-treatment time interval (PTI) and outcomes.</p><p><strong>Results: </strong>69.9% achieved positive outcomes after PRF treatment. The incidence of positive outcomes decreased from 82.14% in the lowest PTI quartile to 48% in the highest. After adjusting for confounding factors, prolonged PTI was associated with an increased risk of negative PRF outcomes. Restricted Cube Spline (RCS) analysis revealed a non-linear relationship between PTI and treatment outcomes, with the risk of negative outcomes increasing rapidly initially before plateauing.</p><p><strong>Conclusions: </strong>The optimal timing for PRF treatment was determined to be within 1.5 months of herpes onset. Single-center results may be influenced by institution-specific practices and physician-related biases, and longer follow-up period is necessary.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"921"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H₂O₂-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.","authors":"Rui-Lin Yang, Yi-Bing Yang, Han-Xiao Wei, Meng Zhang, Kang Yang, Yu-Jie Zhao, Wen Yan, Ying Yang, Tao Zhang","doi":"10.1186/s40001-025-03062-9","DOIUrl":"10.1186/s40001-025-03062-9","url":null,"abstract":"<p><p>Peripheral blood mesenchymal stem cells (PBMSCs) are a less invasive and more accessible source of adult multipotent stem cells than bone marrow mesenchymal stem cells (BMMSCs), because their collection does not involve anaesthesia and the risk of complications. In the present study, we observed that PBMSCs alone exhibited a higher concentration of IL-10 in the supernatant when cultured independently. Furthermore, the supernatant from the Transwell co-culture system of PBMSCs with H₂O₂-induced oxidative stress in B16 melanoma cells, which serves as an in vitro model for vitiligo, demonstrated elevated levels of IL-10. Western blot analysis revealed that the PI3K/AKT signaling pathway was activated in B16 melanoma cells, as evidenced by increased phosphorylation of AKT, enhanced expression of the antioxidant enzyme HO-1 and the anti-apoptotic protein Bcl-2, alongside decreased expression of the pro-apoptotic proteins Bax and Cleaved-Caspase 3. Notably, these effects were inhibited by the IL-10 neutralizing antibody (AB9969) and the PI3K inhibitor (LY294002). Collectively, our findings suggest that PBMSCs may mitigate oxidative damage and apoptosis in B16 melanoma cells through the paracrine activation of the PI3K/AKT signaling pathway by IL-10. This approach offers a novel, readily available, and minimally invasive cellular therapeutic strategy for vitiligo while also providing a theoretical basis for targeting antioxidant pathways in treatment.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"919"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and determinants of puerperal sepsis in Ethiopia: a systematic review and meta-analysis.","authors":"Yonas Abebe, Anteneh Gashaw, Robera Demissie","doi":"10.1186/s40001-025-03138-6","DOIUrl":"10.1186/s40001-025-03138-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Puerperal sepsis is a leading cause of maternal morbidity and is responsible for nearly one-fifth of maternal deaths worldwide. In Ethiopia, it remains a significant contributor to maternal mortality; however, a comprehensive understanding of its determinants is still lacking. Therefore, the aim of this systematic review and meta-analysis is to estimate the pooled prevalence of puerperal sepsis and to identify its determinant factors in Ethiopia, thereby providing comprehensive and up-to-date evidence to inform maternal health interventions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The review was conducted in accordance with the Joanna Briggs Institute methodological guidance for systematic reviews and meta-analyses and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Systematic review and meta-analysis protocol was pre-registered on PROSPERO with registration number CRD42024619492. Databases including Web of Science, PubMed, Google Scholar, Scopus, ScienceDirect and gray literature were explored. Initially, 668 studies were identified. Newcastle-Ottawa scale was used to appraise included studies. The review included primary observation studies including cross-sectional, cohort, and case-control studies conducted on postpartum women in Ethiopia. This review excludes reviews, commentaries, case studies and pure qualitative studies. After screening and assessing eligibility criteria sixteen were included in the meta-analysis and systematic review. Data were extracted using an Excel sheet, and STATA version 15 was used for the meta-analysis. Heterogeneity among studies was evaluated using the Cochrane Q test and I&lt;sup&gt;2&lt;/sup&gt; statistic. A funnel plot and Egger's test were used to assess publication bias. Pooled prevalence of puerperal sepsis and effect sizes of determinant factors were assessed with 95% C. I. The pooled estimates were presented using a random effect model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study involved 5247 postpartum women in Ethiopia. The prevalence of puerperal sepsis was 15.82% (95%CI 9.84-21.80). Determinant factors of puerperal sepsis were cesarean section deliveries AOR 2.86(95%CI 2.17-3.76), more than five repeated vaginal examinations AOR 4.91(95%CI 3.84-6.28), low number of antenatal care contact AOR 5.52 (95%CI 3.63-8.40), prolonged labor AOR 5.56(95%CI 4.14-7.47), premature rupture of membranes AOR 3.86(95%CI 3.00-4.96), rural residence AOR 5.15(95%CI 3.99-6.65),and home deliveries AOR 3.45(95%CI 2.28-5.24).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The prevalence of puerperal sepsis in Ethiopia is high. Cesarean delivery, more than five vaginal examinations, lack of antenatal care, prolonged labor, premature rupture of membranes, rural residence, home delivery, and gestational diabetes were identified as significant risk factors for puerperal sepsis in Ethiopia. Therefore, adhering to labor care guide, and infection prevention protocol are pa","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"915"},"PeriodicalIF":3.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}