European Journal of Medical Research最新文献

{"title":"Evaluation of the systemic immune-inflammation index in relation to histological stages of celiac disease.","authors":"Fatih Kıvrakoğlu, Mustafa Ergin, Kenan Koşar","doi":"10.1186/s40001-025-02973-x","DOIUrl":"https://doi.org/10.1186/s40001-025-02973-x","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease (CD) is an immune-mediated enteropathy characterized by histopathological changes, such as villous atrophy and chronic inflammation, often assessed using the Marsh classification. The systemic immune-inflammation index (SII), a novel inflammatory biomarker, has been increasingly investigated in chronic inflammatory diseases, including CD.</p><p><strong>Objective: </strong>This study aims to evaluate the relationship between SII and histopathological progression in CD, as classified by the Marsh scores, and to assess other hematological and inflammatory parameters.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 115 biopsy-confirmed CD patients from 2 hospitals between February 2022 and November 2023. Demographic, clinical, and laboratory data were analyzed, and SII values were calculated. Statistical comparisons were performed across Marsh stages.</p><p><strong>Results: </strong>SII levels did not significantly differ among Marsh groups (p = 0.408). However, the Marsh Grade 3a group exhibited higher median SII values compared to others. Hemoglobin (Hb) levels showed significant differences across Marsh stages (p = 0.012), with a notable decrease in Marsh Grade 3c. Other parameters, such as ESR and CRP, showed no significant variation across groups.</p><p><strong>Conclusion: </strong>While SII shows potential as an inflammatory marker, its limited association with histological stages suggests a need for larger, prospective studies to validate its utility in clinical practice.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"694"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multinational association for supportive care in cancer (MASCC) versus clinical index of stable febrile neutropenia (CISNE): evaluation of predictive performance and clinical utility in patients with febrile neutropenia.","authors":"Süleyman Alpar, Sarper Yılmaz","doi":"10.1186/s40001-025-02858-z","DOIUrl":"https://doi.org/10.1186/s40001-025-02858-z","url":null,"abstract":"<p><strong>Objectives: </strong>Febrile neutropenia is a life-threatening complication of chemotherapy, requiring prompt risk stratification to guide initial management decisions. While the Multinational Association for Supportive Care in Cancer (MASCC) score has long been used to identify low-risk patients, the Clinical Index of Stable Febrile Neutropenia (CISNE) was developed more recently to refine prognostication among apparently stable individuals. However, there remains no consensus on which score performs better in real-world emergency settings.</p><p><strong>Methods: </strong>This retrospective, two-center study included adult patients diagnosed with FN who presented to the emergency departments of two tertiary hospitals between January 2022 and December 2024. Patients were categorized according to MASCC and CISNE scores based on clinical and laboratory parameters at admission. The primary outcome was defined as a composite of unfavorable in-hospital events, including hypotension, respiratory failure, ICU admission, major bleeding, organ dysfunction, or death. Discriminative ability was evaluated using ROC analysis and AUC comparison, with additional assessment via Net Reclassification Index (NRI) and Decision Curve Analysis (DCA).</p><p><strong>Results: </strong>A total of 528 patients were included; 137 (25.9%) experienced adverse outcomes. MASCC score demonstrated higher sensitivity (78.8%) compared to CISNE (50.4%), while CISNE had higher specificity (88.2% vs. 75.7%). The AUC for MASCC was 0.838 and for CISNE 0.814; the difference was not statistically significant (p = 0.357). However, NRI analysis favored MASCC, indicating more accurate risk classification. DCA further demonstrated superior net clinical benefit of MASCC across relevant probability thresholds.</p><p><strong>Conclusions: </strong>In the acute care setting, the MASCC score showed relatively higher sensitivity and clinical net benefit, supporting its potential value as a practical tool for early risk stratification in patients presenting with febrile neutropenia.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"692"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic CT findings and patient demographics associated with traumatic pneumothorax: recommendations for the emergency department.","authors":"Sercan Aydın, Seda Kahraman Aydın, Barış Gülmez, Beniz İrem Ersoy Sığva, Önder Kavurmacı, Ömer Faruk Dadaş","doi":"10.1186/s40001-025-02969-7","DOIUrl":"https://doi.org/10.1186/s40001-025-02969-7","url":null,"abstract":"<p><strong>Background: </strong>People with thoracic trauma often present to the emergency department with low-energy injuries and sustain rib fractures. This study aimed to assess the risk of traumatic pneumothorax in a patient cohort based on the radiological characteristics of rib fractures, along with patient and environmental variables.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of demographic characteristics, the number and nature of rib fractures, the date of trauma, and the correlation between pneumothorax and rib fractures in patients treated in the thoracic surgery departments of three centers between May 2021 and August 2024.</p><p><strong>Results: </strong>Gender, side of trauma, location of the rib fracture, and season were not found to correlate with traumatic pneumothorax. The probability of pneumothorax reduced by 2.1% with each 1-year increase in age (OR = 0.979; p = 0.006). Each fractured rib increased the incidence of traumatic pneumothorax by 23% (OR = 1.23; p = 0.011). Patients with at least one displaced rib fracture had a 2.08-fold higher incidence of traumatic pneumothorax compared to those without displaced rib fractures (OR = 2.08; p = 0.016). The cut-off number of rib fractures associated with traumatic pneumothorax was determined to be 3.5.</p><p><strong>Conclusions: </strong>Young patients arriving at the emergency room with acute thoracic trauma, those with at least one displaced rib fracture, and individuals with four or more rib fractures are at risk for traumatic pneumothorax. Patients exhibiting these features should be evaluated by thoracic surgery specialists in the emergency department.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"693"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic urticaria and vitamin D supplementations: a systematic review.","authors":"Ayesha Siddiqui, Aruna Bai, Haresh Kumar, Yash Roop Mandhwani, Anjali Bai, Priya Bai, Neha Kumar, F N U Muskan, Sumaiya Jatoi, Zulfiqar Ali, Abida Parveen","doi":"10.1186/s40001-025-02852-5","DOIUrl":"https://doi.org/10.1186/s40001-025-02852-5","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU), especially chronic spontaneous urticaria (CSU), is a long-term inflammatory skin condition marked by wheals and/or angioedema lasting over six weeks. Emerging evidence suggests a link between vitamin D deficiency and immune dysregulation associated with CU. Given vitamin D's immunomodulatory and anti-inflammatory effects, this review explores the therapeutic potential of vitamin D supplementation in CU management.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with PRISMA guidelines Electronic databases (PubMed, Scopus, Web of Science, and Google Scholar) were searched using relevant keywords. Studies included were randomized controlled trials (RCTs), case-control, and observational studies assessing serum vitamin D levels or supplementation in patients with CU. Data extraction and bias assessment were independently conducted using standardized tools: the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Eleven studies involving 1,491 participants were included. Most studies demonstrated significantly lower serum 25(OH)D levels in patients with CU compared to healthy controls. Vitamin D supplementation, particularly in individuals with a deficiency, was associated with reductions in urticaria activity scores, symptom severity, and improved quality of life. High-dose regimens (e.g., 4,000 IU/day or 60,000 IU/week) appeared more effective. However, results varied due to heterogeneity in study design, dosage, and patient characteristics.</p><p><strong>Conclusion: </strong>Vitamin D supplementation may serve as a safe, accessible adjunct to standard CU treatment, particularly for those with confirmed deficiency. While evidence suggests potential benefits, further high-quality RCTs are needed to establish causality, optimal dosing, and long-term efficacy.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"691"},"PeriodicalIF":3.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patient satisfaction and influencing factors in the treatment of striae distensae with novel growth factor-based serum.","authors":"Bárbara Loureiro, Yoshito Ito, Mauricio Gomes Favoreto","doi":"10.1186/s40001-025-02832-9","DOIUrl":"https://doi.org/10.1186/s40001-025-02832-9","url":null,"abstract":"<p><p>Striae distensae, commonly known as stretch marks, are dermal scars resulting from excessive skin stretching and structural remodeling. Despite numerous treatment modalities, patient satisfaction varies significantly, and effective management remains a challenge. This study aimed to evaluate patient satisfaction with novel serum containing amino acids, vitamins, and growth factors for the treatment of striae distensae and to assess the impact of individual characteristics, lesion aspects, and patient habits on treatment outcomes. A total of 156 patients underwent MN-assisted application of the serum. Treatment frequency and duration were determined by physicians on the basis of individual response. Patients completed an online questionnaire assessing demographics, lesion characteristics, lifestyle habits, and satisfaction via the customer satisfaction score (CSAT). Data were analyzed to identify factors influencing treatment satisfaction. Overall, 82.4% of patients were very satisfied, and 78.4% reported significant improvement in striae appearance. Satisfaction was highest in younger patients (≤ 44 years), those with newer striae, and nonsmokers. Patients with medium skin tones reported greater satisfaction than did those with very fair or dark brown/black skin tones. Most patients (65%) required only one treatment session to observe improvements, and 72% noticed visible results within two weeks. Adverse effects were minimal, affecting only 8.4% of the participants. The serum demonstrated high patient satisfaction and rapid improvement in the striae distensae. Factors such as age, striae duration, smoking, and skin tone influenced treatment outcomes. These findings support the importance of personalized treatment approaches for optimal results.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"684"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competing risk analysis of dexmedetomidine use and postoperative outcomes in non-traumatic subarachnoid hemorrhage patients.","authors":"Tian-Hua Lin, Zong-Jie Wang, Yun-Yun Tu, Mu-Hua Dong, Ting Qiu, Wen-Jie Lan, Ying Chen","doi":"10.1186/s40001-025-02962-0","DOIUrl":"10.1186/s40001-025-02962-0","url":null,"abstract":"<p><strong>Background: </strong>Dexmedetomidine is widely used in critically ill patients, but its effects on postoperative outcomes in non-traumatic subarachnoid hemorrhage (SAH) patients remain unclear. This study focuses on exploring the impact of dexmedetomidine on postoperative respiratory failure (RF) and in-hospital mortality.</p><p><strong>Methods: </strong>The data were downloaded from the Medical Information Mart for Intensive Care (MIMIC-IV) database, including 817 non-traumatic SAH patients. Propensity score matching (PSM) was performed. Multivariable logistic regression, sensitivity, interaction, and subgroup analyses were used to examine the association between dexmedetomidine use and RF or in-hospital mortality. A competing risk model was employed, with RF defined as the event of interest and in-hospital mortality as the competing event, to evaluate the survival probabilities for both outcomes.</p><p><strong>Results: </strong>Dexmedetomidine use was a risk factor for RF but a protective factor for in-hospital mortality both pre-/post-PSM (p < 0.05). The protective effect of dexmedetomidine on mortality was more pronounced in younger patients (≤ 62 years) and those without cerebrovascular disease. Competing risk analysis showed that even after adjusting for confounders, dexmedetomidine remained a significant protective factor for in-hospital mortality, but did not affect the incidence of RF.</p><p><strong>Conclusions: </strong>Dexmedetomidine use in non-traumatic SAH patients significantly reduces in-hospital mortality but does not affect the incidence of postoperative RF. These findings highlight the importance of considering competing risks when evaluating the effects of dexmedetomidine on postoperative outcomes.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"688"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ottawa ankle and foot rules in China: applicability in a defensive environment.","authors":"Cheng-Qi Jia, Ngwayi James Reeves Mbori, Siwei Li, Yahui Dai, Feng Xu, Daniel Edward Porter, Jie Tan","doi":"10.1186/s40001-025-02961-1","DOIUrl":"10.1186/s40001-025-02961-1","url":null,"abstract":"<p><strong>Background: </strong>The introduction of any new diagnostic method in a specific clinical setting and culture requires considerable caution, as sensitivity and specificity may be significantly affected. Whether the Ottawa ankle and foot rules (OAFR) are feasible in the Chinese environment is controversial. This study gauges attitudes and calculates the sensitivity and specificity of OAFR in mainland China.</p><p><strong>Methods: </strong>Short surveys were designed and disseminated to explore the perspective of emergency department trauma doctors and non-medical personnel towards OAFR. We conducted a prospective study at three hospital sites (one-level two hospital and two-level three hospitals) in three provinces. Documentation of OAFR outcomes was recorded in all patients with acute ankle and mid-foot injuries who presented to the three hospitals if they met the inclusion criteria. Anteroposterior and lateral radiographs of the ankle and/or foot were obtained for all patients based on the site of injury. All images were subsequently reviewed by a well-trained radiologist who was blinded to both the OAFR documentation and the emergency physician's interpretation. Radiographic results were compared with fracture prediction based on OAFR to calculate sensitivity and specificity in our patient population. Positive and negative predictive values were also calculated.</p><p><strong>Results: </strong>Only 31.5% of trauma doctors claimed to have heard of OAFR before, and 19.5% of them knew them in detail. 69.5% considered that department leadership in support of a strict interpretation of the rules would assist in their implementation. Both doctors and patients cited potential missed fractures as the dominant concern regarding the application of OAFR. 88.0% of non-medical persons claimed that they could accept the doctor's opinion if made based on these rules. Those with higher educational attainment would be more likely to accept the doctor's opinion. Overall sensitivity was 98.4% and specificity was 26.3%, for detecting fractures in acute ankle and mid-foot injuries. Four fractures out of 602 patients were missed based on OAFR, with one displaced 2nd and 3rd metatarsal fracture resulting in surgery.</p><p><strong>Conclusions: </strong>OAFR sensitivity in China is as high as in non-Asian populations. Their use is feasible and could be promoted to limit the unnecessary consumption of scare health resources. Survey data suggests implementation could be accepted by most doctors and patients, but would be hampered by the currently fragile doctor-patient relationship.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"687"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) to tackle central nervous system diseases: role as a promising approach.","authors":"Xiaoxiao Zheng, Wei Yuan, Ling Li, Hongyue Ma, Mingxia Zhu, Xiuli Li, Xinhong Feng","doi":"10.1186/s40001-025-02937-1","DOIUrl":"https://doi.org/10.1186/s40001-025-02937-1","url":null,"abstract":"<p><p>Atherosclerosis-associated disease (ASD) represents a complex pathological condition, characterized by the formation of atherosclerotic plaques within the arterial walls, encompassing cholesterol depositions, which is primarily attributed to elevated levels of low-density lipoprotein-cholesterol (LDL-C). A log-linear association between the absolute magnitude of LDL-C exposure and ASD risk has been widely studied. High levels of LDL-C have been acknowledged as the predominant culprit. The previous research findings have demonstrated that PCSK9 inhibitors (PCSK9i) can remarkably diminish the risk of ASD. The current research has primarily focused on the relevance of PCSK9 to the cardiovascular system and lipid metabolism; however, an increasing body of evidence shows that PCSK9 is pivotal in pathogenic processes in other organ systems. Yet, PCSK9's impact on the brain is complex and not fully clarified, although several recent studies emphasize a putative role of its impact on various neurodegenerative disorders. Among neurological disorders, not only stroke but neurogenesis, neural cell differentiation, central LDL receptor metabolism, neural cell apoptosis, neuroinflammation, alcohol use disorder (AUD), amyotrophic lateral sclerosis(ALS), and Alzheimer's Disease (AD) are related to PCSK9. PCSK9 expression in brain is low but greatly upregulated in neurological disorders. Therefore, PCSK9 is a promising pathway for the treatment of central nervous diseases. This review comprehensively describes evidence from the previous research on the effects of PCSK9i on the central nervous system, with a focus on the clinical potential of PCSK9i. We anticipate that this review will generate data that will help biomedical researchers or clinical workers develop treatments for the neurological diseases based on PCSK9i.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"690"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of differentially expressed immune-related genes in patients with systemic lupus erythematosus and the development of a hub gene-based diagnostic model.","authors":"Quangang Fang, Weili Kong, Huaping Zhou, Yilin Pang, Haiyun Liu","doi":"10.1186/s40001-025-02953-1","DOIUrl":"10.1186/s40001-025-02953-1","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is an incurable autoimmune disease that affects body tissues, but it can be managed with medication. Although therapeutic strategies for SLE have advanced, the underlying molecular mechanisms driving disease pathogenesis remain incompletely understood.</p><p><strong>Methods: </strong>This study analyzed gene expression data from three GEO microarray datasets to explore immunity-related differentially expressed genes (DEGs) in SLE. Using WGCNA, we identified gene modules and integrated them with immune-related DEGs to find candidate hub genes, which were validated using RT-qPCR. We constructed a PPI network and performed gene enrichment analysis to identify nine hub genes through ROC curve analysis. We confirmed the link between these hub genes and immune cells, conducted GSEA, and predicted drugs, miRNAs, and transcription factors (TFs) targeting these genes. LASSO and ROC analyses validated a model using immunity-related DEGs.</p><p><strong>Results: </strong>The forty immune-related DEGs were identified from a total of 1590 DEGs, 452 WGCN module genes, and 1791 immune genes. Nine hub genes (MX1, OAS1, OASL, IRF7, RSAD2, EIF2AK2, ISG15, IFIH1, and STAT1) were highlighted using Cytoscape and ROC analysis, with an AUC greater than 0.7. RT-qPCR confirmed significant overexpression of all hub genes except STAT1 in SLE. ssGSEA and GSEA linked these genes to immune cell infiltration and pathways, including \"cell cycle\" and \"RIG-I-like receptor signaling.\" A diagnostic model with three immune-related hub genes (MX1, IRF7, and EIF2AK2) demonstrated high accuracy (AUC > 0.8) in distinguishing SLE from healthy controls. Additionally, 9 target drugs, 14 target miRNAs, and 23 TFs were identified for these hub genes.</p><p><strong>Conclusions: </strong>MX1, IRF7, and EIF2AK2 may serve as candidate biomarkers for SLE and warrant further investigation.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"689"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal serum total bile acid trajectories and risk of metabolic dysfunction-associated fatty liver disease: a retrospective cohort study.","authors":"Huihui Chen, Xinyan Yu, Xueni Wang, Jiaojiao Huang, Jingni Wu, Xinmei Zhou, Kejia Hu, Zhenya Song","doi":"10.1186/s40001-025-02837-4","DOIUrl":"https://doi.org/10.1186/s40001-025-02837-4","url":null,"abstract":"<p><strong>Background: </strong>Evidence from cohort studies on the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and longitudinal changes in total bile acid (TBA) remains limited. This study aimed to investigate the association of TBA trajectories with new-onset MAFLD and liver fibrosis.</p><p><strong>Methods: </strong>A total of 3259 participants who underwent at least three health examinations at a hospital in Zhejiang between 2019 and 2023 were included. MAFLD was diagnosed via abdominal ultrasound, and liver fibrosis was assessed using the NAFLD fibrosis score (NFS) and fibrosis-4 score (FIB-4). Logistic regression models were used to analyse the associations between TBA trajectories and the risk of MAFLD and liver fibrosis.</p><p><strong>Results: </strong>During follow-up, 715 participants developed MAFLD. Among them, 15.10% had high NFS status, and 12.17% had high FIB-4 status. Compared with the low-stable TBA trajectory group, the high-stable trajectory group had a significantly higher risk of new-onset MAFLD (adjusted OR = 1.448, 95% CI 1.157-1.812). Subgroup analyses confirmed the robustness of these findings. Multinomial logistic regression revealed that the high-stable trajectory was associated with an increased risk of high NFS (adjusted OR = 2.435, 95% CI 1.568-3.781, P < 0.001) and high FIB-4 (adjusted OR = 3.194, 95% CI 2.006-5.087, P < 0.001).</p><p><strong>Conclusions: </strong>TBA trajectories are significantly associated with the risk of new-onset MAFLD and advanced liver fibrosis, as indicated by high NFS and FIB-4 scores. These findings highlight the potential role of TBA dynamics in MAFLD progression and fibrosis risk.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"685"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}